Check out our most popular compounded medications! Get Started
Dashboard
Formulas

Bupivicaine HCl 0.5%/Ketamine HCl 10% Topical Spray

FDA-approved generic
Dose form
Topical Spray
Active ingredients
Bupivacaine Hydrochloride
Ketamine Hydrochloride

Bupivicaine HCl 0.5%/Ketamine HCl 10% Topical Spray is a liquid formulation contained in a spray bottle, specifically designed for topical application to the skin. This formulation is a combination of Bupivicaine, a local anesthetic, and Ketamine, a medication primarily used for starting and maintaining anesthesia. It is intended to provide a convenient and efficient method of delivering these medications to the affected area.

The spray allows for easy and targeted application with a fine mist, ensuring localized treatment or relief. It is particularly useful in treating various disease states that require pain management, such as post-operative pain, neuropathic pain, and complex regional pain syndrome. The formulation aims to alleviate discomfort and promote healing in these conditions.

View more
For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
Starting at
Get started as a patient
Get Started
This medication requires a prescription from your doctor

Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.

For prescribersSign in for prescription details and order forms.
Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Bupivacaine Hydrochloride
Ketamine Hydrochloride
Topical Spray
6536f76c5d6c79fb6add669b

Formula Information

A small arrow pointing down

This formulation combines Bupivicaine HCl 0.5% and Ketamine HCl 10% in a topical spray, designed for direct application to the skin. Bupivicaine HCl is a local anesthetic that works by blocking nerve impulses, thereby reducing pain and discomfort in the applied area. Ketamine HCl, on the other hand, is a potent analgesic that provides additional pain relief.

The spray formulation allows for easy and targeted application, ensuring that the medication is delivered directly to the affected area. This is particularly beneficial for localized pain conditions, as it minimizes systemic exposure and reduces the risk of potential side effects. The fine mist or spray also ensures a uniform distribution of the medication, providing consistent relief across the entire affected area.

This formulation can be used to treat a variety of disease states that involve localized pain. These include, but are not limited to, post-operative pain, neuropathic pain, musculoskeletal pain, and certain types of chronic pain. It can also be used in palliative care settings to manage pain associated with terminal illnesses. As with any medication, it should be used under the guidance of a healthcare professional, and the patient's medical history, current medications, and potential allergies should be taken into consideration.

Patients using this formulation should be aware that while it is designed to provide localized relief, some systemic absorption may occur. This could potentially lead to side effects such as dizziness, nausea, or changes in heart rate. If any of these or other side effects occur, patients should contact their healthcare provider immediately. It is also important to note that this medication should not be used on broken or irritated skin, or in areas with poor circulation.

For prescribers, it is important to note that the concentration of the active ingredients can be adjusted to meet the specific needs of each patient. This allows for a personalized approach to pain management. As with any medication, regular follow-up and monitoring are essential to assess the patient's response to treatment and make any necessary adjustments.

If you have any questions about this formulation, or if you would like more information, please do not hesitate to reach out to us. We are here to help and provide you with the most accurate and up-to-date information.

Drug Interactions

A small arrow pointing down

Bupivicaine HCl 0.5%/Ketamine HCl 10% Topical Spray is a combination medication that works by blocking nerve signals in your body. Bupivicaine is a local anesthetic that numbs specific areas of the body, while Ketamine is a general anesthetic that reduces pain and affects perception. This formulation is used to provide pain relief in various disease states such as post-operative pain, neuropathic pain, and other conditions that require localized pain management.

While this formulation is generally safe for use, it's important to be aware of potential drug interactions. Certain medications may interact with Bupivicaine HCl 0.5%/Ketamine HCl 10% Topical Spray, potentially altering its effectiveness or increasing the risk of side effects.

Medications that may interact with this formulation include, but are not limited to, other local anesthetics, certain antiarrhythmic drugs (such as mexiletine, tocainide), certain antibiotics (such as erythromycin, clarithromycin), certain antifungal medications (such as itraconazole, ketoconazole), certain antidepressants (such as fluoxetine, paroxetine), certain HIV protease inhibitors (such as ritonavir, saquinavir), and certain seizure medications (such as phenytoin, phenobarbital).

It's also important to note that this formulation may interact with other topical products applied to the same area. To avoid interactions, it's recommended to apply different topical products at different times of the day.

Alcohol and other substances that can cause drowsiness or slow your breathing may increase these effects if taken with Bupivicaine HCl 0.5%/Ketamine HCl 10% Topical Spray. Avoid alcoholic beverages while using this medication.

Before starting treatment with Bupivicaine HCl 0.5%/Ketamine HCl 10% Topical Spray, inform your healthcare provider about all the medications you are currently taking, including prescription and non-prescription drugs, vitamins, and herbal supplements. This will help your healthcare provider to prevent potential interactions and monitor for them.

Remember, this is not a complete list of possible drug interactions. Always consult your healthcare provider to ensure the information applies to your personal circumstances. If you have any questions or concerns about the potential interactions of Bupivicaine HCl 0.5%/Ketamine HCl 10% Topical Spray, please don't hesitate to reach out to us at Bayview Pharmacy. We are here to help.

How Does it Work

A small arrow pointing down

The Bupivicaine HCl 0.5%/Ketamine HCl 10% Topical Spray works by delivering two active ingredients directly to the affected area of the skin. Bupivicaine HCl is a local anesthetic that works by blocking nerve impulses in your body, thereby reducing pain and discomfort. It is often used in minor surgical procedures or in relieving pain from certain medical conditions. On the other hand, Ketamine HCl is a potent analgesic that works by blocking certain receptors in the brain that are responsible for transmitting pain signals. This combination of two powerful pain relievers provides a potent and targeted relief for various disease states.

When the spray is applied to the skin, the active ingredients are absorbed into the skin and underlying tissues, where they begin to exert their effects. The Bupivicaine HCl works to numb the area, providing immediate relief from pain, while the Ketamine HCl works to block the pain signals at a deeper level, providing longer-lasting relief. This dual-action approach ensures that the pain is managed effectively and efficiently.

This formulation is particularly useful in treating conditions that cause localized pain, such as post-herpetic neuralgia, neuropathic pain, and certain types of chronic pain. It can also be used to manage pain after minor surgical procedures or injuries. The spray formulation allows for easy application and ensures that the medication is delivered directly to the area that needs it, minimizing systemic side effects and maximizing local pain relief.

It's important to note that while this formulation can provide significant relief from pain, it does not cure the underlying condition causing the pain. Therefore, it should be used as part of a comprehensive treatment plan that may include other medications, physical therapy, and lifestyle changes. As with any medication, it's important to use this product as directed by your healthcare provider to ensure its safety and effectiveness.

If you have any questions about the Bupivicaine HCl 0.5%/Ketamine HCl 10% Topical Spray, or if you would like more information about how it works or how it can be used in your specific situation, please don't hesitate to reach out to us. We are here to help and provide you with the information you need to make informed decisions about your health.

Other Uses

A small arrow pointing down

Aside from its primary use in providing relief from pain or irritation on the skin, Bupivicaine HCl 0.5%/Ketamine HCl 10% Topical Spray may also serve alternative uses.

This formulation employs Bupivicaine, an amide local anesthetic known for its ability to reduce pain and discomfort by numbing the treated site, and Ketamine, a general anesthetic that can prevent pain and sensations. Owing to these properties, the spray can be exploited for other purposes such as alleviating itching or discomfort associated with minor skin conditions like insect bites, minor burns, scrapes, and skin allergies. This is due to its numbing effect on the surface of the skin that may provide momentary relief from irritation.

Additionally, medical practitioners might also use this spray to numb a specific area of the skin when carrying out minor procedures including suturing of minor cuts, or for insertion of intravenous catheters into veins. It could also be beneficial for use in some minor surgical or cosmetic procedures where anesthesia is required.

Furthermore, the spray could potentially be employed for temporary relief from pain associated with conditions like hemorrhoids or anal fissures with the advice from a healthcare provider.

It's important to note, however, that while the spray may help numb the skin surface, it does not treat the underlying conditions causing pain or discomfort. Hence, it should not replace any existing medication for these conditions unless advised by your medical provider.

Remember, it is essential to always follow the instructions given by your healthcare provider regarding its use. Do not use it more frequently or for longer than recommended as it may lead to serious side effects. Report any unusual symptoms or side effects promptly to your healthcare provider.

If you have any questions about the other potential uses of Bupivicaine HCl 0.5%/Ketamine HCl 10% Topical Spray, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of expert compounding pharmacists are here to assist you with all your medication concerns.

Frequently Asked Questions

A small arrow pointing down

What is Bupivicaine HCl 0.5%/Ketamine HCl 10% Topical Spray?

This is a compounded medication that combines Bupivicaine HCl and Ketamine HCl in a liquid formulation. It is designed for topical use through a convenient spray mechanism that allows the patient to easily target the affected area with a fine mist, providing localized treatment or relief.

What are the main uses of Bupivicaine HCl 0.5%/Ketamine HCl 10% Topical Spray?

This compounded formulation is primarily used for pain management, especially in treating localized areas of pain. Each active ingredient contributes to numbing and soothing the pain, making it a useful tool in treating a variety of acute or chronic conditions associated with pain.

How do I apply the spray?

Simply point the bottle at the affected area of skin and spray according to the prescribed dosage.

Does the spray have any side effects?

As with any medication, there may be potential side effects, which can include skin irritation or an allergic reaction to one of the active ingredients. If you experience any adverse effects or discomfort, we recommend that you consult your healthcare provider immediately.

Can anyone use Bupivicaine HCl 0.5%/Ketamine HCl 10% Topical Spray?

This medication is strong and should only be used under the direction of a healthcare provider. It is important to use it as directed and avoid overuse or inappropriate use. If you have any specific health concerns or conditions, consult your doctor before starting this medication.

How quickly does the spray start working?

Typically, the ingredients in the spray begin to work soon after application, but the exact timing can depend on the individual and the specific condition being treated. For detailed information, consult your healthcare provider.

Does the spray have a strong smell or leave a residue?

The spray is designed to provide a fine mist and should not leave a significant residue when used properly. Any noticeable odor will usually depend on the specific formulation and can vary from patient to patient.

How long do the effects of the spray last?

The longevity of the spray's effects can depend on multiple factors, including the exact dosage, the specific condition being treated, and the individual patient. For specific information, a healthcare provider should be consulted.

What should I do if I accidentally ingest the spray?

This formulation is intended for topical use only. If accidentally ingested, contact a healthcare provider or poison control center right away.

What should I do if I miss a dose?

It is important to follow your healthcare provider's directions carefully. If a dose is accidentally missed, use it as soon as you remember unless it is close to the time for your next scheduled dose. Do not use extra medication to make up for a missed dose.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

The conditions listed on this page are indications prescribers have ordered this preparation for. They are not FDA-approved indications, and listing them is not a statement that this preparation is effective for them.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.

This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Bupivicaine HCl 0.5%/Ketamine HCl 10% Topical Spray
Topical Spray
120 mL
controlled

Apply topically to affected area(s)