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Semaglutide 1.5 mg/mL Sublingual Suspension

The Semaglutide 1.5 mg/mL Sublingual Suspension is a specialized liquid medication formulated for sublingual administration. The suspension is dispensed in user-friendly pre-dosed oral syringes, allowing for precise dosing by emptying the contents of the oral syringe directly under the tongue.

The base's permeation-enhancing and mucoadhesive properties facilitate the transport of semaglutide into the mucosal tissues, extending contact time and potentially improving absorption. This sublingual route is particularly beneficial for bypassing gastrointestinal factors that may affect the bioavailability of the medication.

Patients often include semaglutide in their regimens for managing type 2 diabetes, obesity, and weight.

This formulation is NOT the injectable version, and we do not guarantee efficacy. Results may vary.

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Formula Information

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Our Semaglutide 1.5 mg/mL Sublingual Suspension is a meticulously crafted liquid formulation, specifically designed for sublingual administration. This advanced delivery system is encapsulated in pre-filled oral syringes, which allows for precise dosing and ease of use. The formulation is particularly suitable for patients who require smaller doses or for those who may face challenges swallowing traditional solid dosage forms, such as tablets or capsules, including pediatric patients.

The Semaglutide Sublingual Suspension utilizes SubMagna™ SL HMW base, a cutting-edge vehicle that is tailored to enhance the delivery of a broad spectrum of drugs, especially those with high molecular weights. SubMagna SL HMW is an anhydrous, self-emulsifying base that transforms into an emulsion upon contact with saliva. This unique feature significantly improves the solubility and dispersibility of the active pharmaceutical ingredient (API), Semaglutide, under the tongue. The base's permeation-enhancing and mucoadhesive properties are pivotal in facilitating the absorption of the medication into the mucosal tissues, thereby extending contact time and potentially increasing bioavailability.

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, which is primarily used in the treatment of type 2 diabetes mellitus. It works by stimulating insulin secretion and reducing glucagon secretion, which in turn helps to lower blood glucose levels. Additionally, Semaglutide has been shown to reduce cardiovascular events in patients with type 2 diabetes and to aid in weight management. The sublingual route of administration offered by our suspension bypasses the gastrointestinal tract, which can be particularly beneficial for patients who have conditions that affect the absorption of medications or those who experience gastrointestinal side effects.

The anhydrous nature of the SubMagna SL HMW base also contributes to the potential for extended beyond-use-dates (BUDs), offering an advantage in terms of the shelf-life of the suspension. This can be particularly beneficial for patients who do not require daily use of the medication or for those who prefer to have a supply on hand for convenience.

For patients and prescribers considering this innovative Semaglutide Sublingual Suspension, our team at Bayview Pharmacy is committed to providing comprehensive support and guidance. We understand the importance of personalized medication solutions and are here to answer any questions you may have about this formulation. Please do not hesitate to reach out to us for further information or assistance.

Drug Interactions

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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used in the management of type 2 diabetes mellitus to improve glycemic control, alongside diet and exercise. It functions by enhancing insulin secretion, suppressing glucagon secretion, and slowing gastric emptying. When considering drug interactions for semaglutide, it is important to note that the sublingual route of administration may alter the interaction profile compared to the more commonly used subcutaneous route.

One significant interaction to be aware of is with medications that affect gastrointestinal motility, as semaglutide slows gastric emptying. Concurrent use with other drugs that slow gastric emptying, such as opioids or anticholinergics, could enhance this effect and potentially lead to gastrointestinal adverse effects. Conversely, medications that increase gastric motility might decrease the effectiveness of semaglutide.

Patients taking insulin or insulin secretagogues, such as sulfonylureas, should be monitored closely for hypoglycemia when starting semaglutide. The insulin or sulfonylurea dose may need to be reduced to mitigate the risk of hypoglycemia. Additionally, semaglutide may enhance the effects of other antidiabetic agents, necessitating dose adjustments to avoid hypoglycemia.

It is also important to consider the potential for interactions with oral medications due to the sublingual route of administration. Since semaglutide can be absorbed directly into the bloodstream through the mucosal tissues, it may bypass hepatic first-pass metabolism, which could alter the pharmacokinetics of concurrently administered oral drugs that are subject to significant first-pass effect.

Furthermore, the use of SubMagna SL HMW base may influence the absorption of concomitant medications. The permeation-enhancing and mucoadhesive properties of the base could potentially alter the absorption of other sublingually administered drugs. Patients should be advised to separate the administration of semaglutide from other sublingual medications by a reasonable time interval to prevent any unintended interactions.

Patients should be counseled to avoid taking any medications that require an acidic gastric pH for absorption shortly after semaglutide, as the delayed gastric emptying could reduce the effectiveness of these drugs. Examples include certain antifungal agents like ketoconazole or itraconazole, and the protease inhibitor atazanavir.

Lastly, as with all medications, patients should be advised to inform their healthcare providers of all the medications they are taking, including over-the-counter drugs, herbal supplements, and vitamins, to ensure that potential interactions with semaglutide can be appropriately managed.

If you have any questions or require further information regarding the drug interactions associated with semaglutide 1.5 mg/mL sublingual suspension or its use in specific disease states, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is committed to providing comprehensive support to both patients and prescribers.

How Does it Work

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The semaglutide 1.5 mg/mL sublingual suspension is a cutting-edge formulation designed for the treatment of type 2 diabetes and, in some cases, chronic weight management. This liquid formulation is dispensed in pre-dosed oral syringes, allowing for precise and controlled administration. The medication is administered by emptying the contents of the oral syringe directly under the tongue, making it an ideal option for patients who may have difficulty swallowing tablets or capsules, or for those who require smaller doses.

How does it work? Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist. It works by mimicking the effects of the GLP-1 hormone, which is naturally produced in the body. GLP-1 plays a crucial role in regulating blood sugar levels by stimulating insulin secretion and lowering glucagon secretion when blood sugar levels are high. Additionally, it slows gastric emptying and reduces appetite, which can contribute to weight loss in patients with chronic weight management needs.

The innovative SubMagna™ SL HMW base used in this formulation is specifically designed to deliver a wide range of drugs, including those with high molecular weights like semaglutide. When administered sublingually, the anhydrous, self-emulsifying base of SubMagna™ SL HMW interacts with saliva to form an emulsion. This process enhances the solubility and dispersibility of the active pharmaceutical ingredient (API), semaglutide, in this case. The permeation-enhancing and mucoadhesive properties of the base promote the absorption of the molecule into the mucosal tissues under the tongue. This not only facilitates the entry of the drug into the systemic circulation but also prolongs the contact time between the drug and the absorption site, potentially leading to improved bioavailability.

By using the sublingual route, the semaglutide bypasses the gastrointestinal tract, which can degrade some medications or alter their absorption due to various factors such as pH, digestive enzymes, and food interactions. This direct entry into the bloodstream can lead to a more predictable pharmacokinetic profile and may reduce gastrointestinal side effects associated with GLP-1 receptor agonists.

The anhydrous nature of the SubMagna™ SL HMW base also contributes to the stability of the formulation, offering the potential for longer beyond-use-dates (BUDs), which is beneficial for both patients and prescribers by reducing medication waste and ensuring the availability of the medication when needed.

For patients and prescribers interested in this semaglutide sublingual suspension, it is important to understand that this formulation is specifically designed to improve the management of type 2 diabetes and may assist in weight management for certain patients.

If you have any questions or require further information about the semaglutide 1.5 mg/mL sublingual suspension, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to provide the support and guidance you need to make informed decisions about your health care options.

Other Uses

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While the primary indication for Semaglutide 1.5 mg/mL Sublingual Suspension is the management of type 2 diabetes, the unique properties of the SubMagna™ SL HMW base may allow for its use in other therapeutic areas. The sublingual route of administration bypasses the gastrointestinal tract, which can be particularly beneficial for patients with gastrointestinal disorders that affect the absorption of oral medications. Additionally, this route can be advantageous for drugs that undergo significant first-pass metabolism, potentially allowing for a reduction in dose and associated side effects.

Given the permeation-enhancing and mucoadhesive characteristics of the SubMagna™ SL HMW base, this formulation could be explored for use with other high molecular weight drugs that require enhanced absorption into the systemic circulation. For instance, certain peptides and proteins that are typically administered via injection might be candidates for sublingual delivery using this system, potentially improving patient compliance and comfort. Moreover, the anhydrous nature of the base may extend the beyond-use date of the formulation, which is particularly useful for drugs that are sensitive to degradation in aqueous environments.

It is also conceivable that the sublingual suspension could be used in the management of acute conditions where rapid onset of action is desired, as the sublingual route can offer quicker absorption compared to traditional oral administration. This could be relevant in the treatment of pain, nausea, or anxiety, where prompt relief of symptoms is crucial. However, it is important to note that the use of Semaglutide in conditions other than type 2 diabetes has not been established and would require further investigation and approval by regulatory authorities.

Patients and prescribers interested in exploring the potential of Semaglutide 1.5 mg/mL Sublingual Suspension for off-label uses should proceed with caution and consider the current evidence and guidelines. It is essential to consult with a healthcare professional before using this medication for any unapproved indication. For more detailed information or to discuss specific patient needs, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is equipped to provide guidance and support for your unique medication requirements.

Frequently Asked Questions

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What is Semaglutide 1.5 mg/mL Sublingual Suspension?

Semaglutide 1.5 mg/mL Sublingual Suspension is a liquid medication formulated for sublingual administration. It is dispensed in pre-dosed oral syringes for precise dosing and is designed to be absorbed under the tongue. This medication is intended for patients who may require smaller doses or have difficulty swallowing traditional tablets or capsules.

How do I take Semaglutide Sublingual Suspension?

To take Semaglutide Sublingual Suspension, empty the contents of the pre-dosed oral syringe directly under your tongue. Hold the suspension sublingually for the recommended amount of time before swallowing to ensure proper absorption.

What is SubMagna™ SL HMW base?

SubMagna™ SL HMW is an advanced sublingual suspension vehicle that is designed to deliver a wide range of drugs, including those with high molecular weights. It is an anhydrous, self-emulsifying, and permeation-enhancing base that forms an emulsion when it comes into contact with saliva, which helps to improve the solubility and dispersibility of active pharmaceutical ingredients (APIs).

What are the benefits of using SubMagna™ SL HMW base for Semaglutide?

The SubMagna™ SL HMW base enhances the delivery of Semaglutide by improving its solubility and dispersibility under the tongue. Its mucoadhesive properties prolong contact time with mucosal tissues, potentially increasing absorption. Additionally, the anhydrous nature of the base may extend the beyond-use-date of the suspension.

Can I swallow Semaglutide Sublingual Suspension immediately?

No, you should not swallow Semaglutide Sublingual Suspension immediately. It is designed to be held under the tongue for a period of time as specified by your healthcare provider to ensure proper absorption through the mucosal tissues.

Is Semaglutide Sublingual Suspension suitable for children?

While Semaglutide Sublingual Suspension is designed for precise dosing which can be beneficial for pediatric patients, its suitability for children depends on the specific medical condition and should be determined by a healthcare professional.

How should I store Semaglutide Sublingual Suspension?

Semaglutide Sublingual Suspension should be stored according to the instructions provided by the pharmacist or manufacturer. Typically, it should be kept in a cool, dry place away from direct sunlight and out of reach of children.

What should I do if I miss a dose of Semaglutide Sublingual Suspension?

If you miss a dose of Semaglutide Sublingual Suspension, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Are there any side effects associated with Semaglutide Sublingual Suspension?

As with any medication, Semaglutide Sublingual Suspension may cause side effects. Common side effects can include nausea, headache, and dizziness. If you experience any severe or persistent side effects, contact your healthcare provider immediately.

Can Semaglutide Sublingual Suspension be used with other medications?

Semaglutide Sublingual Suspension may interact with other medications. It is important to inform your healthcare provider of all medications you are currently taking, including over-the-counter drugs and supplements, to avoid potential interactions.

How does the sublingual route of administration benefit the bioavailability of Semaglutide?

The sublingual route of administration allows Semaglutide to bypass the gastrointestinal tract, which can affect the bioavailability of the medication. By absorbing directly into the bloodstream through the mucosal tissues under the tongue, the medication may have a more consistent and efficient absorption profile.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
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