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Lactic Acid 18%/Salicylic Acid 18%/Trichloroacetic Acid 12% Topical Liquid

The Lactic Acid 18%/Salicylic Acid 18%/Trichloroacetic Acid 12% Topical Liquid is a specially compounded preparation intended for external use on the skin or mucosal surfaces. This potent combination of acids serves as a chemical peel and is primarily used in the treatment of various skin conditions such as acne, keratosis pilaris, warts, calluses, and psoriasis. Lactic acid acts as a gentle exfoliant, helping to remove dead skin cells and improve skin texture. Salicylic acid, a beta-hydroxy acid, penetrates pores to dissolve debris and oil, reducing inflammation and preventing new acne formation. Trichloroacetic acid, the strongest of the three, causes the top layers of cells to dry up and peel off over a period of several days to one week. By promoting the shedding of the outer layer of skin, this formulation can also help to diminish the appearance of fine lines, superficial scars, and uneven pigmentation. The liquid dosage form ensures precise application to affected areas, minimizing systemic absorption and side effects.

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Topical Liquid
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Formula Information

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Lactic Acid 18%/Salicylic Acid 18%/Trichloroacetic Acid 12% Topical Liquid is a potent compounded formulation designed for dermatological use. This preparation combines the keratolytic and exfoliative properties of lactic acid and salicylic acid with the caustic and protein coagulation effects of trichloroacetic acid. The synergistic action of these ingredients makes the formulation particularly effective for treating a variety of skin conditions that involve abnormal or excessive keratinization, such as actinic keratosis, warts, and certain types of acne. Lactic acid, an alpha hydroxy acid, helps to moisturize the skin and reduce the buildup of dead skin cells, while salicylic acid, a beta hydroxy acid, penetrates the pores to dissolve sebum and other impurities. Trichloroacetic acid, a deeper peeling agent, is used to remove the outer layers of damaged or aged skin, promoting the regeneration of a healthier skin layer.

When applied topically, this formulation works by breaking down the keratin in the skin, which helps to shed the outermost layers and reveal the newer skin beneath. This process can improve the texture and appearance of the skin, reduce the visibility of scars and hyperpigmentation, and facilitate the healing of various skin lesions. The formulation's efficacy in treating these conditions is due to its ability to promote exfoliation and cellular turnover, which is essential for maintaining healthy skin. It is important to note that due to the potency of the acids involved, this formulation should be used with caution, and patients should follow the specific application instructions provided by their healthcare provider to minimize the risk of irritation or chemical burns.

Patients and prescribers should be aware that this formulation is intended for external use only and should be applied sparingly to the affected areas. It is crucial to avoid contact with the eyes, mouth, and other mucous membranes. Patients may experience a burning sensation, erythema, or peeling of the skin following application, which is generally expected as part of the treatment process. However, if severe irritation or an allergic reaction occurs, use should be discontinued immediately, and medical advice should be sought. Sun protection is also recommended during treatment with this formulation due to increased photosensitivity. As with any compounded medication, this formulation should be used under the supervision of a healthcare professional who can monitor its effectiveness and safety.

For further information or questions regarding the use of Lactic Acid 18%/Salicylic Acid 18%/Trichloroacetic Acid 12% Topical Liquid, or to discuss individual patient needs, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing personalized care and support to ensure the safe and effective use of our compounded formulations.

Drug Interactions

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The combination of lactic acid, salicylic acid, and trichloroacetic acid in a topical liquid formulation is primarily used for its keratolytic and caustic properties, making it effective for treating various skin conditions such as warts, calluses, and some types of acne. However, due to the presence of active acids, this formulation can interact with other topical or systemic medications, as well as with certain medical conditions, and these interactions must be carefully considered to ensure patient safety and treatment efficacy.

Firstly, concurrent use of other topical acne medications, particularly those containing retinoids, benzoyl peroxide, or other acids (such as glycolic acid), may increase the risk of local skin irritation. Patients should avoid using multiple exfoliating agents or peeling agents simultaneously unless directed by a healthcare provider, as this can lead to excessive skin dryness, peeling, and irritation. If combination therapy is required, it should be done under close supervision, and the application of different agents may need to be spaced out over time.

Systemic retinoids, such as isotretinoin, can also enhance the potential for irritation when used with this topical formulation. Patients on systemic retinoids should use caution and consult with their healthcare provider before using this topical treatment. Additionally, patients taking medications that increase photosensitivity, such as tetracyclines or thiazide diuretics, should be advised that this topical formulation may also increase sensitivity to sunlight, leading to an elevated risk of sunburn. Sun protection measures, including the use of sunscreen and protective clothing, are recommended when using this formulation.

Patients with skin conditions such as eczema, psoriasis, or rosacea should use this formulation with caution, as it may exacerbate these conditions. The formulation's keratolytic action can be too aggressive for sensitive or compromised skin, leading to worsening of symptoms. It is essential to consult with a healthcare provider before using this formulation in patients with known skin disorders.

It is also important to consider the potential for systemic absorption, particularly with the use of occlusive dressings or application to large areas of skin or mucosal surfaces. While systemic absorption is generally minimal with topical application, the use of this formulation on extensive areas or under occlusive dressings may increase systemic exposure to salicylic acid, which could lead to salicylate toxicity, particularly in patients with impaired renal function or in children.

Patients with diabetes or poor circulation should use this formulation with caution, as their skin may be more prone to irritation and slower healing. Additionally, the use of this formulation on moles, birthmarks, warts with hair growing from them, or genital/anal warts has not been established and should be avoided unless directed by a healthcare provider.

Lastly, patients should be advised to avoid applying this formulation to broken, irritated, or recently shaved skin to prevent excessive irritation or chemical burns. If accidental exposure to sensitive areas occurs, the area should be rinsed thoroughly with water.

Due to the complexity of potential interactions and the caustic nature of the acids involved, it is crucial for patients and prescribers to discuss all current medications, both topical and systemic, as well as any underlying health conditions before initiating treatment with this formulation. If you have any questions or require further information regarding this formulation and its potential interactions, please reach out to us at Bayview Pharmacy for personalized advice and support.

How Does it Work

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The Lactic Acid 18%/Salicylic Acid 18%/Trichloroacetic Acid 12% Topical Liquid is a specially compounded formulation that combines the therapeutic properties of three potent acids to treat a variety of skin conditions. This topical solution is designed to be applied directly to the skin, where it works by causing controlled damage to the epidermis and/or dermis, leading to skin exfoliation and the promotion of new skin growth.

Lactic acid, a type of alpha hydroxy acid (AHA), is known for its ability to exfoliate the skin by breaking down the bonds between dead skin cells, allowing them to be sloughed away. This action helps to improve skin texture and tone, reduce the appearance of fine lines, and stimulate collagen production. Lactic acid also has humectant properties, which means it helps to hydrate the skin by attracting and retaining moisture.

Salicylic acid, a beta hydroxy acid (BHA), penetrates into the pores of the skin to dissolve sebum and other debris that can lead to acne. It is particularly effective in treating comedonal acne, such as blackheads and whiteheads, due to its ability to exfoliate inside the pore. Salicylic acid also has anti-inflammatory properties, which can help to reduce redness and swelling associated with acne lesions.

Trichloroacetic acid (TCA) is a deeper peeling agent that causes the top layers of cells to dry up and peel off over a period of several days. By doing so, it can improve the appearance of more pronounced skin imperfections, such as deeper wrinkles, scars, and areas of hyperpigmentation. TCA peels are considered medium-depth peels and can have a more significant impact on the skin's appearance than AHA or BHA peels alone.

When combined, these three acids provide a comprehensive treatment that can address a range of dermatological issues, including but not limited to, acne, photoaging, hyperpigmentation, and textural irregularities. The formulation's strength and the depth of the peel are determined by the concentration of the acids, with this particular combination offering a potent treatment that should be used under the guidance of a healthcare professional.

It is important for patients and prescribers to understand that this formulation can cause a significant amount of peeling and redness, and there may be a period of downtime required after treatment. Sun protection is crucial following the application of this peel, as the new skin will be particularly sensitive to UV radiation. Additionally, not all skin types are suitable for this treatment, and a thorough evaluation by a healthcare professional is necessary to determine if this formulation is appropriate for a patient's specific skin condition.

If you have any questions or require further information about this formulation and its suitability for treating specific skin conditions, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to ensure the safe and effective use of this topical liquid preparation.

Other Uses

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The triple combination of Lactic Acid 18%, Salicylic Acid 18%, and Trichloroacetic Acid 12% topical liquid is primarily used for its potent keratolytic and caustic properties, harnessing the ability to exfoliate, rejuvenate, and treat a range of dermatological conditions such as warts, keratosis, and acne. However, based on the individual characteristics of each component, this formulation may have additional, less commonly noted uses.

Lactic Acid, an alpha hydroxy acid (AHA), not only aids in skin turnover but also has humectant properties that may benefit individuals with dry skin conditions by providing hydration and improving the skin's moisture-retaining capabilities. Salicylic Acid, a beta hydroxy acid (BHA), is recognized for its ability to deeply penetrate into the pores and dissolve sebum and debris, making it valuable for treating blackheads and whiteheads, in addition to its primary indications. Furthermore, the antifungal and anti-inflammatory properties of Salicylic Acid mean it may be used adjunctively in conditions such as dandruff or seborrheic dermatitis when applied to the scalp.

Trichloroacetic Acid (TCA) is primarily used for skin peels and can improve the appearance of fine lines, superficial scars, and uneven skin pigmentation. Applied in a controlled manner and in professional settings, it reveals fresher and smoother skin. Due to the aggressiveness of TCA, its use could be extended to remove tattoos or treat other skin pigmentation issues when more conventional treatments have been ineffective. However, due to the potential for significant skin irritation, scarring, and post-inflammatory hyperpigmentation, especially in darker skin types, such uses would require careful consideration and expert management.

In addition to these uses, the combination of these acids can serve an aesthetic benefit in improving skin texture and tone, diminishing the appearance of age spots, and potentially aiding in the reduction of stretch marks. The blending of these ingredients can create a compounded treatment alternative for those who require a more robust, tailor-made approach to their skin care when over-the-counter products are insufficient or unsuitable.

This formulation's exfoliating and penetrating abilities also suggest potential utility in preparing the skin for further treatments, such as improving the penetration of other topical medications or preparing the skin for laser treatments. By removing the outermost layer of the epidermis, it may enhance the efficacy of topical treatments applied subsequently.

Given the strength and potential side effects of this preparation, it is critical that it is used under the supervision of a healthcare professional with expertise in dermatology or cosmetic treatment. It should also be noted that due to the potency of the acids used in this formulation, there is a higher risk of irritation, especially for those with sensitive skin or certain skin conditions. It is imperative to follow the recommended application protocol and to employ proper sun protection measures when using this formulation. For specific questions, further information, or consultations on custom formulations or alternative uses, do not hesitate to reach out to us at Bayview Pharmacy. Our dedicated compounding pharmacists are here to assist and provide bespoke medication solutions.

Frequently Asked Questions

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What is Lactic Acid 18%/Salicylic Acid 18%/Trichloroacetic Acid 12% Topical Liquid prescribed for?

This compounded formulation is typically used for skin resurfacing and to treat a variety of skin conditions such as acne, scars, hyperpigmentation, and fine lines. The combination of acids provides exfoliating and renewing benefits to the skin.

How should I apply this topical liquid?

Apply the liquid directly to the affected area as instructed by your healthcare provider. Ensure that the skin is clean and dry. Use a cotton swab or pad to dab a small amount of the solution onto your skin. Avoid contact with healthy skin and mucosal surfaces.

Can this formulation cause skin irritation?

Yes, these active ingredients are strong chemical peels and can cause skin irritation, especially if not used as directed. Redness, peeling, and discomfort are common side effects. Contact your healthcare provider if you experience severe or persistent irritation.

How often should I use this compound formulation?

The frequency of application depends on your specific condition and the advice provided by your healthcare provider. It is important to follow their instructions carefully to avoid overuse or adverse effects.

Should I avoid sunlight after applying this topical liquid?

Yes, it is advisable to avoid direct sunlight following application because your skin will be more susceptible to sunburn. Use a broad-spectrum sunscreen to protect the treated areas when exposed to sunlight and wear protective clothing.

Is this topical liquid safe for all skin types?

Not necessarily. This formulation should only be used under the guidance of a healthcare provider. They will assess if it is suitable for your skin type and condition. Skin sensitivity and prior history of reactions should be considered before use.

How long will it take to see results after starting this medication?

Results can vary based on individual skin conditions and the specific issue being treated. Some patients may notice improvements within a few days, while for others, it may take several weeks. Follow up with your healthcare provider to monitor progress.

Can I use other skincare products alongside this topical liquid?

You should consult your healthcare provider before combining this compound with other skincare products to avoid interactions and increased skin sensitivity. Certain products may need to be avoided while using this formulation.

What should I do if I accidentally apply the liquid to healthy skin or mucosal surfaces?

If the liquid comes into contact with healthy skin or mucosal surfaces, rinse it off thoroughly with water and contact your healthcare provider. They may provide additional instructions to mitigate any potential harm.

Are there any specific storage instructions for this medication?

Yes, store the liquid in a cool, dry place away from direct sunlight and heat. Keep the bottle tightly closed when not in use, and keep out of reach of children and pets. Consult your pharmacist for any specific storage instructions.

Can I apply makeup over areas treated with this topical liquid?

It's best to avoid applying makeup to treated areas as this might cause irritation or interfere with the action of the acids. If makeup must be used, seek advice from your healthcare provider on how to do so safely.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.
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