Azithromycin 75 mg Rectal Suppository is a specialized formulation designed for administration via the rectal route. This solid dosage form is inserted into the rectum, where it dissolves or melts, releasing the medication for local or systemic absorption. The active ingredient, Azithromycin, is a broad-spectrum antibiotic that is effective against a wide variety of bacterial infections.

Azithromycin works by inhibiting the growth of bacteria by interfering with their protein synthesis. It binds to the 50S subunit of the bacterial ribosome, thus inhibiting translation of mRNA. This action prevents the bacteria from growing, and its further reproduction is halted, leading to the eventual elimination of the bacterial infection from the body.

This formulation is particularly useful in treating various bacterial infections, including respiratory infections, skin infections, ear infections, and sexually transmitted diseases. It can also be used in patients who have difficulty swallowing oral medication or for whom intravenous administration is not suitable. The rectal route of administration allows for the medication to be absorbed directly into the bloodstream, bypassing the digestive system, which can lead to a faster onset of action and potentially fewer gastrointestinal side effects.

Patients using this formulation should follow the instructions provided by their healthcare provider. The suppository should be inserted into the rectum as directed, and hygiene practices should be followed to prevent the spread of infection. It's important to complete the full course of treatment, even if symptoms improve before the medication is finished, to ensure the complete eradication of the bacteria and prevent resistance.

Prescribers should consider the patient's overall health status, other medications, and potential drug interactions when prescribing this formulation. Azithromycin is generally well-tolerated, but side effects can occur, including stomach upset, diarrhea, and allergic reactions. Patients should be monitored for these and other potential side effects.

If you have any questions about the Azithromycin 75 mg Rectal Suppository formulation, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to provide the information and support you need to ensure optimal treatment outcomes.

Azithromycin is a macrolide antibiotic that works by stopping the growth of bacteria. This medication is used to treat a variety of bacterial infections, including sexually transmitted infections, respiratory infections, skin infections, ear infections, and others. It is important to note that azithromycin is not effective against viral infections.

When considering the use of Azithromycin 75 mg Rectal Suppository, it is crucial to be aware of potential drug interactions. Drug interactions can change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: live bacterial vaccines, antacids containing aluminum or magnesium, other antibiotics (such as erythromycin, telithromycin), warfarin, digoxin, and drugs that prolong the QT interval (including certain antipsychotic medications, certain antidepressants, and drugs for irregular heart rhythms).

Azithromycin can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include some drugs to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil), certain drugs to treat seizures (such as carbamazepine, phenytoin), among others.

Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, some antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.

It is also important to note that azithromycin should not be used with any other medication containing azithromycin or erythromycin. Using these medications together can increase the risk of certain side effects and can potentially lead to a life-threatening irregular heart rhythm.

Remember that your healthcare provider has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

If you have any questions or concerns about Azithromycin 75 mg Rectal Suppository, or its potential interactions with other medications, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to assist you.

Azithromycin 75 mg Rectal Suppository is a solid dosage form that is inserted into the rectum where it dissolves or melts to release the medication. The active ingredient in this formulation is Azithromycin, a macrolide-type antibiotic. This antibiotic works by stopping the growth of bacteria.

Once the suppository is inserted into the rectum, it begins to dissolve due to the body's natural heat. As it dissolves, the Azithromycin is released and absorbed into the bloodstream through the rectal tissue. This allows the medication to circulate throughout the body and target the bacteria causing the infection.

Azithromycin works by binding to the 50S subunit of the bacterial ribosome, thus inhibiting protein synthesis in susceptible bacteria. It interferes with microbial protein synthesis by binding to the 50S ribosomal subunit. This action prevents bacteria from growing, which leads to their eventual elimination from the body.

Rectal administration of Azithromycin can be beneficial in cases where oral administration is not possible or not recommended. This could be due to nausea, vomiting, difficulty swallowing, or specific drug-drug interactions. Furthermore, rectal administration can provide a more direct route for the medication to enter the bloodstream, potentially allowing for quicker onset of action.

It's important to note that Azithromycin only works against bacterial infections. It will not work for viral infections (such as common cold, flu). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.

As with any medication, it's crucial to use Azithromycin Rectal Suppositories as directed by your healthcare provider. The dosage is based on your medical condition and response to treatment. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and the risk of serious side effects may increase.

If you have any questions about Azithromycin 75 mg Rectal Suppositories or would like more information, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help.

In addition to the common use of Azithromycin 75 mg Rectal Suppository for treating infections caused by susceptible bacterial organisms, this formulation carries potential for other alternative applications. A rectal suppository can be an effective route for those with difficulty swallowing oral medications or for whom injections are not advised.

An important application can be in pediatrics where patients might refuse or find difficulty in ingesting oral forms of Azithromycin. By manipulating the delivery route to rectal administration, it can ensure optimum drug absorption with minimal patient discomfort. Furthermore, utilizing rectal suppositories may also be beneficial for patients experiencing vomiting, rendering oral routes unsuitable. If absorption via the gastrointestinal tract is problematic due to disease or surgery, the rectal route allows the drug to bypass this region, providing optimal medication absorption.

Azithromycin as a rectal suppository could be used off-label for certain non-infective conditions where anti-inflammatory properties can provide benefit. Studies have suggested Azithromycin has anti-inflammatory and immunomodulatory effects. For conditions such as Crohn's disease and ulcerative colitis, where inflammation is a main contributor to patient discomfort, rectal administration of Azithromycin could provide localized anti-inflammatory effects.

While these off-label applications are promising, it is important that each is evaluated in the context of an individual patient's condition and general health. The prescribed dosage, frequency, and duration should reflect the patient’s specific needs and potential risk factors. As with all medications, Azithromycin should be used judiciously and under careful monitoring for signs of adverse reactions.

Also, this formulation may be subject to further research and off-label applications which have not been detailed here. For additional inquiries or information about the possible use of the Azithromycin 75 mg Rectal Suppository, whether listed here or not, please don't hesitate to contact our team at Bayview Pharmacy. We're committed to providing valuable pharmaceutical insight and ensuring the well-being of our patients.