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Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
Prepared to a prescriber's order for one patient. Not FDA-approved.
Aspirin is a salicylate NSAID used for pain, fever and clot prevention; compounding pharmacies prepare it as oral capsules, oral liquids and suppositories.
Aspirin (acetylsalicylic acid) is a nonsteroidal anti-inflammatory drug of the salicylate class. Its acetyl group permanently inactivates cyclooxygenase-1 in platelets, cutting thromboxane A2 so platelets clump less for their 7 to 10 day lifespan, and it blocks prostaglandin synthesis, which eases pain, fever and inflammation. Most manufactured aspirin is over-the-counter: Bayer Genuine Aspirin and store brands are labeled for temporary relief of headache, muscle pain, toothache, menstrual pain and minor arthritis pain. Durlaza, a prescription extended-release capsule (New Haven Pharmaceuticals), is FDA-approved to reduce the risk of death and heart attack in chronic coronary artery disease and of death and recurrent stroke after an ischemic stroke or TIA. A prescriber may order aspirin compounded as a liquid or capsule in a strength that is not manufactured, as a suppository in a strength other than the manufactured over-the-counter suppository, or in a vehicle free of a specific dye or filler. Compounded preparations are not FDA-approved and require a prescription.
Aspirin labels carry no boxed warning, but the OTC Drug Facts carry a Reye's syndrome warning: children and teenagers who have or are recovering from chickenpox or flu-like symptoms should not use aspirin, and behavior changes with nausea and vomiting can be an early sign of this rare but serious illness. Aspirin can cause severe stomach bleeding, more likely in people over 60, with ulcers or bleeding problems, on blood thinners, steroids or other NSAIDs, or drinking three or more alcoholic drinks a day. It can trigger severe allergic reactions and is contraindicated in anyone allergic to NSAIDs or who has asthma with nasal polyps. Interactions include anticoagulants and antiplatelets, methotrexate, valproate, phenytoin, ACE inhibitors, and ibuprofen, which can block aspirin's antiplatelet effect. Do not take aspirin above low-dose strength at or after 20 weeks of pregnancy, and avoid it in the last three months, unless a doctor directs it; LactMed reports that low-dose aspirin is not excreted into milk, while long-term high-dose use probably caused metabolic acidosis in one breastfed infant, so an alternative is preferred over continuous high-dose aspirin while nursing. Seek care for black stools or vomited blood. If side effects are severe or do not go away, talk to your prescriber or pharmacist.
Aspirin acetylates a serine residue of COX-1, irreversibly inactivating the enzyme and preventing thromboxane A2 formation in platelets, which cannot resynthesize COX; it also acetylates COX-2 and alters its activity. Absorption is largely gastric and proximal small bowel and is pH dependent (pKa 3.5), with peak levels 0.3 to 2 hours after immediate-release dosing; liquids absorb more quickly than tablets. Aspirin is rapidly hydrolyzed in plasma to salicylic acid, with a parent half-life of about 20 to 60 minutes; salicylate is extensively albumin-bound, conjugated in the liver to salicyluric acid and glucuronides, and renally excreted, with saturable elimination at higher concentrations and enhanced clearance with urinary alkalinization. Labeled indications: OTC pain and fever (Bayer); secondary prevention in chronic coronary artery disease and after ischemic stroke or TIA (Durlaza). Prescribers have ordered aspirin off-label for Kawasaki disease, rheumatic fever, lupus and rheumatoid arthritis (StatPearls, MedlinePlus). Dosing and route are per prescriber. Monitoring: bleeding signs, renal function with RAS inhibitors, and serum salicylate levels only with prolonged high-dose anti-inflammatory therapy; tinnitus warrants discontinuation. Aspirin-exacerbated respiratory disease and G6PD deficiency are cautions. Not a controlled substance.
Wash your hands. If the suppository is soft, chill it in its wrapper in the refrigerator or under cool water for a few minutes, then unwrap it. For rectal use, coat the tip with a water-soluble lubricant (not petroleum jelly), lie on your side with your upper knee bent, and insert it pointed end first past the muscle at the opening. For vaginal use, lie on your back with knees bent and insert it as far as it comfortably goes, by finger or applicator; bedtime use limits leakage, and a panty liner protects clothing. Stay lying down about 15 minutes. Wash your hands.
Suppositories are nonaqueous, so under USP <795> they can carry a beyond-use date of up to 180 days at controlled room temperature or in the refrigerator when no other stability data apply. Storage depends on the base: fatty bases can soften at room temperature and may be labeled for the refrigerator, while polyethylene glycol bases usually do not need refrigeration. Keep them cool so they do not melt, and refrigerate them if your label says to.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.
Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Insert 1 unwrapped suppository
