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This formulation is a compounded rectal suppository containing Amitriptyline HCl 10 mg, Ketamine HCl 46 mg, Ketoprofen 50 mg, and Lidocaine 10 mg. As a solid dosage form, it is designed to be inserted into the rectum where it dissolves or melts, releasing the medication for local or systemic absorption.
The combination of these active ingredients is intended to treat various disease states. Amitriptyline HCl is a tricyclic antidepressant used for its analgesic properties, Ketamine HCl is an NMDA receptor antagonist used for its potent analgesic effects, Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) used for its anti-inflammatory and analgesic properties, and Lidocaine is a local anesthetic used for its ability to numb the local area.
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This formulation is a compounded rectal suppository containing Amitriptyline HCl 10 mg, Ketamine HCl 46 mg, Ketoprofen 50 mg, and Lidocaine 10 mg. It is a solid dosage form that is inserted into the rectum, where it dissolves or melts to release the medication. This allows for local or systemic absorption of the drugs, depending on the intended therapeutic effect.
Amitriptyline is a tricyclic antidepressant that is used in this formulation for its analgesic properties, particularly in neuropathic pain. It works by increasing the levels of certain chemicals in the brain that help elevate mood and reduce the sensation of pain.
Ketamine is a powerful anesthetic and analgesic. In this formulation, it is used for its ability to provide rapid pain relief, particularly in cases of severe or chronic pain. It works by blocking the NMDA receptors in the brain and spinal cord, which play a key role in transmitting pain signals.
Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is used for its anti-inflammatory and analgesic properties. It works by reducing the production of prostaglandins, chemicals that cause inflammation, pain, and fever in the body.
Lidocaine is a local anesthetic that provides immediate pain relief by blocking the nerve signals in your body. It is used in this formulation to numb the area and provide immediate relief from pain and discomfort.
This combination of medications in a rectal suppository form provides a multi-modal approach to pain management, targeting different aspects of pain perception and inflammation. It can be used in various disease states where pain management is required, such as post-surgical pain, chronic pain conditions, cancer pain, and certain types of neuropathic pain.
As with any medication, this formulation should be used under the supervision of a healthcare provider. It is important to use this medication as directed by your healthcare provider and report any side effects or adverse reactions immediately. If you have any questions about this formulation, please reach out to us at Bayview Pharmacy. We are a team of knowledgeable compounding pharmacists ready to assist you.
This compounded formulation contains Amitriptyline HCl, Ketamine HCl, Ketoprofen, and Lidocaine, each of which can interact with other medications. It's crucial to inform your healthcare provider about all the medications you're currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements.
Amitriptyline HCl, a tricyclic antidepressant, can interact with MAO inhibitors, SSRIs, anticholinergic drugs, and certain antihypertensive medications. Combining these drugs can lead to serious side effects such as serotonin syndrome, increased heart rate, and elevated blood pressure.
Ketamine HCl, an NMDA receptor antagonist, can interact with CNS depressants, opioids, and certain antihypertensive medications. These interactions can lead to increased sedation, respiratory depression, and changes in blood pressure.
Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), can interact with anticoagulants, antiplatelet drugs, corticosteroids, and certain antihypertensive medications. These interactions can increase the risk of gastrointestinal bleeding and reduce the effectiveness of antihypertensive medications.
Lidocaine, a local anesthetic, can interact with antiarrhythmic drugs and certain local anesthetics. These interactions can lead to additive systemic toxicity, including CNS and cardiovascular effects.
This formulation is typically used to manage pain, particularly neuropathic pain, and inflammation. Amitriptyline HCl can help manage chronic pain, especially neuropathic pain. Ketamine HCl can provide analgesia and potentially modulate central sensitization and hyperalgesia. Ketoprofen can reduce inflammation and pain. Lidocaine can provide local anesthesia and reduce pain signals from the affected area.
It's important to use this medication as directed by your healthcare provider. The suppository should be inserted into the rectum as instructed. Wash your hands before and after use. If you experience any side effects, such as severe abdominal pain, blood in your stool, rapid heartbeat, or confusion, contact your healthcare provider immediately.
If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is here to help.
The Amitriptyline HCl 10 mg/Ketamine HCl 46 mg/Ketoprofen 50 mg/Lidocaine 10 mg Rectal Suppository is a compounded medication that combines four active ingredients to provide pain relief and manage various disease states. This formulation is designed as a rectal suppository, a solid dosage form that is inserted into the rectum where it dissolves or melts to release the medication. The medication can then be absorbed locally or systemically, depending on the specific needs of the patient.
Amitriptyline HCl is a tricyclic antidepressant that works by increasing the levels of certain chemicals in the brain that help improve mood, relieve pain, and promote sleep. In this formulation, it is used for its analgesic properties, particularly in neuropathic pain. It can also help with symptoms of depression and anxiety, which are often associated with chronic pain conditions.
Ketamine HCl is a powerful anesthetic that works by blocking certain receptors in the brain that are responsible for transmitting pain signals. It is used in this formulation for its potent analgesic effects, particularly in cases of severe or chronic pain that has not responded to other treatments.
Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by reducing hormones that cause inflammation and pain in the body. It is used in this formulation to help reduce inflammation and provide additional pain relief.
Lidocaine is a local anesthetic that works by blocking nerve signals in your body. It is used in this formulation to numb the local area and provide immediate pain relief.
This combination of medications in a rectal suppository form allows for targeted delivery of the drugs, which can provide faster relief and reduce the risk of systemic side effects. It can be used to treat a variety of disease states, including chronic pain conditions, neuropathic pain, inflammation, and certain mood disorders.
As compounding pharmacists, we can customize this formulation to meet the specific needs of each patient, adjusting the dosage and combination of medications as needed. If you have any questions about this formulation or how it may benefit you or your patients, please don't hesitate to reach out to us at Bayview Pharmacy.
This compound containing Amitriptyline, Ketamine, Ketoprofen, and Lidocaine, primarily in a rectal suppository form, is predominantly recommended for the management of various types of severe pain such as neuropathic pain. However, aside from this primary use, there are other potential applications.
The inclusion of Amitriptyline, a tricyclic antidepressant, may potentially aid in the treatment of depression symptoms in some patients. Its anticholinergic properties also make it beneficial for patients with nighttime incontinence or certain types of gastrointestinal disorders, although this is an off-label usage.
Ketamine, an NMDA antagonist, has not only proven effective in the treatment of chronic pain but may have potential benefits in managing treatment-resistant depression and certain anxiety disorders. Being a powerful anaesthetic, it provides physicians with flexibility in treating various conditions beyond just pain management.
Ketoprofen is an NSAID with potent anti-inflammatory, analgesic, and antipyretic properties, making it useful in managing symptoms of inflammatory conditions like arthritis. It can also be used for acute pain, especially that associated with menstrual cramps. It may be particularly beneficial for patients with both pain and inflammation.
Lidocaine, a local anesthetic, brings quick pain relief in the treated area but it has been used off-label for conditions like arrhythmias. Its non-pain related uses are fairly limited and typically specific to in-hospital procedures.
It's vital for patients and prescribers to understand that the benefits of off-label uses need to be weighed against potential side effects. As a result, close monitoring is essential when using this compound for conditions beyond severe chronic pain. This is particularly applicable for elderly patients or those with compromised organ function.
Remember, this compounding pharmacy can customize dosages based on individual patient needs and tolerances, potentially increasing the efficacy of the compound while minimizing side effects. If there are any questions about utilizing this formulation for a specific condition, consult with your healthcare provider or feel free to reach out to our knowledgeable team at Bayview Pharmacy. We're here to help.
This formulation, which includes Amitriptyline HCl 10 mg, Ketamine HCl 46 mg, Ketoprofen 50 mg, and Lidocaine 10 mg, is designed to provide pain relief and manage certain conditions. The medication is absorbed locally or systemically when it dissolves or melts in the body cavity.
This suppository is inserted into a body cavity, typically the rectum, where it dissolves or melts to release the medication for absorption.
The active ingredients in this compound formulation are Amitriptyline HCl, Ketamine HCl, Ketoprofen, and Lidocaine.
Amitriptyline HCl is an antidepressant that aids in pain relief, Ketamine HCl acts as an anesthetic, Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain, while Lidocaine is a local anesthetic that helps to numb the tissue in a particular area.
Like all medications, this compounded rectal suppository may have potential side effects, which can include nausea, constipation, drowsiness, or allergic reactions. Always consult with a healthcare provider for a comprehensive list of possible side effects.
The time it takes for the suppository to take effect can vary from person to person. Generally, you may expect to feel relief within an hour of administration. However, it's always best to consult with your healthcare provider for specific details regarding your personal medication plan.
The frequency of use will be determined by your healthcare provider, based on your condition and you response to therapy. Always follow your healthcare provider's directions.
It largely depends on the specific condition being treated and the patient’s needs. Suppositories offer certain advantages, such as bypassing the gastrointestinal tract, offering local treatment, and being an alternative for those who have difficulty swallowing pills. They may not be the first line of therapy, but they can be highly effective and beneficial in certain circumstances.
It's important to always inform your healthcare provider about any other medications you are taking to avoid any potential interactions.
Keep the container tightly closed and store it at room temperature, away from heat, moisture, and direct light. Always consult with your healthcare provider or pharmacist for precise storage instructions.
