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Clotrimazole 500 mg Vaginal Suppository

The Clotrimazole 500 mg Vaginal Suppository is a solid dosage form specifically designed for insertion into the vagina. Upon insertion, the suppository dissolves or melts, releasing the antifungal medication, Clotrimazole, for local absorption. This formulation is primarily used to treat various disease states associated with fungal infections, such as vaginal yeast infections (Candidiasis).

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Formula Information

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Clotrimazole 500 mg Vaginal Suppository is a solid dosage form designed for insertion into the vagina. Once inserted, the suppository dissolves or melts, releasing the medication for local absorption. This formulation is specifically designed to deliver a high concentration of clotrimazole directly to the site of infection, providing targeted treatment with minimal systemic absorption.

Clotrimazole is an antifungal medication that works by inhibiting the growth of fungus. It is commonly used to treat vaginal yeast infections, also known as candidiasis. These infections are caused by an overgrowth of a type of fungus called Candida. Symptoms of vaginal yeast infections include itching, burning, and discharge. Clotrimazole works by disrupting the cell wall of the fungus, causing the fungal cells to leak and die, thereby treating the infection.

The 500 mg dosage of clotrimazole in this suppository formulation is a potent dose designed to effectively treat even severe or persistent cases of vaginal yeast infections. It is typically used once daily, preferably at bedtime, for the duration prescribed by the healthcare provider. The duration of treatment may vary depending on the severity of the infection and the patient's response to therapy.

Patients using this formulation should be aware that it is for vaginal use only and should not be swallowed or applied to other areas of the body. Common side effects may include vaginal burning, itching, irritation, or abdominal cramps. If these effects persist or worsen, or if the infection does not improve within a few days, patients should contact their healthcare provider.

Prescribers should note that while clotrimazole is generally well-tolerated, it may interact with certain other medications. Therefore, a complete medication history should be obtained before prescribing this formulation. Additionally, clotrimazole may not be suitable for all patients, such as those with a history of hypersensitivity to clotrimazole or other azole antifungals.

If you have any questions about this formulation, or if you need further information, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to assist you.

Drug Interactions

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Clotrimazole 500 mg Vaginal Suppository is a potent antifungal medication used primarily to treat vaginal yeast infections. It works by stopping the growth of yeast (fungus) that causes the infection. This suppository is inserted into the vagina where it dissolves and releases the medication to the local area. However, it's important to be aware of potential drug interactions that may affect the effectiveness of this medication or increase the risk of side effects.

Clotrimazole may interact with other vaginal products. Using other vaginal products such as tampons, douches, or spermicides may interfere with the effectiveness of this medication. Therefore, it is recommended to avoid using these products while using clotrimazole unless directed by a healthcare professional. Also, it's important to note that this medication may weaken latex products such as condoms and diaphragms, which may result in contraceptive failure.

Systemic absorption of clotrimazole from the vagina is minimal, but it may interact with certain medications if absorbed into the bloodstream. These include warfarin, a blood thinner, and tacrolimus, a medication used to prevent organ transplant rejection. If you are taking these medications, inform your healthcare provider before starting clotrimazole.

Furthermore, it's important to inform your healthcare provider about all the products you use, including prescription drugs, nonprescription drugs, and herbal products, before starting treatment with this medication. This will help your healthcare provider to manage potential drug interactions and ensure safe and effective use of this medication.

Alcohol or tobacco may also interact with clotrimazole. Using alcohol or tobacco with certain medicines may cause interactions to occur. Discuss with your healthcare professional the use of your medicine with alcohol or tobacco.

Lastly, certain medical conditions may affect the use of this medication. Before using clotrimazole, make sure you inform your healthcare provider if you have any other medical conditions, especially liver disease or a history of alcohol abuse. These conditions may increase the risk of serious side effects from clotrimazole.

If you have any questions about the potential drug interactions with clotrimazole 500 mg Vaginal Suppository, please do not hesitate to reach out to us. We are here to provide you with the most accurate and up-to-date information to ensure safe and effective use of this medication.

How Does it Work

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Clotrimazole 500 mg Vaginal Suppository is a solid dosage form that is inserted into the vagina, where it dissolves or melts to release the medication. The active ingredient, clotrimazole, is an antifungal medication that works by inhibiting the growth of fungus. It does this by interfering with the production of the fungal cell membrane. The cell membrane is crucial for the survival and growth of the fungus. When clotrimazole interferes with its production, it causes holes to appear in the membrane. These holes allow essential constituents of the fungal cells to leak out, which kills the fungi and treats the infection.

Once the suppository is inserted into the vagina, it begins to dissolve or melt due to the body's natural heat. As it dissolves, the clotrimazole is released and absorbed by the vaginal tissue. This allows the medication to directly target the site of the fungal infection, providing relief from symptoms such as itching, burning, and discharge that are commonly associated with vaginal yeast infections. The suppository formulation ensures that the medication is delivered directly to the infection site, providing faster relief compared to oral medications.

Clotrimazole 500 mg Vaginal Suppository is typically used to treat vaginal yeast infections, also known as candidiasis. These infections are caused by an overgrowth of a type of fungus called Candida. This medication is also used to prevent the recurrence of these infections. It's important to note that while clotrimazole treats the fungal infection, it does not treat the underlying cause of the overgrowth of Candida. Therefore, it's important to discuss with your healthcare provider about ways to prevent recurrent infections.

For prescribers, it's important to note that while clotrimazole is generally well-tolerated, some patients may experience side effects such as vaginal burning, itching, or irritation when using the suppository. If these symptoms persist or worsen, the patient should be advised to stop using the medication and seek medical attention. Additionally, patients should be advised to complete the full course of treatment even if symptoms improve after a few days to ensure the infection is completely cleared and to prevent recurrence.

If you have any questions about Clotrimazole 500 mg Vaginal Suppository, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Other Uses

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Clotrimazole is best known for treating vaginal yeast infections (Candida), which can create symptoms such as itching, burning, and discomfort. However, this medication also performs exceptionally well in various other treatment areas due to its potent antifungal properties. Apart from treating vaginal yeast infections, Clotrimazole can be utilised for treating infections caused by other types of fungus. These include oral thrush, ringworm, athlete's foot, jock itch, and others. Known as a broad-spectrum antifungal agent, Clotrimazole combats these infections by intervening with the formation of the fungal cell membrane, subsequently leading to the death of the fungal cell.

Other lesser-known uses of Clotrimazole present themselves in the dermatologic realm. In rare instances, it has been used to treat skin conditions like tinea versicolor - a yeast infection that results in patchy skin discoloration. Again, Clotrimazole's antifungal properties are the key reason it has been used for this application. It is necessary to remember that before using Clotrimazole for dermal application, medical advice should be sought to ensure safety and efficacy.

As the vaginally used Clotrimazole has be formulated as a suppository, it has also been proven useful for treating rectal yeast infections. During such occasions, it may be ideal for individuals with candidiasis in multiple body cavities. Please also consider that the efficiency and safety of Clotrimazole in treating other types of fungal infections apart from those mentioned might vary significantly, so it's unquestionably essential to seek a physician's advice before considering variant uses of the medicine.

For prescribers with patients battling resistant and persistent fungal infections, Clotrimazole might be a viable option worth exploring. Always consider the patient's history, current medical conditions, and possible drug interactions before prescribing. Although Clotrimazole is well tolerated by most individuals, there could be instances of drug interactions which can complicate treatment. Specific contraindications, potential side effects and the possible development of resistance should also be communicated with the patient.

Lastly, we strongly recommend that patients and prescribers contact us with any queries pertaining to Clotrimazole or its applications. Our compounding pharmacists at Bayview Pharmacy are more than eager to help you navigate through the intricacies of Clotrimazole usage and will respond with accurate, evidence-based information suiting your unique needs.

Frequently Asked Questions

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What is a Clotrimazole 500 mg Vaginal Suppository?

This is a solid dosage form containing Clotrimazole, a medication used to treat various fungal infections. It is designed to be inserted into the vagina, where it dissolves or melts to release the medication for local absorption.

How does a Clotrimazole 500 mg Vaginal Suppository work?

The suppository dissolves within the vagina, releasing Clotrimazole, a potent antifungal medication. It works by stopping the growth of yeast (fungus) that causes the infection.

What infections can a Clotrimazole 500 mg Vaginal Suppository treat?

Clotrimazole is typically used to treat vaginal yeast infections, but it can also be used to treat other types of fungal infections as prescribed by your healthcare provider.

How should I use Clotrimazole 500 mg Vaginal Suppository?

You should insert the suppository into the vagina as instructed by your healthcare provider. Dosage is usually once or twice a day for a prescribed number of days.

What should I do if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What side effects can occur with a Clotrimazole 500 mg Vaginal Suppository?

Common side effects may include vaginal burning and itching. If these effects persist or get worse, notify your healthcare provider immediately.

Who should not use a Clotrimazole 500 mg Vaginal Suppository?

You should not use this if you are allergic to Clotrimazole or any ingredients of the suppository. It's also not recommended if you have certain medical conditions. Always consult your healthcare provider before starting a new medication.

Can I use a Clotrimazole 500 mg Vaginal Suppository during my period?

Yes, you can. However, do not use tampons, douches, spermicides or any other vaginal products while using this medication.

Can I have sex while using a Clotrimazole 500 mg Vaginal Suppository?

Sexual intercourse is not recommended as it may interfere with the treatment. Also, clotrimazole can weaken latex condoms and diaphragms which may result in unreliable contraception.

Can I expect immediate relief after using a Clotrimazole 500 mg Vaginal Suppository?

Relief of symptoms usually begins within a few days after starting the treatment. However, the symptoms may persist for the full duration of treatment or may recur if the full course of treatment is not completed. If your symptoms do not improve within 3 days or continue after 7 days, consult your healthcare provider.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.
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