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Carbamazepine 300 mg Rectal Suppository

FDA-approved generic
Dose form
Suppository
Active ingredients
Carbamazepine

The Carbamazepine 300 mg Rectal Suppository is a solid dosage form specifically designed for insertion into the rectum. Upon insertion, the suppository dissolves or melts, releasing the active ingredient, Carbamazepine, for local or systemic absorption. Carbamazepine is a medication primarily used to treat certain disease states such as epilepsy, trigeminal neuralgia, and bipolar disorder. This rectal suppository formulation provides an alternative route of administration for patients who may have difficulty swallowing tablets or for those who require immediate medication absorption.

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For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
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This medication requires a prescription from your doctor
Ships within 1 to 2 business days after pharmacist verification
HSA and FSA eligible
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Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.

For prescribersSign in for prescription details and order forms.
Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Carbamazepine
Suppository
6538105387d1ba1b3606329e
Service area

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Bayview fills prescriptions for patients in Connecticut, Florida, Maine, Massachusetts, New Hampshire, New Jersey, Pennsylvania and Rhode Island. New York patients are served on a limited basis while nonresident pharmacy registration is pending.

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Formula Information

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Carbamazepine 300 mg Rectal Suppository is a specialized formulation designed for rectal administration. This solid dosage form is inserted into the rectum, where it dissolves or melts to release the medication. The active ingredient, Carbamazepine, is then absorbed locally or systemically to exert its therapeutic effects.

Carbamazepine is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder. It is also used to treat trigeminal neuralgia, a condition that causes severe facial pain. The rectal suppository form of Carbamazepine provides an alternative route of administration for patients who may have difficulty swallowing tablets or for whom oral administration is not suitable.

The rectal route of administration allows for the medication to be absorbed directly into the bloodstream, bypassing the first-pass metabolism in the liver. This can result in a more rapid onset of action and potentially fewer side effects. However, it's important to note that individual absorption rates can vary, and the full effects of the medication may not be felt immediately.

As with any medication, Carbamazepine Rectal Suppositories should be used under the supervision of a healthcare provider. Patients should be monitored for potential side effects, which may include dizziness, drowsiness, unsteadiness, nausea, and vomiting. Any adverse reactions should be reported to a healthcare provider immediately.

It's also important to note that Carbamazepine can interact with other medications, so patients should inform their healthcare provider of all medications they are currently taking. This includes prescription medications, over-the-counter drugs, and dietary supplements.

Carbamazepine Rectal Suppositories are a specialized formulation that requires compounding by a pharmacist. At Bayview Pharmacy, our team of knowledgeable compounding pharmacists is here to answer any questions you may have about this formulation. Please don't hesitate to reach out to us for more information.

Drug Interactions

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Carbamazepine is an anticonvulsant medication that is used to treat various conditions such as epilepsy, trigeminal neuralgia, and bipolar disorder. It works by reducing the abnormal electrical activity in the brain, which helps to prevent seizures and episodes of extreme mood swings.

When used as a rectal suppository, the medication is absorbed through the rectal tissue and enters the bloodstream, providing systemic effects. This route of administration can be beneficial for patients who have difficulty swallowing tablets or for those who cannot tolerate oral medications due to nausea or vomiting.

However, it's important to be aware of potential drug interactions when using carbamazepine. This medication can interact with a wide range of other drugs, potentially altering their effects or increasing the risk of side effects.

Carbamazepine can decrease the effectiveness of certain medications, including some types of birth control (like oral contraceptives, patches, or rings), anticoagulants (like warfarin), and certain HIV medications. If you're taking any of these medications, your healthcare provider may need to adjust your dosage or monitor you more closely for side effects.

Conversely, certain medications can increase the levels of carbamazepine in your body, potentially leading to toxicity. These include certain antifungal medications (like fluconazole), macrolide antibiotics (like erythromycin), and calcium channel blockers (like diltiazem).

Additionally, carbamazepine can interact with grapefruit juice, which can increase the levels of the medication in your body and increase the risk of side effects. It's generally recommended to avoid consuming grapefruit or grapefruit juice while taking this medication.

It's important to tell your healthcare provider about all the medications, supplements, and herbal products you're currently taking before starting treatment with carbamazepine.

Remember, this is not a complete list of potential drug interactions. Always consult with your healthcare provider or pharmacist for personalized advice regarding drug interactions. If you have any questions or concerns, don't hesitate to reach out to us at Bayview Pharmacy. We're here to help.

How Does it Work

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Carbamazepine 300 mg Rectal Suppository is a solid dosage form that is inserted into the rectum, where it dissolves or melts to release the medication. The active ingredient, Carbamazepine, is then absorbed into the bloodstream through the rectal mucosa. This route of administration bypasses the first-pass metabolism in the liver, which can be beneficial for patients who have difficulty swallowing tablets or for those who need immediate relief from symptoms.

Carbamazepine is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder, as well as trigeminal neuralgia. It works by reducing excessive nerve signals in the brain and restoring the normal balance of nerve activity. Specifically, it stabilizes hyper-excited nerve fibers, inhibits repetitive neuronal firing, and reduces post-tetanic potentiation.

In the case of epilepsy, Carbamazepine can help to reduce the frequency of seizures by stabilizing the electrical activity in the brain. For patients with bipolar disorder, it can help to reduce episodes of mania or depression. In treating trigeminal neuralgia, it works by altering nerve impulses that cause severe facial pain.

It's important to note that while Carbamazepine can help control symptoms, it does not cure these conditions. Regular use as directed by a healthcare provider is necessary to obtain the maximum benefit of this medication. Side effects can occur, including dizziness, drowsiness, unsteadiness, nausea, and vomiting. If these persist or worsen, or if more serious side effects occur, the patient should contact their healthcare provider immediately.

As compounding pharmacists, we can customize this medication to the specific needs of the patient, including adjusting the dose or changing the form of administration. We can also add flavorings to make the medication more palatable, or remove certain ingredients to prevent allergic reactions. If you have any questions about Carbamazepine 300 mg Rectal Suppository or any other medication, please don't hesitate to reach out to us at Bayview Pharmacy.

Other Uses

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Carbamazepine is primarily used to control different types of seizures in epilepsy and relieve certain types of nerve pain such as trigeminal neuralgia. Given its use as an antiepileptic and neuropathic pain reliever, it is also often used off-label for a variety of conditions.

In psychiatric practice, Carbamazepine can be used as a mood stabilizer in bipolar disorder, especially with patients who do not respond well to other mood stabilizers. It can also be used effectively in the treatment of acute manic episodes and maintenance of bipolar disorder.

Another off-label use of Carbamazepine includes its use for alcohol withdrawal syndrome to manage the symptoms better. Carbamazepine has also been used effectively in the treatment of restless legs syndrome and postherpetic neuralgia, a painful condition that can follow shingles.

Lastly, Carbamazepine has shown some benefit in the treatment of certain forms of tinnitus. The 300 mg rectal suppository formulation allows for a more continuous and steady release of medication, which might be beneficial for some of these off-label uses.

However, it’s crucial that prescribers obtain informed consent when prescribing medications off-label and patients should know that these uses are not reviewed or approved by the FDA. As always, the potential benefits and risks of any medication should be weighed carefully. If you have any further questions about the uses of this formulation, please don't hesitate to reach out to us at Bayview Pharmacy.

Frequently Asked Questions

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What is Carbamazepine 300 mg Rectal Suppository?

Carbamazepine 300 mg Rectal Suppository is a solid dosage form of Carbamazepine that is designed to be inserted into a body cavity, most commonly the rectum. It is engineered to dissolve or melt once inserted to release the medication for both local and systemic absorption.

How does the Carbamazepine 300mg Rectal Suppository work?

After insertion into the rectum, the suppository melts or dissolves, releasing the Carbamazepine medication. The rectal tissue then absorbs the medicine, allowing it to enter the bloodstream and produce its therapeutic effects.

Who should use the Carbamazepine 300mg Rectal Suppository?

Carbamazepine 300mg Rectal Suppository is prescribed by a physician. It's typically recommended for patients who have difficulty in swallowing tablets or for those where oral administration is not possible. Always consult with your healthcare provider for guidance.

How to use the Carbamazepine 300mg Rectal Suppository?

You should use this medication as instructed by your healthcare provider. It's typically inserted into the rectum, but your healthcare provider will give you detailed instructions on how to use and administer the suppository.

What are the side effects of Carbamazepine 300mg Rectal Suppository?

Like all medicines, Carbamazepine 300mg Rectal Suppository can cause side effects, although not everybody gets them. Common side effects may include nausea, dizziness, and headache. More serious side effects could include blood disorders, skin reactions, and liver problems. Always consult with your healthcare provider to understand the possible side effects.

Can I stop taking this medication abruptly?

No, you should not discontinue this medication without your healthcare provider’s approval. Abruptly stopping the Carbamazepine 300mg Rectal Suppository can increase your risk of seizures or other serious health effects.

How to store the Carbamazepine 300mg Rectal Suppository?

Always store the suppositories in a cool, dry place, away from direct sunlight and out of the reach of children. Do not store them in the bathroom or near a sink due to humidity. Check the expiry date before using any suppository.

Can I use Carbamazepine 300mg Rectal Suppository if I am pregnant or breastfeeding?

The use of Carbamazepine 300mg Rectal Suppository during pregnancy or while breastfeeding should only be considered if the potential benefit justifies the potential risk to the fetus or infant, respectively. Always consult your healthcare provider before making any decision about medication use.

Can I drink alcohol while using the Carbamazepine 300mg Rectal Suppository?

Discuss with your healthcare provider for more information.

What should I do if I miss a dose of Carbamazepine 300mg Rectal Suppository?

If you miss a dose, take the missed dose as soon as you remember. If it's near the time of the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up. If you are unsure, it is always best to consult your healthcare provider.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

The conditions listed on this page are indications prescribers have ordered this preparation for. They are not FDA-approved indications, and listing them is not a statement that this preparation is effective for them.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Carbamazepine 300 mg Rectal Suppository
Suppository
30 suppositories
controlled

Insert 1 unwrapped suppository

Twice daily