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Aloe Vera 0.2%/Ketoprofen 2%/Lidocaine 2%/Misoprostol 0.0024%/Phenytoin Sodium 5% Topical Cream

This formulation is a semisolid preparation, dispensed in a pump mechanism for easy and controlled application on the skin. It is a compounded topical cream containing Aloe Vera 0.2%, Ketoprofen 2%, Lidocaine 2%, Misoprostol 0.0024%, and Phenytoin Sodium 5%. The cream is designed for localized treatment and absorption of these active ingredients.

The Aloe Vera in the formulation aids in soothing and healing the skin. Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), helps in reducing inflammation and pain. Lidocaine, a local anesthetic, provides temporary relief from pain and discomfort. Misoprostol, a prostaglandin, aids in protecting the stomach lining and is also used in the treatment of stomach ulcers. Phenytoin Sodium, an anticonvulsant, is used to control seizures and also promotes healing of the skin.

This formulation is used in the treatment of various disease states including inflammation, pain, stomach ulcers, and seizures. It is also beneficial in promoting skin healing and providing relief from discomfort associated with these conditions.

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Topical Cream
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Formula Information

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This formulation is a compounded topical cream containing Aloe Vera 0.2%, Ketoprofen 2%, Lidocaine 2%, Misoprostol 0.0024%, and Phenytoin Sodium 5%. It is a semisolid preparation dispensed in a pump mechanism, designed for convenient and controlled application on the skin for localized treatment or absorption of active ingredients.

Aloe Vera, a natural plant extract, is known for its soothing and healing properties. It can help to reduce inflammation and promote wound healing. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. Lidocaine is a local anesthetic that works by blocking nerve signals in your body, providing temporary relief from pain and discomfort. Misoprostol is a synthetic prostaglandin E1 analog with gastric antisecretory and antiulcer properties. It can help to protect the stomach lining and reduce the risk of stomach ulcers. Phenytoin Sodium is an anticonvulsant that can also promote healing in decubitus ulcers (pressure sores).

This formulation is used to treat a variety of conditions, including but not limited to, localized pain, inflammation, and skin ulcers. The combination of these active ingredients provides a multi-faceted approach to treatment, addressing pain, inflammation, and promoting healing. It is applied topically, which allows for targeted treatment of the affected area and reduces the risk of systemic side effects.

Patients should apply the cream as directed by their healthcare provider, typically to the affected area 3-4 times daily. It is important to wash hands before and after application and to avoid contact with eyes, mouth, and other mucous membranes. If any adverse reactions occur, such as rash, itching, swelling, severe dizziness, or trouble breathing, patients should seek medical attention immediately.

Prescribers should consider the patient's overall health status, other medications, and potential drug interactions when prescribing this formulation. Regular follow-up and monitoring are recommended to assess the patient's response to treatment and adjust the regimen as necessary.

If you have any questions about this formulation, its uses, or how to prescribe it, please don't hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is here to assist you.

Drug Interactions

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This formulation contains a combination of Aloe Vera, Ketoprofen, Lidocaine, Misoprostol, and Phenytoin Sodium. Each of these ingredients has its own unique properties and potential interactions with other medications.

Aloe Vera is generally considered safe for topical use and is not known to interact with other medications. However, it may increase the absorption of other topical medications, potentially enhancing their effects. Therefore, caution should be exercised when using this formulation with other topical treatments.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can interact with other NSAIDs, increasing the risk of gastrointestinal bleeding. It can also interact with blood thinners, such as warfarin, and certain high blood pressure medications, such as ACE inhibitors and diuretics. Patients should inform their healthcare provider if they are taking any of these medications.

Lidocaine is a local anesthetic that can interact with other local anesthetics and certain heart medications, such as beta-blockers and calcium channel blockers. It can also interact with antiarrhythmic drugs, such as amiodarone and quinidine. Patients should inform their healthcare provider if they are taking any of these medications.

Misoprostol is a prostaglandin that can interact with antacids and other medications that affect stomach acid, such as proton pump inhibitors and H2 blockers. It can also interact with certain medications used for gout, such as colchicine, and certain medications used for seizures, such as phenytoin. Patients should inform their healthcare provider if they are taking any of these medications.

Phenytoin Sodium is an anticonvulsant that can interact with a wide range of medications, including other anticonvulsants, certain antibiotics, certain antifungal medications, certain heart medications, and certain HIV medications. It can also interact with certain medications used for mental health conditions, such as antidepressants and antipsychotics. Patients should inform their healthcare provider if they are taking any of these medications.

This formulation is designed for localized treatment or absorption of active ingredients. It can be used to treat a variety of conditions, including pain, inflammation, and certain skin conditions. However, it should be used with caution in patients with certain medical conditions, such as liver disease, kidney disease, heart disease, and stomach ulcers. Patients should inform their healthcare provider if they have any of these conditions.

If you have any questions about this formulation or its potential interactions with other medications, please reach out to us. We are here to help.

How Does it Work

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This topical cream formulation combines the therapeutic benefits of Aloe Vera, Ketoprofen, Lidocaine, Misoprostol, and Phenytoin Sodium. Each of these ingredients plays a unique role in treating various disease states, providing a comprehensive approach to patient care.

Aloe Vera, at a concentration of 0.2%, is a natural substance known for its soothing and healing properties. It helps to moisturize the skin, promote wound healing, and has anti-inflammatory effects. This makes it beneficial in conditions where the skin is irritated or inflamed.

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), is included at a concentration of 2%. It works by reducing the production of prostaglandins, substances in the body that cause inflammation and pain. By applying Ketoprofen topically, it directly targets the area of discomfort, providing localized relief from pain and inflammation.

Lidocaine, a local anesthetic, is also included at a concentration of 2%. It works by blocking nerve signals in the body, providing temporary relief from pain and discomfort. This makes it particularly useful in conditions where the skin is painful or sensitive to touch.

Misoprostol, at a concentration of 0.0024%, is a synthetic prostaglandin E1 analogue. It has protective effects on the gastric mucosa, reducing the risk of NSAID-induced gastric ulcers. Although its use in a topical formulation is less common, it may contribute to the overall anti-inflammatory effect of the cream.

Phenytoin Sodium, at a concentration of 5%, is an antiepileptic drug that also has effects on cellular proliferation and immune response. In a topical formulation, it can promote wound healing and reduce inflammation. This makes it beneficial in conditions where the skin is damaged or healing is impaired.

This semisolid preparation is dispensed in a pump mechanism, designed for convenient and controlled application on the skin. The active ingredients are absorbed through the skin, providing localized treatment for the affected area. This formulation is designed to treat a variety of disease states, including but not limited to, inflammatory skin conditions, painful skin conditions, and conditions where wound healing is impaired.

If you have any questions about this formulation, or if you are a prescriber interested in using this formulation for your patients, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Other Uses

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This formulation primarily leverages Aloe Vera for its soothing and healing properties, Ketoprofen for its anti-inflammatory effects, Lidocaine for its analgesic action, Misoprostol for the promotion of healing in ulcerated or eroded areas, and Phenytoin Sodium for its potential to promote tissue regeneration. It is typically used for localized treatment of skin conditions that involve inflammation, pain, and erosion of the skin surface; but it has secondary uses as well.

Aside from the above-mentioned conditions, this cream can also be a significant advantage in post-surgical care wherein the promotion of healing, reduction of inflammation, and pain management are of utmost importance. It is particularly beneficial following certain dermatologic procedures like laser therapy, chemical peels, and dermabrasion where the skin surface undergoes substantial stress and damage.

The combination of Aloe Vera, Lidocaine, and Phenytoin Sodium can also be used to manage the symptoms of chronic conditions like diabetic neuropathy and post-herpetic neuralgia, where alleviation of pain and promotion of tissue healing can greatly enhance the quality of life for affected individuals.

In sports medicine, this formulation can be effectively used to manage localized soft tissue injuries like sprains and strains. Ketoprofen can help in reducing inflammation and pain, while Lidocaine provides immediate analgesic relief.

Interestingly, Misoprostol has been shown to be effective in the treatment of pressure ulcers, due to its healing properties. Therefore, this cream can be used as part of the management plan for bedsores and pressure ulcers in bedridden patients.

The wide range of uses for this formulation makes it a valuable addition to the treatment shortlist for a variety of conditions involving inflammation, pain, and impaired skin integrity. We strongly recommend patients and prescribers to reach out to us with any questions or concerns regarding the optimal use of this formulation for their specific needs.

Frequently Asked Questions

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What is this compounded formulation supposed to do?

This is a topical treatment cream that contains Aloe Vera, Ketoprofen, Lidocaine, Misoprostol, and Phenytoin Sodium. It's designed to relieve pain, decrease inflammation, and promote healing. Each component has a specific role to play, while working together for overall effectiveness.

How often can I apply this cream?

The frequency of application can vary depending on the individual’s ailment and the physician's instructions. Always consult your doctor or pharmacist for personalized instructions.

What is the best way to apply this cream?

This cream is dispensed through a pump mechanism for a controlled quantity. Apply it evenly over the affected area. After application, it's advisable to wash your hands unless they're the treated area.

What are the side effects?

Side effects can include slight burning, stinging, or redness at the application site. If these persist or worsen, contact your doctor immediately. Rarely, a serious allergic reaction to this formulation may happen.

Can this cream interact with other medications?

Yes, this compounded formulation can interact with other medication you may be taking. It's always advisable to inform your physician about any other medications you are currently taking.

Can I use this cream if I am pregnant or breastfeeding?

Pregnant and breastfeeding individuals are advised to consult their healthcare providers before using this cream, as it contains Misoprostol, a substance that can influence pregnancy outcomes.

Is it safe for children to use this cream?

Using this cream on children should be decided by a healthcare provider. Some ingredients may not be suitable for pediatric use. Please consult a healthcare professional before use.

Can I use this cream for long-term treatment?

The safety and efficacy of long-term use of this cream has not been established. Please consult with your healthcare provider for personalized treatment plans.

What happens if I apply more of the cream than recommended?

Applying more than the recommended quantity might not necessarily improve your ailment faster and may increase your risk of side effects. Please follow the recommended dosage or your healthcare provider’s instructions.

Can I use this cream on broken skin or open wounds?

It is not recommended to use this compounded formulation of Aloe Vera, Ketoprofen, Lidocaine, Misoprostol, and Phenytoin Sodium on broken skin or open wounds unless specifically advised by a healthcare professional.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.
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