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Description: This compounded vaginal gel is a unique formulation that combines estradiol (0.5 mg/ml), estriol (0.5 mg/ml), and testosterone (20 mg/ml) in a gel-like semisolid base. The gel is packaged in a tube designed for ease of use and precise application to the vaginal area. The combination of these hormones is intended to address symptoms associated with menopause, such as vaginal atrophy, dryness, and irritation. Additionally, it may be used to help manage conditions like hypoactive sexual desire disorder (HSDD) in postmenopausal women. The gel's consistency ensures that the medication is delivered directly to the affected area, providing both lubrication and the desired therapeutic effects.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
The Estradiol 0.5 mg/ml, Estriol 0.5 mg/ml, Testosterone 20 mg/ml Vaginal Gel is a specialized compounding formulation designed to address a variety of gynecological conditions through the synergistic effects of its active ingredients. Estradiol and Estriol, both forms of estrogen, are commonly used in hormone replacement therapy to alleviate symptoms associated with menopause, such as vaginal dryness, atrophy, and irritation. These estrogens help to restore the vaginal mucosa, improve lubrication, and maintain the tissue's elasticity and health. Testosterone, included at a concentration of 20 mg/ml, is not traditionally associated with female therapies; however, recent studies have shown that it can be beneficial in improving sexual function, libido, and overall quality of life in women, particularly those experiencing menopausal symptoms.
This compounded vaginal gel is formulated to allow for precise dosing and targeted application. The gel base provides a convenient and comfortable means of delivering the active hormones directly to the affected area, ensuring optimal absorption and minimizing systemic exposure. This localized approach can lead to fewer systemic side effects compared to oral hormone therapies. The gel's consistency is designed to minimize leakage and ensure that the medication remains in contact with the vaginal tissues for an extended period, enhancing the therapeutic effects.
Patients using this formulation may experience relief from the atrophic changes associated with menopause, including improvements in vaginal tissue health, decreased discomfort during intercourse, and a reduction in urinary symptoms. Additionally, the inclusion of testosterone may contribute to an increase in sexual desire and satisfaction, which can be adversely affected by hormonal changes during menopause. It is important for prescribers to consider the individual needs of their patients, as hormone therapy should be tailored to the lowest effective dose for the shortest duration consistent with treatment goals and risks for the individual woman.
As with any hormone therapy, potential risks and side effects should be discussed with patients, including the possibility of systemic absorption and its implications. Regular monitoring and follow-up are essential to ensure the safety and efficacy of the treatment. This compounded formulation is made to order and can be adjusted according to the specific requirements of the patient, based on the prescriber's discretion and the patient's response to therapy.
For patients and prescribers interested in utilizing this compounded vaginal gel formulation, or for those seeking more information on its use and potential benefits, please reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is available to answer any questions and provide guidance on the best practices for prescribing and using this medication.
The formulation you have described contains a combination of hormones: estradiol, estriol, and testosterone, which are intended for vaginal application. When considering drug interactions, it is important to note that these hormones can interact with a variety of medications and substances. For instance, certain drugs may increase the breakdown of hormones in the body, potentially reducing the effectiveness of this formulation. These include some anticonvulsants like phenobarbital and phenytoin, as well as some antibiotics such as rifampicin. Conversely, drugs that inhibit the metabolism of estrogens and testosterone, such as certain protease inhibitors and azole antifungals, may increase the levels of hormones and the risk of side effects.
Additionally, patients should be aware that the use of this formulation in conjunction with other hormonal therapies, such as oral contraceptives or hormone replacement therapy, may alter the intended effects and could potentially lead to an excess of hormones, which may increase the risk of hormone-related side effects. It is also important to consider the impact on blood clotting; estrogens can increase the risk of thromboembolic events, and when combined with drugs that affect coagulation, such as warfarin, careful monitoring is required.
Furthermore, the use of this vaginal gel may influence the effectiveness of other vaginal products due to alterations in vaginal absorption or physical interactions with the gel base. Patients should inform their healthcare provider of all medications, supplements, and herbal products they are using to ensure that potential interactions are assessed and managed appropriately.
This compounded formulation is designed to treat symptoms associated with menopause, such as vaginal atrophy, dryness, and irritation, as well as to provide local hormone replacement. Estradiol and estriol are forms of estrogen that can help replenish the diminished levels of estrogen in menopausal women, thereby alleviating these symptoms. Testosterone is included to address issues related to sexual function, such as libido and arousal, which can also be affected by menopause. The combination of these hormones aims to provide a comprehensive approach to managing menopausal symptoms with a focus on gynecological health.
It is crucial for both patients and prescribers to be aware of these potential interactions and to monitor for any adverse effects. If you have any questions or require further information regarding this formulation and its interactions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure safe and appropriate use of this medication.
The Estradiol 0.5 mg/ml, Estriol 0.5 mg/ml, and Testosterone 20 mg/ml Vaginal Gel is a compounded medication designed to deliver a combination of hormones directly to the vaginal tissue. This gel-like semisolid formulation is dispensed in a tube, which allows for easy and controlled application. The medication is intended to be applied inside the vagina, where it can exert its effects locally with minimal systemic absorption.
Estradiol and estriol are forms of estrogen, a hormone that plays a critical role in the health and function of the vaginal tissue, as well as in the regulation of the menstrual cycle and the maintenance of the female reproductive system. In this formulation, estradiol and estriol can help alleviate symptoms of estrogen deficiency, such as vaginal dryness, itching, and irritation, which are common in menopausal and postmenopausal women. These estrogens can also aid in maintaining the thickness and elasticity of the vaginal walls, potentially improving comfort during sexual activity and reducing the risk of urinary tract infections.
Testosterone, although typically considered a male hormone, is also present in females and plays a role in sexual function and libido. The inclusion of testosterone in this formulation at a concentration of 20 mg/ml can help address issues of decreased sexual desire and arousal that some women experience, particularly during the menopausal transition. The use of testosterone in this manner is based on its ability to enhance blood flow and sensitivity in the vaginal area, which can contribute to an improved sexual response.
The combination of these hormones in a gel formulation allows for the hormones to be absorbed directly by the vaginal tissue, which can lead to a more targeted effect and potentially fewer systemic side effects compared to oral hormone replacement therapy. This is particularly beneficial for women who may not be able to tolerate systemic hormone therapy or for those who prefer a localized treatment approach.
This compounded medication is typically used to treat symptoms associated with menopause, such as atrophic vaginitis, which is the thinning, drying, and inflammation of the vaginal walls due to a decrease in estrogen. It may also be used for other gynecological conditions as determined by a healthcare provider. As with any medication, it is important to use this formulation as directed by a healthcare professional and to report any adverse effects or concerns promptly.
If you have any questions about how this formulation works or if it is appropriate for your specific condition, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to make informed decisions about your health care.
This compounded vaginal gel is used to deliver a combination of hormones, including Estradiol, Estriol, and Testosterone, directly to the vaginal area for therapeutic purposes. It can aid in the management of menopausal symptoms like vaginal atrophy, dryness, and possibly libido enhancement.
Clean your hands thoroughly before use. Squeeze the prescribed amount of gel onto your fingertip or an applicator provided by your pharmacist. Gently insert into the vagina and apply the gel as directed by your healthcare provider. Usually, it is applied once daily or as prescribed.
A gel formulation provides a more direct application to the targeted area, potentially offering quicker local effects with possibly less systemic absorption compared to oral forms. It may also provide additional lubrication to alleviate symptoms of dryness.
As with any medication, there may be side effects. Common ones may include local irritation, itching, or redness. Systemic side effects due to the absorption of hormones can occur, such as breast tenderness or changes in mood. If you experience any severe side effects, contact your healthcare provider immediately.
It's best to consult with your healthcare provider for personal advice. Generally, the gel is intended for therapeutic purposes, and residual gel may alter the texture or pH during intercourse, potentially affecting its use as a lubricant.
Store the gel at room temperature away from direct sunlight and heat. Keep the tube tightly closed when not in use and out of reach of children and pets.
If you miss a dose, apply it as soon as you remember. If it's close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
This medication may not be safe during pregnancy or breastfeeding. It's essential to consult with your healthcare provider before starting any new medication, including this compounded vaginal gel, if you are pregnant or plan to become pregnant, or are breastfeeding.
Response time varies from person to person, based on the condition being treated and individual hormonal levels. Some relief from vaginal symptoms may be noticed within a few weeks, whereas other effects may take longer to manifest. Consult your healthcare provider regarding what to expect in your specific case.
Hormones can interact with various medications, potentially altering their effects. It's important to inform your healthcare provider about all medications you're taking, including over-the-counter drugs, herbal supplements, and vitamins, to assess for interactions.
Your healthcare provider may recommend hormone testing before prescribing the gel to determine appropriate dosages and to tailor the treatment to your individual needs. Regular monitoring might also be suggested to evaluate the efficacy and adjust dosages if necessary.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.
Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.
Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Insert/apply intravaginally
