This formulation combines Baclofen, Diazepam, and Ketamine HCl into a vaginal suppository. Baclofen is a muscle relaxant and antispastic agent, Diazepam is a benzodiazepine that provides sedative, muscle relaxant, and anticonvulsant effects, and Ketamine HCl is an NMDA receptor antagonist that provides analgesic and anesthetic effects. The combination of these three active ingredients provides a multi-modal approach to pain management, muscle relaxation, and sedation.

The suppository dosage form allows for local absorption in the vaginal area, which can be beneficial for conditions such as pelvic pain, endometriosis, and interstitial cystitis. The medication can also be absorbed systemically to provide relief for conditions such as fibromyalgia, neuropathic pain, and certain types of chronic pain. The suppository form can be particularly beneficial for patients who have difficulty swallowing pills or for whom oral administration is not ideal.

As with any medication, this formulation should be used under the supervision of a healthcare provider. Potential side effects can include drowsiness, dizziness, and potential dependency with long-term use. It is important to use this medication as directed by your healthcare provider and to report any side effects or concerns immediately.

At Bayview Pharmacy, we specialize in compounding customized medications to meet the unique needs of each patient. Our team of knowledgeable compounding pharmacists is available to answer any questions you may have about this formulation. Please do not hesitate to reach out to us if you need further information or assistance.

This formulation combines Baclofen, Diazepam, and Ketamine HCl in a vaginal suppository. Each of these medications has a unique mechanism of action and potential for drug interactions. It's important to consider these interactions when prescribing or using this formulation.

Baclofen is a muscle relaxant and antispastic agent. It may interact with other central nervous system depressants, including alcohol, antihistamines, and opioids, potentially leading to increased sedation or respiratory depression. Concurrent use with monoamine oxidase inhibitors (MAOIs) may result in hypotension.

Diazepam is a benzodiazepine used for its anxiolytic, anticonvulsant, muscle relaxant, and sedative properties. It can interact with other central nervous system depressants, leading to increased sedation or respiratory depression. Diazepam may also interact with certain antifungal agents, such as ketoconazole and itraconazole, which can increase diazepam levels and potentially lead to toxicity. Additionally, smoking can decrease the effectiveness of diazepam.

Ketamine HCl is a noncompetitive NMDA receptor antagonist used for its analgesic and anesthetic properties. It may interact with other central nervous system depressants, potentially leading to increased sedation or respiratory depression. Concurrent use with medications that increase heart rate or blood pressure, such as pseudoephedrine or certain antidepressants, may lead to increased cardiovascular risk.

This formulation is typically used for conditions that require muscle relaxation, pain relief, and sedation. This may include conditions such as severe muscle spasms, chronic pain, or certain gynecological conditions. The suppository form allows for local absorption in the vaginal area, which can be beneficial for conditions that affect this area specifically.

It's important to note that this formulation should be used under the supervision of a healthcare provider due to the potential for serious side effects and interactions. Patients should inform their healthcare provider of all medications they are currently taking, including over-the-counter medications and supplements, to avoid potential interactions.

If you have any questions about this formulation or its potential interactions, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information you need to use this medication safely and effectively.

The Baclofen 4 mg/Diazepam 5 mg/Ketamine HCl 17.25 mg Vaginal Suppository is a unique formulation designed to deliver medication directly to the site of action or for systemic absorption. This formulation combines three active ingredients, each with a distinct mechanism of action, to provide comprehensive treatment for certain disease states.

Baclofen is a muscle relaxant and an antispastic agent. It works by restoring the normal transmission of nerve signals in certain parts of the brain. This helps to reduce muscle spasms, which can be beneficial in conditions such as multiple sclerosis or spinal cord injury.

Diazepam is a benzodiazepine, a class of drugs that act on the central nervous system. It enhances the effect of a neurotransmitter called gamma-aminobutyric acid (GABA), which inhibits activity in the brain. This results in a calming effect, reducing anxiety and muscle spasms, and inducing sleepiness.

Ketamine HCl is a powerful anesthetic that works by blocking the N-methyl-D-aspartate (NMDA) receptor in the brain. This interrupts the transmission of pain signals in the central nervous system, providing potent analgesic (pain-relieving) effects. It is often used in the management of chronic pain conditions, including neuropathic pain.

When combined in a suppository form, these three medications can provide targeted relief from symptoms such as muscle spasms, anxiety, and chronic pain. The suppository is inserted into the vagina, where it dissolves or melts, allowing the medication to be absorbed directly into the bloodstream. This allows for faster onset of action and can reduce systemic side effects compared to oral administration.

This formulation can be used to treat a variety of disease states, including but not limited to, chronic pain conditions, muscle spasticity, and certain neurological disorders. It is important to note that the use of this formulation should be under the guidance of a healthcare provider, as the medications included can have significant side effects and interactions with other drugs.

If you have any questions about this formulation, its uses, or how it works, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help.

The combination of Baclofen, Diazepam, and Ketamine HCl in a Vaginal Suppository is primarily used for localized pain relief, muscle relaxation, and anti-inflammation in pelvic areas. Its primary indications are for conditions requiring muscle relaxation and neuropathic pain management, such as in case of endometriosis, pelvic inflammatory disease, vestibulodynia, and interstitial cystitis.

However, this suppository formulation can also be considered for other off-label uses. For instance, its muscle-relaxant and analgesic effects may prove beneficial for patients with severe, chronic constipation that does not respond to laxative therapy, by helping to ease the defecation process. Additionally, the anesthetic property of Ketamine may potentially help patients with hemorrhoids by relieving pain. Similarly, instances of severe muscle spasms or contractures, particularly in conditions like multiple sclerosis, may also respond well to this vaginal suppository, due to the muscle relaxant effects of Baclofen and Diazepam.

Furthermore, physicians and patients should also consider this formulation for cases involving chronic pain syndromes, where usual treatments have been ineffective. This could include conditions like fibromyalgia, sciatica, or even post-herpetic neuralgia. The combination of a muscle relaxant (Baclofen), sedative (Diazepam), and anesthetics (Ketamine) may provide significant relief for patients with these often difficult-to-treat conditions.

The suppository formulation may also offer advantages over systemic oral or injectable formulations. It provides direct drug delivery to the affected area, potentially reducing systemic side effects. It can also provide a suitable alternative for patients who have difficulty swallowing pills or for those where intravenous administration is not convenient.

Please note that, as this is a prescription medication, all uses - including the ones mentioned here - must be under the directive of a qualified healthcare provider. Healthcare providers looking to prescribe this medication and patients prescribed this medication should reach out to us with any questions or concerns about its use, potential side effects, or any other queries.