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Aloe Vera 0.2%/Ketoprofen 2%/Lidocaine 2%/Misoprostol 0.0024%/Phenytoin 2% Topical Cream

This formulation is a semisolid preparation, dispensed in a pump mechanism for easy and controlled application on the skin. It contains Aloe Vera 0.2%, Ketoprofen 2%, Lidocaine 2%, Misoprostol 0.0024%, and Phenytoin 2%. The Aloe Vera is known for its soothing and healing properties, while Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation. Lidocaine is a local anesthetic that numbs the skin, Misoprostol is used to prevent stomach ulcers, and Phenytoin is an anti-epileptic drug that slows down impulses in the brain that cause seizures.

This topical cream is designed for localized treatment or absorption of these active ingredients. It is used to treat a variety of disease states, including skin inflammation, pain, stomach ulcers, and seizures. The pump mechanism allows for convenient and controlled application, ensuring the right amount of cream is applied to the affected area.

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Topical Cream
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Formula Information

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This formulation is a compounded topical cream containing Aloe Vera 0.2%, Ketoprofen 2%, Lidocaine 2%, Misoprostol 0.0024%, and Phenytoin 2%. It is a semisolid preparation dispensed in a pump mechanism, designed for convenient and controlled application on the skin for localized treatment or absorption of active ingredients.

Aloe Vera, a natural plant extract, is known for its soothing and healing properties. It can help reduce inflammation and promote wound healing. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. Lidocaine is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes. This can help to reduce pain or discomfort caused by minor skin irritations or procedures.

Misoprostol is a synthetic prostaglandin E1 analog with gastric antisecretory and antiulcer properties. It can help to protect the stomach lining and decrease the risk of stomach ulcers. Phenytoin is an anticonvulsant that also has anti-arrhythmic and muscle relaxant properties. It can help to slow down impulses in the brain that cause seizures and also help to reduce muscle spasms.

This formulation can be used to treat a variety of disease states. The combination of these active ingredients can help to reduce inflammation, numb the skin, promote wound healing, protect the stomach lining, and reduce muscle spasms. It can be particularly useful in treating conditions such as arthritis, neuropathic pain, skin irritations, and stomach ulcers.

Patients should apply this cream as directed by their healthcare provider, typically to the affected area(s) of skin. It is important to wash hands before and after applying this medication, and to avoid getting the cream in the eyes, nose, or mouth. If any side effects occur, such as redness, irritation, or a rash, patients should contact their healthcare provider immediately.

Prescribers should consider the individual patient's condition and medical history when deciding to use this formulation. It is important to monitor the patient's response to treatment and adjust the dosage or discontinue use if necessary. As with all medications, this formulation should be used with caution in patients with a history of allergies to any of the active ingredients.

If you have any questions about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is here to help.

Drug Interactions

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This topical cream formulation contains a combination of Aloe Vera, Ketoprofen, Lidocaine, Misoprostol, and Phenytoin. Each of these ingredients has a specific role in managing various skin conditions, providing anti-inflammatory, analgesic, and healing properties. However, it's important to be aware of potential drug interactions that may occur with this formulation.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can increase the risk of bleeding when used with other drugs that have the same effect, such as anticoagulants (e.g., warfarin) and antiplatelet drugs (e.g., aspirin). It may also interact with other NSAIDs, increasing the risk of gastrointestinal side effects. Additionally, it can reduce the effectiveness of certain blood pressure medications.

Lidocaine, a local anesthetic, can interact with other local anesthetics and certain antiarrhythmic drugs (e.g., amiodarone, mexiletine). Concurrent use may lead to additive systemic toxicity, including effects on the central nervous and cardiovascular systems.

Misoprostol, a prostaglandin analogue, can interact with antacids and may increase the risk of diarrhea. It should not be used in pregnant women as it can induce labor or cause abortion. Misoprostol may also interact with magnesium-containing antacids, leading to an increased risk of magnesium toxicity.

Phenytoin, an anticonvulsant, has a wide range of interactions. It can affect the metabolism of several drugs, including warfarin, digoxin, corticosteroids, and certain antibiotics. It can also interact with alcohol, increasing the risk of phenytoin toxicity. Additionally, drugs that alter the acidity of the urine can affect the elimination of phenytoin.

Aloe Vera, generally considered safe, can interact with certain drugs. It may decrease the absorption of oral drugs, and it can lower blood sugar levels, potentially affecting diabetes medications. It may also increase the risk of bleeding when used with anticoagulants or antiplatelet drugs.

This formulation is designed to treat various skin conditions by reducing inflammation, providing pain relief, and promoting healing. However, it's important to discuss all medications, supplements, and health conditions with your healthcare provider before starting this treatment. If you have any questions or concerns, please don't hesitate to reach out to us at Bayview Pharmacy.

How Does it Work

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This topical cream formulation combines the therapeutic benefits of Aloe Vera, Ketoprofen, Lidocaine, Misoprostol, and Phenytoin. Each of these ingredients plays a unique role in treating various disease states, providing a comprehensive approach to patient care.

Aloe Vera, at a concentration of 0.2%, is known for its soothing and healing properties. It helps to moisturize the skin, promote wound healing, and has anti-inflammatory effects. This makes it beneficial in conditions where the skin is irritated or inflamed.

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), is included at a concentration of 2%. It works by reducing the production of prostaglandins, substances in the body that cause inflammation. This helps to relieve pain and reduce swelling in conditions such as arthritis, sprains, and strains.

Lidocaine, also at a concentration of 2%, is a local anesthetic. It works by blocking nerve signals in your body, providing temporary relief from pain and discomfort. It is commonly used in conditions where pain relief is needed on the skin, such as minor burns, insect bites, or skin irritations.

Misoprostol, at a concentration of 0.0024%, is a prostaglandin analogue. It helps to protect the stomach lining by reducing the amount of acid that comes in contact with it. This can be beneficial in conditions where the skin is damaged or irritated.

Phenytoin, at a concentration of 2%, is an anticonvulsant that also has effects on the skin. It promotes healing by modulating the overproduction of skin cells in conditions such as psoriasis and eczema. It also has anti-inflammatory effects that can help to reduce swelling and discomfort.

This formulation is dispensed in a pump mechanism, which allows for convenient and controlled application on the skin. The active ingredients are absorbed through the skin, providing localized treatment for the affected area. This can help to reduce systemic side effects that can occur with oral medications.

As compounding pharmacists, we are able to customize this formulation to meet the specific needs of each patient. If you have any questions about this formulation or how it can be used to treat specific disease states, please don't hesitate to reach out to us at Bayview Pharmacy.

Other Uses

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This formulation contains a combination of ingredients designed to target and alleviate various sources of discomfort. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works to reduce inflammation, swelling, and pain. Lidocaine is a local anesthetic that helps numb the treated area, offering temporary relief from pain and discomfort associated with skin conditions or nerve-related issues. Misoprostol is added for its protective effects against gastric ulcers. In a topical formulation, it offers potential tissue-protective effects. Phenytoin offers potential wound healing properties due to its ability to promote fibroblast proliferation and collagen deposition. Aloe Vera, known for its soothing and anti-inflammatory properties, may also promote wound healing and skin hydration.

Although this cream is primarily designed for topical pain and wound management, there may be other possible uses. Beyond the mentioned indications, this topical cream may be used off-label for conditions where a combination of its active ingredients may provide relief. These may include but are not limited to localized muscle or joint pain, inflammatory skin conditions, certain types of neuropathic pain, bedsores, and minor burns. Importantly, each active ingredient in the formulation has a unique mechanism of action that can address different components of these conditions. Each use would, of course, depend on the individual patient, their current health state, and the discretion of the prescribing physician.

Patients should always consult with their healthcare provider or pharmacy before using this medication for conditions other than what it was prescribed for. They should also report any side effects or unexpected reactions that occur when using the medication. Prescribers should consider the potential benefits and risks before recommending this medication for any off-label use, as its safety and effectiveness may vary based on the condition, the patient, and their overall health. Any questions about this medication, its potential uses, or how to apply it should be directed to our team at Bayview Pharmacy.

Frequently Asked Questions

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What is this compounded formulation for?

This compounded formulation is designed for topical application on the skin for localized treatment or absorption of active ingredients. It exists to help manage pain, inflammation, and expedite healing.

How is this formulation administered?

The formulation is in a semi-solid form and is dispensed through a pump mechanism. This design allows for easy, controlled application on the skin.

What are the active ingredients in this formulation?

The active ingredients in this formulation are Aloe Vera 0.2%, Ketoprofen 2%, Lidocaine 2%, Misoprostol 0.0024%, and Phenytoin 2%.

What are the functions of these active ingredients?

Aloe Vera has healing and anti-inflammatory properties, Ketoprofen is a nonsteroidal anti-inflammatory drug for pain relief and reduction of swelling, Lidocaine is a local anesthetic, Misoprostol prevents stomach ulcers, and Phenytoin helps healing by modulating the wound healing responses.

Is this cream absorbed into the blood system?

Yes, this cream is designed to be absorbed through the skin. However, the extent of absorption can depend on factors such as the area of application and the integrity of the skin.

What are the potential side effects of this cream?

Side effects can vary based on individual reactions to the active components. They may include skin irritation, redness, or discomfort at the site of application. Always contact your healthcare provider if you experience severe or persistent side effects.

How should I store this formulation?

Store this cream at room temperature, away from direct light and heat. Also, keep it out of reach of children and pets to avoid accidental ingestion or misuse.

Can this compounded formulation be used with other medications?

You must consult your healthcare provider before using this cream with other medicines, as it can interact with them causing undesirable effects.

What should I do in case of an allergic reaction?

If you experience any signs of allergy such as hives, difficulty breathing, or swelling of your face, lips, tongue, or throat, stop using the cream and seek immediate medical help.

How often should I use this compounded formulation?

The frequency of use will be determined by your healthcare provider based on your condition and response to treatment.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.
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