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Acyclovir 5%/Amitriptyline HCl 5%/Deoxy Glucose 0.2%/Diphenhydramine HCl 2%/Ketoprofen 10%/Lidocaine HCl 5% Topical Gel

This formulation is a compounded topical gel containing Acyclovir 5%, Amitriptyline HCl 5%, Deoxy Glucose 0.2%, Diphenhydramine HCl 2%, Ketoprofen 10%, and Lidocaine HCl 5%. It is a semisolid formulation dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency aids in the targeted treatment or absorption of the active ingredients.

The combination of these active ingredients is designed to treat a variety of disease states. Acyclovir is an antiviral medication used to treat infections caused by certain types of viruses. Amitriptyline HCl is a tricyclic antidepressant that can help manage chronic pain. Deoxy Glucose has potential anticancer and antiviral effects. Diphenhydramine HCl is an antihistamine that can relieve redness, itching, and swelling caused by various skin conditions. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can reduce pain and inflammation. Lastly, Lidocaine HCl is a local anesthetic that can provide numbing relief to the skin.

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Topical Gel
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Formula Information

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This formulation is a multi-component topical gel that combines Acyclovir 5%, Amitriptyline HCl 5%, Deoxy Glucose 0.2%, Diphenhydramine HCl 2%, Ketoprofen 10%, and Lidocaine HCl 5%. It is designed to be dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively for targeted treatment.

Acyclovir is an antiviral medication used to treat infections caused by certain types of viruses. It is commonly used for the treatment of cold sores, shingles, and chickenpox. Amitriptyline HCl is a tricyclic antidepressant that is used to treat various types of pain. It works by increasing the levels of certain chemicals in the brain that help elevate the mood and reduce the sensation of pain.

Deoxy Glucose is a glucose analog that is used in medical imaging to help identify areas of the body where cells are consuming glucose at a higher rate. In this formulation, it may help to enhance the absorption of other active ingredients. Diphenhydramine HCl is an antihistamine that is used to relieve symptoms of allergies, hay fever, and the common cold. It works by blocking the effects of histamine, a substance in the body that causes allergy symptoms.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain, swelling, and joint stiffness caused by arthritis. It works by reducing the levels of prostaglandins, chemicals that cells produce in response to injury and certain diseases. These chemicals cause pain, swelling, and inflammation. Lidocaine HCl is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes. It is used to relieve pain and discomfort from various conditions such as skin irritations and minor burns.

This formulation is designed to provide targeted relief from pain and inflammation, while also treating certain types of viral infections. It is important to use this medication as directed by your healthcare provider. If you have any questions about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. We are a team of knowledgeable compounding pharmacists who are here to assist you.

Drug Interactions

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This topical gel formulation contains a combination of Acyclovir, Amitriptyline HCl, Deoxy Glucose, Diphenhydramine HCl, Ketoprofen, and Lidocaine HCl. Each of these active ingredients has its own potential for drug interactions, which can be increased when used in combination. It's important to inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements.

Acyclovir, an antiviral medication, may interact with probenecid and tenofovir, potentially increasing the risk of kidney problems. Amitriptyline, a tricyclic antidepressant, has numerous potential interactions, including with MAO inhibitors, SSRIs, anticholinergic drugs, and certain heart medications. It's also important to avoid alcohol while using amitriptyline.

Deoxy Glucose, a glucose analog, may interact with other glucose-lowering medications, potentially leading to hypoglycemia. Diphenhydramine, an antihistamine, may interact with other CNS depressants, including alcohol, sedatives, and tranquilizers, potentially increasing drowsiness and reducing mental alertness.

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), may interact with blood thinners, other NSAIDs, corticosteroids, and certain blood pressure medications. It may also increase the risk of gastrointestinal bleeding when taken with alcohol or aspirin. Lidocaine, a local anesthetic, may interact with other local anesthetics and certain heart medications.

This formulation is designed for topical application and is intended to minimize systemic absorption. However, some absorption can still occur, especially if the medication is applied to broken or irritated skin, used over large areas, or used for prolonged periods. This can increase the risk of systemic side effects and drug interactions.

This formulation is used to treat a variety of conditions, including viral skin infections (acyclovir), nerve pain (amitriptyline), inflammation and pain (ketoprofen), local anesthesia (lidocaine), and itching (diphenhydramine). Deoxy Glucose is included to enhance the absorption and effectiveness of the other ingredients.

It's important to use this medication exactly as directed by your healthcare provider. Do not use more than the recommended dose or apply more frequently than instructed. If you experience any unusual side effects or if your condition does not improve or worsens, contact your healthcare provider immediately.

If you have any questions about this formulation or its potential interactions, please reach out to us. We are here to help and provide you with the most accurate and up-to-date information.

How Does it Work

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This formulation is a combination of six active ingredients: Acyclovir, Amitriptyline HCl, Deoxy Glucose, Diphenhydramine HCl, Ketoprofen, and Lidocaine HCl. Each of these ingredients plays a unique role in the treatment of various disease states.

Acyclovir is an antiviral medication that works by slowing the growth and spread of the herpes virus in the body. It is used to treat infections caused by certain types of viruses, including cold sores, shingles, and chickenpox. It does not cure these infections, but it can decrease the severity and length of outbreaks.

Amitriptyline HCl is a tricyclic antidepressant that works by affecting the balance of certain natural chemicals (neurotransmitters) in the brain. It is used to treat symptoms of depression, and in this formulation, it can also help to relieve certain types of nerve pain.

Deoxy Glucose is a glucose analog that is absorbed by cells but cannot be metabolized, effectively blocking the cells' use of natural glucose. This can help to starve and kill off certain types of cells, including some cancer cells.

Diphenhydramine HCl is an antihistamine that works by blocking the effects of the naturally occurring chemical histamine in the body. It is used to relieve symptoms of allergy, hay fever, and the common cold, including rash, itching, watery eyes, itchy eyes/nose/throat, cough, runny nose, and sneezing.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. It is used to treat pain or inflammation caused by arthritis, and in this formulation, it can also help to relieve localized pain and inflammation on the skin.

Lidocaine HCl is a local anesthetic that works by blocking nerve signals in your body. It is used to relieve pain and discomfort caused by skin irritations, including minor cuts, burns, and insect bites.

This formulation is dispensed through a pump mechanism, which allows for easy and precise application on the skin. The gel-like consistency helps to ensure that the active ingredients are absorbed effectively into the skin for targeted treatment.

If you have any questions about this formulation or how it works, please don't hesitate to reach out to us. We are here to help.

Other Uses

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Our unique compounding formulation combining Acyclovir, Amitriptyline HCl, Deoxy Glucose, Diphenhydramine HCl, Ketoprofen, and Lidocaine HCl in a topical gel has a significant range of potential uses beyond those originally envisioned. This formulation has primarily been used to manage conditions such as herpes cold sores, post-herpetic neuralgia, and neuropathic pain. However, given the diverse active ingredients, this could potentially be employed in other therapeutic scenarios as well.

For instance, considering the characteristics of Amitriptyline HCl - a tricyclic antidepressant often used to manage chronic pain - the gel could be explored for treating other chronic pain conditions, such as fibromyalgia or potentially arthritis. Of course, such use must be done under the close supervision of a healthcare professional to ensure safe and effective use.

Furthermore, Diphenhydramine HCl, a strong antihistamine, can potentially relieve allergy symptoms, itching, and hives caused by certain allergic reactions on the skin. Therefore, the compounded preparation might be beneficial in managing topical allergic reactions or insect bites. The anti-inflammatory action of Ketoprofen may assist in reducing local inflammation, contributing to symptomatic relief.

The addition of Lidocaine HCl, a local anesthetic, combined with the other elements, may work synergistically to numb skin and manage superficial pain. This characteristic could make this preparation particularly useful in certain procedures requiring minimal superficial anesthesia or for early stages of painful skin conditions like shingles.

However, caution must be exercised when using this formulation for other uses, as not all potential uses have been explored in clinical studies. While promising, off-label uses should always be discussed with a healthcare provider who can evaluate the potential risks and benefits based on the individual's unique health status. We at Bayview Pharmacy advise strictly adhering to your prescribing healthcare professional's advice when using this medication.

Please feel free to contact us at Bayview Pharmacy with any questions you may have about this specialized compounding formulation. Our expert team of pharmacists is always here to assist you and provide in-depth, personalized advice.

Frequently Asked Questions

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What is the purpose of the compounded formulation of Acyclovir 5%/Amitriptyline HCl 5%/Deoxy Glucose 0.2%/Diphenhydramine HCl 2%/Ketoprofen 10%/Lidocaine HCl 5% Topical Gel?

This compound formulation contains multiple active ingredients, each with a specific role, designed to provide targeted treatment through topical application. It is typically used for conditions like skin infections, inflammation, pain, and itchiness.

How should I apply this topical gel?

The gel should be applied directly to the skin over the affected area. It is dispensed through a pump mechanism, allowing for easy and precise application. Always follow your healthcare provider's directions on how much and how often to apply the gel.

What is the consistency of this gel?

The gel has a semisolid consistency that feels comfortable on the skin and gets readily absorbed to offer targeted treatment.

What should I expect after I apply the gel?

After you apply the gel, you should expect the active ingredients to absorb into your skin and provide relief from your symptoms. The gel's onset and overall effect may vary depending on the exact condition being treated.

Are there any side effects associated with this gel?

Some side effects may occur, such as skin irritation or allergic reactions. If you experience any unusual symptoms, discontinuing use and consulting your healthcare provider is recommended.

Can I use this gel with other medications?

Always discuss your current medications with your healthcare provider before starting any new treatment, including this topical gel. Some medications might interact with the active ingredients in the gel, causing unwanted effects.

Can I use this gel during pregnancy or breastfeeding?

Before using this gel during pregnancy or while breastfeeding, please consult with your healthcare provider. Although it is a topical treatment, some ingredients may get absorbed systemically and may have potential effects on the baby.

Is this gel safe for children?

The safety of this gel in children will depend on the age and condition being treated. Always consult your child's healthcare provider before starting this or any new medication.

Should I use the gel if it changes color or becomes runny?

If there is any change in the color, consistency, or smell of the gel, the product may be compromised. Contact your pharmacy or healthcare provider for guidance before using it.

What should I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. However, if it’s near the time for your next dose, skip the missed dose and continue as per your regular schedule. Do not double the dose to catch up.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.
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