This formulation is a topical liquid preparation that combines Clindamycin HCl, Gentamicin Sulfate, and Polymyxin B Sulfate. These three active ingredients work synergistically to provide a potent antimicrobial effect, making it an effective treatment for a variety of skin and mucosal infections.

Clindamycin HCl is a lincosamide antibiotic that works by inhibiting bacterial protein synthesis, thereby stopping the growth of bacteria. It is particularly effective against gram-positive bacteria and certain types of anaerobic bacteria. Gentamicin Sulfate is an aminoglycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Polymyxin B Sulfate is a potent antibiotic that works by altering the bacterial cell wall, leading to increased permeability and eventual cell death. It is particularly effective against gram-negative bacteria.

Together, these three antibiotics provide a broad spectrum of antimicrobial activity, making this formulation effective against a wide range of bacterial infections. This includes skin and soft tissue infections such as cellulitis, folliculitis, and impetigo, as well as certain types of wound infections. It can also be used to treat mucosal infections such as conjunctivitis and otitis externa.

Being a topical preparation, this formulation is designed for direct application to the skin or mucosal surfaces. This allows for targeted treatment, delivering the antibiotics directly to the site of infection. This not only enhances the therapeutic effect but also minimizes systemic absorption, reducing the risk of systemic side effects. However, as with any medication, it is important to use this formulation as directed by a healthcare provider to ensure optimal efficacy and safety.

For patients, it is important to note that this formulation should be used only for the condition for which it was prescribed, and it should not be shared with others. It is also important to complete the full course of treatment, even if symptoms improve before the medication is finished. This is to ensure that the infection is completely cleared and to prevent the bacteria from becoming resistant to the antibiotics.

For prescribers, it is important to consider the patient's overall health status, potential drug interactions, and possible allergies when prescribing this formulation. Regular monitoring may also be necessary to assess the patient's response to treatment and to detect any potential side effects.

If you have any questions about this formulation, please do not hesitate to reach out to us. Our team of compounding pharmacists at Bayview Pharmacy is always here to provide the information and support you need.

This formulation combines three potent antibiotics: Clindamycin HCl, Gentamicin Sulfate, and Polymyxin B Sulfate. Each of these antibiotics works in a different way to inhibit bacterial growth, making this formulation effective against a wide range of bacterial infections. It is particularly useful for treating skin and mucosal surface infections, as it can be applied directly to the affected area, providing targeted treatment while minimizing systemic effects.

However, it's important to be aware of potential drug interactions. Clindamycin, Gentamicin, and Polymyxin B can all interact with certain other medications, potentially affecting their effectiveness or increasing the risk of side effects. For example, Clindamycin can interact with erythromycin and neuromuscular blocking agents, potentially leading to increased side effects. Gentamicin can interact with loop diuretics, increasing the risk of ototoxicity, and with neuromuscular blocking agents, potentially leading to increased neuromuscular blockade. Polymyxin B can interact with curariform drugs, potentially leading to increased neuromuscular blockade, and with nephrotoxic or ototoxic drugs, potentially increasing the risk of nephrotoxicity or ototoxicity.

It's also important to note that this formulation should not be used in patients with a history of hypersensitivity to any of its components. Additionally, prolonged use of topical antibiotics may result in overgrowth of non-susceptible organisms, including fungi. If superinfection occurs, appropriate therapy should be initiated.

Patients should be advised to apply the medication as directed by their healthcare provider, and to avoid contact with the eyes, nose, mouth, and other mucous membranes. If irritation or hypersensitivity develops, they should discontinue use and consult their healthcare provider. Patients should also be advised to report any signs of local adverse reactions to their healthcare provider.

Prescribers should consider the potential for drug interactions when prescribing this formulation, and should monitor patients for signs of adverse reactions. They should also be aware of the potential for bacterial resistance and superinfection, and should consider alternative therapy if treatment is not effective.

If you have any questions about this formulation or its use, please don't hesitate to reach out to us. We're here to help.

This formulation combines three active ingredients: Clindamycin HCl, Gentamicin Sulfate, and Polymyxin B Sulfate, each with its own unique mechanism of action to combat bacterial infections on the skin or mucosal surfaces. The liquid preparation is designed for direct application, providing targeted therapeutic benefits and minimizing systemic effects.

Clindamycin HCl is a lincosamide antibiotic that works by inhibiting bacterial protein synthesis. It binds to the 50S subunit of the bacterial ribosome, preventing the addition of new amino acids to the growing peptide chain. This effectively halts the production of essential proteins needed by the bacteria to grow and multiply, thereby stopping the spread of the infection.

Gentamicin Sulfate is an aminoglycoside antibiotic that also inhibits bacterial protein synthesis, but it does so by binding to the 30S subunit of the bacterial ribosome. This causes misreading of the genetic code and leads to the production of faulty, non-functional proteins, which disrupts bacterial cell processes and leads to cell death.

Polymyxin B Sulfate is a polypeptide antibiotic that disrupts the bacterial cell membrane. It binds to the lipid A component of lipopolysaccharides on the outer membrane of Gram-negative bacteria, displacing the divalent cations (Ca2+ and Mg2+) that stabilize the membrane structure. This causes increased permeability and eventual cell death due to loss of cellular contents.

Together, these three antibiotics provide broad-spectrum coverage against a wide range of bacteria, including both Gram-positive and Gram-negative organisms. The topical application allows for high local concentrations of the antibiotics at the site of infection, enhancing their effectiveness while reducing the risk of systemic side effects. This makes the formulation particularly useful for treating localized skin and soft tissue infections, such as wounds, burns, and ulcers, as well as certain types of skin and eye infections.

If you have any questions about this formulation, its mechanism of action, or its appropriate use, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to assist you.

This specially compounded preparation of Clindamycin HCl, Gentamicin Sulfate, and Polymyxin B Sulfate may be indicated for a variety of dermatological and mucosal conditions beyond those initially prescribed. In clinical practice, the extensive antibacterial activity of this combination is often utilized against both gram-negative and gram-positive organisms, contributing to its efficacy in treating an array of skin and mucosal infections such as cellulitis, folliculitis, and acne vulgaris.

Apart from being used for the treatment of common skin and mucosal infections, this formulation could also be considered for treating more severe conditions such as infected wounds, burns, and ulcers, where highly potent antimicrobial activity is required. Moreover, dermatologists may also prescribe this solution for off-label uses such as impetigo, rosacea, and other inflammatory skin conditions associated with a bacterial superinfection.

Although designed for topical use, the formulation might also find some off-label use in ophthalmology, where it could be potentially utilized as a preliminary treatment for bacterial conjunctivitis, keratitis, or other ocular surface infections prior to culture results. However, any off-label use should be under a healthcare professional's direct supervision and only when the benefit outweighs the risk involved.

We encourage prescribers to consider the unique properties of this combination when deciding on indications. As this topical solution is compounded specifically, the exact dosage and application frequency could be altered according to the severity and extent of the infection, contributing to a personalized patient care approach. However, it is crucial to note that the side effects associated with each component, such as local irritation or potential allergic reaction should be closely monitored, and therapy should be discontinued if such events occur.

Patients should be encouraged to report any side effects or lack of improvement in their condition despite therapy. They should also be counseled to store the medication appropriately and not share their medication with others, even if the symptoms are similar, to reduce the risk of antibiotic resistance.

Please feel free to reach out to us at Bayview Pharmacy with any questions regarding this combination or its potential uses. We are here to assist with all your pharmaceutical needs, providing in-depth information and counsel for both patients and prescribers.