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Amitriptyline HCl 10 mg Rectal Suppository

FDA-approved generic
Dose form
Suppository
Active ingredients
Amitriptyline Hydrochloride

The Amitriptyline HCl 10 mg Rectal Suppository is a solid dosage form specifically designed for insertion into the rectum. Upon insertion, the suppository dissolves or melts, releasing the medication for local or systemic absorption. Amitriptyline HCl is a tricyclic antidepressant used to treat various disease states including depression, anxiety disorders, and certain types of nerve pain.

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For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
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Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.

For prescribersSign in for prescription details and order forms.
Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Amitriptyline Hydrochloride
Suppository
653063e425ca64212c507c97
Service area

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Bayview fills prescriptions for patients in Connecticut, Florida, Maine, Massachusetts, New Hampshire, New Jersey, Pennsylvania and Rhode Island. New York patients are served on a limited basis while nonresident pharmacy registration is pending.

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Formula Information

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Amitriptyline HCl 10 mg Rectal Suppository is a specialized formulation designed for rectal administration. This solid dosage form is inserted into the rectum, where it dissolves or melts to release the medication. The active ingredient, Amitriptyline HCl, is then absorbed locally or systemically to exert its therapeutic effects.

Amitriptyline is a tricyclic antidepressant (TCA) that works by increasing the levels of certain chemicals in the brain that help improve mood, relieve anxiety, and treat certain types of chronic pain. Although it is primarily used to treat depression, it is also beneficial in managing other conditions such as neuropathic pain, fibromyalgia, and certain anxiety disorders.

As a rectal suppository, this formulation offers several advantages. It provides an alternative route of administration for patients who have difficulty swallowing pills or for whom oral administration is not suitable. It also allows for direct absorption into the systemic circulation, bypassing the first-pass metabolism in the liver, which can lead to a more rapid onset of action and potentially fewer side effects.

It's important to note that the use of Amitriptyline HCl 10 mg Rectal Suppository should be under the supervision of a healthcare provider. The medication can cause side effects such as dry mouth, constipation, blurred vision, and drowsiness. It may also interact with other medications, so it's crucial to inform your healthcare provider of all the medications you are currently taking.

Patients should follow the prescribed dosage and administration instructions carefully. The suppository should be inserted into the rectum as directed by the healthcare provider. Proper hygiene is essential before and after administration to prevent infection.

As compounding pharmacists, we are committed to providing high-quality, personalized medications to meet the unique needs of each patient. If you have any questions about Amitriptyline HCl 10 mg Rectal Suppository or any other medication, please don't hesitate to reach out to us. We are here to help.

Drug Interactions

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Amitriptyline HCl is a tricyclic antidepressant that is used to treat various conditions such as depression, neuropathic pain, and migraine prophylaxis. It works by increasing the levels of certain chemicals in the brain that help elevate mood, reduce pain, and prevent migraines. However, it can interact with several other medications, potentially altering their effects or increasing the risk of adverse reactions.

One of the most significant interactions is with monoamine oxidase inhibitors (MAOIs). Combining these two types of medications can lead to a potentially life-threatening condition called serotonin syndrome, characterized by symptoms such as agitation, hallucinations, rapid heartbeat, fever, and loss of coordination. Therefore, it is crucial to avoid using MAOIs within two weeks of starting or stopping amitriptyline.

Other medications that can interact with amitriptyline include other antidepressants, antipsychotics, certain antihistamines, and drugs that affect the heart's rhythm (QT prolonging drugs). These can increase the risk of side effects such as drowsiness, dizziness, dry mouth, blurred vision, and heart problems. It is essential to inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs and herbal supplements.

Furthermore, amitriptyline can interact with certain substances such as alcohol and grapefruit juice. Alcohol can enhance the sedative effects of amitriptyline, leading to increased drowsiness and potentially dangerous impairment of motor skills. Grapefruit juice can increase the levels of amitriptyline in the blood, potentially leading to an increased risk of side effects.

It is also important to note that amitriptyline can affect the results of certain laboratory tests, potentially leading to false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Lastly, this medication should be used with caution in patients with certain medical conditions such as heart disease, liver disease, thyroid problems, urinary retention, and glaucoma. It is crucial to discuss your medical history with your healthcare provider before starting treatment with amitriptyline.

If you have any questions about the potential interactions of amitriptyline or its use in treating specific conditions, please do not hesitate to reach out to us. We are here to provide you with the most accurate and up-to-date information to ensure the safe and appropriate use of your medications.

How Does it Work

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Amitriptyline HCl 10 mg Rectal Suppository is a solid dosage form that is inserted into the rectum, where it dissolves or melts to release the medication. The active ingredient, Amitriptyline HCl, is a tricyclic antidepressant (TCA) that works by altering the levels of certain chemicals in the brain, specifically serotonin and norepinephrine. These chemicals are known to affect mood and mental balance.

Once the suppository is inserted into the rectum, it begins to dissolve due to the body's natural heat. As it dissolves, the Amitriptyline HCl is released and absorbed through the rectal tissue into the bloodstream. This method of administration bypasses the digestive system, which can be beneficial for patients who have difficulty swallowing pills or for those who experience nausea or vomiting when taking oral medications.

Amitriptyline HCl is used to treat a variety of conditions, including depression, anxiety disorders, and certain types of nerve pain. It can also be used to prevent migraines and to treat certain types of eating disorders. By increasing the levels of serotonin and norepinephrine in the brain, Amitriptyline HCl can help to improve mood, reduce anxiety, relieve pain, and improve sleep.

It's important to note that while Amitriptyline HCl can help to manage these conditions, it is not a cure. It can take a few weeks of regular use before the full benefits of the medication are felt. It's also important to continue taking the medication as directed by your healthcare provider, even if you feel better, as abruptly stopping the medication can lead to withdrawal symptoms.

As with any medication, Amitriptyline HCl can cause side effects. Common side effects include dry mouth, constipation, blurred vision, and drowsiness. If these side effects persist or worsen, or if you experience any serious side effects such as chest pain, rapid heartbeat, or severe nausea and vomiting, contact your healthcare provider immediately.

If you have any questions about Amitriptyline HCl 10 mg Rectal Suppository, or if you would like more information about this or any other medication, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Other Uses

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Amitriptyline HCl is a tricyclic antidepressant. In this 10 mg rectal suppository formulation, its primary use is in therapeutic relief and management of depression and other mood or mental disorders. However, this versatile compound is also useful for other medical conditions.

Another use for this formulation is for managing chronic pain, particularly neurologic pain syndromes, such as post-herpetic neuralgia or peripheral neuropathy. Because the medication is delivered rectally, it might be beneficial for patients having difficulty with oral medication due to nausea or vomiting, and might present fewer systemic side effects.

Patients suffering from migraine prevention can also benefit from this formulation. Another off-label use is in the treatment of irritable bowel syndrome (IBS). It can help manage the condition’s symptoms (changes in bowel habits and abdominal pain) due to its painkilling effects at the nerve level.

It's also worth noting that this medication may be used in the treatment of nocturnal enuresis (bed-wetting) in children. It can help reduce the instances of bed-wetting, contributing positively to the child's quality of life and mental health.

Please bear in mind that the utilization of medications for uses other than those approved by regulatory bodies is considered off-label use, and such use should only be considered when other treatment options have been exhausted or are not suitable. Direct physician oversight and monitoring are essential. Inform your physician if you are using it off-label for these other uses, so any risks or side effects can be properly managed.

If you have any further questions or concerns about using this Amitriptyline HCl 10 mg Rectal Suppository formulation for other uses, please don’t hesitate to reach out to us at Bayview Pharmacy.

Frequently Asked Questions

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What is Amitriptyline HCl 10 mg Rectal Suppository?

This is a solid dosage form of Amitriptyline HCl 10 mg that is meant to be inserted into a body cavity, typically the rectum. Once inserted, it dissolves or melts to release the medication for either local or systemic absorption.

What is the purpose of using a rectal suppository?

A rectal suppository delivers medication directly to the area it needs to work. This can allow the drug to act more quickly and effectively, and can also reduce the risk of systemic side effects.

What conditions is this suppository used to treat?

Amitriptyline HCl is often used to treat mental/mood problems such as depression. It may help improve mood and feelings of well-being, relieve anxiety and tension, help you sleep better, and increase your energy level. Consult with your physician to ensure it is right for your specific medical needs.

How is Amitriptyline HCl 10 mg Rectal Suppository administered?

This suppository is typically inserted into the rectum. It's important to follow the instructions provided by your healthcare professional for correct administration.

What happens once the suppository dissolves?

Once the suppository dissolves, the medication is released and absorbed by the body - either locally in the rectum or vagina, or systemically throughout the body, depending on the specific drug formulation.

Can this type of suppository be used vaginally as well?

While some suppositories may be used either rectally or vaginally, it's essential to follow your doctor's directions and the prescription information. Some medications are specially formulated for a specific administration route.

How should I store the suppository?

Suppositories should generally be stored in a cool, dry place below 25°C. They should also be kept out of reach of children. Always check the specific product instructions or consult your pharmacist.

What should I do if I forget to use my Amitriptyline HCl 10 mg Rectal Suppository?

If you miss a dose, use it as soon as you remember. If it's near the time for the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Can I experience side effects with this suppository?

Yes, you can experience side effects such as nausea, vomiting, constipation, dry mouth, drowsiness, increased appetite, weight gain, or tiredness. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Can anyone use this type of suppository?

No, not everyone can or should use this type of suppository. People with certain medical conditions, those taking certain medications, and children, may not be candidates. Always consult with a healthcare provider before starting any new medication.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

The conditions listed on this page are indications prescribers have ordered this preparation for. They are not FDA-approved indications, and listing them is not a statement that this preparation is effective for them.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Amitriptyline HCl 10 mg Rectal Suppository
Suppository
30 suppositories
controlled

Insert 1 unwrapped suppository

Once daily at bedtime