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Amantadine HCl 10%/Diclofenac Sodium 8%/Gabapentin 6%/Lidocaine 5% Topical Gel

This formulation combines Amantadine HCl 10%, Diclofenac Sodium 8%, Gabapentin 6%, and Lidocaine 5% in a semisolid topical gel. The gel is dispensed through a pump mechanism, allowing for easy and precise application on the skin. The active ingredients in this formulation work together to provide targeted treatment for a variety of disease states.

Amantadine HCl is an antiviral medication that also has antiparkinsonian properties. Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation. Gabapentin is an anticonvulsant and nerve pain medication, often used to treat seizures and pain caused by shingles. Lidocaine is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes.

This combination of medications in a topical gel form is designed to provide relief from symptoms associated with conditions such as neuropathic pain, arthritis, shingles, and Parkinson's disease. The gel-like consistency allows for targeted treatment or absorption of the active ingredients, providing relief directly to the area of discomfort.

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Topical Gel
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Formula Information

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This formulation is a compounded topical gel containing Amantadine HCl 10%, Diclofenac Sodium 8%, Gabapentin 6%, and Lidocaine 5%. It is a semisolid formulation that is dispensed through a pump mechanism, allowing for easy and precise application on the skin. The gel-like consistency ensures that the active ingredients are absorbed effectively for targeted treatment.

Amantadine HCl is an antiviral medication that also has properties to relieve pain, particularly neuropathic pain. Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation by inhibiting the production of prostaglandins, substances in the body that cause inflammation. Gabapentin is an anticonvulsant that is often used to treat nerve pain. It works by stabilizing electrical activity in the brain and also affects the way the body senses pain. Lidocaine is a local anesthetic that works by blocking nerve signals in your body and is commonly used to relieve pain or discomfort caused by skin irritations.

This unique combination of ingredients works synergistically to provide relief from various disease states. It is particularly effective in managing neuropathic pain, inflammation, and skin irritations. The topical application allows for targeted treatment, reducing systemic side effects often associated with oral medications. It is important to use this medication as directed by your healthcare provider and to not use more than the recommended dose.

Patients should be aware that while this formulation can provide significant relief from pain and inflammation, it may also cause some side effects. These can include skin irritation at the application site, dizziness, or nausea. If these side effects persist or worsen, contact your healthcare provider immediately.

Prescribers should consider this formulation for patients who have not responded to traditional oral medications or who cannot tolerate them due to side effects. It is also an excellent option for patients who prefer a topical treatment method. As with all medications, it is important to monitor your patient's response to the treatment and adjust the dosage as necessary.

If you have any questions about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Drug Interactions

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This formulation combines four active ingredients: Amantadine HCl, Diclofenac Sodium, Gabapentin, and Lidocaine. Each of these ingredients has its own potential drug interactions, which can be exacerbated when used in combination. It's important to note that while this formulation is topical, systemic absorption can still occur, especially with prolonged use or application to large areas of skin.

Amantadine HCl is an antiviral medication that also has properties for treating Parkinson's disease and certain types of pain. It can interact with anticholinergic drugs, increasing the risk of side effects such as dry mouth, blurred vision, and urinary retention. Other potential interactions include live influenza vaccine, quinidine, and quinine, which can increase the risk of cardiac arrhythmias.

Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation. It can interact with other NSAIDs, increasing the risk of gastrointestinal bleeding. It can also interact with antihypertensive drugs, potentially reducing their effectiveness. Other potential interactions include warfarin, increasing the risk of bleeding, and lithium, potentially increasing lithium levels and toxicity.

Gabapentin is an anticonvulsant and nerve pain medication. It can interact with antacids, reducing the absorption of gabapentin. It can also interact with opioids, potentially increasing the risk of sedation and respiratory depression. Other potential interactions include alcohol, which can increase the risk of CNS depression, and certain antidiabetic drugs, potentially causing additive lowering of blood glucose levels.

Lidocaine is a local anesthetic. It can interact with other local anesthetics and antiarrhythmic drugs, potentially causing additive systemic toxicity. Other potential interactions include monoamine oxidase inhibitors (MAOIs), potentially increasing the risk of hypertension and serotonin syndrome, and certain antiviral drugs, potentially increasing the risk of lidocaine toxicity.

This formulation is intended for targeted treatment or absorption of active ingredients in a gel-like consistency. It can be used to treat a variety of disease states, including neuropathic pain, osteoarthritis pain, and certain types of skin pain. However, due to the potential for drug interactions, it's important for patients and prescribers to consider all medications the patient is currently taking, including over-the-counter drugs and dietary supplements.

If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us. We're here to help ensure that your treatment is as safe and effective as possible.

How Does it Work

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This formulation is a combination of four active ingredients: Amantadine HCl, Diclofenac Sodium, Gabapentin, and Lidocaine, each with a unique mechanism of action to provide relief from pain and inflammation.

Amantadine HCl is an antiviral medication that also has properties to relieve pain, particularly nerve pain. It works by blocking the action of certain chemicals in the body that may contribute to the sensation of pain.

Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing substances in the body that cause pain and inflammation. It is often used to treat mild to moderate pain, or signs and symptoms of osteoarthritis or rheumatoid arthritis.

Gabapentin is a medication used to treat nerve pain. It works by stabilizing electrical activity in the brain and affecting the way the nerves send messages to the brain about pain.

Lidocaine is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes. It works by blocking nerve signals in your body.

When combined in a topical gel, these four medications can provide targeted relief from pain and inflammation. The gel is applied directly to the area of pain, allowing for the active ingredients to be absorbed through the skin and act on the affected area. This can provide more direct relief and reduce the potential for systemic side effects that can occur with oral medications.

This formulation is particularly useful in treating conditions such as neuropathic pain, osteoarthritis, rheumatoid arthritis, and other conditions that cause inflammation and nerve pain. The combination of ingredients works to not only reduce inflammation but also to numb the area and reduce the sensation of pain.

As with any medication, it's important to use this formulation as directed by your healthcare provider. If you have any questions about this formulation or how to use it, don't hesitate to reach out to us at Bayview Pharmacy. We're here to help.

Other Uses

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Amantadine HCl, Diclofenac Sodium, Gabapentin, and Lidocaine Topical Gel is primarily formulated for the management of various types of neuralgic and neuropathic pain conditions. However, beyond the traditional use, it may exhibit efficacy for other conditions as well.

For instance, this formulation might provide symptomatic relief to patients suffering from conditions like osteoarthritis or rheumatoid arthritis. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) often used to reduce inflammation and pain associated with these types of conditions. Combined with lidocaine's local anesthetic properties, it could potentially help alleviate pain in patients with arthritic conditions. Please note that the use of this formulation for such purposes should be carefully considered and monitored due to potential systemic absorption and subsequent side effects of diclofenac.

Beyond that, the formulation could potentially be used for post-herpetic neuralgia, a complication of shingles characterized by severe pain. Gabapentin is commonly used in managing this, and thus the gel might be beneficial when it comes to providing targeted topical relief.

In addition, the formulation could be considered for management of pain from diabetic peripheral neuropathy. This painful condition is often characterized by numbness and pain in the hands and feet, and the inclusion of Gabapentin and Lidocaine in this gel could help manage these symptoms.

The use of this formulation beyond its traditional applications should be done under the supervision of a healthcare provider who can effectively monitor potential side effects and efficacy. Everyone is different, and what works for one person may not necessarily work for another. Potential side effects from this gel can include skin reactions, dizziness, and systemic NSAID-related effects among others. Therefore, always consult with your healthcare provider before embarking on new treatments.

We would like to remind both patients and prescribers that this medication should only be used as directed by a healthcare professional. If you consider using this formulation for any other purpose, please contact us at Bayview Pharmacy. We're here to provide you with all the necessary information to ensure safe and optimal use of this medication. If you have any other questions, feel free to reach out to us at any time.

Frequently Asked Questions

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What is this compounded formulation of Amantadine HCl 10%/Diclofenac Sodium 8%/Gabapentin 6%/Lidocaine 5% Topical Gel?

This is a semisolid, gel-like combination of four active ingredients and it is designed for targeted application on the skin.

How is this formulation dispensed?

The formulation is dispensed through a pump mechanism, which allows for an easy and precise amount of the medication to be applied to the skin.

What are the active ingredients in this formulation?

The active ingredients in this formulation are Amantadine HCl at 10%, Diclofenac Sodium at 8%, Gabapentin at 6% and Lidocaine at 5%.

How does this formulation work?

The active ingredients in this formulation work together to reduce pain and inflammation in the targeted area by being directly absorbed through the skin where applied.

How should I use this formulation?

You should apply the gel to the affected area as directed by your healthcare provider. The pump mechanism on the container will allow you to dispense the precise amount needed.

Can this formulation be used anywhere on the body?

This should be used only on the skin and in the specific area directed by your healthcare provider. Do not apply it near the eyes or mouth or on open wounds.

What if I apply more than the prescribed amount?

If more than the prescribed amount is used, wipe off the excess and contact your healthcare provider. Overuse may lead to more severe side effects.

What do I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. However, if it is close to the time for your next dose, just skip the missed dose and apply at the next scheduled time. Do not double the dose.

What are the potential side effects of this formulation?

As with any medication, side effects may occur. Common ones may include skin irritation or rash. If you experience serious side effects such as increased pain, swelling, or blistering, contact your healthcare provider immediately.

How should I store this formulation?

Keep this medication at room temperature and away from light and moisture. Do not freeze or store in extremely hot temperatures.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.
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