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Amitriptyline 8%/Cyclobenzaprine 2%/Diclofenac 9%/DMSO 5%/Lido 4%/Menthol 2% Topical Ointment

FDA-approved generic
Dose form
Topical Ointment
Active ingredients
Dimethyl Sulfoxide
Menthol
Amitriptyline Hydrochloride
Cyclobenzaprine Hydrochloride
Diclofenac Sodium
Lidocaine Hydrochloride

This formulation is a semi-solid topical ointment containing Amitriptyline 8%, Cyclobenzaprine 2%, Diclofenac 9%, DMSO 5%, Lidocaine 4%, and Menthol 2%. It is dispensed in a tube and is designed for external application to the skin. The greasy or oily base of the ointment aids in the delivery of these therapeutic agents for localized treatment.

The combination of these active ingredients is intended to treat a variety of disease states. Amitriptyline and Cyclobenzaprine are used for their analgesic and muscle relaxant properties, respectively, which can help in conditions involving muscle spasms or chronic pain. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that helps reduce inflammation and pain. DMSO enhances the absorption of the other ingredients, while Lidocaine provides local anesthesia, numbing the treated area. Menthol adds a cooling effect, which can soothe irritated skin and provide additional pain relief.

This formulation is typically used for conditions such as skin inflammation, infections, or wound healing. It provides targeted relief by delivering the medication directly to the area of discomfort or disease.

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For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
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Requires a prescription from your own provider. Bayview is a pharmacy and does not prescribe.
Ships within 1 to 2 business days after pharmacist verification
HSA and FSA eligible
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Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.

For prescribersSign in for prescription details and order forms.
Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Dimethyl Sulfoxide
Menthol
Amitriptyline Hydrochloride
Cyclobenzaprine Hydrochloride
Diclofenac Sodium
Lidocaine Hydrochloride
Topical Ointment
65303c679b7e5ff303b65306
Service area

Can we ship this formula to your state?

Bayview fills prescriptions for patients in Connecticut, Florida, Maine, Massachusetts, New Hampshire, New Jersey, Pennsylvania and Rhode Island. New York patients are served on a limited basis while nonresident pharmacy registration is pending.

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Formula Information

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This formulation is a compounded topical ointment containing Amitriptyline 8%, Cyclobenzaprine 2%, Diclofenac 9%, DMSO 5%, Lidocaine 4%, and Menthol 2%. It is designed to be applied externally to the skin, providing localized treatment for a variety of conditions.

It works by increasing the levels of certain chemicals in the brain that help improve mood, sleep, and the body's response to pain.

Cyclobenzaprine is a muscle relaxant that works by blocking nerve impulses (or pain sensations) that are sent to your brain. It is used to relieve muscle spasms and to improve mobility.

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing substances in the body that cause pain and inflammation. It is used to treat mild to moderate pain, or signs and symptoms of osteoarthritis or rheumatoid arthritis.

DMSO (Dimethyl Sulfoxide) is a chemical compound which is a by-product of wood processing. It has been used to help penetrate the skin and promote absorption of the other ingredients in the formulation.

Lidocaine is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes. It is used to relieve pain and discomfort from skin irritations and minor cuts.

Menthol is a natural substance found in mint plants. It provides a cooling sensation when applied to the skin, helping to relieve minor pain and inflammation.

This formulation is dispensed in a semi-solid form in a tube, providing a greasy or oily base that aids in the delivery of the medication. It is typically used for conditions such as skin inflammation, infections, or wound healing. The combination of these ingredients provides a multi-modal approach to pain management, targeting different aspects of the pain pathway.

As with any medication, it is important to use this formulation as directed by your healthcare provider. If you have any questions or concerns about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is here to assist you.

Drug Interactions

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This topical ointment contains a combination of Amitriptyline, Cyclobenzaprine, Diclofenac, DMSO, Lidocaine, and Menthol. Each of these ingredients has a specific role in treating various skin conditions, inflammation, infections, or aiding in wound healing. However, it's important to be aware of potential drug interactions that may occur with this formulation.

Amitriptyline, a tricyclic antidepressant, may interact with other antidepressants, antipsychotics, certain antihistamines, and drugs that affect serotonin levels, such as St. John's wort. It can also interact with certain heart medications and increase the risk of side effects.

Cyclobenzaprine, a muscle relaxant, may interact with other CNS depressants like alcohol, barbiturates, benzodiazepines, and narcotics. Combining these substances can lead to increased sedation and potentially dangerous respiratory depression. It can also interact with certain antidepressants, leading to a potentially life-threatening condition called serotonin syndrome.

Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), may interact with other NSAIDs, blood thinners, and certain blood pressure medications. These interactions can increase the risk of bleeding and kidney damage. It can also interact with certain heart medications, potentially reducing their effectiveness.

DMSO (Dimethyl Sulfoxide) is a solvent that helps in the absorption of the other ingredients in the ointment. It may interact with certain blood thinners, increasing the risk of bleeding. It can also interact with certain diabetes medications, potentially causing hypoglycemia.

Lidocaine, a local anesthetic, may interact with other local anesthetics and certain heart medications. These interactions can increase the risk of serious side effects such as slow heart rate, low blood pressure, and seizures.

Menthol, used for its cooling and analgesic properties, generally has fewer interactions. However, it can cause skin irritation in some people, especially when used with other topical medications.

It's important to inform your healthcare provider of all medications, supplements, and herbal products you are currently taking before starting this treatment. If you experience any unusual symptoms or side effects, contact your healthcare provider immediately. This formulation should only be used as directed by a healthcare professional and should not be used in larger amounts or for longer than recommended.

If you have any questions or concerns about this formulation or its potential interactions, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need.

How Does it Work

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This topical ointment is a combination of several active ingredients, each with a specific role in managing pain and inflammation. The formulation is designed to be applied directly to the skin, where it can act locally on the affected area. The greasy or oily base of the ointment aids in the delivery of the medication, ensuring that the active ingredients are absorbed effectively.

It works by increasing the levels of certain chemicals in the brain that help elevate the pain threshold so that you feel less pain. In a topical formulation, amitriptyline can provide localized pain relief without the systemic side effects associated with oral administration.

Cyclobenzaprine (2%) is a muscle relaxant that works by blocking nerve impulses (or pain sensations) that are sent to your brain.

Diclofenac (9%) is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing substances in the body that cause pain and inflammation. It is commonly used to treat mild to moderate pain, or signs and symptoms of osteoarthritis or rheumatoid arthritis.

DMSO (5%) is a solvent that enhances the absorption of the other ingredients in the formulation. It helps in penetrating the skin and improving the delivery of the other active ingredients to the site of pain or inflammation.

Lidocaine (4%) is a local anesthetic that works by causing temporary numbness in the area where it is applied. It works by blocking nerve signals in your body and is often used to reduce pain or discomfort caused by skin irritations.

Menthol (2%) produces a cooling effect by stimulating the nerves that perceive cold sensations and by dilating the blood vessels, which can help to relieve pain. It also provides a soothing sensation that can help to distract from the pain.

This formulation is typically used for conditions such as skin inflammation, infections, or wound healing. It provides localized treatment, delivering the active ingredients directly to the area where they are needed, which can help to reduce side effects compared to oral medications.

If you have any questions about this formulation, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help.

Frequently Asked Questions

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What is Amitriptyline 8%/Cyclobenzaprine 2%/Diclofenac 9%/DMSO 5%/Lido 4%/Menthol 2% Topical Ointment?

This is a specialized compounded formulation that contains a combination of medications, including Amitriptyline, Cyclobenzaprine, Diclofenac, DMSO, Lidocaine, and Menthol. It's designed as a semi-solid for external use, applied to the skin to address conditions like skin inflammation, infections, or assist in wound healing.

How should I apply this compounded formulation?

It should be applied directly to the skin, over the affected area. However, the frequency and dosage will depend on your specific situation and your healthcare provider's instructions.

Does this ointment leave a greasy or oily feel on the skin?

Yes, this ointment does have a greasy or oily base. This is designed to enhance the delivery of therapeutic agents in the medication, aiding in treatment efficiency.

Can I use this ointment for other skin conditions not listed?

It's essential to use this medication only as directed by your healthcare provider. If you have another condition that you feel may benefit from this treatment, please discuss this with your healthcare provider.

What should I do if I experience any side effects?

If you experience any negative side effects or reactions, you should contact your healthcare provider immediately.

Can this medication be used for internal wounds or infections?

No, this ointment is specifically designed for external use only and should not be used to treat internal wounds or infections.

Will this ointment stain my clothes?

As with most topical ointments, there is a potential for it to leave stains on clothing. It's recommended to make sure the ointment has fully absorbed into your skin before coming into contact with clothing or bedding.

Can I use this ointment on broken or irritated skin?

It's advisable to discuss this with your healthcare provider. The ointment is meant for applying to skin affected by specific conditions, and its suitability for use on broken or severely irritated skin should be evaluated by a healthcare professional.

Can the ointment be used by individuals of all ages?

The suitability of this ointment for individuals of different ages will depend on their specific medical circumstances and should be determined by a healthcare provider. Rear in mind that the formulation might have different effects on children and older adults.

Will this ointment cure my skin condition?

This formulation is designed to help manage symptoms and facilitate healing, but it might not necessarily cure your skin condition. It's crucial to use the medication in conjunction with other advice and treatments as recommended by your healthcare provider.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Amitriptyline 8%/Cyclobenzaprine 2%/Diclofenac 9%/DMSO 5%/Lido 4%/Menthol 2% Topical Ointment
Topical Ointment
30 g
controlled

Apply topically to affected area(s)

Three times daily