Sublingual Semaglutide and Tirzepatide are now available! Get Started
Dashboard
Formulas

Estradiol 1 mg/Progesterone 100 mg Slow Release (MEM4) Oral Capsules

The Estradiol 1 mg/Progesterone 100 mg Slow Release (MEM4) Oral Capsules are a hormone replacement therapy (HRT) formulation designed to alleviate symptoms of menopause, such as hot flashes, night sweats, and vaginal dryness. This formulation is also used to prevent osteoporosis in postmenopausal women by maintaining bone density. Additionally, it may be prescribed for hormone-related irregularities in menstrual cycles and to provide endometrial protection in women with an intact uterus who are receiving estrogen therapy.

These capsules are compounded with Methocel E4M, a hydrophilic matrix that forms a gel barrier upon hydration, ensuring a slow and steady release of estradiol and progesterone. This controlled-release mechanism allows for consistent hormone levels over time, minimizing fluctuations that can lead to side effects and improving overall patient adherence to the therapy regimen. The use of Methocel E4M in the formulation provides a convenient dosing schedule, potentially reducing the frequency of doses required and offering a more consistent therapeutic effect.

Want a different strength?
Click the Text Us button below.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
Starting at
Must be E-Prescribed
Get Started
Generate LeafletShow Leaflet
This medication requires a prescription from your doctor
Are you a prescriber? Sign Up
Trusted by 60,357 patients to date.
A group of faces of our past satisfied patients.
A svg symbol of a mortar and pestle with ingredients going in.
Custom made in our compounding labs.
Sliders that show the customization of ingredients.
Personalized treatment for better results.
User with a gear showing the personalization of the formulation.
All strengths and ingredients are tailored to your needs.
This medication is not available at retail pharmacies. It is compounded, and may be more effective at treating you or your patient.
Slow Release Capsules
655e57cb9e52e680f10861cd
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Loading icon rotating.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Dosing Calculator

Get general dosing information for a patient by using this calculator.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Loading icon rotating.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Formula Information

A small arrow pointing down

Our Estradiol 1 mg/Progesterone 100 mg Slow Release (MEM4) Oral Capsules are expertly compounded to provide a balanced hormone replacement therapy (HRT) for individuals experiencing symptoms of menopause or other conditions related to hormone imbalances. The formulation utilizes Methocel E4M, a high-viscosity grade hydroxypropyl methylcellulose (HPMC), which is a controlled-release polymer that ensures a slow and steady release of the active ingredients, estradiol and progesterone, into the bloodstream. This method of delivery is particularly beneficial for maintaining consistent hormone levels throughout the day, potentially reducing the incidence of peaks and troughs associated with immediate-release formulations.

Estradiol, a form of estrogen, is essential for managing menopausal symptoms such as hot flashes, night sweats, vaginal dryness, and osteoporosis prevention. Progesterone is added to the formulation to counterbalance the effects of estrogen on the endometrium, thereby reducing the risk of endometrial hyperplasia and cancer which can be associated with estrogen therapy alone. The combination of these hormones in a slow-release capsule can help in restoring hormonal balance, improving quality of life, and protecting long-term health.

The use of Methocel E4M in our capsules not only provides a controlled release of the hormones but also contributes to improved patient compliance by reducing the dosing frequency. Patients are often more likely to adhere to a treatment regimen that is convenient and easy to follow. Additionally, the slow release of hormones can lead to fewer side effects and a more stable hormonal environment, which is crucial for individuals sensitive to hormonal fluctuations.

It is important for prescribers to consider individual patient needs when recommending HRT, including the patient's medical history, risk factors, and personal preferences. Our pharmacy team is available to collaborate with healthcare providers to ensure that the formulation meets the specific requirements of each patient. We are committed to providing high-quality, customized medications to support patient health and well-being.

If you have any questions about our Estradiol 1 mg/Progesterone 100 mg Slow Release (MEM4) Oral Capsules or would like to discuss a patient's specific needs, please do not hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is here to assist you with any inquiries or concerns you may have regarding this formulation or any other compounding needs.

Drug Interactions

A small arrow pointing down

The Estradiol 1 mg/Progesterone 100 mg Slow Release (MEM4) Oral Capsules are a hormone replacement therapy (HRT) designed to alleviate symptoms of menopause, such as hot flashes, vaginal dryness, and bone loss prevention. The combination of estradiol and progesterone in a slow-release formulation helps to maintain stable hormone levels and mimics the natural release of these hormones in the body. However, it is important to consider potential drug interactions when prescribing or taking this medication.

Estradiol, a form of estrogen, can interact with a variety of substances. It may reduce the effectiveness of aromatase inhibitors (e.g., anastrozole, letrozole) which are used in breast cancer treatment. Concurrent use with thyroid hormone replacement therapy may necessitate adjustments in the thyroid hormone dose, as estrogens can increase thyroid-binding globulin (TBG) levels, leading to decreased free thyroid hormone levels. Patients on anticoagulants like warfarin may require closer monitoring and possible dose adjustments, as estrogen can affect coagulation parameters. Additionally, certain antiepileptic drugs (e.g., phenobarbital, phenytoin, carbamazepine) and some antibiotics (e.g., rifampicin) can increase the metabolism of estradiol, potentially reducing its effectiveness.

Progesterone may also interact with other medications. Enzyme inducers such as carbamazepine, phenytoin, and rifampicin can increase the metabolism of progesterone, potentially leading to decreased efficacy. Conversely, ketoconazole and other CYP3A4 inhibitors can increase progesterone levels, which may necessitate dose adjustments. Progesterone can also interact with benzodiazepines, as both can act on GABA receptors, potentially leading to increased sedative effects.

It is also important to note that both estradiol and progesterone can interact with grapefruit juice, which can inhibit the metabolism of these hormones and lead to increased levels in the body. Patients should be advised to avoid grapefruit and grapefruit juice while taking this medication. Additionally, smoking can increase the metabolism of estradiol, reducing its effectiveness and potentially increasing the risk of cardiovascular events, especially in women over 35 years of age.

Given the complexity of these interactions, it is crucial for prescribers to review all medications, including over-the-counter drugs and herbal supplements, that a patient is taking before prescribing this HRT formulation. Adjustments to therapy may be necessary, and patients should be monitored for signs of excess or inadequate hormone exposure. If you have any questions or require further information regarding drug interactions with this formulation, please reach out to us at Bayview Pharmacy for assistance.

How Does it Work

A small arrow pointing down

The Estradiol 1 mg/Progesterone 100 mg Slow Release (MEM4) Oral Capsules are a specialized formulation designed to provide a steady release of hormones into the bloodstream. This is achieved through the incorporation of Methocel E4M, a hydrophilic methylcellulose polymer that forms a gel matrix when it comes into contact with gastric fluids. As the capsule dissolves, the Methocel E4M swells and forms a viscous gel barrier around the active ingredients, estradiol and progesterone. This barrier controls the rate at which the hormones are released from the capsule and absorbed by the body.

The mechanism of Methocel E4M involves the gradual erosion of the gel layer and the diffusion of the active ingredients through the gel matrix into the surrounding gastrointestinal environment. The controlled-release property of Methocel E4M ensures that estradiol and progesterone are delivered at a consistent rate, maintaining stable hormone levels over an extended period, typically 24 hours. This slow-release action minimizes the peaks and troughs associated with immediate-release formulations, leading to a reduction in the frequency of dosing and potentially reducing the risk of side effects.

Estradiol and progesterone are hormones that play vital roles in the female reproductive system. Estradiol, a form of estrogen, is responsible for the development and maintenance of female reproductive tissues and secondary sexual characteristics. It is also involved in regulating the menstrual cycle and has effects on other body systems, including bone density and cardiovascular health. Progesterone is crucial for regulating the menstrual cycle, maintaining pregnancy, and preparing the body for conception. It works in conjunction with estradiol to provide hormonal balance.

This particular formulation is used to treat various disease states such as menopausal symptoms, including hot flashes, night sweats, and vaginal dryness. It may also be used in hormone replacement therapy (HRT) for women with low hormone levels or in certain cases of infertility where hormonal supplementation is required. The slow-release capsules ensure that the patient receives a steady dose of hormones, which can lead to better symptom control and a lower incidence of hormonal fluctuations that can cause discomfort or mood changes.

For patients and prescribers considering the use of Estradiol 1 mg/Progesterone 100 mg Slow Release (MEM4) Oral Capsules, it is important to understand that this formulation is designed to mimic the body's natural hormone release as closely as possible, providing a more natural rhythm of hormone delivery. This can be particularly beneficial for patients who are sensitive to hormone fluctuations or who have difficulty adhering to multiple daily dosing schedules. As with any medication, it is essential to follow the prescribed dosing regimen and to consult with a healthcare provider regarding any potential interactions with other medications or medical conditions.

If you have any questions about the Estradiol 1 mg/Progesterone 100 mg Slow Release (MEM4) Oral Capsules or would like more information on how this formulation can benefit specific disease states, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the support and guidance you need to make informed decisions about your hormonal health.

Other Uses

A small arrow pointing down

The Estradiol 1 mg/Progesterone 100 mg Slow Release (MEM4) Oral Capsules, formulated with Methocel E4M, primarily cater to hormone replacement therapy (HRT) in postmenopausal women or those facing conditions of hormonal imbalances such as hypoestrogenism and progesterone deficiency. However, beyond these standard indications, there are additional therapeutic avenues where this formulation could be beneficial. For instance, in conditions like premenstrual syndrome (PMS) or premenstrual dysphoric disorder (PMDD), the steady release of estradiol and progesterone may help in alleviating the cyclical mood fluctuations and other related symptoms. Additionally, this preparation could offer a therapeutic choice for individuals undergoing certain fertility treatments, where the regulation of these hormones is critical.

Another potential use of this slow-release formulation may lie in its ability to mitigate the risk of endometrial hyperplasia, which can occur when estrogen is administered without adequate opposition from progesterone in women with an intact uterus. Moreover, the synergy between estradiol and progesterone in these capsules might benefit women with menopausal symptoms that are not adequately managed by standard therapy, possibly due to poor compliance or fluctuating hormone levels throughout the day. The controlled-release nature of this capsule ensures a consistent delivery of hormones, potentially leading to more stable hormone levels and a reduction in the intensity and occurrence of symptoms.

It is important to note that the use of the MEM4 formulation for indications other than those for which it is explicitly prescribed should be made under medical guidance, considering the patient's unique medical history and condition. There may also be off-label uses that are discovered through clinical practice and research. Healthcare providers contemplating this formulation for other uses are encouraged to stay informed on the latest scientific evidence to ensure its safe and effective application. Additionally, patients with individual concerns or unique health circumstances should consult with their healthcare provider to ascertain if this treatment modality is appropriate for their specific condition.

Despite the potential benefits, it is essential to consider the potential risks and contraindications associated with hormone therapies, especially in populations with increased risk of cardiovascular disease, thromboembolic disease, or various types of cancer. Therefore, a careful benefit-risk assessment is paramount before prescribing this hormone combination, and monitoring should be ongoing during treatment. At Bayview Pharmacy, we are committed to providing comprehensive and personalized pharmaceutical care. If you have any questions about the potential other uses of our Estradiol 1 mg/Progesterone 100 mg Slow Release Oral Capsules or if you need more information for your patients, please do not hesitate to reach out to us.

Frequently Asked Questions

A small arrow pointing down

What are Estradiol 1 mg/Progesterone 100 mg Slow Release (MEM4) Oral Capsules?

Estradiol 1 mg/Progesterone 100 mg Slow Release (MEM4) Oral Capsules are a hormone replacement therapy medication that contains a combination of estrogen and progesterone in a controlled-release formulation. They are designed to release the hormones gradually to ensure a sustained therapeutic effect, which may improve symptom control for conditions related to hormone deficiency or imbalance.

How do the MEM4 oral capsules work?

The MEM4 oral capsules utilize Methocel E4M, a type of controlled-release polymer, to encapsulate the active ingredients. The polymer gradually dissolves in the digestive tract, releasing estradiol and progesterone slowly and consistently over an extended period, which mimics the body's natural hormone release and helps maintain stable blood levels of the hormones.

What are the benefits of using a controlled-release hormone capsule?

Controlled-release hormone capsules provide a steadier release of hormones into the bloodstream, which can reduce the frequency of dosing, minimize the potential for peaks and troughs in hormone levels, and help improve overall patient compliance with the medication regimen. Additionally, it can enhance the convenience and comfort for patients who may experience side effects from fluctuations in hormone levels.

How often should I take Estradiol/Progesterone Slow Release capsules?

Your dosage schedule will be determined by your healthcare provider based on your specific needs and treatment goals. However, due to the controlled-release nature of these capsules, the frequency of dosing may be less than that of immediate-release formulations. Always follow the dosing instructions provided by your doctor or pharmacist.

Can I take MEM4 oral capsules with food?

It is generally acceptable to take MEM4 oral capsules with or without food. However, it's important to be consistent with how you take your medication. If you choose to take it with food, try to do so with similar types of meals each day to ensure consistent absorption of the medication.

What should I do if I miss a dose of my Estradiol/Progesterone capsules?

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up doses to make up for the missed one. Consult your healthcare provider for specific advice if you miss doses frequently.

Are there any side effects associated with Estradiol 1 mg/Progesterone 100 mg Slow Release capsules?

As with any medication, there may be side effects. Common side effects can include headaches, breast tenderness, nausea, and mood swings. If you experience any severe or persistent side effects, it's important to contact your healthcare provider immediately.

How should I store my MEM4 oral capsules?

Store your capsules at room temperature away from direct sunlight, moisture, and heat. Keep the medication out of reach of children and pets. If you have questions about storage, consult your pharmacist for specific instructions.

Can MEM4 oral capsules be used during pregnancy?

MEM4 oral capsules are not recommended for use during pregnancy. If you are pregnant, planning to become pregnant, or become pregnant while using these capsules, contact your healthcare provider immediately to discuss your medication and treatment plan.

Will taking Estradiol/Progesterone Slow Release capsules affect my ability to drive or operate machinery?

These capsules should not affect your ability to drive or operate machinery. However, if you experience drowsiness, dizziness, or any other side effect that could impair your ability to perform these tasks safely, avoid them and consult your healthcare provider.

Can I drink alcohol while taking Estradiol/Progesterone Slow Release capsules?

While taking these capsules, it's advisable to limit or avoid alcohol consumption, as alcohol can affect the absorption and metabolism of hormones, and may also increase the risk of liver problems and other side effects. If you have specific questions about alcohol consumption, it's best to speak with your healthcare provider.

Related Formulas

Related Products
Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
NEW PRESCRIPTION ORDER FORM
1
Circle for steps.
Patient Information
2
Circle for steps.
Prescriber and Prescription Information
3
Circle for steps.
Fax order form to Bayview Pharmacy at 401-284-4506.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.