The Estradiol 0.75 mg/Estriol 1.75 mg/ml Vaginal Cream is a specially compounded semisolid formulation designed for vaginal administration. This cream is dispensed in a tube, which allows for convenient and precise application. The combination of estradiol and estriol in this formulation is intended to deliver a dual estrogenic effect, which can be beneficial in treating various gynecological conditions that are associated with estrogen deficiency, such as atrophic vaginitis, vulvar atrophy, and symptoms of menopause.

Estradiol is a potent form of estrogen and is identical to the hormone produced naturally by the ovaries. It plays a crucial role in maintaining the health and function of the vaginal tissue, urinary tract, and supporting structures. Estriol, on the other hand, is a weaker estrogen that is thought to offer benefits with potentially fewer side effects, making it a good partner to estradiol in this formulation. The combination of these two estrogens can help to alleviate symptoms such as vaginal dryness, itching, burning, and discomfort during intercourse, which are often experienced by women during menopause or due to other hormonal imbalances.

The cream's base is designed to ensure that the active hormones are delivered directly to the affected area, allowing for localized treatment with minimal systemic absorption. This can be particularly advantageous for patients who may be at risk for systemic side effects or those who prefer localized therapy. The formulation is also compounded to ensure stability and consistency of the active ingredients, providing reliable dosing with each application.

For patients and prescribers considering this formulation, it is important to note that hormone replacement therapy (HRT) should be tailored to the individual's needs and medical history. A thorough evaluation of the risks and benefits should be conducted before initiating treatment. Additionally, regular monitoring and follow-up with a healthcare provider are essential to ensure the safety and efficacy of the therapy. Patients should be instructed on the proper use of the vaginal cream, including the application technique and dosage frequency, to maximize therapeutic outcomes and minimize potential side effects.

If you have any questions or require further information about the Estradiol 0.75 mg/Estriol 1.75 mg/ml Vaginal Cream, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing comprehensive support and guidance to both patients and prescribers to ensure optimal treatment outcomes.

The estradiol and estriol vaginal cream is a compounded medication that combines two forms of estrogen, estradiol and estriol, for local application in the vaginal area. This formulation is primarily used to treat symptoms associated with menopause, such as vaginal atrophy, dryness, itching, and burning. It may also be used for other gynecological conditions as prescribed by a healthcare provider. The cream works by delivering estrogens directly to the vaginal tissue, which can help to restore the tissue and alleviate symptoms.

When using this estradiol and estriol vaginal cream, it is important to consider potential drug interactions. Estrogens can interact with various medications, potentially altering their effects. For example, they may reduce the effectiveness of aromatase inhibitors (such as anastrozole, letrozole) and tamoxifen, which are used in the treatment of certain types of breast cancer. Concurrent use of these medications should be discussed with a healthcare provider.

Estrogens may also interact with thyroid hormone replacement therapy. They can increase the amount of thyroid-binding globulin, which may alter the amount of thyroid hormone that is free and active in the body. Patients on thyroid replacement therapy may require monitoring and possible dose adjustments of their thyroid medication when using estrogen-containing products.

Additionally, estrogens can affect the metabolism of certain drugs by inducing or inhibiting liver enzymes. This can lead to increased or decreased levels of drugs such as cyclosporine, prednisolone, theophylline, and certain benzodiazepines, among others. Patients should inform their healthcare provider of all medications they are taking, including over-the-counter drugs and herbal supplements, to assess for potential interactions.

It is also important to note that smoking can increase the risk of serious cardiovascular side effects from estrogen use, especially in women over 35 years of age. Patients are advised to avoid smoking while using this medication.

Patients should be aware that the use of estrogens has been associated with an increased risk of endometrial cancer in women with a uterus who are not also taking progestins. Healthcare providers may prescribe a progestin to take with this medication to lower this risk. It is also associated with an increased risk of blood clots, stroke, and heart attack, particularly in women who smoke or have other risk factors for these conditions.

Before starting treatment with estradiol and estriol vaginal cream, patients should have a thorough medical evaluation, and prescribers should review the patient's medical history to identify any potential drug interactions or contraindications. Ongoing monitoring and regular follow-up appointments are recommended to assess the effectiveness of the treatment and to make any necessary adjustments.

If you have any questions or require further information regarding drug interactions with this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure safe and effective use of this medication.

The Estradiol 0.75 mg/Estriol 1.75 mg/ml Vaginal Cream is a specially compounded formulation that combines two forms of estrogen: estradiol and estriol. Estradiol is a potent form of estrogen, which is the primary female sex hormone, while estriol is a weaker form of estrogen that is produced in significant amounts during pregnancy. When compounded into a cream, these hormones are designed to be absorbed directly through the vaginal mucosa, leading to localized effects with minimal systemic absorption.

This cream works by supplementing the body's natural estrogen levels, which may decrease due to menopause or other hormonal imbalances. Estrogen plays a crucial role in maintaining the health and function of the vaginal tissue. It promotes the growth of the lining of the vagina, increases vaginal lubrication, and maintains the tissue's elasticity and thickness. By delivering estrogens directly to the vaginal area, this cream can help alleviate symptoms such as vaginal dryness, itching, and irritation, which are often associated with estrogen deficiency.

In addition to providing symptomatic relief, the use of this vaginal cream may also help in the prevention of certain gynecological conditions. For example, it can aid in the management of atrophic vaginitis, a condition characterized by thinning and inflammation of the vaginal walls due to decreased estrogen levels. The cream can also be used as part of the treatment for vulvar atrophy and as an adjunctive therapy to improve the quality of life for postmenopausal women experiencing urogenital symptoms.

It is important for patients and prescribers to understand that this formulation is intended for vaginal use only and should be applied as directed by a healthcare professional. The semisolid consistency of the cream allows for easy application, and it is typically dispensed in a tube with an applicator to ensure accurate dosing and convenience. Patients should follow the prescribed dosing regimen and report any adverse effects or concerns to their healthcare provider.

For prescribers considering this formulation for their patients, it is essential to evaluate the patient's individual needs, hormone levels, and risk factors before initiating treatment. Regular monitoring and follow-up are recommended to assess the effectiveness of the therapy and to make any necessary adjustments to the treatment plan.

If you have any questions about this formulation or its use in treating specific gynecological conditions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to ensure the safe and effective use of this medication.

The Estradiol 0.75 mg/Estriol 1.75 mg/ml Vaginal Cream is primarily indicated for the management of menopausal symptoms, including vulvar and vaginal atrophy, which are associated with a decline in estrogen levels. However, its usage may extend beyond these primary indications under certain circumstances. While the formulation in question is designed to address gynecological conditions, the combined estrogenic effects of estradiol and estriol can also potentially be beneficial for secondary outcomes related to menopausal symptoms such as some urinary symptoms, which might include urinary urgency and recurrent urinary tract infections resulting from urogenital atrophy.

In some cases, the cream could be used off-label to help improve the elasticity and health of the vaginal tissues prior to gynecological surgery, aiming to reduce the risk of postoperative complications related to poor tissue integrity. Furthermore, there is also evidence suggesting that local estrogen therapy like this cream may have a positive effect on sexual function, improving lubrication, and potentially alleviating pain during intercourse for postmenopausal women experiencing dyspareunia as a result of thinning and inflammation of the vaginal walls.

Aside from its gynecological applications, research has indicated that systemic absorption of estrogen from the vaginal application is minimal, however, the long-term effects of this minimal absorption on conditions such as osteoporosis and cardiovascular health are not fully established. As such, it is not recommended to use this formulation as a primary treatment for these conditions, but it can be considered as an adjunctive therapy in some instances, under the guidance of a healthcare provider. It's important to note that estrogen therapy is contraindicated in certain patient populations, including those with a history of hormone-sensitive cancers, liver disease, or thromboembolic disorders. The risks and benefits should be carefully weighed with a healthcare professional before initiating treatment with any estrogen-containing product.

For prescribers considering this formulation for other uses, it is essential to keep abreast of the latest research and consider each patient's individual risks. Patients are encouraged to discuss any concerns or questions with their healthcare provider or reach out to us, the compounding pharmacists at Bayview Pharmacy, for more specific information regarding the potential uses and implications of the Estradiol 0.75 mg/Estriol 1.75 mg/ml Vaginal Cream. It is our commitment to provide both patients and healthcare providers with in-depth, personalized information to safely and effectively use the medications compounded at our pharmacy.