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Arginine 6%/Papaverine HCl 3% Topical Cream

FDA-approved generic
Dose form
Topical Cream
Active ingredients
Papaverine Hydrochloride
Arginine Hydrochloride

Arginine 6%/Papaverine HCl 3% Topical Cream is a specially compounded semisolid preparation, dispensed in a pump mechanism for easy and controlled application. This formulation is designed to deliver localized treatment on the skin, facilitating the absorption of the active ingredients, Arginine and Papaverine HCl.

Arginine, an essential amino acid, plays a crucial role in cell division and wound healing, while Papaverine HCl is a vasodilator that helps improve blood flow. Together, these ingredients work synergistically to treat various disease states.

This formulation is particularly beneficial for patients suffering from conditions such as erectile dysfunction, peripheral vascular disease, and Raynaud's disease. By improving blood flow and promoting healing, this topical cream provides targeted relief and promotes overall health.

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For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
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This medication requires a prescription from your doctor
Ships within 1 to 2 business days after pharmacist verification
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Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.

For prescribersSign in for prescription details and order forms.
Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Papaverine Hydrochloride
Arginine Hydrochloride
Topical Cream
653174d2f10545815b3d1cad
Service area

Can we ship this formula to your state?

Bayview fills prescriptions for patients in Connecticut, Florida, Maine, Massachusetts, New Hampshire, New Jersey, Pennsylvania and Rhode Island. New York patients are served on a limited basis while nonresident pharmacy registration is pending.

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Formula Information

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This formulation is a topical cream containing Arginine 6% and Papaverine HCl 3%. Arginine is an amino acid that plays a crucial role in cell division, wound healing, removing ammonia from the body, immune function, and the release of hormones. It is also well-known for its potential to improve blood flow, which is why it is often used in creams and lotions for topical application. Papaverine HCl is a vasodilator, which means it helps to widen blood vessels, allowing for improved blood flow. This can be particularly beneficial in the treatment of conditions that are caused by restricted blood flow.

The cream is dispensed in a pump mechanism, which allows for convenient and controlled application. This is particularly beneficial for localized treatment, as it ensures that the active ingredients are delivered directly to the area that requires treatment. The semisolid preparation is designed to be easily absorbed by the skin, ensuring that the active ingredients can get to work quickly.

Arginine and Papaverine HCl work together in this formulation to improve blood flow to the area where the cream is applied. This can be beneficial in the treatment of a variety of disease states. For example, it can be used to treat erectile dysfunction, as this condition is often caused by restricted blood flow. It may also be beneficial in the treatment of peripheral vascular disease and Raynaud's disease, both of which are characterized by restricted blood flow to certain parts of the body. Additionally, the improved blood flow can aid in wound healing and may help to reduce the symptoms of conditions such as claudication (leg pain caused by restricted blood flow).

It's important to note that while this formulation can help to improve blood flow and may aid in the treatment of these conditions, it should be used under the guidance of a healthcare professional. As with any medication, it may not be suitable for everyone and may cause side effects. If you have any questions about this formulation, or if you would like more information, please don't hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is always here to help.

Drug Interactions

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Arginine and Papaverine HCl are active ingredients in this topical cream formulation. Arginine is an amino acid that plays a crucial role in cell division, wound healing, and the removal of ammonia from the body. It also aids in the production of nitric oxide, which is important for vascular health. Papaverine HCl is a vasodilator that helps to increase blood flow to specific areas of the body.

This formulation is designed to be applied topically, directly to the skin, where it can be absorbed locally. It is dispensed via a pump mechanism for convenient and controlled application. The cream is typically used to treat conditions that benefit from increased blood flow, such as erectile dysfunction, claudication, and Raynaud's disease.

While this formulation is generally safe for use, it's important to be aware of potential drug interactions. Arginine may interact with medications that lower blood pressure, as it can further decrease blood pressure levels. These medications include diuretics, ACE inhibitors, and beta-blockers. If you're taking any of these medications, please consult with your healthcare provider before using this cream.

Papaverine HCl may interact with antihypertensive drugs, leading to an additive hypotensive effect. It may also interact with anticholinergic drugs, increasing the risk of side effects such as dry mouth, blurred vision, and urinary retention. If you're taking any of these medications, it's important to discuss this with your healthcare provider.

Additionally, both Arginine and Papaverine HCl may interact with sildenafil (Viagra) and other similar medications used to treat erectile dysfunction. Using these medications together may increase the risk of side effects and should be done under the supervision of a healthcare provider.

It's also important to note that this cream should not be used on broken or irritated skin, as this can increase the absorption of the active ingredients and potentially lead to systemic side effects. Always apply the cream to clean, intact skin.

As with any medication, it's important to use this cream as directed by your healthcare provider. If you have any questions or concerns about this formulation or its potential interactions with other medications you're taking, please don't hesitate to reach out to us at Bayview Pharmacy.

How Does it Work

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The Arginine 6%/Papaverine HCl 3% Topical Cream is a specially formulated compound that combines the therapeutic benefits of both Arginine and Papaverine HCl. This cream is designed to be applied topically, directly onto the skin, where it can be absorbed locally to provide targeted treatment.

Arginine is an amino acid that plays a crucial role in many cellular functions. It is a precursor to nitric oxide, a potent vasodilator that helps to improve blood flow. When applied topically, Arginine can help to increase local blood circulation, which can aid in the healing of wounds and other skin conditions. It can also help to alleviate symptoms associated with poor circulation, such as cold hands and feet.

Papaverine HCl, on the other hand, is a non-narcotic alkaloid extracted from the opium poppy. It is a smooth muscle relaxant, which means it can help to relax the muscles in the walls of blood vessels. This can lead to an increase in blood flow, which can be beneficial in the treatment of conditions such as erectile dysfunction and peripheral vascular disease.

When combined in a topical cream, Arginine and Papaverine HCl work synergistically to improve local blood flow and relax smooth muscles. This can help to alleviate symptoms associated with a variety of disease states, including erectile dysfunction, peripheral vascular disease, and certain skin conditions. The cream is dispensed in a pump mechanism, which allows for convenient and controlled application of the medication.

It's important to note that while this cream can provide significant relief for certain conditions, it is not a cure. It should be used as part of a comprehensive treatment plan, under the supervision of a healthcare provider. As with any medication, it's important to use this cream as directed to ensure its safety and effectiveness.

If you have any questions about the Arginine 6%/Papaverine HCl 3% Topical Cream, or if you would like more information about how it works, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Other Uses

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Arginine 6%/Papaverine HCl 3% Topical Cream is a unique compounding formulation primarily used for addressing certain vascular-related conditions. Though this is the leading use, it is worth noting that the active ingredients in this formulation offer a variety of complimentary applications because of their properties.

For instance, the compound Arginine, an amino acid, can help improve wound healing. Research shows that the topical application of arginine can promote the production of collagen, a protein important for skin renewal and repair. Hence, this cream could be used as an adjunctive treatment for wounds, burns and skin ulcers.

Papaverine HCl, the other active ingredient, is a potent muscle relaxant often used for treating conditions like erectile dysfunction, when presented in a different formula. However, when compounded within this topical cream, it may offer muscle relaxation properties that could help patients with muscle spasms or contractures. It could also potentially be applied to the chest area to alleviate discomfort associated with certain cardiovascular conditions, like angina, leveraging its vasodilation effects.

Finally, considering the vasodilative properties of both the components, this formulation could potentially be used to improve local blood flow in conditions associated with poor circulation, further adding to its versatility. However, for any off-label use, it is crucial to consult with a healthcare provider to ensure safety and efficacy.

This is just a brief overview of the potential alternate uses for this specific compounding formulation. More comprehensive scientific evidence is needed to corroborate these claims conclusively. For further queries or detailed discussion, feel free to reach out to our team at Bayview Pharmacy. We are always here to assist you with your healthcare needs and provide personalized consultation.

Frequently Asked Questions

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What is Arginine 6%/Papaverine HCl 3% Topical Cream?

This is a compounded formulation presented as a semisolid cream that contains 6% Arginine and 3% Papaverine HCl. It is dispensed in a pump mechanism for controlled application on the skin.

What is the purpose of the pump mechanism in this cream's packaging?

The pump mechanism is designed for convenient usage and to provide controlled application of the cream, ensuring an accurate dose of the active ingredients is applied each time.

How does this Arginine 6%/Papaverine HCl 3% Topical Cream work?

The active ingredients in the cream work by being absorbed through the skin for localized treatment. Arginine and Papaverine HCl have different properties and work in synergy as per the intended treatment.

What skin conditions does this cream treat?

The cream's specific application will be as prescribed by your healthcare provider. It is of utmost importance to only use the cream as instructed by a trained medical professional.

How does Arginine function in the cream?

Arginine is an essential amino acid that plays several key roles in the body. In a topical cream, it contributes to wound healing, collagen production, and improved circulation.

What is the role of Papaverine HCl in the cream?

Papaverine HCl is a vasodilator. This means it helps to widen blood vessels, which can improve blood flow. This can be particularly beneficial for topical treatments targeting certain skin conditions.

Is this product the same as other Arginine and Papaverine HCl creams?

While it contains Arginine and Papaverine, the specific proportions and other ingredients may vary. Always use the product as specified by your healthcare provider.

Can I use Arginine 6%/Papaverine HCl 3% Topical Cream safely?

Only a healthcare provider can confirm whether this product is safe for your use based on your health and medical history. Always follow their instructions and immediately report any side effects.

How does absorption through the skin work?

The active ingredients in the cream are absorbed through the skin through a process called transdermal absorption. The ingredients then work on the local area for treatment.

Can I expect immediate results with this cream?

The rate of results can vary depending on individual responses and the condition that is being treated. It is essential to discuss expectations and treatment timeline with your healthcare provider.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

The conditions listed on this page are indications prescribers have ordered this preparation for. They are not FDA-approved indications, and listing them is not a statement that this preparation is effective for them.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Arginine 6%/Papaverine HCl 3% Topical Cream
Topical Cream
30 g
controlled

Apply topically to affected area(s)

As needed, no more than once daily and 3 times weekly