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The Doxylamine Succinate 10 mg/Pyridoxine HCl 10 mg Slow Release (MEM4) Oral Capsules are a specialized pharmaceutical formulation designed to alleviate symptoms associated with specific disease states. Each capsule contains a combination of doxylamine succinate and pyridoxine hydrochloride (vitamin B6), both dosed at 10 mg, and is compounded using Methocel E4M. This controlled-release polymer ensures that the active ingredients are released gradually over an extended period, providing sustained therapeutic effects.
This formulation is primarily used to treat nausea and vomiting of pregnancy (NVP), commonly known as morning sickness, which can significantly impact a pregnant woman's quality of life. The slow release mechanism of the capsules allows for reduced dosing frequency, which may enhance patient compliance and provide consistent symptom relief throughout the day. Additionally, the use of Methocel E4M in the capsule matrix helps to maintain steady blood levels of the active ingredients, potentially minimizing the risk of peaks and troughs that could lead to side effects or decreased efficacy.
By combining doxylamine succinate, an antihistamine that possesses antiemetic properties, with pyridoxine hydrochloride, which has been shown to have a beneficial effect on NVP, this formulation offers a dual approach to managing symptoms.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
The Doxylamine Succinate 10 mg/Pyridoxine HCl 10 mg Slow Release (MEM4) Oral Capsules are a specialized pharmaceutical formulation designed to provide a controlled release of the active ingredients doxylamine succinate and pyridoxine hydrochloride. Doxylamine succinate is an antihistamine with sedative properties, commonly used to treat symptoms of allergies, the common cold, and as a short-term sleep aid. Pyridoxine hydrochloride, also known as vitamin B6, is essential for many bodily functions, including neurotransmitter synthesis, and is often used to prevent or treat low levels of vitamin B6, as well as to alleviate nausea and vomiting during pregnancy.
This unique formulation incorporates Methocel E4M, a hydrophilic methylcellulose derivative, which acts as a controlled-release polymer. When encapsulated with the active ingredients, Methocel E4M swells and forms a gel barrier upon contact with gastrointestinal fluids. This gel barrier controls the rate at which the active ingredients are released into the body, ensuring a gradual and sustained release over an extended period. This slow-release mechanism allows for a reduction in dosing frequency, which can lead to improved patient compliance, especially beneficial for those who require consistent therapeutic levels of medication throughout the day or night.
The dual action of doxylamine's antiemetic effects and pyridoxine's role in nausea reduction provides a synergistic approach to managing NVP symptoms. The controlled-release aspect of the formulation ensures that the therapeutic effects are maintained, potentially providing relief for a more extended period than immediate-release formulations.
For patients and prescribers considering this formulation, it is important to note that the slow-release capsules should be swallowed whole and not crushed or chewed, to maintain the integrity of the controlled-release system. As with any medication, potential side effects, contraindications, and interactions with other drugs should be reviewed with a healthcare provider. The compounding pharmacists at Bayview Pharmacy are available to answer any questions regarding this formulation and can provide additional information tailored to individual patient needs or prescriber requirements. If you have any questions or require further assistance, please do not hesitate to reach out to us.
The combination of Doxylamine Succinate and Pyridoxine HCl in a slow-release formulation is commonly used to manage symptoms of nausea and vomiting during pregnancy, a condition known as morning sickness. Doxylamine is an antihistamine that can help reduce nausea and vomiting, while Pyridoxine, a form of vitamin B6, has been shown to improve symptoms of morning sickness. When considering the use of this combination therapy, it is important to be aware of potential drug interactions that may occur.
Doxylamine Succinate may interact with other central nervous system depressants, such as alcohol, benzodiazepines, opioids, and other antihistamines, potentially enhancing sedative effects. Caution is advised when patients are taking these medications concurrently. Additionally, monoamine oxidase inhibitors (MAOIs) can increase the anticholinergic effects of antihistamines, leading to an increased risk of side effects such as dry mouth, urinary retention, and constipation. It is generally recommended to avoid the use of MAOIs within two weeks of taking medications containing Doxylamine.
Pyridoxine HCl can interact with medications that affect vitamin B6 levels. For example, isoniazid, used to treat tuberculosis, can deplete vitamin B6 and may necessitate supplementation. Conversely, high doses of Pyridoxine can decrease the efficacy of levodopa, a medication used to treat Parkinson's disease, unless a dopa decarboxylase inhibitor is also being used. Additionally, Pyridoxine may reduce the effectiveness of phenobarbital and phenytoin, two antiepileptic drugs.
Since this formulation is designed to release the active ingredients slowly over time, it is important to consider that interactions may be prolonged or delayed. Patients should be advised not to crush or chew the capsules, as this could disrupt the controlled-release mechanism and potentially lead to a rapid release of the active ingredients, increasing the risk of side effects and interactions.
Patients should be encouraged to inform their healthcare providers of all medications, supplements, and herbal products they are currently taking to avoid potential interactions. Healthcare providers should review the patient's medication regimen for possible interactions before prescribing this slow-release formulation of Doxylamine Succinate and Pyridoxine HCl.
If you have any questions or require further information regarding drug interactions with this formulation, please reach out to us at Bayview Pharmacy. Our team is committed to ensuring the safe and appropriate use of medications and is available to provide the necessary support and guidance.
The Doxylamine Succinate 10 mg/Pyridoxine HCl 10 mg Slow Release (MEM4) Oral Capsules are a specialized pharmaceutical formulation designed to manage symptoms associated with certain conditions, such as nausea and vomiting during pregnancy. This formulation utilizes Methocel E4M, a hydrophilic matrix of hypromellose, which is a type of controlled-release polymer. When the capsule is ingested, the Methocel E4M swells upon contact with gastric fluids, forming a gel-like matrix that encapsulates the active ingredients, doxylamine succinate and pyridoxine HCl.
Doxylamine succinate is an antihistamine that works by blocking histamine receptors in the brain, which helps to reduce symptoms of nausea and vomiting. The combination of these two ingredients in a slow-release formulation ensures a steady absorption and prolonged effect, which can be particularly beneficial for managing symptoms that require consistent relief over time.
The slow-release mechanism of Methocel E4M is based on the principle of diffusion and erosion. As the gel matrix forms, it creates a barrier through which the active ingredients must diffuse to reach the bloodstream. This process is controlled by the rate at which the polymer matrix erodes and the drug dissolves. The result is a gradual and sustained release of doxylamine succinate and pyridoxine HCl, maintaining therapeutic levels in the body for an extended period. This reduces the need for frequent dosing, which can improve patient compliance and convenience, especially for patients experiencing discomfort due to frequent nausea and vomiting.
By using this controlled-release technology, the Doxylamine Succinate/Pyridoxine HCl Slow Release Capsules can provide a more consistent therapeutic effect, potentially leading to better management of symptoms and an overall improvement in the quality of life for patients. It is important for both patients and prescribers to understand the benefits and mechanisms of this formulation to ensure optimal use and adherence to the treatment regimen. If you have any questions or require further information about this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the support and guidance you need.
This medication is a compounded formulation consisting of Doxylamine Succinate and Pyridoxine Hydrochloride (Vitamin B6), each at a strength of 10 mg, encapsulated in a slow-release formula. It is designed to gradually release the active ingredients over an extended period of time, enhancing therapeutic effects and improving patient compliance.
The capsule is formulated with Methocel E4M, a hydrophilic controlled-release polymer, which swells in the presence of gastric fluid and gradually releases the incorporated drugs, Doxylamine Succinate and Pyridoxine HCl, over an extended period. This mechanism ensures a sustained release of the active ingredients into the body, resulting in a reduced need for frequent dosing.
Sustained release capsules offer several benefits, including maintaining steadier blood levels of the medication, reducing the frequency of doses needed throughout the day, and minimizing potential side effects associated with peak concentrations of drugs. This leads to improved patient adherence to the medication regimen.
This combination medication is commonly used for the management of nausea and vomiting associated with pregnancy, commonly known as morning sickness, where a sustained release can help manage symptoms over a longer period of time.
Like all medications, these capsules can cause side effects. Common side effects include drowsiness, dry mouth, and dizziness. Less common side effects could include gastrointestinal disturbances, headache, or allergic reactions. If you experience any severe side effects, contact your healthcare provider immediately.
Take the medication exactly as prescribed by your healthcare provider. The slow release capsules should be swallowed whole with water, and not chewed or crushed, as this may affect the controlled-release mechanism.
Yes, you can take Doxylamine Succinate/Pyridoxine HCl Slow Release Oral Capsules with or without food. However, taking it with a meal may help if you experience stomach upset.
If you miss a dose of the medication, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
You should continue to take the medication for the duration prescribed by your healthcare provider, even if you feel better, to ensure that you are adequately managing your symptoms. If you have questions about the duration of treatment, consult with your healthcare provider.
Store Doxylamine Succinate/Pyridoxine HCl Slow Release Oral Capsules at room temperature away from light and moisture. Keep them out of reach of children and pets, and do not store in the bathroom as the humidity could affect the capsules.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Take 1 capsule by mouth
