Metformin HCl 5% / Spironolactone 5% / Progesterone 1% Topical Gel
Metformin Hydrochloride 5% / Spironolactone 5% / Progesterone 1% Topical Gel is a prescription medication used to treat Polycystic Ovary Syndrome (PCOS) in women. It is a combination of three drugs that work together to help regulate reproductive hormones and reduce inflammation. The combination of Metformin and Spironolactone helps to reduce testosterone levels, while the Progesterone helps to balance the estrogen and progesterone levels, resulting in improved fertility and regular menstrual cycles.
Controlled substances must be E-Prescribed. Visit your Tutorials tab to learn how to prescribe.
Formula Information
Metformin HCl 5% / Spironolactone 5% / Progesterone 1% Topical Gel is a topical formulation developed to treat Women's Health - Polycystic Ovary Syndrome (PCOS). This combination of medications works together to improve overall fertility and to reduce the associated symptoms of PCOS. Metformin HCl 5% acts as an insulin sensitizer, helping reduce androgen levels and decrease the risk of diabetes. Spironolactone 5% is an aldosterone antagonist, which helps reduce the level of circulating androgens and ultimately improve hirsutism and acne. Progesterone 1% works to restore a progesterone balance and normalize the menstrual cycle. This formulation helps to regulate ovulation and reduce the risk of anovulatory infertility. It also helps to reduce the risk of endometrial hyperplasia, a precursor to endometrial cancer. This formulation has been demonstrated to be effective in treating PCOS symptoms, improving fertility and reproductive health. If your patients have any questions regarding our Metformin HCl 5% / Spironolactone 5% / Progesterone 1% Topical Gel, please reach out to us.
Drug Interactions
Metformin Hydrochloride 5% / Spironolactone 5% / Progesterone 1% Topical Gel is a prescription medication used to treat Polycystic Ovary Syndrome (PCOS) in women. It is a combination of three drugs that work together to help regulate reproductive hormones and reduce inflammation. The combination of Metformin and Spironolactone helps to reduce testosterone levels, while the Progesterone helps to balance the estrogen and progesterone levels, resulting in improved fertility and regular menstrual cycles.
How Does it Work
Metformin HCl 5% / Spironolactone 5% / Progesterone 1% Topical Gel is an effective combination therapy for the treatment of Women's Health - Polycystic Ovary Syndrome (PCOS). PCOS is a complex condition that affects many women, caused by an imbalance of hormones in the body. Metformin HCl is the primary component of this combination therapy, and it works by increasing the body's sensitivity to insulin and decreasing the release of glucose from the liver into the blood. This helps to prevent the overproduction of androgens, which can lead to symptoms such as hirsutism, acne, and irregular periods. Spironolactone is a diuretic also used in this combination therapy, and it works by blocking the action of certain hormones in the body, reducing the production of androgens. Finally, Progesterone 1% Topical Gel is an important component that works by helping the body to prepare for pregnancy and reducing the risk of miscarriage. In combination, these three components work to reduce the symptoms of PCOS and allow women to live a healthier lifestyle.
Other Uses
This compounded formulation of Metformin HCl 5% / Spironolactone 5% / Progesterone 1% Topical Gel may be useful for dermatological disorders in both males and females. This specific formulation may be beneficial for the treatment of acne, androgenic alopecia, seborrhea and hirsutism due to its anti-androgenic properties. It has also been used to assist with the treatment of psoriasis, keratosis pilaris, and melasma. It has been hypothesized that the topical application of this compounded formulation may be beneficial in the treatment of scleroderma, lichen planus and vitiligo. The topical application of this compounded formulation may also be beneficial in the treatment of inflammatory skin diseases such as atopic dermatitis, pyotrhoic dermatitis, and contact dermatitis.
Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.