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Formulas

Amitriptyline 5%/Ketamine HCl 5.75%/Ketoprofen 10% Topical Ointment

FDA-approved generic
Dose form
Topical Ointment
Active ingredients
Ketamine Hydrochloride
Ketoprofen
Amitriptyline Hydrochloride

This formulation is a semi-solid topical ointment containing Amitriptyline 5%, Ketamine HCl 5.75%, and Ketoprofen 10%. It is dispensed in a tube and is designed for external application to the skin. The greasy or oily base of the ointment aids in the delivery of these therapeutic agents for localized treatment.

The combination of Amitriptyline, a tricyclic antidepressant, Ketamine, an NMDA receptor antagonist, and Ketoprofen, a nonsteroidal anti-inflammatory drug, provides a multi-modal approach to pain management. This formulation is typically used for conditions such as skin inflammation, infections, or wound healing. It is particularly beneficial for patients suffering from neuropathic pain conditions, where conventional treatments may not provide adequate relief.

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For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
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This medication requires a prescription from your doctor
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Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.

For prescribersSign in for prescription details and order forms.
Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Ketamine Hydrochloride
Ketoprofen
Amitriptyline Hydrochloride
Topical Ointment
652ef57ce5ce2a158004fd1a
Service area

Can we ship this formula to your state?

Bayview fills prescriptions for patients in Connecticut, Florida, Maine, Massachusetts, New Hampshire, New Jersey, Pennsylvania and Rhode Island. New York patients are served on a limited basis while nonresident pharmacy registration is pending.

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Formula Information

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This formulation combines Amitriptyline 5%, Ketamine HCl 5.75%, and Ketoprofen 10% in a topical ointment. It works by increasing the levels of certain chemicals in the brain that help improve mood, sleep, and the body's response to pain. Ketamine HCl is a powerful anesthetic that can provide significant pain relief when used topically. It works by blocking certain receptors in the brain that are responsible for transmitting pain signals. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain in the body by reducing the production of certain substances that cause inflammation and pain.

The ointment is designed to be applied externally to the skin. The greasy or oily base of the ointment aids in the delivery of the medication, allowing it to penetrate the skin and provide localized treatment. The combination of these three active ingredients provides a multi-pronged approach to pain management, addressing both the symptoms and the underlying causes of pain.

Patients should apply the ointment as directed by their healthcare provider, typically to the affected area several times a day. It's important to wash hands before and after applying the ointment, and to avoid getting the ointment in the eyes, nose, or mouth. Side effects may include skin irritation at the application site, drowsiness, or dizziness. If these side effects persist or worsen, patients should contact their healthcare provider immediately.

Prescribers should consider this formulation for patients who have not responded to other forms of pain management, or who cannot tolerate oral medications due to side effects or other medical conditions. As with all medications, it's important to consider the potential risks and benefits, and to monitor patients closely for side effects or adverse reactions.

If you have any questions about this formulation, please don't hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is always here to help.

Drug Interactions

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This formulation combines Amitriptyline, Ketamine HCl, and Ketoprofen in a topical ointment. Each of these active ingredients has a specific role in managing pain and inflammation, particularly in localized areas. Amitriptyline is a tricyclic antidepressant that can help manage chronic pain. Ketamine HCl is an NMDA receptor antagonist that can provide analgesic effects. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that can reduce inflammation and pain.

However, as with any medication, there are potential drug interactions to be aware of. Amitriptyline can interact with other antidepressants, including selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), and other tricyclic antidepressants. It can also interact with anticholinergic drugs, thyroid medications, and certain heart medications. It's important to inform your healthcare provider of all medications you're currently taking, including over-the-counter drugs and supplements.

Ketamine HCl can interact with central nervous system depressants, including alcohol, benzodiazepines, and opioids. It can also interact with certain antibiotics, heart medications, and medications used for Parkinson's disease. Again, it's crucial to inform your healthcare provider of all medications you're currently taking.

Ketoprofen can interact with other NSAIDs, blood thinners, certain heart medications, and certain types of antidepressants. It can also interact with alcohol, leading to an increased risk of stomach bleeding. Inform your healthcare provider if you're taking any of these medications or if you consume alcohol regularly.

While this formulation is designed for topical use and therefore has a lower risk of systemic absorption, interactions can still occur. It's important to use this medication as directed by your healthcare provider and to monitor for any potential side effects or interactions. If you notice any unusual symptoms or reactions, contact your healthcare provider immediately.

This formulation is typically used for conditions such as skin inflammation, infections, or wound healing. The combination of analgesic and anti-inflammatory effects can help manage pain and reduce inflammation in these conditions. However, it's important to note that this medication should not be used on broken or infected skin unless directed by a healthcare provider.

If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us. We're here to help ensure that you're using your medication safely and effectively.

How Does it Work

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This formulation combines three active ingredients: Amitriptyline, Ketamine HCl, and Ketoprofen, each with a unique mechanism of action to provide relief from pain and inflammation. It is designed to be applied topically, directly to the skin, where it can act locally on the affected area.

Amitriptyline is a tricyclic antidepressant that is used in this formulation for its analgesic properties. It works by increasing the levels of certain chemicals in the brain that help elevate mood and reduce the sensation of pain. When applied topically, Amitriptyline can help numb the skin and underlying tissues, reducing pain and discomfort in the area of application.

Ketamine HCl is a powerful anesthetic that works by blocking the NMDA receptors in the brain and spinal cord, which play a key role in transmitting pain signals. In a topical formulation, Ketamine can provide localized pain relief without the systemic side effects associated with oral or injectable administration.

Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that works by reducing the production of prostaglandins, chemicals in the body that cause inflammation and increase the sensation of pain. By inhibiting their production, Ketoprofen can help reduce inflammation and pain in the area where the ointment is applied.

The ointment base in this formulation aids in the delivery of these medications to the skin. It provides a protective barrier that helps keep the skin moisturized, while also allowing the active ingredients to penetrate the skin and reach the underlying tissues where they can exert their therapeutic effects.

This formulation is typically used for conditions that involve pain and inflammation of the skin and underlying tissues, such as skin infections, wounds, or inflammatory skin conditions. By providing localized treatment, it can help reduce pain and inflammation in the affected area without the systemic side effects associated with oral or injectable medications.

As with any medication, it's important to use this formulation as directed by your healthcare provider. If you have any questions about how to use this medication or if you experience any side effects, please reach out to us at Bayview Pharmacy. We're here to help.

Frequently Asked Questions

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What is Amitriptyline 5%/Ketamine HCl 5.75%/Ketoprofen 10% Topical Ointment?

This compound is a topical ointment that combines three active ingredients: Amitriptyline 5%, Ketamine HCl 5.75%, and Ketoprofen 10%. It's a semi-solid formulation dispensed in a tube and intended for external application onto the skin.

How does Amitriptyline 5%/Ketamine HCl 5.75%/Ketoprofen 10% Topical Ointment work?

This ointment acts by providing a greasy or oily base that assists in the delivery of these therapeutic agents into the skin for localized treatment. Each active ingredient delivers a unique therapeutic effect, combining to treat conditions such as skin inflammation, infections, or support wound healing.

What are the indications for using this compound?

Physicians often prescribe this medication to treat local pain or inflammation, skin infections, and promote wound healing. However, the exact indications would depend on your doctor's assessment of your medical condition.

How should I use this ointment?

Apply the ointment externally on the affected skin area as directed by your physician. Remember to follow the prescribed dosage and never use it more frequently or for a longer duration than recommended.

What precautions should I take while using this compound?

Before using this medication, inform your doctor or pharmacist about your medical history or any allergies you have. Do not apply this ointment to open wounds or damaged skin. Also, avoid contact with eyes or mucous membranes.

Can pregnant or breastfeeding women use this ointment?

Before using this or any medication, pregnant or breastfeeding women should consult their healthcare provider to discuss any potential risks to the mother and the baby.

Does this ointment have any side effects?

Like all medications, this topical ointment can cause side effects, although not everyone gets them. Common side effects may include skin irritation or rash. If you experience any significant side effects, please contact your healthcare provider immediately.

What should I do if I miss a dose?

If you miss a dose, apply it as soon as you remember. However, if it's near the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Should this ointment be stored at any specific conditions?

Store this medication at room temperature, away from light and moisture. Do not store in the bathroom or near a heat source. Make sure the medication is kept out of reach of children and pets to prevent accidental ingestion or application.

Can I continue using the ointment if my symptoms have disappeared?

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.

This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Amitriptyline 5%/Ketamine HCl 5.75%/Ketoprofen 10% Topical Ointment
Topical Ointment
30 g
controlled

Apply topically to affected area(s)

Three times daily