Sublingual Semaglutide and Tirzepatide are now available! Get Started
Dashboard
Formulas

Estriol 1 mg Slow Release (MEM4) Oral Capsules

Our Estriol 1 mg Slow Release (MEM4) Oral Capsules are meticulously crafted to provide a consistent and prolonged delivery of estriol, utilizing Methocel E4M, a sophisticated controlled-release polymer. This formulation is specifically designed to maintain steady hormone levels, thereby offering sustained relief from menopausal symptoms such as hot flashes, vaginal dryness, and osteoporosis prevention. The slow-release mechanism ensures a reduced dosing frequency, which can significantly enhance patient adherence to the treatment regimen. By incorporating this advanced delivery system, our capsules are optimized for those seeking a long-term, stable approach to managing the challenges associated with menopause and related hormonal imbalances.

Want a different strength?
Click the Text Us button below.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
Starting at
Must be E-Prescribed
Get Started
Generate LeafletShow Leaflet
This medication requires a prescription from your doctor
Are you a prescriber? Sign Up
Trusted by 60,357 patients to date.
A group of faces of our past satisfied patients.
A svg symbol of a mortar and pestle with ingredients going in.
Custom made in our compounding labs.
Sliders that show the customization of ingredients.
Personalized treatment for better results.
User with a gear showing the personalization of the formulation.
All strengths and ingredients are tailored to your needs.
This medication is not available at retail pharmacies. It is compounded, and may be more effective at treating you or your patient.
Slow Release Capsules
655eaef2e40e397d3e1b018f
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Loading icon rotating.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Dosing Calculator

Get general dosing information for a patient by using this calculator.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Loading icon rotating.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Formula Information

A small arrow pointing down

Estriol 1 mg Slow Release (MEM4) Oral Capsules are a specialized formulation designed to provide a controlled release of estriol, a naturally occurring estrogen. These capsules are compounded using Methocel E4M, a hydrophilic methylcellulose polymer that swells and forms a gel when in contact with gastric fluids. This gel matrix creates a barrier that controls the rate at which water enters the capsule, thereby regulating the dissolution of estriol and ensuring a slow and steady release of the hormone into the bloodstream. This mechanism allows for a sustained therapeutic effect, which can be particularly beneficial for patients requiring consistent hormone levels throughout the day to manage their symptoms effectively.

Estriol is used in the treatment of various conditions related to estrogen deficiency, such as menopausal symptoms including hot flashes, vaginal dryness, and osteoporosis prevention. It may also be used in certain cases of hypoestrogenism and as part of hormone replacement therapy (HRT) in postmenopausal women. The slow release formulation of estriol 1 mg capsules can help in maintaining a more stable hormonal environment, potentially reducing the risk of fluctuations that can lead to symptom recurrence or exacerbation.

For prescribers, it is important to note that the use of estriol and other estrogens must be individualized based on the patient's specific needs and existing medical conditions. Regular monitoring of patient response and potential side effects is recommended. The slow release formulation may also aid in improving patient compliance, as the reduced dosing frequency is often more convenient for the patient. Additionally, the Methocel E4M polymer used in these capsules is generally well-tolerated and has a long history of use in controlled-release pharmaceutical applications.

Patients should be advised that while the slow release capsules provide a steady release of estriol, they must be taken as directed by their healthcare provider to ensure optimal benefits. It is also important for patients to understand that while this formulation may help in managing symptoms associated with estrogen deficiency, it does not cure the underlying conditions and regular follow-up appointments are necessary to assess the efficacy and safety of the treatment.

If you have any questions regarding Estriol 1 mg Slow Release (MEM4) Oral Capsules or require further information on how this formulation can be integrated into a patient's treatment plan, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is committed to providing the highest level of support and expertise to both patients and prescribers.

Drug Interactions

A small arrow pointing down

Estriol is a naturally occurring estrogen used in hormone replacement therapy, primarily for the treatment of menopausal symptoms such as hot flashes, vaginal dryness, and osteoporosis prevention. When considering the use of Estriol 1 mg Slow Release (MEM4) Oral Capsules, it is important to be aware of potential drug interactions that may affect the efficacy of the medication or the safety of the patient.

Firstly, estriol metabolism may be affected by concurrent use of substances that influence liver enzymes, particularly cytochrome P450 enzymes such as CYP3A4. Medications that induce these enzymes, such as carbamazepine, phenytoin, rifampicin, and St. John's Wort, may decrease the plasma concentration of estriol, potentially reducing its effectiveness. Conversely, inhibitors of these enzymes, such as ketoconazole, itraconazole, and grapefruit juice, may increase estriol levels, raising the risk of estrogen-related side effects.

Thyroid function tests may be altered by the use of estrogens, and adjustments in thyroid hormone replacement therapy may be necessary. Estrogens can increase thyroxine-binding globulin (TBG) levels, leading to increased circulating total thyroid hormone, as measured by protein-bound iodine (PBI), T4 levels (by column or by radioimmunoassay), or T3 levels (by radioimmunoassay). T3 resin uptake is decreased, reflecting the elevated TBG. Patients on thyroid replacement therapy may require higher doses of thyroid hormone.

Estrogens may also affect the pharmacodynamics of anticoagulants like warfarin. Patients taking anticoagulants should be closely monitored for changes in prothrombin time or INR, especially when starting or stopping estrogen therapy. The dose of the anticoagulant may need to be adjusted.

Concomitant use of estriol with other hormone therapies, such as progestins or other estrogens, should be approached with caution. The addition of a progestin is generally recommended for women with an intact uterus to reduce the risk of endometrial hyperplasia and carcinoma, which can be induced by estrogen therapy. However, the combination of hormones should be tailored to the individual patient's needs and monitored by a healthcare provider.

Some medications may interfere with the controlled-release mechanism of Methocel E4M. Medications that alter gastrointestinal motility or pH, such as antacids, H2 blockers, and proton pump inhibitors, may affect the release and absorption of estriol from the MEM4 formulation. It is advisable to monitor the therapeutic response when starting or stopping such medications.

It is also important to consider the potential for increased risk of serious cardiovascular events, such as thromboembolism, in women taking estrogens, particularly in the presence of risk factors such as smoking, hypertension, or a history of thrombotic events. Patients should be counseled on the signs and symptoms of thromboembolic events and the importance of seeking medical attention promptly.

Lastly, lifestyle factors such as smoking can also impact the metabolism of estriol, with smokers potentially requiring higher doses to achieve the same therapeutic effect as non-smokers. Smoking also increases the risk of serious cardiovascular side effects from estrogen use.

Due to the complexity of hormone therapy and the potential for significant drug interactions, it is crucial for prescribers to thoroughly review a patient's medication history and for patients to inform their healthcare provider of all medications, supplements, and herbal products they are taking. If you have any questions or require further information regarding the Estriol 1 mg Slow Release (MEM4) Oral Capsules, please reach out to us at Bayview Pharmacy for personalized advice and support.

How Does it Work

A small arrow pointing down

The Estriol 1 mg Slow Release (MEM4) Oral Capsules are a specialized formulation designed to deliver a consistent and controlled amount of estriol, a naturally occurring estrogen, over an extended period. This is achieved through the use of Methocel E4M, a hydrophilic polymer that swells and forms a gel when it comes into contact with gastric fluids. Methocel E4M is a type of hypromellose, which is widely used in pharmaceutical formulations as a controlled-release agent due to its high viscosity and gel-forming properties.

Upon ingestion, the Methocel E4M in the capsule begins to hydrate and swell, forming a gel matrix around the estriol. This matrix creates a barrier that slows the rate at which the estriol is released from the capsule and absorbed into the bloodstream. The rate of drug release is primarily controlled by the rate at which the gastric fluid penetrates the gel matrix and the rate at which the estriol dissolves within the matrix. This results in a slower, more prolonged release of the hormone, which can maintain more consistent blood levels over time compared to immediate-release formulations.

Estriol is a form of estrogen that is particularly useful in the treatment of menopausal symptoms, such as hot flashes, vaginal dryness, and osteoporosis prevention. By providing a slow and steady release of estriol, the MEM4 formulation can help to alleviate these symptoms with a reduced dosing frequency. This can improve patient compliance, as taking medication less frequently is often more convenient and easier to remember. Additionally, the sustained release of estriol can help to minimize the fluctuations in hormone levels that might be associated with immediate-release formulations, potentially reducing the risk of side effects and providing a more stable hormonal environment.

For prescribers, it is important to note that the pharmacokinetic profile of the Estriol 1 mg Slow Release (MEM4) Oral Capsules may differ from that of immediate-release estriol formulations. Dosing regimens should be adjusted accordingly, and patients should be monitored for efficacy and tolerability. As with any hormone replacement therapy, the risks and benefits should be carefully considered on an individual basis.

If you have any questions about the Estriol 1 mg Slow Release (MEM4) Oral Capsules or would like more information on how this formulation can benefit your patients, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the support and expertise you need to ensure optimal patient care.

Other Uses

A small arrow pointing down

Estriol is a naturally occurring estrogen used primarily for hormone replacement therapy in menopausal women. While estriol 1 mg slow-release oral capsules are formulated for this primary purpose, they can also serve alternative therapeutic roles. The slow-release mechanism provided by Methocel E4M is especially beneficial for maintaining stable hormone levels throughout the day, which may minimize the fluctuations that can contribute to symptoms such as hot flashes, night sweats, and mood swings.

Aside from menopausal hormone therapy, estriol has been explored for use in other conditions where estrogen plays a therapeutic role. Some studies suggest that estriol may have a potential benefit in managing the symptoms of multiple sclerosis (MS) in women, particularly during relapses. Moreover, due to its weak estrogenic effects compared with other estrogens, estriol is being studied for its possible role in the prevention of breast cancer and cardiovascular disease, though more research is needed in these areas. Furthermore, because estriol is less potent than other forms of estrogen, it may be considered for patients seeking hormone replacement therapy who have a history of certain hormone-sensitive conditions, after rigorous evaluation by their healthcare provider.

It is important to note that while these alternative uses of estriol show promise, they are not universally accepted or approved by regulatory agencies, and clinical guidelines for these indications are not yet well-established. Healthcare providers considering prescribing estriol 1 mg slow-release oral capsules for off-label uses should do so based on a comprehensive assessment of the individual patient's needs and health status, and patients should be informed of the evidence supporting such use, potential risks, and alternative options available.

For both prescribers and patients interested in estriol 1 mg slow-release oral capsules for use outside of HRT in menopause, it's essential to maintain an open line of communication, discuss the current literature, understand the individual patient profile, and monitor the treatment outcomes vigilantly. For any questions or additional information regarding these or other potential uses for our estriol slow release formulation, please reach out to us at Bayview Pharmacy. We remain committed to providing support and guidance for healthcare professionals and patients alike.

Frequently Asked Questions

A small arrow pointing down

What is Estriol 1mg Slow Release (MEM4) Oral Capsule?

Estriol 1mg Slow Release (MEM4) Oral Capsule is a hormone replacement therapy medication formulated with Methocel E4M, a controlled-release polymer, to gradually release estriol, ensuring sustained therapeutic effects over an extended period of time.

What is Methocel E4M and how does it work in this medication?

Methocel E4M is a type of cellulose-derived polymer used to control the release of active ingredients in a capsule. In Estriol 1mg Slow Release capsules, it regulates the release of estriol into the body, providing a consistent dosage throughout a prolonged period and potentially reducing side effects associated with peak dosing.

How often do I need to take Estriol 1mg Slow Release Capsules?

Due to the controlled-release design of the medication, the dosing frequency might be reduced compared to immediate-release formulations. However, it is important to follow your healthcare provider's prescription to determine the exact dosing schedule for your treatment plan.

What are the benefits of taking a controlled-release formulation like Estriol 1mg Slow Release Capsules?

The benefits of a controlled-release formulation include more stable blood levels of the medication, less frequent dosing, a potential reduction in side effects, and improved patient compliance due to the convenience of fewer doses.

Can Estriol 1mg Slow Release Capsules be used for acute symptoms?

Estriol 1mg Slow Release Capsules are designed for sustained release and may not be suitable for the immediate relief of acute symptoms. Discuss with your healthcare provider for appropriate treatments for acute symptoms.

Can I take Estriol 1mg Slow Release Capsules with my other medications?

It's essential to inform your healthcare provider about all the medications and supplements you're taking to avoid potential interactions. Your provider will assess the compatibility of Estriol Slow Release Capsules with your other treatments.

What should I do if I miss a dose of Estriol 1mg Slow Release Capsules?

If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and resume your usual dosing schedule. Do not double up on doses to make up for a missed one.

Are there any side effects associated with Estriol 1mg Slow Release Capsules?

As with all medications, there may be side effects. Common side effects include nausea, headache, breast tenderness, and abdominal pain. If you experience any severe or persistent side effects, it's important to contact your healthcare provider.

How should I store Estriol 1mg Slow Release Capsules?

Store the capsules at room temperature away from direct light and moisture. Keep the medication out of reach of children and pets.

Is Estriol 1mg Slow Release (MEM4) Oral Capsule right for me?

Whether Estriol 1mg Slow Release is suitable for you can only be determined by your healthcare provider. They will consider your medical history, symptoms, and treatment goals before prescribing this medication.

Can I open the capsule to take a divided dose or mix with food?

Opening the capsule or splitting the dose is not recommended as it can interfere with the controlled-release mechanism and affect how the medication works. Always take the capsule whole, unless your healthcare provider advises otherwise.

Related Formulas

Related Products
Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
NEW PRESCRIPTION ORDER FORM
1
Circle for steps.
Patient Information
2
Circle for steps.
Prescriber and Prescription Information
3
Circle for steps.
Fax order form to Bayview Pharmacy at 401-284-4506.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.