Sublingual Semaglutide (generic Ozempic®) now available! Get Started
Dashboard
Formulas

Acetaminophen 325 mg/Promethazine HCl 20 mg Suppository

The Acetaminophen 325 mg/Promethazine HCl 20 mg Suppository is a solid dosage form designed for insertion into a body cavity, typically the rectum or vagina. Upon dissolution or melting, it releases the medication for local or systemic absorption. This formulation is commonly used to alleviate pain, nausea, vomiting, allergic reactions, and motion sickness.

Want a different strength?
Click the Text Us button below.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
Starting at
Must be E-Prescribed
Get Started
Generate LeafletShow Leaflet
This medication requires a prescription from your doctor
Are you a prescriber? Sign Up
Trusted by 60,357 patients to date.
A group of faces of our past satisfied patients.
A svg symbol of a mortar and pestle with ingredients going in.
Custom made in our compounding labs.
Sliders that show the customization of ingredients.
Personalized treatment for better results.
User with a gear showing the personalization of the formulation.
All strengths and ingredients are tailored to your needs.
This medication is not available at retail pharmacies. It is compounded, and may be more effective at treating you or your patient.
Suppository
6427079ea64324184e5185c0
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Loading icon rotating.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Dosing Calculator

Get general dosing information for a patient by using this calculator.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Loading icon rotating.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Formula Information

A small arrow pointing down

Acetaminophen 325 mg/Promethazine HCl 20 mg Suppository is a compounded medication that combines two active ingredients, acetaminophen and promethazine hydrochloride, to treat a variety of conditions. This medication is a solid dosage form that is inserted into a body cavity, typically the rectum or vagina, where it dissolves or melts to release the medication for local or systemic absorption.

Acetaminophen is an analgesic and antipyretic that works to reduce pain and fever. Promethazine hydrochloride, on the other hand, is an antihistamine and sedative that helps to reduce inflammation and provide relief from itching and other symptoms. This combination of ingredients makes Acetaminophen 325 mg/Promethazine HCl 20 mg Suppository an effective treatment for a variety of conditions, including allergies, colds, flu, and other respiratory illnesses. It can also be used to treat nausea, vomiting, and motion sickness.

When used as directed, Acetaminophen 325 mg/Promethazine HCl 20 mg Suppository is a safe and effective medication. It is crucial to follow the instructions provided by your healthcare provider when taking this medication. This medication should not be used in children under the age of two, as it can cause serious side effects. If you have any questions about this medication or its use, please consult with your healthcare provider.

Drug Interactions

A small arrow pointing down

This compounded formulation of Acetaminophen 325 mg/Promethazine HCl 20 mg Suppository is designed for the treatment of symptoms such as nausea, vomiting, and pain associated with certain medical conditions. It is crucial to understand that this formulation is contraindicated in patients with a known hypersensitivity to either Acetaminophen or Promethazine HCl. Furthermore, it should not be administered to patients with a history of asthma, glaucoma, or urinary retention.

Patients are advised to abstain from alcohol while on this medication due to potential interactions. It is also important to note that this formulation may cause drowsiness, and patients should avoid operating heavy machinery or driving while on this medication. This formulation may also cause an increase in blood pressure and heart rate, so it should be used with caution in patients with hypertension or tachycardia.

There may be potential interactions with other medications, including anticholinergics, antihistamines, and monoamine oxidase inhibitors (MAOIs). Therefore, it is essential for patients to inform their healthcare provider of all medications they are currently taking before starting this formulation.

If you have any questions or concerns about this formulation, please do not hesitate to contact your healthcare provider or pharmacist for further information and guidance.

How Does it Work

A small arrow pointing down

This compounded formulation of Acetaminophen 325 mg/Promethazine HCl 20 mg Suppository is a powerful combination of two medications designed to alleviate a range of symptoms. Acetaminophen, a well-known analgesic and antipyretic, functions by inhibiting the production of prostaglandins, substances in the body that contribute to pain and fever. Promethazine HCl, on the other hand, is an effective antihistamine that blocks the action of histamine, a compound involved in allergic reactions. Together, these two medications work synergistically to reduce pain, fever, and allergic reactions.

When using this formulation, it is crucial to follow the instructions provided by your healthcare provider. The suppository should be inserted into the rectum, ensuring it is inserted as far as possible for optimal absorption. It is important not to break or cut the suppository before insertion. Once inserted, the suppository should remain in place for at least 15 minutes before removal to ensure the medication has sufficient time to dissolve or melt and release the medication for local or systemic absorption.

It is important to note that this formulation is not recommended for use in children under the age of 2 years. Additionally, it is not advised for use in pregnant or breastfeeding women due to potential risks. If you have any questions or concerns about using this formulation, please do not hesitate to reach out to your healthcare provider or pharmacist for further guidance and advice.

Other Uses

A small arrow pointing down

This compounded formulation of Acetaminophen 325 mg/Promethazine HCl 20 mg Suppository is a versatile medication that can be used to treat a variety of conditions. It may be used to alleviate symptoms of migraine headaches, colds, and flu-like symptoms. It can also be effective in reducing fever and managing itching and swelling associated with certain skin conditions. This formulation may also be beneficial for those suffering from insomnia, anxiety, and agitation. It can also be used to treat vertigo and reduce the symptoms of motion sickness.

Patients should be aware that this medication may cause drowsiness, and it is advised not to operate heavy machinery or drive while taking this medication. Dry mouth is another potential side effect, and patients are advised to drink plenty of fluids to stay hydrated. It is important to note that this formulation may interact with other medications, and should be used with caution in patients with a history of glaucoma, urinary retention, or asthma.

If you have any questions about this formulation or its potential uses and side effects, it is recommended to consult with your healthcare provider or pharmacist. They can provide you with the most accurate and personalized advice based on your specific health situation and medication regimen.

Frequently Asked Questions

A small arrow pointing down

What is the Acetaminophen 325 mg/Promethazine HCl 20 mg Suppository?

This is a compounded medication that combines Acetaminophen and Promethazine HCl in a suppository form. It is a solid dosage that is inserted into a body cavity, typically the rectum or vagina, where it dissolves or melts to release the medication for local or systemic absorption.

What is this medication used for?

Acetaminophen is used to relieve pain and reduce fever, while Promethazine HCl is used to treat allergies, motion sickness, nausea, and vomiting. The combination of these two medications in a suppository form allows for effective treatment of these symptoms.

How should I use this medication?

This medication should be inserted into the rectum or vagina as directed by your healthcare provider. It is designed to dissolve or melt once inserted, releasing the medication for absorption.

What should I do if I miss a dose?

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

What are the potential side effects of this medication?

Common side effects may include drowsiness, dizziness, constipation, and dry mouth. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Can I take this medication if I am pregnant or breastfeeding?

Consult your healthcare provider before using this medication if you are pregnant or breastfeeding. The effects on the unborn baby or nursing infant are not fully known.

Can I drink alcohol while using this medication?

Alcohol may increase the risk of liver damage while using this medication. It is best to consult your healthcare provider before consuming alcohol while using this medication.

What should I do if I have an allergic reaction to this medication?

If you have an allergic reaction, such as hives, difficulty breathing, or swelling of your face, lips, tongue, or throat, seek medical attention immediately.

Can I drive or operate machinery after using this medication?

This medication may cause drowsiness or dizziness. Do not drive, use machinery, or do anything that needs alertness until you can do it safely.

How should I store this medication?

Store this medication at room temperature, away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Related Formulas

Related Products
Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.