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The Atropine Sulfate 0.25 mg/Morphine Sulfate 15 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum. Upon insertion, the suppository dissolves or melts, releasing the active ingredients for local or systemic absorption. This formulation is primarily used for the treatment of severe pain, bowel motility issues, and palliative care in end-of-life situations. The combination of Atropine Sulfate and Morphine Sulfate provides both analgesic and antispasmodic effects.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
This formulation combines Atropine Sulfate and Morphine Sulfate in a rectal suppository dosage form. Atropine Sulfate is an antimuscarinic agent that works by blocking the action of acetylcholine, a neurotransmitter that transmits signals in the nervous system. This helps to reduce certain types of muscle spasms and secretions. Morphine Sulfate, on the other hand, is a potent opioid analgesic that works by binding to opioid receptors in the brain and spinal cord, thereby reducing the perception of pain.
The rectal suppository dosage form is a solid medication that is inserted into the rectum, where it dissolves or melts to release the medication. This allows for local or systemic absorption of the medication. The advantage of this dosage form is that it bypasses the first-pass metabolism in the liver, which can lead to a higher bioavailability of the medication. It is also a useful alternative for patients who have difficulty swallowing oral medications.
This formulation is typically used to manage severe pain and to reduce secretions in the airways, stomach, and intestines. However, it is important to note that this medication should be used under the supervision of a healthcare provider due to the risk of serious side effects, including respiratory depression and addiction.
Patients using this formulation should follow the dosing instructions provided by their healthcare provider. The suppository should be inserted into the rectum as directed, and patients should avoid activities requiring mental alertness or coordination until they know how the medication affects them. Common side effects may include constipation, nausea, and dizziness. Patients should seek immediate medical attention if they experience difficulty breathing, severe drowsiness, or a slow heart rate.
Prescribers should consider the patient's overall health status, other medications, and individual response to treatment when deciding on the appropriate dose. Regular monitoring is recommended to assess the patient's response to treatment and to detect any adverse effects. It is also important to educate patients about the risks of opioid addiction and to implement strategies to prevent misuse and abuse.
If you have any questions about this formulation, please do not hesitate to reach out to us. Our team of compounding pharmacists at Bayview Pharmacy is always here to assist you.
Atropine Sulfate and Morphine Sulfate are two potent medications that can interact with a variety of other drugs. It's crucial to understand these potential interactions to ensure safe and appropriate use of this rectal suppository formulation.
Atropine Sulfate can interact with drugs that affect the nervous system, including sedatives, tranquilizers, and medications for Parkinson's disease. It can also interact with certain heart medications, such as digoxin and quinidine. Concurrent use of these drugs can lead to increased side effects or decreased effectiveness of the medications.
Morphine Sulfate, an opioid analgesic, can interact with other central nervous system depressants like alcohol, antihistamines, barbiturates, benzodiazepines, and other opioids. This can lead to increased sedation, respiratory depression, and even coma. It can also interact with monoamine oxidase inhibitors (MAOIs), leading to severe reactions including high fever, muscle rigidity, and seizures. Morphine can also interact with certain heart medications, such as beta-blockers, leading to decreased effectiveness of these drugs.
This formulation is typically used to manage severe pain and to reduce secretions in the bronchi, salivary glands, and stomach before surgery or to control symptoms of certain medical conditions like irritable bowel syndrome. The Atropine Sulfate works by decreasing the activity of the digestive system and the secretions in the body, while the Morphine Sulfate works by changing the way the brain and nervous system respond to pain.
It's important to inform your healthcare provider of all the medications you are currently taking, including prescription and over-the-counter drugs, vitamins, and herbal supplements. This will help your healthcare provider to monitor for drug interactions and manage them appropriately.
Patients should also be aware of the potential for serious interactions and should seek immediate medical attention if they experience symptoms such as severe drowsiness, slow or shallow breathing, severe constipation, or a slow heart rate.
If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help ensure your safety and the effectiveness of your medication.
The Atropine Sulfate 0.25 mg/Morphine Sulfate 15 mg Rectal Suppository is a solid dosage form that is inserted into the rectum, where it dissolves or melts to release the medication. This formulation is designed for local or systemic absorption, depending on the specific needs of the patient.
Atropine Sulfate is an antimuscarinic agent that works by blocking the action of acetylcholine, a neurotransmitter that transmits signals in the nervous system. By blocking the action of acetylcholine, Atropine Sulfate can reduce the activity of the parasympathetic nervous system, which controls functions such as heart rate, digestion, and salivation. This can help to reduce symptoms such as excessive salivation or bronchial secretions.
Morphine Sulfate, on the other hand, is a powerful opioid analgesic that works by binding to opioid receptors in the brain and spinal cord. This can block the transmission of pain signals, providing relief from severe pain. Morphine Sulfate can also affect areas of the brain that control emotion, which can further help to reduce the perception of pain.
This can be particularly useful in the management of conditions such as terminal cancer, where patients may experience severe pain and other distressing symptoms.
It's important to note that this formulation should be used under the supervision of a healthcare professional, as both Atropine Sulfate and Morphine Sulfate can have serious side effects if not used correctly. These can include constipation, dry mouth, blurred vision, drowsiness, and addiction or dependence in the case of Morphine Sulfate.
If you have any questions about this formulation, or if you would like more information about how it works, please don't hesitate to reach out to us. We are here to help and provide you with the information you need to make informed decisions about your healthcare.
This is a solid dosage form that's inserted into a body cavity, typically the rectum, where it dissolves or melts to release the medication for either local or systemic absorption. It contains Atropine Sulfate and Morphine Sulfate as the active ingredients.
This suppository is typically inserted into the rectum where it melts at body temperature, releasing the medication for absorption into the body.
The main active ingredients in this compounded formulation are Morphine Sulfate at 15 mg for pain relief, and Atropine Sulfate at 0.25 mg, which has various uses including reducing salivary secretions and gastroduodenal motility.
Atropine Sulfate is used in this formulation to reduce certain types of gastrointestinal or urinary tract activity, as well as to reduce secretions in the throat, lungs, and nose. It also helps to relieve symptoms of nausea and vomiting.
It is a potent opioid agonist that works by acting directly on the central nervous system to decrease the feeling of pain.
As with all medications, it is important that this medication is used under the supervision of a healthcare provider, who has deemed it appropriate for the individual's needs based on their medical history and circumstances.
As with any medication, there may be side effects. These can vary widely from person to person and may include gastrointestinal discomfort, constipation, flushing, and dry mouth. It's important to discuss potential side effects with a healthcare provider before starting any new medication regimen.
Duration of the effect can vary largely depending on the individual's response to the medication. It's advised to discuss this with your healthcare provider for a better understanding of what to expect in your specific case.
It's essential to discuss with your healthcare provider about all the medications, supplements, or herbs you’re currently taking to avoid any potential drug interactions.
This medication should be kept in its original packaging and stored at room temperature, away from direct heat and light. Always keep medicines out of the reach of children and pets.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Insert 1 unwrapped suppository
