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Ampicillin 125 mg/Nystatin 10 000 IU Rectal Suppository

The Ampicillin 125 mg/Nystatin 10 000 IU Rectal Suppository is a solid dosage form designed for insertion into the rectum. Upon insertion, the suppository dissolves or melts, releasing the active ingredients, Ampicillin and Nystatin, for local or systemic absorption.

Ampicillin is a broad-spectrum antibiotic used to treat a variety of bacterial infections, while Nystatin is an antifungal medication used to treat fungal infections. The combination of these two medications in a rectal suppository form allows for targeted treatment of infections in the rectal area, providing relief from symptoms and promoting healing.

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Formula Information

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The Ampicillin 125 mg/Nystatin 10 000 IU Rectal Suppository is a solid dosage form designed for insertion into the rectum. This formulation is designed to dissolve or melt once inserted, releasing the medication for local or systemic absorption. This method of administration is particularly beneficial for patients who may have difficulty swallowing oral medications or for those who require direct application of medication to the rectal or vaginal area.

Ampicillin is a type of antibiotic that works by stopping the growth of bacteria. It is used to treat a wide variety of bacterial infections, including those of the respiratory tract, middle ear, sinuses, skin, and urinary tract. It is also used to prevent certain types of bacterial infections. Nystatin, on the other hand, is an antifungal medication that works by stopping the growth of fungus. It is used to treat infections caused by fungus, which can invade any part of the body including the mouth, throat, esophagus, lungs, and blood.

Together, the combination of Ampicillin and Nystatin in this suppository formulation provides a broad-spectrum approach to treating infections. This can be particularly useful in cases where the patient is dealing with both bacterial and fungal infections simultaneously, or in cases where the exact nature of the infection is unknown. The rectal administration allows for the medication to be delivered directly to the site of infection, providing rapid relief from symptoms.

As with any medication, it is important for patients to use this product under the guidance of a healthcare professional. Patients should ensure they understand the correct method for administering the suppository and should follow the prescribed dosage instructions. Side effects can include diarrhea, nausea, and abdominal cramping. If these or any other side effects occur, patients should contact their healthcare provider immediately.

For prescribers, it is important to note that this formulation may not be suitable for all patients. Those with a history of allergic reactions to penicillin or other antibiotics should not use this product. Additionally, the use of this medication should be avoided in patients with a history of kidney disease or asthma, unless directed by a healthcare provider.

If you have any questions about the Ampicillin 125 mg/Nystatin 10 000 IU Rectal Suppository, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you with any queries or concerns you may have.

Drug Interactions

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Ampicillin and Nystatin are two active ingredients in this rectal suppository formulation. Ampicillin is a broad-spectrum penicillin antibiotic that is used to treat a variety of bacterial infections, while Nystatin is an antifungal medication used to treat fungal infections. This combination is typically used to treat infections in the rectal or vaginal area that are caused by susceptible bacteria and fungi.

It's important to note that Ampicillin can interact with other medications, potentially affecting their efficacy or increasing the risk of adverse effects. For instance, Ampicillin can decrease the effectiveness of oral contraceptives, potentially leading to unintended pregnancy. It can also interact with certain blood thinners, such as warfarin, increasing the risk of bleeding. Other medications that may interact with Ampicillin include probenecid, allopurinol, and certain live vaccines.

Nystatin, on the other hand, has fewer known drug interactions. However, it can interact with certain other antifungal medications, potentially leading to increased risk of side effects. It's also important to note that Nystatin can cause irritation and sensitivity reactions, particularly when used in a suppository form.

Both Ampicillin and Nystatin can cause allergic reactions in some individuals. Symptoms of an allergic reaction can include rash, itching, swelling, severe dizziness, and trouble breathing. If you experience any of these symptoms after using the suppository, seek medical attention immediately.

It's crucial to inform your healthcare provider of all the medications, supplements, and herbal products you are currently taking before starting treatment with this formulation. This includes prescription and over-the-counter medications, as well as any vitamins or dietary supplements. This will help your healthcare provider to prevent potential drug interactions and ensure the safe and effective use of this medication.

Remember, this medication should only be used if prescribed by a healthcare provider and should be used exactly as directed. Do not use this medication for longer than prescribed or in larger amounts than recommended. If you have any questions or concerns about this medication, do not hesitate to reach out to us at Bayview Pharmacy. We are here to help.

How Does it Work

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The Ampicillin 125 mg/Nystatin 10 000 IU Rectal Suppository is a solid dosage form that is inserted into the rectum, where it dissolves or melts to release the medication. This formulation combines two active ingredients, ampicillin and nystatin, which work together to treat certain bacterial and fungal infections.

Ampicillin is a type of antibiotic that works by stopping the growth of bacteria. It does this by preventing the bacteria from forming the cell wall that surrounds each cell. Without a cell wall, the bacteria cannot survive, which helps to clear the infection. Ampicillin is effective against a wide range of bacteria and is often used to treat infections of the respiratory tract, urinary tract, and gastrointestinal tract, among others.

Nystatin, on the other hand, is an antifungal medication. It works by binding to sterols in the cell membrane of susceptible fungi, causing leakage of cell contents and subsequent cell death. This helps to clear the fungal infection. Nystatin is often used to treat infections caused by Candida, a type of yeast.

When used as a rectal suppository, the medication is typically absorbed locally, directly into the tissues of the rectum. This allows for a high concentration of the medication to be delivered directly to the site of infection, which can be particularly beneficial for treating infections in this area. However, some of the medication may also be absorbed systemically, which can help to treat infections elsewhere in the body.

It's important to note that this medication should only be used if prescribed by a healthcare provider, as misuse or overuse of antibiotics and antifungals can lead to decreased effectiveness and resistance. Always follow the instructions provided by your healthcare provider or pharmacist when using this medication.

If you have any questions about this formulation, or if you are experiencing any side effects, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help.

Other Uses

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While the primary use of Ampicillin 125 mg/Nystatin 10 000 IU Rectal Suppository formulation is on treating bacterial and fungal infections located in the rectal or vaginal area, it can be employed for other purposes too. Ampicillin, a broad-spectrum antibiotic, can tackle a range of bacterial infections while Nystatin is effective against most yeasts and molds. That being said, this compound could also play a crucial role in prophylactic treatment, acting as a preventive measure for patients who are susceptible to these infections, such as individuals with compromised immune systems, or those undergoing invasive procedures where risk of bacterial or fungal contamination is high.

Additionally, this formulation could be utilized as an alternative route of medication for individuals who can't tolerate oral medications, or in instances where oral administration is ineffective. The rectal route bypasses part of the digestive system, which could be beneficial for patients with gastrointestinal issues. It enables systemic absorption of the medication, delivering the drug to the entire body, making it a viable alternative for delivering these drugs systemically if oral administration isn't feasible or desirable.

However, it must be emphasized that medications have their side effects, and that using drugs off-label can be risky and should be done under a healthcare provider's supervision. Also, individual patient factors such as medical history, allergies, and concurrent medications should be considered before recommending alt-use scenarios.

Understand that rectal administration is not suitable for all medications, and the use of Ampicillin/Nystatin suppositories for conditions other than they were intended for should be validated on a case-by-case basis. Always consult with a healthcare provider for advice regarding off-label uses. For any questions or inquiries, feel free to contact our team of compounding pharmacists at Bayview Pharmacy. We are more than willing to provide comprehensive advisory support to patients and prescribers alike.

Frequently Asked Questions

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What is an Ampicillin 125 mg/Nystatin 10 000 IU Rectal Suppository?

It is a compounded medication in a solid dosage form that is meant for insertion into a body cavity, typically the rectum. The suppository dissolves or melts to release the medication either for local treatment or systemic absorption.

What are the medications contained in this suppository?

This suppository contains two types of medications, Ampicillin 125 mg and Nystatin 10 000 IU. Ampicillin is an antibiotic used for treating bacterial infections, while Nystatin is an antifungal medication used for treating fungal infections.

How is this suppository used?

This suppository is used by inserting it into the rectum, where it melts or dissolves to release the medications for absorption.

Which conditions does this suppository treat?

This suppository is typically used to treat bacterial and yeast infections in the lower gastrointestinal tract.

How often do I have to use this suppository?

The frequency of use depends on the specific recommendation of your healthcare provider. Always follow their instructions closely.

What should I do if I missed a dose?

If you miss a dose, use it as soon as you can. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Can I use this suppository for a yeast infection?

Yes, one of the active ingredients in this suppository is Nystatin, which treats fungal or yeast infections.

Are there any possible side effects?

With any medication, there can be side effects. Possible side effects may include irritation at the site of insertion and gastrointestinal disturbances. Always notify your healthcare provider if you experience any unusual conditions.

What precautions should I take when using this suppository?

Always wash your hands before and after use. If you are allergic to either Ampicillin or Nystatin, inform your healthcare provider. Additionally, inform your provider about any other medications you are taking.

Can I use this suppository if I am pregnant or breastfeeding?

If you are pregnant or breastfeeding, consult with your healthcare provider before using this medication. They can better advise if it is safe for you during these conditions.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.
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