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Formulas

Amphotericin B 25 mg/Nystatin 250 000 IU Oral Capsules

Amphotericin B 25 mg/Nystatin 250 000 IU Oral Capsules are a solid dosage form, composed of two gelatin or vegetarian shells that enclose the precise dosage of the active ingredients, Amphotericin B and Nystatin. This formulation is designed for easy swallowing and convenient administration.

Amphotericin B is a polyene antifungal medication that works by binding to the sterols in the cell membrane of susceptible fungi, causing a change in membrane permeability and ultimately leading to fungal cell death. Nystatin is another antifungal medication that works by binding to sterols in the fungal cell membrane, altering membrane permeability and causing leakage of intracellular components.

This combination of Amphotericin B and Nystatin in a single capsule is used to treat various fungal infections. These may include systemic mycoses such as cryptococcosis, North American blastomycosis, coccidioidomycosis, and histoplasmosis. It can also be used to treat mucocutaneous and cutaneous mycoses, and oral thrush caused by Candida species.

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Formula Information

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Amphotericin B 25 mg/Nystatin 250 000 IU Oral Capsules are a potent antifungal formulation designed to treat a variety of fungal infections. This formulation is presented in a solid dosage form, specifically in the form of capsules. These capsules are composed of two gelatin or vegetarian shells that enclose the medication. This design allows for convenient and easy swallowing, and provides a precise dosage of the active ingredients, Amphotericin B and Nystatin.

Amphotericin B is a polyene antifungal medication that works by binding to the ergosterol found in the cell membranes of fungi, causing them to become permeable and leading to cell death. It is used to treat a wide range of systemic fungal infections, including those caused by Candida or Aspergillus species. Nystatin, on the other hand, is an antifungal medication that works by binding to sterols in the fungal cell membrane, disrupting the membrane and causing leakage of cellular contents, which leads to cell death. It is commonly used to treat infections caused by Candida, such as oral thrush and vaginal yeast infections.

Together, Amphotericin B and Nystatin provide a broad spectrum of antifungal activity, making this formulation effective against a wide range of fungal infections. It is important to note that the use of this medication should be under the supervision of a healthcare provider, as both Amphotericin B and Nystatin can cause side effects, including nausea, vomiting, diarrhea, stomach pain, and rash. Patients should be monitored for these side effects and any signs of allergic reaction.

As compounding pharmacists, we are able to customize this formulation to meet the specific needs of each patient. This includes adjusting the dosage, changing the form of the medication, and adding flavorings to make the medication more palatable. We are also available to answer any questions or concerns you may have about this formulation. Please do not hesitate to reach out to us if you need any further information.

Drug Interactions

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Amphotericin B and Nystatin are both antifungal medications used to treat a variety of fungal infections. Amphotericin B works by binding to ergosterol, a component of the fungal cell membrane, leading to cell death. Nystatin works in a similar way, but is primarily used for infections caused by Candida species.

While these medications are generally safe and effective, they can interact with other medications, potentially leading to adverse effects or reduced efficacy. It's important to inform your healthcare provider of all medications you are currently taking, including prescription drugs, over-the-counter medications, and dietary supplements.

Amphotericin B can interact with the following medications:

  • Antineoplastic agents (e.g., cisplatin, methotrexate): These medications can increase the risk of kidney damage when taken with Amphotericin B.
  • Antiviral medications (e.g., ganciclovir, foscarnet): These medications can also increase the risk of kidney damage when taken with Amphotericin B.
  • Corticosteroids and corticotropin (ACTH): These medications can increase the risk of hypokalemia (low potassium levels) when taken with Amphotericin B.
  • Digitalis glycosides: The risk of digitalis toxicity may be increased due to hypokalemia induced by Amphotericin B.

Nystatin can interact with the following medications:

  • Antibiotics (e.g., tetracycline): These medications can reduce the effectiveness of Nystatin by decreasing the amount of Nystatin that is absorbed by the body.

It's also important to note that both Amphotericin B and Nystatin can cause side effects, including nausea, vomiting, diarrhea, stomach pain, and rash. If you experience any of these side effects, or if your symptoms do not improve or worsen after taking this medication, contact your healthcare provider immediately.

This formulation is designed to provide a precise dosage of the active ingredients, allowing for convenient and easy swallowing. However, it's important to take this medication exactly as prescribed by your healthcare provider. Do not take more or less of this medication, or take it more often than prescribed.

If you have any questions about this medication, its potential interactions, or how to take it, please reach out to us. We are here to help ensure that your treatment is safe and effective.

How Does it Work

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Amphotericin B and Nystatin are both antifungal medications that work by binding to sterols in the fungal cell membrane. The primary sterol in fungal cells is ergosterol. When these medications bind to ergosterol, they disrupt the integrity of the cell membrane, causing leakage of cellular contents and ultimately leading to cell death.

Amphotericin B is a polyene antifungal that is often used for systemic infections. It has a broad spectrum of activity and is effective against many types of fungi, including Candida and Aspergillus species. However, it has significant side effects, including kidney damage, and is usually reserved for severe or refractory infections.

Nystatin is another polyene antifungal, but it is not absorbed from the gastrointestinal tract and is therefore used primarily for oral or cutaneous candidiasis. It is also effective against other types of yeast and some molds.

In this formulation, Amphotericin B and Nystatin are combined in a solid dosage form composed of two gelatin or vegetarian shells that enclose the medication. This allows for convenient and easy swallowing and provides a precise dosage of the active ingredients. The capsules are designed to dissolve in the stomach, releasing the medication where it can be absorbed into the bloodstream and transported to the site of infection.

This formulation is used to treat a variety of fungal infections, including systemic candidiasis, aspergillosis, and other serious fungal infections. It may also be used for prophylaxis in patients with a high risk of developing fungal infections, such as those with a weakened immune system due to chemotherapy or HIV/AIDS.

It's important to note that while this formulation can be very effective, it also has potential side effects and interactions. These can include nausea, vomiting, diarrhea, stomach pain, rash, and more serious effects such as kidney damage. Therefore, it's crucial that patients and prescribers carefully consider the risks and benefits before starting therapy.

If you have any questions about this formulation or its use, please don't hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is always here to help.

Other Uses

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Aside from the primary indications, the formulation of Amphotericin B 25 mg/Nystatin 250 000 IU Oral Capsules can also be used in other instances as deemed necessary by a healthcare provider. For instance, they are often recommended in preventive strategies for patients who are at high risk of developing fungal infections. This includes immuno-compromised individuals such as patients who recently underwent organ transplantation, chemotherapy, and those with HIV/AIDS. Furthermore, the combination therapy of Amphotericin B and Nystatin is often used when single-agent therapy is not successful.

Amphotericin B can be used as an alternative treatment for various systemic fungal infections, such as aspergillosis, blastomycosis, histoplasmosis, and cryptococcosis, especially for patients intolerant or unresponsive to first-line antifungal treatment. Nystatin, on the other hand, has an additional possible application in treating intestinal candidiasis and can be used prophylactically to reduce the incidence of candida infections in patients with neutropenia resulting from chemotherapy.

It is essential to note that these uses are off-label and should be pursued only on the recommendation and under close supervision of a healthcare provider. The dual therapy might not serve as the primary choice in such instances but might prove beneficial depending on the patient's medical history and current health status. This formulation may also be beneficial for traverse use where the infection site is difficult to reach, the drug can traverse the blood-brain barrier, or where fungi are resistant to other antifungal treatments.

Please note that the above-mentioned alternative uses are based on clinical expertise and various studies. It's essential to always consult with a healthcare professional or pharmacist before considering any change in your treatment plan. At Bayview Pharmacy, we are always available to answer your questions, provide a detailed consultation, and ensure that you understand your medication. So, if you have any questions, don't hesitate to reach out to us.

Frequently Asked Questions

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What are Amphotericin B 25 mg/Nystatin 250 000 IU Oral Capsules?

These are solid dosage forms composed of two gelatin or vegetarian shells that enclose medication. They contain the drugs Amphotericin B and Nystatin, which are used to treat certain fungal infections.

How are these capsules designed for easy swallowing?

The capsules are designed with smooth, rounded shapes that ease the process of swallowing. They can also be swallowed with water or other liquids for further convenience.

What is the composition of the capsules' shell?

The capsule shells are made of either gelatin or a vegetarian alternative. They are used to hold the active drug ingredients in place and dissolve upon ingestion.

How does a capsule ensure precise dosage?

Each capsule is designed to contain a precise amount of the active ingredients. This ensures that each dosage provides the exact amount of medication required for treatment.

Are these capsules suitable for vegetarians?

Yes, the capsules can be created with a vegetarian shell option, making them suitable for people with dietary restrictions such as vegetarianism.

Is the capsule casing absorbed in the body?

Yes. After swallowing, the shell breaks down in the stomach and is absorbed by the body, releasing the medicine for action.

How is the medication in these capsules released in the body?

The medication is released when the shell dissolves in the stomach after ingestion. The active ingredients are then absorbed into the bloodstream for efficient action.

Can I open the capsule if I have trouble swallowing it?

It is generally recommended to swallow the capsules whole. However, if you experience difficulty, consult your healthcare provider for alternative methods of taking the medication.

Does drinking liquid aid in swallowing the capsule?

Yes, drinking a sip of water or another type of liquid can help make swallowing the capsule easier and smoother. However, certain medications may require specific liquids for swallowing; always check with your healthcare provider.

Are there any specific storage instructions for these capsules?

Store the capsules at room temperature, away from moisture and direct light. Keep them out of reach of children and pets. Do not store in a bathroom. Do not dispose of medications in wastewater or household waste.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
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