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Clotrimazole 1%/Diphenhydramine 1%/Hydrocortisone 0.5%/Nystatin 100 MIU/g Topical Ointment

This formulation is a combination of Clotrimazole 1%, Diphenhydramine 1%, Hydrocortisone 0.5%, and Nystatin 100 MIU/g, compounded into a topical ointment. It is a semi-solid preparation, dispensed in a tube for external application to the skin. The greasy or oily base of the ointment aids in the delivery of the therapeutic agents for localized treatment.

The Clotrimazole component is an antifungal medication used to treat skin infections such as athlete's foot, jock itch, and ringworm. Diphenhydramine is an antihistamine that reduces the effects of the natural chemical histamine in the body, providing relief from itching and hives. Hydrocortisone is a corticosteroid that reduces inflammation, swelling, and redness. Nystatin is an antifungal medication that prevents fungus from growing on your skin.

This formulation is typically used for conditions such as skin inflammation, infections, or wound healing. It provides a multi-pronged approach to treat a variety of skin conditions, offering both anti-inflammatory and antifungal benefits, while also addressing symptoms such as itching and redness.

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Topical Ointment
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Formula Information

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This formulation is a combination of four active ingredients: Clotrimazole, Diphenhydramine, Hydrocortisone, and Nystatin, each serving a unique therapeutic purpose. Clotrimazole is an antifungal medication that works by inhibiting the growth of fungus, making it effective in treating skin infections caused by fungus. Diphenhydramine is an antihistamine that reduces the effects of the natural chemical histamine in the body, providing relief from itching and hives on the skin. Hydrocortisone is a corticosteroid that reduces swelling, itching, and redness that can occur in various types of skin conditions. Nystatin is another antifungal medication that prevents fungus from growing on your skin.

The formulation is designed as a semi-solid topical ointment, which is dispensed in a tube for easy application. The greasy or oily base of the ointment aids in the delivery of the medication, ensuring that the active ingredients are effectively absorbed by the skin for localized treatment. This makes the formulation ideal for treating conditions such as skin inflammation, infections, or aiding in wound healing.

For patients, it's important to note that this medication should be used as directed by your healthcare provider. The affected area should be cleaned and dried before application. The medication should be applied thinly and evenly to the affected area(s) and gently rubbed in, usually twice daily or as directed by your doctor. Do not apply this medication in the eyes, nose, mouth, or vagina. If you are using this medication on a child's diaper area, do not use tight-fitting diapers or plastic pants. After applying the medication, wash your hands, unless you are using this medication to treat the hands. Do not wrap, cover, or bandage the area unless directed to do so by your doctor.

For prescribers, it's crucial to consider the patient's overall health status, other medications, and any known allergies before prescribing this formulation. It's also important to educate patients about potential side effects, which may include burning, stinging, swelling, or irritation at the application site. If these effects persist or worsen, the patient should be advised to stop using this medication and consult a healthcare provider immediately.

If you have any questions or need further information about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always ready to assist you.

Drug Interactions

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This formulation contains four active ingredients: Clotrimazole, Diphenhydramine, Hydrocortisone, and Nystatin. Each of these ingredients has a specific role in treating various skin conditions, but they may also interact with other medications.

Clotrimazole is an antifungal medication that treats skin infections caused by fungus. It may interact with certain medications such as tacrolimus and warfarin. If you are taking these medications, inform your healthcare provider as the combination may increase the risk of side effects.

Diphenhydramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. It may interact with medications such as anticholinergics, monoamine oxidase inhibitors (MAOIs), and other CNS depressants (e.g., sedatives, tranquilizers). These interactions could increase the risk of side effects such as drowsiness, dizziness, and difficulty concentrating.

Hydrocortisone is a corticosteroid that reduces inflammation, itching, and redness. It may interact with medications such as aldesleukin, mifepristone, and other corticosteroids. These interactions could potentially increase the risk of systemic side effects such as adrenal suppression and Cushing's syndrome.

Nystatin is another antifungal medication used to treat skin infections caused by yeast. It has minimal systemic absorption and is unlikely to interact with other medications. However, it's always important to inform your healthcare provider about all the medications you are currently taking, including over-the-counter drugs and dietary supplements.

This formulation is designed for external use only and should not be used on large areas of the body, in open wounds, or on broken or damaged skin. It should also not be used if you have an allergy to any of the ingredients in the formulation. If you experience any unusual symptoms while using this medication, such as increased skin irritation or signs of a systemic allergic reaction (e.g., rash, itching/swelling, severe dizziness, trouble breathing), seek medical attention immediately.

Remember, this formulation is intended to treat specific skin conditions and should not be used for other conditions without the advice of a healthcare provider. Always follow the directions provided by your healthcare provider or pharmacist when using this medication. If you have any questions about this formulation or its use, please reach out to us at Bayview Pharmacy.

How Does it Work

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This formulation is a combination of four active ingredients: Clotrimazole, Diphenhydramine, Hydrocortisone, and Nystatin, each with a specific role in treating various skin conditions. The ointment is designed to be applied topically, directly to the affected area of the skin, where it delivers its therapeutic effects.

Clotrimazole is an antifungal medication that works by inhibiting the growth of fungus on the skin. It disrupts the production of ergosterol, a crucial component of fungal cell membranes, leading to alterations in membrane permeability and ultimately cell death. This makes it effective in treating fungal skin infections such as ringworm, athlete's foot, and jock itch.

Diphenhydramine is an antihistamine that works by blocking the action of histamine, a substance in the body that causes allergic symptoms. When applied topically, it can help to reduce itching, redness, and swelling associated with allergic reactions or insect bites.

Hydrocortisone is a corticosteroid that works by reducing inflammation and immune responses. It does this by mimicking the effects of cortisol, a hormone naturally produced by the adrenal glands. Hydrocortisone can help to relieve symptoms such as itching, redness, and swelling associated with conditions like eczema, dermatitis, and psoriasis.

Nystatin is another antifungal medication that works by binding to sterols in the fungal cell membrane, causing leakage of cellular contents and cell death. It is particularly effective against Candida species, making it useful in treating conditions such as candidiasis (yeast infection).

The ointment base in this formulation aids in the delivery of these medications to the skin. It provides a protective barrier, helps to keep the skin moisturized, and allows for the slow release of the active ingredients, enhancing their effectiveness. The semi-solid nature of the ointment also makes it easy to apply and ensures that it stays in contact with the skin for a prolonged period, allowing for maximum absorption of the medications.

This formulation is typically used for localized treatment of various skin conditions, including fungal infections, inflammation, and allergic reactions. It should be applied as directed by a healthcare provider, usually in a thin layer to the affected area of the skin. It's important to note that while this ointment can help to manage symptoms, it may not cure the underlying condition, especially if it is chronic or recurrent. Therefore, it's crucial to follow up with a healthcare provider for a comprehensive treatment plan.

If you have any questions about this formulation, how to use it, or what to expect, don't hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is always here to help.

Other Uses

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This combination formulation of Clotrimazole 1%/Diphenhydramine 1%/Hydrocortisone 0.5%/Nystatin 100 MIU/g Topical Ointment, often used for skin inflammation, infections, and wound healing, has also been beneficial to patients dealing with varying dermatological concerns. One such other use is for alleviating symptoms of eczema, whereby the hydrocortisone functions as an anti-inflammatory agent and addresses redness and swelling, while the diphenhydramine serves as an antihistamine, alleviating itchiness frequently experienced in this condition.

Furthermore, this combination ointment may be used to treat minor cuts, burns, and abrasions. The hydrocortisone and diphenhydramine relieve itching and inflammation, the clotrimazole addresses any potential fungal infection, and the nystatin combats certain yeast infections that may coincide. However, it is essential to always consult a healthcare provider for deep or severe wounds as this ointment is for minor skin damage only.

Another potential use of this formulation could be for the treatment of certain types of dermatitis, including seborrheic dermatitis and contact dermatitis. The combination of antifungal (clotrimazole and nystatin), anti-inflammatory (hydrocortisone), and itch-reducing (diphenhydramine) ingredients may help to alleviate symptoms of these conditions, while preventing potential secondary infections. However, it's crucial that patients and prescribers recognize that this medication is not intended for prolonged use, and like any medication, it should be used under the guidance of a healthcare professional.

Please note that though these are potential uses, each patient and their circumstances are unique, and it is always recommended to seek medical advice before using medication for an unlabelled indication — particularly for prolonged periods of time. It's important to remember that this preparation shouldn't be used to treat viral infections, like those caused by Herpes simplex virus, due to its particular composition. It's also imperative to note that clotrimazole, one of the constituents of this formulation, should be used with caution in the first trimester of pregnancy. For any questions about use, safety, or anything else, feel free to get in touch with us at Bayview Pharmacy, where our experienced team of pharmacists is always ready to provide advice.

Frequently Asked Questions

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What is Clotrimazole 1%/Diphenhydramine 1%/Hydrocortisone 0.5%/Nystatin 100 MIU/g Topical Ointment?

This is a compounded medication formulation, a semi-solid preparation designed for topical application to the skin. It contains the active ingredients Clotrimazole, Diphenhydramine, Hydrocortisone, and Nystatin, often used to treat conditions like skin inflammations, infections or promote wound healing.

What is the purpose of the different ingredients in the compound?

Clotrimazole is an antifungal that treats skin infections caused by fungus, Diphenhydramine is an antihistamine that reduces itching and swelling, Hydrocortisone is a steroid that reduces redness, itching, and swelling, and Nystatin is another antifungal for treating fungal skin infections.

How should I use this ointment?

This ointment should be applied topically to the affected area. Always follow your healthcare professional's instructions or the directions provided on the label.

What is the base of this ointment?

The base of this ointment is greasy or oily which aids in the delivery of the active compounds.

How is this compound dispensed?

This compound is dispensed in a tube for convenient application to the skin.

What should I do if I miss a dose?

If you missed applying a dose, apply it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and proceed with your regular dosing routine. Don't double dose.

Are there any known side effects from this ointment?

Side effects can include skin irritation, burning, or redness. However, severe side effects aren't common. Always contact your healthcare provider if you experience any unusual reactions after using the ointment.

What should I do if this ointment gets in my eyes?

Rinse your eyes thoroughly with water and contact your healthcare provider immediately.

Can this ointment cure all types of skin infections?

This ointment is designed to treat specific conditions such as certain skin inflammations, infections, and promote wound healing. It may not be effective for all types of skin conditions. Always consult with your healthcare provider before using any new medication.

Do I need a prescription for Clotrimazole 1%/Diphenhydramine 1%/Hydrocortisone 0.5%/Nystatin 100 MIU/g Topical Ointment?

Yes, this is a compounded medication and requires a valid prescription from your healthcare provider.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.
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