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The Estradiol 0.75 mg/Estriol 1.75 mg/ml Vaginal Cream is a compounded semisolid formulation, specifically designed for vaginal administration. Packaged in a tube for ease of use, this cream allows for precise dosing and application. The combination of estradiol and estriol in this cream is intended to address symptoms associated with menopausal changes, such as vaginal atrophy, dryness, itching, and irritation. Additionally, it may be used in the management of vulvar and vaginal atrophy due to estrogen deficiency and for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
The Estradiol 0.75 mg/Estriol 1.75 mg/ml Vaginal Cream is a specially compounded semisolid formulation designed for vaginal administration. This cream is dispensed in a tube, which allows for convenient and precise application. The combination of estradiol and estriol in this formulation is intended to deliver a dual estrogenic effect, which can be beneficial in treating various gynecological conditions that are associated with estrogen deficiency, such as atrophic vaginitis, vulvar atrophy, and symptoms of menopause.
Estradiol is a potent form of estrogen and is identical to the hormone produced naturally by the ovaries. It plays a crucial role in maintaining the health and function of the vaginal tissue, urinary tract, and supporting structures. Estriol, on the other hand, is a weaker estrogen that is thought to offer benefits with potentially fewer side effects, making it a good partner to estradiol in this formulation. The combination of these two estrogens can help to alleviate symptoms such as vaginal dryness, itching, burning, and discomfort during intercourse, which are often experienced by women during menopause or due to other hormonal imbalances.
The cream's base is designed to ensure that the active hormones are delivered directly to the affected area, allowing for localized treatment with minimal systemic absorption. This can be particularly advantageous for patients who may be at risk for systemic side effects or those who prefer localized therapy. The formulation is also compounded to ensure stability and consistency of the active ingredients, providing reliable dosing with each application.
For patients and prescribers considering this formulation, it is important to note that hormone replacement therapy (HRT) should be tailored to the individual's needs and medical history. A thorough evaluation of the risks and benefits should be conducted before initiating treatment. Additionally, regular monitoring and follow-up with a healthcare provider are essential to ensure the safety and efficacy of the therapy. Patients should be instructed on the proper use of the vaginal cream, including the application technique and dosage frequency, to maximize therapeutic outcomes and minimize potential side effects.
If you have any questions or require further information about the Estradiol 0.75 mg/Estriol 1.75 mg/ml Vaginal Cream, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing comprehensive support and guidance to both patients and prescribers to ensure optimal treatment outcomes.
The estradiol and estriol vaginal cream is a compounded medication that combines two forms of estrogen, estradiol and estriol, for local application in the vaginal area. This formulation is primarily used to treat symptoms associated with menopause, such as vaginal atrophy, dryness, itching, and burning. It may also be used for other gynecological conditions as prescribed by a healthcare provider. The cream works by delivering estrogens directly to the vaginal tissue, which can help to restore the tissue and alleviate symptoms.
When using this estradiol and estriol vaginal cream, it is important to consider potential drug interactions. Estrogens can interact with various medications, potentially altering their effects. For example, they may reduce the effectiveness of aromatase inhibitors (such as anastrozole, letrozole) and tamoxifen, which are used in the treatment of certain types of breast cancer. Concurrent use of these medications should be discussed with a healthcare provider.
Estrogens may also interact with thyroid hormone replacement therapy. They can increase the amount of thyroid-binding globulin, which may alter the amount of thyroid hormone that is free and active in the body. Patients on thyroid replacement therapy may require monitoring and possible dose adjustments of their thyroid medication when using estrogen-containing products.
Additionally, estrogens can affect the metabolism of certain drugs by inducing or inhibiting liver enzymes. This can lead to increased or decreased levels of drugs such as cyclosporine, prednisolone, theophylline, and certain benzodiazepines, among others. Patients should inform their healthcare provider of all medications they are taking, including over-the-counter drugs and herbal supplements, to assess for potential interactions.
It is also important to note that smoking can increase the risk of serious cardiovascular side effects from estrogen use, especially in women over 35 years of age. Patients are advised to avoid smoking while using this medication.
Patients should be aware that the use of estrogens has been associated with an increased risk of endometrial cancer in women with a uterus who are not also taking progestins. Healthcare providers may prescribe a progestin to take with this medication to lower this risk. It is also associated with an increased risk of blood clots, stroke, and heart attack, particularly in women who smoke or have other risk factors for these conditions.
Before starting treatment with estradiol and estriol vaginal cream, patients should have a thorough medical evaluation, and prescribers should review the patient's medical history to identify any potential drug interactions or contraindications. Ongoing monitoring and regular follow-up appointments are recommended to assess the effectiveness of the treatment and to make any necessary adjustments.
If you have any questions or require further information regarding drug interactions with this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure safe and appropriate use of this medication.
The Estradiol 0.75 mg/Estriol 1.75 mg/ml Vaginal Cream is a specially compounded formulation that combines two forms of estrogen: estradiol and estriol. Estradiol is a potent form of estrogen, which is the primary female sex hormone, while estriol is a weaker form of estrogen that is produced in significant amounts during pregnancy. When compounded into a cream, these hormones are designed to be absorbed directly through the vaginal mucosa, leading to localized effects with minimal systemic absorption.
This cream works by supplementing the body's natural estrogen levels, which may decrease due to menopause or other hormonal imbalances. Estrogen plays a crucial role in maintaining the health and function of the vaginal tissue. It promotes the growth of the lining of the vagina, increases vaginal lubrication, and maintains the tissue's elasticity and thickness. By delivering estrogens directly to the vaginal area, this cream can help alleviate symptoms such as vaginal dryness, itching, and irritation, which are often associated with estrogen deficiency.
In addition to providing symptomatic relief, the use of this vaginal cream may also help in the prevention of certain gynecological conditions. For example, it can aid in the management of atrophic vaginitis, a condition characterized by thinning and inflammation of the vaginal walls due to decreased estrogen levels. The cream can also be used as part of the treatment for vulvar atrophy and as an adjunctive therapy to improve the quality of life for postmenopausal women experiencing urogenital symptoms.
It is important for patients and prescribers to understand that this formulation is intended for vaginal use only and should be applied as directed by a healthcare professional. The semisolid consistency of the cream allows for easy application, and it is typically dispensed in a tube with an applicator to ensure accurate dosing and convenience. Patients should follow the prescribed dosing regimen and report any adverse effects or concerns to their healthcare provider.
For prescribers considering this formulation for their patients, it is essential to evaluate the patient's individual needs, hormone levels, and risk factors before initiating treatment. Regular monitoring and follow-up are recommended to assess the effectiveness of the therapy and to make any necessary adjustments to the treatment plan.
If you have any questions about this formulation or its use in treating specific gynecological conditions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide you with the information and support you need to ensure the safe and appropriate use of this medication.
This compounded medication is used for the treatment of certain gynecological conditions, such as vaginal atrophy, dryness, itching, and pain during intercourse, which are often symptoms of menopause or estrogen deficiency. It provides a combination of estradiol and estriol, which are forms of estrogen, to help alleviate these symptoms.
The cream should be applied as directed by your healthcare provider. Generally, it is applied intravaginally using the applicator provided with the tube. The applicator is filled with the prescribed amount of cream and then inserted into the vagina, usually at bedtime, to ensure optimal absorption and minimize leakage.
The frequency of application depends on the instructions provided by your healthcare provider. It is typically applied once daily at bedtime, but your provider may recommend a different regimen based on your individual treatment needs and response to therapy. Always follow the prescribed instructions.
It is generally advisable to avoid using vaginal creams during menstruation. However, your healthcare provider will be able to give you specific advice on whether to continue or pause treatment during your period.
Common side effects may include local reactions like itching, irritation, or increased vaginal discharge. Some women may experience systemic side effects due to hormone absorption, such as breast tenderness or headaches. If you experience any severe side effects or signs of an allergic reaction, contact your healthcare provider immediately.
It is generally recommended to wait a few hours after applying the cream before engaging in sexual activity. The medication should have enough time to absorb, and waiting helps prevent transferring the medication to your partner.
This vaginal cream is not a contraceptive. If you are using the cream for menopausal symptoms, additional birth control may not be necessary. However, if you are of childbearing age, discuss with your healthcare provider about appropriate contraceptive measures while using this medication.
Some medications and supplements might interfere with hormone absorption or increase the risk of side effects. It is important to inform your healthcare provider about all the medications and supplements you're currently taking to avoid any potential interactions.
The medication should be stored at room temperature, away from direct light, heat, and moisture. Keep the tube tightly closed when not in use, and store it out of reach of children and pets.
If you miss a dose, apply it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not double up doses to make up for the missed application.
Estrogens are generally not recommended for use during pregnancy. If you become pregnant while using this medication or are planning to become pregnant, inform your healthcare provider right away for proper guidance.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Insert/apply intravaginally
