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Amitriptyline 5%/Camphor 2%/Cyclobenzaprine 5%/Doxepin 2%/Gaba 5%/Keto 10%/Lido 5%/Menthol 2%/Tramadol 5% Topical Cream

This formulation is a compounded topical cream containing Amitriptyline 5%, Camphor 2%, Cyclobenzaprine 5%, Doxepin 2%, Gaba 5%, Ketoconazole 10%, Lidocaine 5%, Menthol 2%, and Tramadol 5%. It is a semisolid preparation dispensed in a pump mechanism, designed for convenient and controlled application on the skin for localized treatment or absorption of active ingredients.

The cream is formulated to treat a variety of disease states. Amitriptyline and Doxepin are tricyclic antidepressants that can help manage chronic pain. Camphor and Menthol provide a cooling effect and help to soothe irritated skin. Cyclobenzaprine is a muscle relaxant that can help relieve muscle spasms. Gaba is a neurotransmitter that can help reduce anxiety and improve mood. Ketoconazole is an antifungal medication that can treat fungal infections. Lidocaine is a local anesthetic that can provide temporary relief from pain or discomfort. Tramadol is an opioid pain medication used to treat moderate to severe pain.

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Topical Cream
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Formula Information

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This formulation is a complex blend of active ingredients, each with its own unique therapeutic properties, combined in a topical cream designed for localized treatment. The cream is dispensed via a pump mechanism, which allows for convenient and controlled application on the skin.

Amitriptyline (5%) is a tricyclic antidepressant that has been found to be effective in treating neuropathic pain. It works by increasing the levels of certain chemicals in the brain that help elevate mood and reduce pain sensation. Camphor (2%) is a topical analgesic and counterirritant that provides a cooling sensation and helps to reduce pain and swelling.

Cyclobenzaprine (5%) is a muscle relaxant that works by blocking nerve impulses (or pain sensations) that are sent to your brain. Doxepin (2%) is a tricyclic antidepressant that increases the concentrations of certain neurotransmitters in the brain that help reduce itching and hives. Gaba (5%) is a neurotransmitter in the central nervous system that helps to reduce pain and inflammation.

Ketoprofen (10%) is a nonsteroidal anti-inflammatory drug (NSAID) that reduces hormones that cause inflammation and pain in the body. Lidocaine (5%) is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes. Menthol (2%) provides a cooling sensation and helps to numb the skin, reducing feelings of pain.

Tramadol (5%) is a narcotic-like pain reliever that works in the brain to change how your body feels and responds to pain. It is used to treat moderate to severe pain.

This formulation is designed to treat a variety of disease states, including neuropathic pain, muscle spasms, inflammation, and itching. The combination of these active ingredients provides a multi-modal approach to pain management, targeting different aspects of pain perception and inflammation.

As with any medication, it is important to use this formulation as directed by your healthcare provider. Side effects may include skin irritation, redness, or rash. If you experience any unusual symptoms, contact your healthcare provider immediately.

If you have any questions about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you.

Drug Interactions

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This topical cream is a complex formulation containing several active ingredients, each with its own potential for drug interactions. It is important to note that while the risk of systemic absorption and hence systemic drug interactions is lower with topical applications compared to oral or parenteral administration, it is not zero. Therefore, potential interactions should still be considered.

Amitriptyline is a tricyclic antidepressant that can interact with other medications that affect serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (MAOIs). Combining these medications can increase the risk of serotonin syndrome, a potentially life-threatening condition. Amitriptyline can also interact with anticholinergic drugs, increasing the risk of side effects such as dry mouth, constipation, and confusion.

Camphor, menthol, and lidocaine are topical analgesics. They are generally considered safe with minimal systemic absorption, but they can potentially interact with other topical products applied to the same area of skin. Concurrent use of multiple topical products can increase the risk of skin irritation or sensitivity reactions.

Cyclobenzaprine is a muscle relaxant that can interact with other CNS depressants, including alcohol, benzodiazepines, and opioids, potentially leading to increased sedation or respiratory depression. It can also interact with other medications that affect serotonin levels, similar to amitriptyline.

Doxepin, like amitriptyline, is a tricyclic antidepressant and has similar potential interactions. It can also interact with antihistamines, leading to increased sedation.

Gaba (gamma-aminobutyric acid) is a neurotransmitter that can interact with other medications that affect GABA levels or activity, including benzodiazepines, barbiturates, and alcohol. These interactions can potentially increase the risk of sedation or CNS depression.

Ketoconazole is an antifungal medication that can interact with many other drugs due to its effect on liver enzymes. It can increase the levels of many other medications, potentially leading to increased side effects or toxicity.

Tramadol is an opioid analgesic that can interact with other opioids, benzodiazepines, alcohol, and other CNS depressants, potentially leading to increased sedation or respiratory depression. It can also interact with other medications that affect serotonin levels, similar to amitriptyline and doxepin.

This formulation is designed to treat a variety of conditions, including neuropathic pain, muscle spasms, and certain skin conditions. The combination of ingredients provides both analgesic and anti-inflammatory effects, as well as local anesthesia and muscle relaxation. However, due to the complex nature of this formulation and the potential for drug interactions, it should be used under the supervision of a healthcare provider. If you have any questions about this formulation or its potential interactions, please reach out to us at Bayview Pharmacy.

How Does it Work

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This topical cream is a complex formulation of multiple active ingredients, each with its own unique mechanism of action. The cream is designed to be applied directly to the skin, where it can be absorbed locally to provide targeted relief from various symptoms. The pump mechanism allows for controlled application, ensuring that the correct dose is applied each time.

Amitriptyline and Doxepin are tricyclic antidepressants that work by increasing the levels of certain chemicals in the brain that help elevate mood. In this formulation, they are used for their analgesic properties, helping to relieve pain in the area where the cream is applied. They can also help to reduce itching and inflammation.

Camphor and Menthol are topical analgesics that provide a cooling sensation when applied to the skin. This can help to numb the skin and reduce pain. They also have mild anti-inflammatory properties.

Cyclobenzaprine is a muscle relaxant that works by blocking nerve impulses (or pain sensations) that are sent to your brain. This can help to relieve muscle spasms and associated pain.

Gaba (Gamma-aminobutyric acid) is a naturally occurring amino acid that works as a neurotransmitter in your brain. It is thought to help reduce pain and inflammation by inhibiting certain nerve transmissions in your brain.

Keto (Ketoprofen) is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body.

Lido (Lidocaine) is a local anesthetic that works by causing temporary numbness in the area where it is applied. This can help to relieve pain and discomfort.

Tramadol is a strong painkiller that works by blocking the transmission of pain signals in the central nervous system. This can help to reduce pain in the area where the cream is applied.

This formulation is designed to treat a variety of disease states, including neuropathic pain, musculoskeletal pain, inflammation, and certain skin conditions. By combining these active ingredients into a single topical cream, it allows for targeted treatment of symptoms with minimal systemic absorption, reducing the risk of side effects.

If you have any questions about this formulation, please don't hesitate to reach out to us. We are here to help and provide you with the information you need to make informed decisions about your treatment options.

Other Uses

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This topical cream is primarily indicated for the localized treatment of chronic pain, muscle spasms and associated inflammatory conditions. However, it may also be used for other therapeutic indications. The combination of amitriptyline, camphor, cyclobenzaprine, doxepin, gaba, keto, lido, menthol, and tramadol in this formulation allows for a broad range of potential uses.

For instance, Amitriptyline and Doxepin, as tricyclic antidepressants, may provide symptomatic relief for certain dermatological conditions such as pruritus, lichen simplex chronicus, and neurodermatitis. The addition of cyclobenzaprine, a muscle relaxant, and tramadol, a centrally acting opioid analgesic, could potentially be beneficial in the management of symptoms associated with fibromyalgia and other similar conditions causing muscle stiffness and pain.

The menthol in this formulation has local anesthetic and counterirritant properties, aiding in relief from minor aches and muscle cramps. GABA (gamma-aminobutyric acid), a naturally occurring amino acid, works as a neurotransmitter in the brain and may impart a calming effect, potentially beneficial for neuropathic pain and anxiety. The cream additionally contains Lidocaine (Lido), commonly used to relieve pain and discomfort from skin irritations, burns, and insect bites.

The formulated Ketoconazole (Keto) is an antifungal medication that might be beneficial to patients suffering from tinea infections such as athlete’s foot, jock itch, and ringworm. Additionally, Camphor could potentially provide a cooling effect and act as a mild local anesthetic.

Keep in mind that regardless of potential indications, this topical cream should be used under the supervision and guidance of a healthcare provider. Always consult with a healthcare provider before starting any new medication. It's important to understand that the efficacy and safety of this formulation for the listed conditions have not been fully established in controlled clinical studies. Individual results may vary and potential side effects should be monitored closely.

If you have any questions regarding this formulation or its potential uses, please feel free to reach out to us at Bayview Pharmacy. Our compounding pharmacists are always ready to provide the necessary support and information.

Frequently Asked Questions

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What is Amitriptyline 5%/Camphor 2%/Cyclobenzaprine 5%/Doxepin 2%/Gaba 5%/Keto 10%/Lido 5%/Menthol 2%/Tramadol 5% Topical Cream?

This is a compounded medication containing nine active ingredients, which are designed to relieve pain and inflammation when applied topically to the skin. The cream is encapsulated within a pump mechanism for ease of application and to provide a controlled dosage.

How do I use this topical cream?

Apply a thin layer onto the skin over the affected area and gently massage until it is fully absorbed. Do not cover treated skin unless your doctor has told you to. Always follow your doctor's instructions about how often to apply the cream.

What precautions should I take while using this cream?

Do not use this cream if you are allergic to any of the ingredients. Avoid applying it to open wounds, burns, or broken or inflamed skin. Also, avoid contact with eyes or mucous membranes. If accidental eye contact occurs, rinse thoroughly with water.

What are the potential side effects of this cream?

Possible side effects may include redness, burning, or stinging at the application site. If these persist or worsen, or if you experience severe rash, itching, swelling, severe dizziness, or trouble breathing, seek medical help immediately.

Can I use this cream if I am pregnant or breastfeeding?

Consult your healthcare provider before using this medication if you are pregnant, planning to become pregnant, or are breastfeeding. The active ingredients may have potential effects on the fetus or breastfeeding infant.

How should I store this cream?

Store this medication at room temperature, away from moisture and heat. Do not freeze. Keep it out of reach of children.

What should I do if I miss a dose?

If you miss a dose, use it as soon as you remember. If it's almost time for your next dose, skip the missed one and continue with your regular dosing schedule. Do not use extra cream to make up for the missed dose.

Can I use other creams or lotions with this cream?

Wait at least 5-10 minutes after applying this cream before applying any other skin products to allow it to be absorbed properly. If you're unsure, consult with your healthcare provider.

How long does it take for this cream to work?

The time for improvement can vary depending on the individual and the condition being treated. Regular use as prescribed by your doctor will provide the best results.

What if my symptoms do not improve?

If your symptoms do not improve or if they worsen, contact your healthcare provider. Do not increase the dosage or frequency of application without consulting your healthcare provider.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.
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