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Estradiol 0.125 mg/Estriol 0.5 mg Oral Capsules

FDA-approved generic
Dose form
Capsules
Active ingredients
Estradiol
Estriol

The Estradiol 0.125 mg/Estriol 0.5 mg Oral Capsules are a solid dosage form that consists of two halves of either gelatin or vegetarian-based shells. These shells are filled with a precise dose of the active ingredients, estradiol and estriol, which are forms of estrogen, a female hormone. The capsules are designed to be easily swallowed, ensuring patient comfort and adherence to the prescribed therapy.

This formulation is specifically compounded to treat symptoms associated with menopause, such as hot flashes, vaginal dryness, and osteoporosis prevention. It may also be used for hormone replacement therapy in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. The combination of estradiol and estriol in these capsules aims to provide a balanced approach to estrogen replacement, potentially offering a favorable efficacy and safety profile for the indicated disease states.

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For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
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This medication requires a prescription from your doctor
Ships within 1 to 2 business days after pharmacist verification
HSA and FSA eligible
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Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.

For prescribersSign in for prescription details and order forms.
Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Estradiol
Estriol
Capsules
655e7a8eb5b1f80afd745759
Service area

Can we ship this formula to your state?

Bayview fills prescriptions for patients in Connecticut, Florida, Maine, Massachusetts, New Hampshire, New Jersey, Pennsylvania and Rhode Island. New York patients are served on a limited basis while nonresident pharmacy registration is pending.

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Formula Information

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Estradiol 0.125 mg/Estriol 0.5 mg Oral Capsules are a bioidentical hormone replacement therapy (HRT) designed to alleviate symptoms associated with menopause and other hormonal imbalances. This formulation combines two estrogens, estradiol and estriol, in a solid dosage form. The capsules are made from either gelatin or vegetarian shells, which are easily swallowed and ensure the precise delivery of the active ingredients. Estradiol is the primary and most potent estrogen hormone produced by the ovaries and is crucial for many processes in the body. Estriol, a weaker estrogen, is thought to offer benefits without the risks associated with stronger estrogens.

The use of these oral capsules can help manage symptoms such as hot flashes, night sweats, vaginal dryness, and mood swings. Additionally, this HRT may aid in preventing bone loss that can lead to osteoporosis in postmenopausal women. The combination of estradiol and estriol aims to provide a balanced approach to estrogen supplementation, potentially reducing the risk of side effects that can be associated with estrogen therapy. It is important for patients and prescribers to consider the individual's health history, risks, and benefits when deciding to use this therapy.

For prescribers, it is essential to monitor the patient's response to the therapy and adjust the dosage as necessary. Regular follow-ups and assessments of risk factors for cardiovascular disease, breast cancer, and endometrial cancer are recommended. Patients should be informed about the signs and symptoms of serious side effects, including blood clots, stroke, and heart attack. It is also important for patients to understand that this medication should be taken at the same time each day to maintain consistent hormone levels in the body.

Bayview Pharmacy's team of compounding pharmacists ensures that each batch of Estradiol 0.125 mg/Estriol 0.5 mg Oral Capsules is prepared with the utmost precision and quality control. We are committed to providing personalized care and can tailor the formulation to meet the specific needs of each patient. If you have any questions or require further information about this formulation, please do not hesitate to reach out to us. Our knowledgeable staff is here to support both patients and healthcare providers in the safe and appropriate use of compounded medications.

Drug Interactions

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Estradiol and estriol are forms of estrogen, a female sex hormone that regulates many processes in the body. This combination of estradiol and estriol in oral capsule form is often used in hormone replacement therapy to treat symptoms of menopause such as hot flashes, vaginal dryness, and osteoporosis prevention. It is important to consider potential drug interactions when prescribing or taking this medication.

One significant interaction is with drugs that induce liver enzymes, such as rifampin, barbiturates, carbamazepine, phenytoin, and St. John's Wort. These medications can increase the metabolism of estrogens, potentially reducing their effectiveness. Conversely, drugs like erythromycin, ketoconazole, itraconazole, and grapefruit juice can inhibit the metabolism of estrogens, leading to increased levels and potential side effects.

Estrogens can also affect the anticoagulant effects of warfarin, necessitating close monitoring of prothrombin time and INR to avoid bleeding complications. Additionally, they may alter the pharmacokinetics of other drugs such as corticosteroids, thyroid hormone, and certain benzodiazepines, which may require dosage adjustments of these medications.

Concomitant use of estrogens with other hormone therapies, such as progestins or testosterone, should be carefully considered and monitored due to the potential for additive effects or alterations in hormone levels. Estrogens may also interfere with the effectiveness of antihypertensive drugs and diuretics, and they can exacerbate fluid retention associated with these medications.

It is also important to note that smoking tobacco can reduce the efficacy of estrogen therapy and increase the risk of cardiovascular side effects. Patients are advised to avoid smoking while taking this medication. Additionally, patients with a history of hormone-sensitive cancers or thromboembolic disorders should use estrogen therapy with caution, as it may exacerbate these conditions.

Patients should be advised to inform their healthcare providers of all medications, supplements, and herbal products they are taking to ensure safe and appropriate use of estradiol and estriol oral capsules. If you have any questions or concerns about potential drug interactions with this formulation, please reach out to us at Bayview Pharmacy for further assistance.

How Does it Work

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The Estradiol 0.125 mg/Estriol 0.5 mg Oral Capsules are a bioidentical hormone replacement therapy (HRT) designed to alleviate symptoms associated with menopause and other hormonal imbalances. This formulation combines two forms of estrogen: estradiol, the primary and most potent form of estrogen found in the body, and estriol, a weaker form of estrogen that is abundant during pregnancy. The precise dosing of estradiol and estriol in these capsules aims to restore hormonal balance in the body, which can be disrupted during menopause or due to other health conditions.

The capsules are solid dosage forms consisting of two halves of a gelatin or vegetarian shell. These shells are filled with the active medication in powder form and then sealed together. This design ensures that patients receive an exact dose of the medication in a form that is easy to swallow. The encapsulation also protects the active ingredients from degradation by environmental factors, such as light and moisture, thus maintaining the stability and efficacy of the medication over time.

When ingested, the capsules dissolve in the stomach, releasing the active hormones for absorption into the bloodstream. Estradiol works by binding to estrogen receptors throughout the body, mimicking the effects of natural estrogen. It can help alleviate symptoms such as hot flashes, night sweats, vaginal dryness, and mood swings. Estriol, being a weaker estrogen, contributes to the therapeutic effects without significantly increasing the risks associated with stronger estrogens. The combination of estradiol and estriol in this formulation is thought to provide a balanced approach to hormone therapy, potentially offering benefits while minimizing side effects.

This HRT is often prescribed for women experiencing menopausal symptoms, but it may also be used for other conditions that result from estrogen deficiency or imbalance, such as osteoporosis or certain menstrual disorders. It is important for prescribers to consider the individual needs of the patient, including their medical history and any potential risks associated with hormone therapy, before initiating treatment with this formulation.

Patients and prescribers should be aware that hormone replacement therapy is not suitable for everyone and that it requires careful monitoring. It is essential to follow the prescribed dosage and to attend regular follow-up appointments to assess the effectiveness of the treatment and to monitor for any adverse effects. If you have any questions or concerns about this formulation or its use in treating specific disease states, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and appropriate use of this medication.

Frequently Asked Questions

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What are Estradiol 0.125 mg/Estriol 0.5 mg Oral Capsules?

Estradiol 0.125 mg/Estriol 0.5 mg Oral Capsules are a compounded medication used for hormone replacement therapy. They contain two forms of estrogen: estradiol and estriol in specified doses.

How should I take these oral capsules?

Take the capsules exactly as prescribed by your healthcare provider, typically once a day. Swallow the capsules whole with water; do not open, chew, or crush them.

What are the advantages of using capsules for hormone therapy?

Capsules provide an exact dosage of the hormones needed in a convenient form that's easy to take, improving compliance and ensuring consistent delivery of the medication.

Can I open the capsule if I have trouble swallowing it?

No, you should not open the capsule. If you have trouble swallowing pills, consult your healthcare provider for advice. Opening the capsule can affect the delivery of the medication and its effectiveness.

Are these capsules made using gelatin or vegetarian materials?

The capsules are composed of either gelatin or vegetarian-friendly shells. Please check the label or consult your pharmacist to confirm the type used in your specific prescription.

What should I do if I miss a dose?

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Can I take these capsules with food?

It's best to follow the advice of your healthcare provider. Generally, these capsules can be taken with or without food, but some people may find taking them with food helps to minimize stomach upset.

Are there any potential side effects of taking Estradiol 0.125 mg/Estriol 0.5 mg Oral Capsules?

Yes, like all medications, these capsules can cause side effects. Common side effects include nausea, headache, breast tenderness, or spotting. Contact your healthcare provider if you experience any severe or persistent side effects.

How should I store these capsules?

Store the capsules at room temperature, away from direct light, moisture, and heat, and keep them out of reach of children and pets.

Can men take these Estradiol/Estriol capsules?

These capsules are typically prescribed for women's hormone replacement therapy. A healthcare provider's guidance is necessary to determine if a medication is appropriate for a man's use.

Is it safe to take Estradiol/Estriol capsules during pregnancy?

No, taking these hormones is generally contraindicated during pregnancy. If you become pregnant or plan to become pregnant while taking these medications, inform your healthcare provider immediately.

Do I need to follow up with my doctor regularly while taking Estradiol/Estriol capsules?

Yes, regular follow-ups with your healthcare provider are important to monitor your response to the medication and to adjust the dose if necessary.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Estradiol 0.125 mg/Estriol 0.5 mg Oral Capsules
Capsules
90 capsules
controlled

Take 1 capsule by mouth

Once daily