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Azelaic Acid 15%/Ivermectin 1%/Metronidazole 1% Topical Cream

This formulation is a semisolid preparation of Azelaic Acid 15%, Ivermectin 1%, and Metronidazole 1% Topical Cream, dispensed in a pump mechanism for convenient and controlled application on the skin. The active ingredients are designed for localized treatment or absorption, effectively treating a variety of disease states.

Azelaic Acid, a dicarboxylic acid, works by reducing the growth of bacteria in the follicles and helping to renew and rejuvenate the skin. Ivermectin, an anti-parasitic agent, is used to treat various parasitic infestations, while Metronidazole, an antibiotic and antiprotozoal medication, is used to treat a variety of infections caused by anaerobic bacteria and microorganisms.

Together, these active ingredients work synergistically to treat conditions such as rosacea, acne, and various skin infections, providing relief from inflammation, redness, and other associated symptoms.

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Topical Cream
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Formula Information

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This formulation combines Azelaic Acid 15%, Ivermectin 1%, and Metronidazole 1% in a topical cream. It is a semisolid preparation dispensed in a pump mechanism, designed for convenient and controlled application on the skin. This formulation is intended for localized treatment or absorption of active ingredients.

Azelaic Acid is a dicarboxylic acid that works by reducing the growth of skin bacteria that can block pores, and by reducing inflammation. It is commonly used to treat mild to moderate acne, and rosacea. Ivermectin is an anti-parasitic medication that works by paralyzing and killing parasites. It is used to treat conditions such as rosacea, and other skin conditions caused by parasites. Metronidazole is an antibiotic and antiprotozoal medication that works by inhibiting the growth of certain bacteria and parasites. It is used to treat various skin conditions such as rosacea, and bacterial infections.

Together, these three active ingredients work synergistically to treat a variety of skin conditions. The Azelaic Acid reduces inflammation and bacterial growth, the Ivermectin treats parasitic infections, and the Metronidazole treats bacterial infections. This combination can be particularly effective in treating rosacea, which can have a complex etiology involving both bacteria and parasites.

It is important to use this medication exactly as prescribed by your healthcare provider. Apply a thin layer of the cream to the affected area, usually once or twice daily, or as directed by your healthcare provider. Avoid getting this medication in your eyes or inside the nose or mouth. If this occurs, rinse thoroughly with water. Do not apply this medication on sunburned, windburned, dry, chapped, irritated, or broken skin.

Side effects may include burning, stinging, tingling, or redness of the skin. If any of these effects persist or worsen, notify your healthcare provider promptly. Remember that your healthcare provider has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.

If you have any questions about this formulation, or if you would like more information, please do not hesitate to reach out to us at Bayview Pharmacy. We are a team of knowledgeable compounding pharmacists, and we are here to help.

Drug Interactions

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This topical cream formulation combines Azelaic Acid 15%, Ivermectin 1%, and Metronidazole 1%. Each of these active ingredients has a specific role in treating various skin conditions. Azelaic Acid is used to treat mild to moderate acne and rosacea due to its antibacterial and anti-inflammatory properties. Ivermectin is an anti-parasitic agent used to treat skin conditions like rosacea and inflammatory lesions. Metronidazole is an antibiotic and antiprotozoal medication used to treat various infections, including skin conditions like rosacea.

While this formulation is generally safe and effective, it's important to be aware of potential drug interactions. Here are some key points to consider:

Azelaic Acid: This component has minimal systemic absorption, and thus, systemic drug interactions are unlikely. However, it may cause skin irritation, especially when used with other topical products that can cause irritation, such as abrasive soaps and cleansers, or skin products with high alcohol content.

Ivermectin: This drug has a wide range of interactions. It can interact with certain medications that affect P-glycoprotein/ABCB1 transporters. Examples include clarithromycin, erythromycin, and ritonavir. Concurrent use of these medications may increase the systemic absorption of ivermectin, potentially leading to increased risk of side effects.

Metronidazole: While topical metronidazole has minimal systemic absorption, it should be used with caution in patients taking anticoagulants like warfarin, as it may potentiate the anticoagulant effect. Also, it should not be used concurrently with alcohol or propylene glycol-containing products, as it may result in a disulfiram-like reaction (nausea, vomiting, flushing, etc.).

It's important to inform your healthcare provider about all the medications you are currently taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements. This will help your healthcare provider to manage potential drug interactions effectively.

Patients should also be aware that this formulation may cause local skin reactions, such as burning, stinging, or irritation. If these reactions persist or worsen, discontinue use and consult your healthcare provider.

Remember, this formulation is intended for topical use only and should not be ingested or applied to the eyes or mucous membranes. Always use this medication as directed by your healthcare provider.

If you have any questions or concerns about this formulation or its potential interactions, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you.

How Does it Work

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This topical cream formulation combines three active ingredients: Azelaic Acid (15%), Ivermectin (1%), and Metronidazole (1%). Each of these ingredients plays a unique role in treating various skin conditions, and their combined effect can provide a comprehensive treatment approach.

Azelaic Acid is a dicarboxylic acid that works by inhibiting the growth of skin bacteria that can block pores, and by reducing inflammation. It is often used to treat acne and rosacea, as it can reduce the redness, swelling, and pimples that occur with these conditions. Azelaic Acid also helps to decrease the production of keratin, a substance that can lead to the development of acne.

Ivermectin is an anti-parasitic medication that works by causing paralysis and death of parasites. In the context of this topical cream, it is used to treat skin conditions caused by parasites, such as rosacea. Ivermectin has been shown to reduce inflammatory lesions and decrease the redness associated with rosacea.

Metronidazole is an antibiotic and antiprotozoal medication that works by inhibiting nucleic acid synthesis by disrupting the DNA of microbial cells. This action is primarily bactericidal. Metronidazole is used to treat a variety of infections, including those caused by bacteria and parasites. In this topical cream, it is used to treat skin conditions such as rosacea and dermatitis, as it can reduce inflammation and redness.

The semisolid preparation of this cream is designed for convenient and controlled application on the skin. The pump mechanism allows for a consistent amount of cream to be dispensed each time, ensuring that the correct dose is applied. This formulation is designed for localized treatment, meaning it should be applied directly to the affected area of the skin. The active ingredients in the cream are then absorbed through the skin, where they can begin to treat the underlying condition.

It's important to note that while this cream can provide significant relief from symptoms, it may not cure the underlying condition. Therefore, it's crucial to use this medication as directed by a healthcare provider and to continue using it for the full duration of treatment, even if symptoms improve before the treatment period is complete.

If you have any questions about this formulation, how it works, or how it should be used, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help.

Other Uses

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This Azelaic Acid 15%/Ivermectin 1%/Metronidazole 1% Topical Cream formulation is primarily used to treat skin conditions like rosacea, a condition characterized by the excessive redness and inflammation of the skin, and cutaneous infestations, infection and inflammation due to parasites affecting the skin. However, it also has several other potential uses.

Azelaic acid has been shown to be beneficial in the treatment of acne due to its ability to kill the bacteria that cause acne and reduce the production of keratin, a natural substance that can lead to the development of acne. It may also play a role in the management of melasma, a condition that causes dark, discolored patches on the skin, due to its mild bleaching effect. Considering these properties, the inclusion of azelaic acid may also make this cream useful for patients looking to improve acne or achieve more even skin tone.

Similarly, ivermectin can be used to treat a range of skin infestations beyond rosacea, including scabies and lice. While not a primary use, some dermatologists recommend ivermectin for the treatment of certain inflammatory conditions like acne and rosacea due to its anti-inflammatory properties. Moreover, metronidazole is known for its antimicrobial properties and may help in the management of bacterial skin infections or "secondary" skin infections where bacteria invade the skin following another inflammatory skin condition.

Although these uses are possible, each individual may react differently to the ingredients, and thus, alternative uses should be discussed with a healthcare provider before application. Additionally, as with any medication, side effects such as dryness, irritation, and burning or itching sensations may occur. Caution is advised for use in pregnant or breastfeeding women, and use in children. Also, patients with hypersensitivity to any of these ingredients should not use this compound.

Remember that this compound should be used as directed by a healthcare provider, and the exact disease condition, as well as risk factors and current health status, should be considered before its application. This information is intended to complement, not substitute, the direct supervision and advice of a healthcare provider.

If you have any further questions regarding this formulation, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you.

Frequently Asked Questions

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What exactly is the Azelaic Acid 15%/Ivermectin 1%/Metronidazole 1% Topical Cream?

This is a compound medication that contains Azelaic Acid 15%, Ivermectin 1%, and Metronidazole 1%. It is a semisolid preparation designed for convenient and controlled application on the skin for localized treatment or absorption.

What is the purpose of the Azelaic Acid in the formulation?

Azelaic Acid has antibacterial properties and can help to decrease inflammation, which helps with conditions such as rosacea and acne.

What role does Ivermectin and Metronidazole play in this topical cream?

Ivermectin is an anti-parasitic agent that helps relieve skin irritation while Metronidazole is an antibiotic effective in treating certain skin infections.

How do I apply this topical cream?

The cream is dispensed by a pump mechanism. You apply it to the skin where treatment is required. Only a thin layer is needed and it is advisable to wash your hands after application.

Can I use this cream on any part of the body?

This cream is designed for skin application only and it should not be used on or around mucous membranes or the eyes. Always follow the application directions given by your healthcare provider.

Is this cream suitable for all skin types?

While this cream is generally safe for most skin types, individual tolerance can vary. Consult with your healthcare provider if you have any significant allergies or skin sensitivities.

Are there any possible side effects with this topical cream?

Common side effects may include skin dryness or irritation, burning or tingling sensation upon application. If these effects persist or worsen, consult with your healthcare provider right away.

Can this topical cream interact with other medications?

Though it's less likely, some topical medications can interact with other drugs. To ensure safety, let your healthcare provider know about all the medications you're currently taking.

How should I store this medication?

Store this medication at room temperature, away from heat and direct light. Do not freeze the cream, and remember to keep it out of reach of children.

Is this cream safe to use for pregnant or breastfeeding women?

Some ingredients might be absorbed into the bloodstream and can affect pregnancy or a nursing infant. Therefore, it's crucial to consult with a healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding before using this product.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.
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