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This formulation is an oral liquid medication containing Atovaquone 62.5 mg and Proguanil HCl 25 mg per 5 mL. It is specifically designed for easy ingestion and accurate dosage delivery, making it an ideal choice for individuals who find swallowing solid dosage forms challenging, such as pediatric and geriatric populations.
The Atovaquone and Proguanil HCl combination in this formulation is commonly used to treat and prevent malaria, a disease state caused by parasites that enter the body through the bite of a mosquito. It works by killing the organisms that cause malaria.
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This formulation is a specially prepared oral liquid medication containing Atovaquone 62.5 mg and Proguanil HCl 25 mg per 5 mL. It is designed to provide a convenient and easily ingested dosage form, particularly beneficial for patients who find swallowing solid dosage forms challenging. This includes pediatric and geriatric populations, or those with dysphagia or other swallowing difficulties.
Atovaquone and Proguanil HCl are antimalarial medications that work synergistically to prevent and treat malaria, a life-threatening disease caused by parasites that are transmitted to people through the bites of infected mosquitoes. Atovaquone disrupts the mitochondrial electron transport within the malarial parasite, while Proguanil, primarily its metabolite cycloguanil, inhibits dihydrofolate reductase, disrupting DNA synthesis and cell multiplication.
It's important to note that the effectiveness of this medication is dependent on adherence to the prescribed dosage regimen. Missing doses or not completing the full course of therapy may decrease the effectiveness of the immediate treatment and increase the likelihood that the parasites will develop resistance and will not be treatable by Atovaquone-Proguanil or other antimalarials in the future.
Common side effects may include stomach pain, nausea, vomiting, headache, and dizziness. Serious side effects are rare but may include severe allergic reactions, liver problems, or heart rhythm disorders. Patients should be advised to seek immediate medical attention if they experience symptoms of these serious side effects.
Prescribers should consider the patient's overall health status, other medications being taken, and potential drug interactions before prescribing this medication. It is contraindicated in patients with severe renal impairment and caution should be exercised in patients with liver disease. It is also important to note that Atovaquone-Proguanil is not recommended for use in pregnancy unless the potential benefit to the mother outweighs the potential risk to the fetus.
If you have any questions or need further information about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always ready to assist you.
Atovaquone and Proguanil Hydrochloride is a combination medication used to treat and prevent malaria, a disease caused by parasites. These medications work by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.
Atovaquone and Proguanil Hydrochloride oral liquid should be taken with food or a milky drink that is high in fat. This will help your body absorb the medication better. It is important to continue taking this medication exactly as prescribed by your doctor. Do not take more or less of it or take it more often than prescribed by your doctor.
While Atovaquone and Proguanil Hydrochloride is a highly effective medication, it may interact with other drugs. It is important to inform your healthcare provider about all the medications you are currently taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
Atovaquone and Proguanil Hydrochloride may interact with rifampin or rifabutin, which can make the medication less effective. It may also interact with tetracycline, metoclopramide, indinavir, or certain medications for seizures, which can affect how Atovaquone and Proguanil Hydrochloride works in your body.
Warfarin and other anticoagulants may interact with Atovaquone and Proguanil Hydrochloride, potentially leading to an increased risk of bleeding. If you are taking an anticoagulant, your healthcare provider may need to monitor your bleeding risk or adjust your medication dosage.
It is also important to note that Atovaquone and Proguanil Hydrochloride can cause serious side effects if taken with certain other medications. These include certain antifungal medications, certain antibiotics, and certain HIV/AIDS medications. Always inform your healthcare provider about all the medications you are currently taking to avoid potential drug interactions.
If you have any questions about Atovaquone and Proguanil Hydrochloride, or about potential drug interactions, please do not hesitate to reach out to us. We are here to help ensure that your medication is safe and effective for you.
Atovaquone and Proguanil Hydrochloride (HCl) are two active ingredients in this oral liquid formulation. Both are antimalarial medications that work together to treat and prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.
Atovaquone works by disrupting the mitochondrial electron transport within the malarial parasite, thereby inhibiting its growth and reproduction. It specifically targets the cytochrome bc1 complex, which is essential for the parasite's survival. By inhibiting this complex, atovaquone effectively halts the production of adenosine triphosphate (ATP), the energy currency of the cell, leading to the death of the parasite.
Proguanil HCl, on the other hand, primarily acts by inhibiting the enzyme dihydrofolate reductase (DHFR) in the malarial parasite. DHFR is a crucial enzyme involved in the synthesis of nucleotides required for DNA replication. By inhibiting DHFR, proguanil prevents the parasite from multiplying in the red blood cells.
Together, Atovaquone and Proguanil HCl provide a synergistic effect. While Atovaquone kills the existing parasites, Proguanil HCl prevents any new parasites from growing, effectively treating and preventing malaria.
This oral liquid formulation is specifically designed for easy ingestion and accurate dosage. It is particularly useful for patients who have difficulty swallowing solid dosage forms, such as children and the elderly. The liquid form allows for the medication to be absorbed quickly and efficiently, providing rapid relief from symptoms.
It's important to note that while this medication is effective in treating and preventing malaria, it does not prevent mosquito bites. Therefore, it's crucial to take other preventive measures such as using mosquito nets and repellents, and wearing protective clothing.
If you have any questions about this formulation or its use, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.
Besides the primary purpose of treating malaria, Atovaquone/Proguanil HCl, in the form of a 62.5 mg/25 mg per 5 mL oral liquid, might also be used for other clinical indications where off-label use has been suggested. It has been reviewed in the medical literature as an alternative for pneumocystis pneumonia (PCP) prophylaxis, especially in patients who are intolerant or allergic to first-line therapies like trimethoprim-sulfamethoxazole.
Atovaquone and proguanil are both antiparasitic medications, and their combined use enhances their effect, thereby making them useful in treating not only malaria but also certain parasitic infections such as toxoplasmosis and babesiosis. Furthermore, the oral liquid formulation provided by this compound delivers a more accessible, precise dosage, which benefit those who have difficulty swallowing solid dosage forms or who require accurate dosage adjustments, such as pediatric and geriatric patients.
The combined therapy can be useful in tackling the issue of drug resistance seen in various regions around the world. Atovaquone-Proguanil (Malarone) is also sometimes used in certain cases for prophylaxis in travelers to countries where malaria is rampant. However, before it properties are applied in different conditions, it is recommended that physicians must first weigh the potential benefits versus the risks associated to it.
Please remember that usage other than that it is intended for, must be under the strict supervision and discretion of a healthcare provider. As experienced compounding pharmacists, we are here to provide guidance and assistance for any queries related to this formulation or any other pharmaceutical matters. Feel free to reach out to us when required.
This is a compounded formulation of a liquid medication specifically designed for oral administration. It consists of Atovaquone and Proguanil HCl as active ingredients and is expressed in a concentration per 5 mL of liquid.
The liquid formulation is often used when swallowing solid dosage forms is challenging, majorly for the pediatric and geriatric populations. However, it can be used by any patient group based on individual healthcare provider's recommendations.
This medication is in a liquid form to provide a convenient and easily ingested dosage. It is specifically formulated to ensure the accurate delivery of the medication and is ideal for patients who struggle with swallowing solid forms of medication.
This medication should be stored as directed by the pharmacist or healthcare provider, typically in a cool, dry place out of sight and reach of children. The medication should not be used past the expiry date issued.
No. If you have a known allergy or have previously exhibited an allergic reaction to either Atovaquone or Proguanil HCl, you should not take this medication. Always disclose your complete medical history to your healthcare provider.
As with any medication, side effects may occur. Some common side effects can include nausea, vomiting, or abdominal pain. If you experience any side effects, seek immediate medical attention and talk to your healthcare provider.
Consult your healthcare provider before taking this medication during pregnancy or while breastfeeding. The effects of the medication on the unborn baby or nursing child are not completely known, therefore professional advice is necessary.
Your healthcare provider will guide you on when and how to take this medication. It is critical to follow their instructions carefully to gain maximum benefit from the medication.
If you miss a dose, take it as soon as you remember. However, if your next dose is soon, then skip the missed dose to avoid taking double doses. Always remember to inform your healthcare provider about any missed doses.
In case of a suspected overdose, seek immediate medical attention. Overdosing can lead to serious health complications. Always take the medication as prescribed to avoid overdose.
