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Amitriptyline 5%/Cyclobenzaprine 5%/Gabapentin 5%/Ketoprofen 10%/Lidocaine 5%/Tramadol 5% Topical Cream

FDA-approved generic
Dose form
Topical Cream
Active ingredients
Amitriptyline Hydrochloride
Cyclobenzaprine Hydrochloride
Gabapentin
Ketoprofen
Lidocaine Hydrochloride
Tramadol Hydrochloride

This formulation is a compounded topical cream containing Amitriptyline 5%, Cyclobenzaprine 5%, Gabapentin 5%, Ketoprofen 10%, Lidocaine 5%, and Tramadol 5%. It is a semisolid preparation dispensed in a pump mechanism, designed for convenient and controlled application on the skin for localized treatment or absorption of active ingredients.

The cream is specifically formulated to treat a variety of disease states. Amitriptyline, a tricyclic antidepressant, and Gabapentin, an anticonvulsant, are used for their analgesic properties in managing neuropathic pain. Cyclobenzaprine, a muscle relaxant, aids in relieving muscle spasms. Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), and Lidocaine, a local anesthetic, provide relief from inflammation and localized pain. Tramadol, an opioid analgesic, is used for its potent pain-relieving properties.

Together, these active ingredients work synergistically to provide comprehensive pain management.

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For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
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This medication requires a prescription from your doctor
Ships within 1 to 2 business days after pharmacist verification
HSA and FSA eligible
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Get a one-page sheet with everything your doctor needs to prescribe this and send it to Bayview.

Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.

For prescribersSign in for prescription details and order forms.
Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Amitriptyline Hydrochloride
Cyclobenzaprine Hydrochloride
Gabapentin
Ketoprofen
Lidocaine Hydrochloride
Tramadol Hydrochloride
Topical Cream
652f26acbf19fb8ff3fe5ca4
Service area

Can we ship this formula to your state?

Bayview fills prescriptions for patients in Connecticut, Florida, Maine, Massachusetts, New Hampshire, New Jersey, Pennsylvania and Rhode Island. New York patients are served on a limited basis while nonresident pharmacy registration is pending.

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Currently licensed Limited basis, registration pending Not available for this formula Not currently licensed

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Formula Information

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This formulation is a compounded topical cream containing Amitriptyline 5%, Cyclobenzaprine 5%, Gabapentin 5%, Ketoprofen 10%, Lidocaine 5%, and Tramadol 5%. It is a semisolid preparation dispensed in a pump mechanism, designed for convenient and controlled application on the skin for localized treatment or absorption of active ingredients.

Amitriptyline is a tricyclic antidepressant that is used in this formulation for its analgesic properties. It works by increasing the levels of certain chemicals in the brain that help elevate mood and reduce pain sensation. Cyclobenzaprine is a muscle relaxant that works by blocking nerve impulses (or pain sensations) that are sent to your brain. Gabapentin is an anticonvulsant and nerve pain medication that is used to treat nerve pain and control seizures. It works by affecting the chemicals and nerves in the body that are involved in the cause of seizures and some types of pain.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. Lidocaine is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes. Tramadol is an opioid pain medication used to treat moderate to severe pain. It works in the brain to change how your body feels and responds to pain.

This formulation is used to treat a variety of disease states that involve pain and inflammation. These may include conditions like fibromyalgia, neuropathic pain, musculoskeletal pain, and certain types of arthritis. The combination of these medications in a topical form allows for targeted relief at the site of pain, with a reduced risk of systemic side effects compared to oral medications.

It is important to use this medication as directed by your healthcare provider. Apply a thin layer of the cream to the affected area, usually 3 to 4 times daily or as directed by your doctor. Wash your hands immediately after use unless you are treating an area on the hands. Avoid getting the product in your eyes, nose, or mouth. If you do get the medication in those areas, flush with plenty of water.

As with any medication, there may be potential side effects. These can include skin irritation at the application site, such as redness, burning, or itching. If these effects persist or worsen, notify your doctor or pharmacist promptly. It is important to note that this is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

If you have any questions about this formulation, its use, or potential side effects, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you.

Drug Interactions

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This topical cream formulation contains a combination of Amitriptyline, Cyclobenzaprine, Gabapentin, Ketoprofen, Lidocaine, and Tramadol. Each of these active ingredients has a specific role in managing various disease states, primarily related to pain and inflammation. However, it's important to be aware of potential drug interactions that may occur with this formulation.

Amitriptyline, a tricyclic antidepressant, may interact with MAO inhibitors, leading to serious, potentially fatal, interactions. It may also interact with anticholinergic drugs, increasing the risk of side effects such as dry mouth, constipation, and confusion. Concurrent use with other CNS depressants may enhance the sedative effect.

Cyclobenzaprine, a muscle relaxant, may interact with MAO inhibitors, causing hypertensive crisis. It may also interact with CNS depressants, enhancing their sedative effects. Concurrent use with serotonergic drugs may increase the risk of serotonin syndrome.

Gabapentin, an anticonvulsant, may interact with antacids, reducing its absorption. It may also interact with opioids, enhancing the risk of CNS depression, including respiratory depression.

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), may interact with anticoagulants, increasing the risk of bleeding. It may also interact with other NSAIDs, leading to an increased risk of gastrointestinal bleeding. Concurrent use with ACE inhibitors or ARBs may decrease their effectiveness and increase the risk of renal impairment.

Lidocaine, a local anesthetic, may interact with antiarrhythmic drugs, leading to additive cardiac effects. It may also interact with other local anesthetics, leading to additive systemic toxicity.

Tramadol, an opioid analgesic, may interact with other opioids, leading to additive CNS and respiratory depression. It may also interact with serotonergic drugs, increasing the risk of serotonin syndrome. Concurrent use with anticoagulants may increase the risk of bleeding.

This formulation is primarily used for the management of localized pain and inflammation. Amitriptyline and Gabapentin are used for neuropathic pain, Cyclobenzaprine for muscle spasms, Ketoprofen for inflammation, Lidocaine for numbing the application area, and Tramadol for severe pain. However, the combined use of these drugs in a single formulation should be done under the supervision of a healthcare provider due to the potential for drug interactions.

If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information you need to use this formulation safely and effectively.

How Does it Work

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This topical cream is a compounded medication that contains six active ingredients: Amitriptyline, Cyclobenzaprine, Gabapentin, Ketoprofen, Lidocaine, and Tramadol. Each of these ingredients plays a unique role in managing pain and inflammation.

Amitriptyline is a tricyclic antidepressant that works by increasing the levels of certain chemicals in the brain that help improve mood, pain threshold, and sleep. When applied topically, it can help reduce pain and inflammation in the area of application.

Cyclobenzaprine is a muscle relaxant that works by blocking nerve impulses (or pain sensations) that are sent to your brain.

Gabapentin is an anticonvulsant and nerve pain medication. It works by affecting the chemicals and nerves in the body that are involved in the cause of seizures and some types of pain. Topically, it can help to reduce nerve pain in the area of application.

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body. When applied topically, it can help reduce inflammation and pain in the area of application.

Lidocaine is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes. This can help to reduce pain and discomfort in the area of application.

Tramadol is a narcotic-like pain reliever. It works in the brain to change how your body feels and responds to pain. When applied topically, it can help to reduce pain in the area of application.

This formulation is dispensed in a pump mechanism, which allows for convenient and controlled application on the skin. The active ingredients are then absorbed through the skin, providing localized treatment for pain and inflammation.

This formulation can be used to treat a variety of disease states that involve pain and inflammation, including but not limited to: neuropathic pain, fibromyalgia, arthritis, and musculoskeletal pain. As with any medication, it is important to use this formulation as directed by your healthcare provider.

If you have any questions about this formulation, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help.

Frequently Asked Questions

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What is the purpose of this compounded formulation cream?

This cream is intended to help reduce localized pain and discomfort. It contains several active ingredients including Amitriptyline, Cyclobenzaprine, Gabapentin, Ketoprofen, Lidocaine, and Tramadol, each of which contributes towards pain management.

How should I apply the cream?

The cream should be applied directly to the skin over the area of pain. Dispensed by a pump mechanism, it ensures controlled application. Apply as directed by your healthcare provider.

What are the possible side effects of this cream?

While side effects vary for each individual, they may include skin irritation or rash at the site of application. If you experience any severe or lasting side effects, inform your healthcare provider immediately.

Can I use the cream on an open wound?

No, the cream is not designed for use on open wounds, damaged skin, or mucous membranes. It should only be used on intact skin.

How does the pump mechanism work?

The pump mechanism ensures a consistent dose with each application. To use, simply depress the pump and apply the dispensed amount on the skin. Always follow the dosage directions provided by your healthcare provider.

Can I use the cream more than once a day?

You should follow your healthcare provider's directions on the frequency of usage. Avoid using more than advised as this could potentially lead to an overdose of the active ingredients.

Can I apply the cream with other ointments or creams?

Please consult with your healthcare provider before using this cream with other topical medications. There could be potential interactions which may affect the efficacy of the medications.

Should I wash the treated area after application?

No, the cream should remain on the skin to ensure optimum absorption of the active ingredients. Avoid washing or rubbing the treated area immediately after application.

What should I do if I accidentally ingest some of the cream?

If the cream is accidentally ingested, seek immediate medical attention. Although applied topically, the active ingredients can still have internal effects if ingested.

Should I store the cream in any specific conditions?

The cream should be stored at room temperature, away from heat and direct sunlight. Keep the container tightly closed when not in use and out of reach of children and pets.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.

This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Amitriptyline 5%/Cyclobenzaprine 5%/Gabapentin 5%/Ketoprofen 10%/Lidocaine 5%/Tramadol 5% Topical Cream
Topical Cream
30 g
controlled

Apply topically to affected area(s)

Three times daily