This formulation combines Belladonna Extract and Morphine Sulfate in a rectal suppository dosage form. Belladonna Extract, derived from the deadly nightshade plant, is used for its antispasmodic properties, helping to reduce muscle spasms in the gastrointestinal tract. Morphine Sulfate, a potent opioid analgesic, is used for its powerful pain-relieving properties. Together, these two active ingredients work synergistically to provide both pain relief and muscle relaxation.

The rectal suppository dosage form is a solid medication that is inserted into the rectum, where it dissolves or melts to release the medication. This allows for local absorption in the rectal area, which can be beneficial for conditions affecting the lower gastrointestinal tract. Additionally, the medication can also be absorbed systemically, providing relief throughout the body.

This formulation is particularly useful in treating disease states that involve both pain and muscle spasms. This includes conditions such as irritable bowel syndrome (IBS), where painful cramping can be a common symptom. The Belladonna Extract helps to reduce the muscle spasms that cause the cramping, while the Morphine Sulfate provides relief from the pain. Additionally, this formulation can also be used in palliative care settings, providing relief from pain and discomfort in patients with serious illnesses.

It's important for patients and prescribers to understand that this formulation, like all medications containing opioids, carries a risk of dependency and should be used under the close supervision of a healthcare provider. Side effects can include constipation, nausea, and drowsiness. Patients should also be aware that Belladonna Extract can cause dry mouth, blurred vision, and sensitivity to light.

If you have any questions about this formulation, or if you would like more information on how it can be used to treat specific disease states, please don't hesitate to reach out to us. Our team of knowledgeable compounding pharmacists at Bayview Pharmacy is always here to help.

The combination of Belladonna Extract and Morphine Sulfate in a rectal suppository form can be used to treat a variety of conditions, including severe pain, muscle spasms, and certain gastrointestinal disorders. However, it's important to be aware of potential drug interactions that could occur with this formulation.

Firstly, Belladonna Extract can interact with other medications that have anticholinergic effects. These include certain antihistamines (like diphenhydramine), tricyclic antidepressants (like amitriptyline), and certain Parkinson's disease drugs (like benztropine). Combining Belladonna with these medications can increase the risk of side effects such as dry mouth, blurred vision, and urinary retention.

Morphine Sulfate, on the other hand, can interact with a variety of medications. These include other opioid pain medications, certain drugs used to treat depression and mental/mood disorders (like selective serotonin reuptake inhibitors or SSRIs, and monoamine oxidase inhibitors or MAOIs), certain medications used to treat migraines (like triptans), and certain muscle relaxants. These interactions can increase the risk of serious side effects, including slowed or difficulty breathing, severe drowsiness/dizziness, and potentially fatal interactions.

Furthermore, both Belladonna Extract and Morphine Sulfate can interact with alcohol and other substances that cause drowsiness or slow your breathing. Combining these substances can lead to potentially dangerous effects, including extreme drowsiness, slowed or stopped breathing, coma, or death.

It's important to tell your doctor about all the medications you're currently taking, including prescription and over-the-counter drugs, vitamins, and herbal products. Also, let your healthcare provider know about any allergies you have to avoid potential allergic reactions.

This formulation should be used with caution in patients with certain medical conditions, including those with a history of respiratory problems, kidney or liver disease, mental/mood disorders, personal or family history of substance use disorders, stomach/intestinal problems, and certain heart conditions.

Remember, this medication is intended to be used as directed by a healthcare professional. Do not increase your dose, take it more frequently, or use it for a longer time than prescribed. Properly stop the medication when so directed.

If you have any questions or concerns about this formulation, don't hesitate to reach out to us. We're here to help ensure that your medication is safe and effective for you.

The Belladonna Extract 16.2 mg/Morphine Sulfate 7.5 mg Rectal Suppository is a unique formulation that combines the therapeutic benefits of both belladonna and morphine. This suppository is designed to be inserted into the rectum, where it dissolves or melts to release the medication. The medication is then absorbed by the rectal mucosa and enters the bloodstream for local or systemic effects.

Belladonna extract, derived from the deadly nightshade plant, contains alkaloids such as atropine and scopolamine. These compounds work by blocking the action of acetylcholine, a neurotransmitter in the body. This results in a reduction of muscle spasms and secretions in the gastrointestinal tract, making belladonna particularly useful in treating conditions such as irritable bowel syndrome and diverticulitis.

Morphine sulfate, on the other hand, is a potent opioid analgesic. It works by binding to opioid receptors in the brain and spinal cord, blocking the transmission of pain signals to the brain. This makes morphine an effective treatment for severe pain conditions.

When combined in a rectal suppository, belladonna and morphine can provide significant relief for patients suffering from severe pain and spasmodic conditions. The rectal route of administration allows for the medication to be absorbed directly into the bloodstream, bypassing the first-pass metabolism in the liver and providing a rapid onset of action. This makes it an ideal option for patients who cannot take oral medication or for whom oral medication is not effective.

It's important to note that this formulation should be used under the supervision of a healthcare provider due to the potential for serious side effects and the risk of dependency and withdrawal associated with morphine use. Patients should follow the prescribed dosage and frequency to minimize these risks.

If you have any questions about the Belladonna Extract 16.2 mg/Morphine Sulfate 7.5 mg Rectal Suppository, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to provide you with the information you need to make informed decisions about your healthcare.

The Belladonna Extract 16.2 mg/Morphine Sulfate 7.5 mg Rectal Suppository formulation is primarily used as an analgesic and antispasmodic. While its primary indication is for pain management and muscle spasms, it may also be used for other conditions as determined by your healthcare provider.

Due to its antispasmodic effects, Belladonna Extract in the suppository may be used to relieve gastrointestinal disorders such as irritable bowel syndrome (IBS), peptic ulcer disease, diverticulitis and colitis. This is due to belladonna's ability to reduce gastrointestinal muscle contractions. However, this use should be considered off-label and undertaken only under medical supervision, as there is limited clinical evidence supporting these uses.

Morphine Sulfate, a potent opioid analgesic, primarily provides systemic relief from severe pain, but it can also mitigate cough in certain non-malignant conditions as an off-label use. Morphine’s use in this context is due its capacity to suppress the cough reflex in the brain. Please note that the use of morphine for cough suppression is off-label and should be under the direction of a healthcare provider.

This compounded suppository formulation may also be considered for patients who cannot tolerate oral medications, or for those who have difficulty with other routes of administration, such as the elderly or those with swallowing difficulties.

As with any medication, it is crucial that the Belladonna Extract/Morphine Sulfate Rectal Suppository is used only under the advice and supervision of a healthcare provider, due to the potential for serious side effects, including addiction, especially with long-term use. Potential side effects can also include impairment of mental and/or physical abilities required for the performance of potentially hazardous tasks (such as driving or operating machinery).

Queries on this formulation should be directed to your compounding pharmacist. Don't hesitate to reach out to us at Bayview Pharmacy if you have any concerns or questions about this medication. Our knowledgeable team is here to help you in any way we can.