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This formulation is a specially designed topical liquid that combines Clindamycin HCl 1.09 mg, Gentamicin Sulfate 1.695 mg, and Polymyxin B Sulfate 3000 units/mL. It is intended for direct application to the skin or mucosal surfaces, providing targeted therapeutic benefits. This formulation is often chosen for localized treatment or when avoiding systemic effects is desired.
Clindamycin is a lincosamide antibiotic that is used to treat serious infections caused by bacteria. Gentamicin is an aminoglycoside antibiotic that fights bacteria in the body, and Polymyxin B is used to treat various types of infections, especially those caused by bacteria.
Together, these ingredients work synergistically to combat bacterial infections on the skin or mucosal surfaces, providing a potent and targeted treatment option. This formulation is particularly useful in treating conditions such as bacterial skin infections, wound infections, and other related conditions.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
This formulation is a topical liquid preparation that combines Clindamycin HCl, Gentamicin Sulfate, and Polymyxin B Sulfate. These three active ingredients work synergistically to provide a potent antimicrobial effect.
Clindamycin HCl is a lincosamide antibiotic that works by inhibiting bacterial protein synthesis, thereby stopping the growth of bacteria. Gentamicin Sulfate is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Polymyxin B Sulfate is a potent antibiotic that works by altering the bacterial cell wall, leading to increased permeability and eventual cell death.
Together, these three antibiotics provide a broad spectrum of antimicrobial activity. This includes skin and soft tissue infections such as cellulitis, folliculitis, and impetigo, as well as certain types of wound infections. It can also be used to treat mucosal infections such as conjunctivitis and otitis externa.
Being a topical preparation, this formulation is designed for direct application to the skin or mucosal surfaces. This allows for targeted treatment, delivering the antibiotics directly to the site of infection. This not only enhances the therapeutic effect but also minimizes systemic absorption, reducing the risk of systemic side effects. However, as with any medication, it is important to use this formulation as directed by a healthcare provider to ensure optimal efficacy and safety.
For patients, it is important to note that this formulation should be used only for the condition for which it was prescribed, and it should not be shared with others. It is also important to complete the full course of treatment, even if symptoms improve before the medication is finished. This is to ensure that the infection is completely cleared and to prevent the bacteria from becoming resistant to the antibiotics.
For prescribers, it is important to consider the patient's overall health status, potential drug interactions, and possible allergies when prescribing this formulation. Regular monitoring may also be necessary to assess the patient's response to treatment and to detect any potential side effects.
If you have any questions about this formulation, please do not hesitate to reach out to us. Our team of compounding pharmacists at Bayview Pharmacy is always here to provide the information and support you need.
This formulation combines three potent antibiotics: Clindamycin HCl, Gentamicin Sulfate, and Polymyxin B Sulfate. Each of these antibiotics works in a different way to inhibit bacterial growth. It is particularly useful for treating skin and mucosal surface infections, as it can be applied directly to the affected area, providing targeted treatment while minimizing systemic effects.
However, it's important to be aware of potential drug interactions. Clindamycin, Gentamicin, and Polymyxin B can all interact with certain other medications, potentially affecting their effectiveness or increasing the risk of side effects. For example, Clindamycin can interact with erythromycin and neuromuscular blocking agents, potentially leading to increased side effects. Gentamicin can interact with loop diuretics, increasing the risk of ototoxicity, and with neuromuscular blocking agents, potentially leading to increased neuromuscular blockade. Polymyxin B can interact with curariform drugs, potentially leading to increased neuromuscular blockade, and with nephrotoxic or ototoxic drugs, potentially increasing the risk of nephrotoxicity or ototoxicity.
It's also important to note that this formulation should not be used in patients with a history of hypersensitivity to any of its components. Additionally, prolonged use of topical antibiotics may result in overgrowth of non-susceptible organisms, including fungi. If superinfection occurs, appropriate therapy should be initiated.
Patients should be advised to apply the medication as directed by their healthcare provider, and to avoid contact with the eyes, nose, mouth, and other mucous membranes. If irritation or hypersensitivity develops, they should discontinue use and consult their healthcare provider. Patients should also be advised to report any signs of local adverse reactions to their healthcare provider.
Prescribers should consider the potential for drug interactions when prescribing this formulation, and should monitor patients for signs of adverse reactions.
If you have any questions about this formulation or its use, please don't hesitate to reach out to us. We're here to help.
This formulation combines three active ingredients: Clindamycin HCl, Gentamicin Sulfate, and Polymyxin B Sulfate, each with its own unique mechanism of action to combat bacterial infections on the skin or mucosal surfaces. The liquid preparation is designed for direct application, providing targeted therapeutic benefits and minimizing systemic effects.
Clindamycin HCl is a lincosamide antibiotic that works by inhibiting bacterial protein synthesis. It binds to the 50S subunit of the bacterial ribosome, preventing the addition of new amino acids to the growing peptide chain. This effectively halts the production of essential proteins needed by the bacteria to grow and multiply, thereby stopping the spread of the infection.
Gentamicin Sulfate is an aminoglycoside antibiotic that also inhibits bacterial protein synthesis, but it does so by binding to the 30S subunit of the bacterial ribosome. This causes misreading of the genetic code and leads to the production of faulty, non-functional proteins, which disrupts bacterial cell processes and leads to cell death.
Polymyxin B Sulfate is a polypeptide antibiotic that disrupts the bacterial cell membrane. It binds to the lipid A component of lipopolysaccharides on the outer membrane of Gram-negative bacteria, displacing the divalent cations (Ca2+ and Mg2+) that stabilize the membrane structure. This causes increased permeability and eventual cell death due to loss of cellular contents.
Together, these three antibiotics provide broad-spectrum coverage against a wide range of bacteria, including both Gram-positive and Gram-negative organisms. The topical application allows for high local concentrations of the antibiotics at the site of infection, enhancing their effectiveness while reducing the risk of systemic side effects. This makes the formulation particularly useful for treating localized skin and soft tissue infections, such as wounds, burns, and ulcers, as well as certain types of skin and eye infections.
If you have any questions about this formulation, its mechanism of action, or its appropriate use, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to assist you.
This is a compounded formulation which combines three active ingredients (Clindamycin HCL, Gentamicin Sulfate, and Polymyxin B Sulfate) intended for topical application. It is specifically designed to be applied directly to the skin or mucosal surfaces for targeted therapeutic benefits.
This formulation is often chosen for localized treatment of infections or inflammation. It is designed to offer targeted therapeutic benefits without causing systemic effects that oral or injectable medications might produce.
This liquid should be applied directly to the affected skin or mucosal surfaces as directed by your healthcare provider. Do not ingest or apply to eyes unless specifically directed by a healthcare provider.
Topical medications can sometimes cause local irritation, including redness, itching, or burning. If you experience any of these side effects or other concerning symptoms, please consult with your healthcare provider immediately.
The three active ingredients in this formulation work in synergy to fight infections.
This usually depends on the nature and severity of the wound. Always consult with your healthcare provider before using this or any medication on an open wound.
No. It's crucial to continue using the medication for the full course of therapy as prescribed by your healthcare provider, even if symptoms improve. This is to ensure the complete eradication of the bacteria causing the infection.
No. If you’re allergic to any of the active ingredients in this formulation, you should not use this product. Please consult your healthcare provider for an alternative treatment.
Before starting any medication, pregnant or breastfeeding women should consult a healthcare provider. This product is meant for external use and is unlikely to be absorbed systemically in significant amounts, but you should always go for professional advice.
Always consult with your healthcare provider before combining medications. Mixing medications can sometimes cause adverse reactions or decrease their effectiveness.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
