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Caffeine 100 mg/Promethazine HCl 50 mg/Dihydroergotamine Mesylate 5 mg Suppository

FDA-approved generic
Dose form
Suppository
Active ingredients
Caffeine
Promethazine Hydrochloride
Dihydroergotamine Mesylate

Bayview Pharmacy's Caffeine 100 mg/Promethazine HCl 50 mg/Dihydroergotamine Mesylate 5 mg Suppository is a compounded medication. This solid dosage form is inserted into a body cavity, where it dissolves or melts to release the medication. It is typically used for the treatment of various types of headaches including migraines, cluster headaches, menstrual migraines, post-traumatic headaches, and tension headaches.

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For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
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This medication requires a prescription from your doctor
Ships within 1 to 2 business days after pharmacist verification
HSA and FSA eligible
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Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.

For prescribersSign in for prescription details and order forms.
Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Caffeine
Promethazine Hydrochloride
Dihydroergotamine Mesylate
Suppository
6427079ea6432488dc5187d3
Service area

Can we ship this formula to your state?

Bayview fills prescriptions for patients in Connecticut, Florida, Maine, Massachusetts, New Hampshire, New Jersey, Pennsylvania and Rhode Island. New York patients are served on a limited basis while nonresident pharmacy registration is pending.

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Currently licensed Limited basis, registration pending Not available for this formula Not currently licensed

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Formula Information

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This compounded formulation of Caffeine 100 mg/Promethazine HCl 50 mg/Dihydroergotamine Mesylate 5 mg Suppository is a potent treatment for various headache disorders, including Migraine, Cluster Headache, Menstrual Migraine, Post-Traumatic Headache, and Tension Headache. The combination of these three active ingredients, each with a unique mechanism of action, provides a comprehensive approach to headache management.

Caffeine, a stimulant, works by reducing the severity of headaches. Promethazine HCl, an antihistamine, aids in reducing inflammation and pain. Dihydroergotamine Mesylate, an ergot alkaloid, contributes to reducing the frequency and intensity of headaches. This combination of medications can be used both as a preventative measure and as an acute treatment, making it a versatile option for patients suffering from various types of headaches.

The suppository form of this formulation is designed for easy administration and is typically well tolerated by most patients. It is a solid dosage form that is inserted into a body cavity, usually the rectum or vagina, where it dissolves or melts to release the medication for local or systemic absorption. This method of administration allows for the medication to be absorbed directly into the bloodstream, bypassing the digestive system and providing faster relief.

However, it is crucial to note that this formulation should not be used in patients with a history of cardiovascular disease, as it may increase the risk of adverse events. Potential side effects to monitor include nausea, dizziness, or drowsiness. Always consult with a healthcare professional before starting any new medication regimen.

If you have any questions about this formulation or how it can be used to treat headache disorders, please do not hesitate to contact us at Bayview Pharmacy. Our team of compounding pharmacists is equipped with the knowledge and expertise to assist you with your medication needs.

Drug Interactions

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This compounded formulation of Caffeine 100 mg/Promethazine HCl 50 mg/Dihydroergotamine Mesylate 5 mg Suppository is specifically designed to provide relief from various types of headaches including migraines, cluster headaches, menstrual migraines, post-traumatic headaches, and tension headaches. Each component of this formulation plays a crucial role in managing these conditions.

Caffeine, a well-known stimulant, works by increasing alertness and reducing fatigue, thereby helping to alleviate the severity of headaches. Promethazine HCl, an antihistamine, aids in reducing inflammation and pain associated with headaches. Dihydroergotamine Mesylate, an ergot alkaloid, contributes to the reduction of headache frequency and severity by constricting blood vessels in the brain.

It is important to use this medication as directed by a healthcare provider. Overuse or misuse can lead to potential side effects and may not provide the desired relief. The recommended dose should not be exceeded, and this medication should not be used for more than 5 consecutive days. Potential side effects to be aware of include nausea, vomiting, dizziness, and drowsiness.

If you have any questions or concerns about this formulation, it is recommended to consult with your healthcare provider or pharmacist to ensure safe and appropriate use.

How Does it Work

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This compounded formulation is a suppository that contains Caffeine 100 mg, Promethazine HCl 50 mg, and Dihydroergotamine Mesylate 5 mg. It is specifically designed to treat various types of headaches including migraines, cluster headaches, menstrual migraines, post-traumatic headaches, and tension headaches. The unique combination of these three active ingredients works synergistically to alleviate the symptoms associated with these conditions.

The caffeine component of this formulation functions to reduce the intensity of the headache. Promethazine HCl is included to help manage nausea and vomiting that often accompany severe headaches. Dihydroergotamine Mesylate is a potent medication that helps to decrease the frequency and severity of headaches.

To use this suppository, it should be inserted into the rectum as soon as possible after the onset of the headache. It is recommended to use this formulation no more than three times a day, and for no more than five consecutive days. If the headache persists beyond this period, it is advised to seek medical attention.

It is crucial to understand that this formulation should not be used in conjunction with other headache medications, as this could potentially increase the risk of side effects. Furthermore, this formulation is contraindicated in patients with a history of heart disease, high blood pressure, or stroke.

If you have any questions or concerns about this formulation or its usage, please do not hesitate to contact us. We are here to provide you with the necessary guidance and support.

Other Uses

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This compounded formulation of Caffeine 100 mg/Promethazine HCl 50 mg/Dihydroergotamine Mesylate 5 mg Suppository is specifically designed for the treatment of various types of headaches including migraine, cluster headache, menstrual migraine, post-traumatic headache, and tension headache. It is crucial to understand that this formulation is not intended for any other use apart from the ones specified. It is also advised not to use this formulation in conjunction with other medications, as it could potentially heighten the risk of adverse effects.

Patients should be aware that this formulation may cause side effects such as drowsiness, dizziness, or blurred vision. Therefore, it is recommended not to operate heavy machinery or drive while under this medication. If any of these side effects are experienced, it is important to immediately contact a healthcare provider.

Furthermore, this formulation may interact with other medications. Therefore, patients should inform their healthcare provider about any other medications they are currently taking. This is to ensure the safe and appropriate use of this medication. If there are any questions or concerns regarding this formulation, patients are encouraged to seek advice from their healthcare provider.

Frequently Asked Questions

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What is the purpose of this compounded formulation of Caffeine 100 mg/Promethazine HCl 50 mg/Dihydroergotamine Mesylate 5 mg Suppository?

This formulation is designed to deliver specific doses of caffeine, promethazine HCl, and dihydroergotamine mesylate. These medications can be used to treat a variety of conditions, including migraines, nausea, and vomiting, among others.

How is this suppository administered?

This suppository is typically inserted into a body cavity, most commonly the rectum or vagina. It then dissolves or melts, releasing the medication for local or systemic absorption.

What are the benefits of using a suppository?

Suppositories can provide a more direct route of administration, bypassing the digestive system which can be beneficial for those with gastrointestinal issues. They also allow for steady, controlled release of medication.

What are the potential side effects of this formulation?

Side effects can vary depending on the individual and the specific medications involved. Common side effects may include dizziness, drowsiness, or gastrointestinal discomfort. Always consult with your healthcare provider for a complete list of potential side effects.

Can this suppository be used in conjunction with other medications?

It's important to discuss all medications and supplements you're currently taking with your healthcare provider before starting any new treatment, including this suppository. Some substances may interact with the ingredients in this formulation.

How should this suppository be stored?

Suppositories should be stored in a cool, dry place, away from heat and direct sunlight. They should also be kept out of reach of children and pets.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.

Can anyone use this suppository?

This formulation is typically prescribed for specific conditions and may not be suitable for everyone. Always consult with your healthcare provider before starting any new medication.

What should I do if I experience an adverse reaction?

If you experience any adverse reactions, such as severe dizziness, difficulty breathing, or hives, seek immediate medical attention. For less severe reactions, contact your healthcare provider for guidance.

Can I stop using the suppository if my symptoms improve?

Even if your symptoms improve, do not stop using the suppository without first consulting your healthcare provider. Stopping medication prematurely may lead to a relapse or worsening of symptoms.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

The conditions listed on this page are indications prescribers have ordered this preparation for. They are not FDA-approved indications, and listing them is not a statement that this preparation is effective for them.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Caffeine 100 mg/Promethazine HCl 50 mg/Dihydroergotamine Mesylate 5 mg Suppository
Suppository
30 suppositories
controlled

Insert 1 unwrapped suppository

As needed