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Sodium Thiosulfate 20%/Zinc Oxide 20% Topical Ointment

The Sodium Thiosulfate 20%/Zinc Oxide 20% Topical Ointment is a semi-solid formulation designed for external application to the skin. This ointment is dispensed in a tube and provides a greasy or oily base, which facilitates the localized delivery of the active ingredients. Sodium thiosulfate is known for its role in detoxifying chemical irritants and treating cyanide poisoning when used systemically, but in topical formulations, it may help in conditions involving calcifications in the skin. Zinc oxide is a well-established skin protectant with astringent, soothing, and protective properties, making it beneficial for a variety of dermatological conditions.

This combination ointment is primarily used for its protective and therapeutic effects in the treatment of skin conditions such as irritant and contact dermatitis, intertrigo, and diaper rash. It may also be beneficial in the management of minor skin irritations, abrasions, and wounds, providing an environment conducive to healing. The inclusion of zinc oxide in the formulation also offers mild antiseptic and antibacterial properties, which can be helpful in preventing infection in damaged or sensitive skin areas.

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Topical Ointment
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Formula Information

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Our Sodium Thiosulfate 20%/Zinc Oxide 20% Topical Ointment is a carefully compounded semi-solid formulation that is designed for external application to the skin. This ointment is dispensed in a tube, providing a convenient and controlled method of application. The ointment base is greasy or oily, which not only aids in the delivery of the active ingredients but also provides a protective layer on the skin, enhancing the therapeutic effects and improving patient comfort.

The active ingredients in this formulation, sodium thiosulfate and zinc oxide, work synergistically to treat a variety of skin conditions. Sodium thiosulfate is known for its properties as an antidote to cyanide poisoning when used intravenously, but in topical formulations, it serves as an antifungal and has potential anti-inflammatory effects. It may be beneficial in the treatment of conditions such as tinea versicolor and as part of the management of calciphylaxis in dialysis patients, where it helps to reduce calcification and skin ulcers.

Zinc oxide, on the other hand, is a well-known skin protectant with astringent, soothing, and antiseptic properties. It is commonly used in diaper rash ointments and sunscreens. In our formulation, zinc oxide works to protect the skin, reduce irritation and inflammation, and promote wound healing. It is particularly effective in treating weeping or oozing associated with skin inflammation and can act as a mild antiseptic to prevent bacterial infections.

This combination ointment is particularly suited for localized treatment of skin conditions where both anti-inflammatory and protective properties are desired. It can be used in the management of minor skin infections, inflammatory dermatoses, and to aid in the healing of minor wounds. The formulation is compounded under strict aseptic conditions to ensure the highest quality and efficacy of the product.

For patients and prescribers considering the use of this Sodium Thiosulfate 20%/Zinc Oxide 20% Topical Ointment, it is important to apply it as directed, typically to clean, dry skin. The frequency and duration of application will depend on the condition being treated and should be as recommended by a healthcare professional. As with all medications, potential side effects may include local skin irritation or allergic reactions. It is important to monitor the treatment area for any signs of adverse effects and consult a healthcare provider if concerns arise.

If you have any questions or require further information about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing personalized care and is ready to assist with any inquiries you may have regarding the use and benefits of this topical ointment.

Drug Interactions

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The Sodium Thiosulfate 20%/Zinc Oxide 20% Topical Ointment is a specialized formulation intended for external use on the skin. Sodium thiosulfate is known for its properties in neutralizing certain chemical reactions on the skin, such as those caused by irritants or allergens, and is also used in the treatment of cyanide poisoning when administered systemically. Zinc oxide is a well-known skin protectant with astringent, soothing, and antiseptic properties, making it beneficial for the treatment of a variety of skin conditions including diaper rash, minor burns, severely chapped skin, and other minor skin irritations.

When considering drug interactions for this topical ointment, it is important to note that the systemic absorption of both sodium thiosulfate and zinc oxide through intact skin is minimal. However, if the skin is broken or if the ointment is applied to large areas of skin, there is a potential for increased absorption, which could theoretically lead to interactions with other systemically administered medications. For instance, zinc when absorbed systemically can interact with certain antibiotics such as quinolones and tetracyclines, reducing their absorption and efficacy. Patients should be advised to inform their healthcare provider of all medications they are taking, including over-the-counter drugs and supplements, to assess any potential interactions.

Additionally, the use of other topical products on the same area of skin where the Sodium Thiosulfate/Zinc Oxide Ointment has been applied should be done with caution. The presence of other topical agents could alter the absorption or the activity of the active ingredients, or could lead to increased irritation or other adverse effects. It is advisable to consult with a healthcare provider before combining this ointment with other topical preparations.

Patients with known allergies to sulfites should use sodium thiosulfate with caution, as allergic reactions may occur. Zinc oxide is generally considered safe, but in rare cases, it may cause local irritation or allergic reactions. If any signs of hypersensitivity or adverse reactions occur, use of the ointment should be discontinued and medical advice should be sought.

It is also important to consider the inert ingredients in the ointment base, as they can sometimes cause skin irritation or allergic reactions in sensitive individuals. Patients should review the full list of ingredients and discuss any known sensitivities with their healthcare provider before using the ointment.

In summary, while the potential for systemic drug interactions with the Sodium Thiosulfate 20%/Zinc Oxide 20% Topical Ointment is low, caution should be exercised when used with other topical agents or in patients taking systemic medications that could interact with zinc. Always consult with a healthcare provider before starting any new medication, including topical formulations. If you have any questions or concerns regarding the use of this ointment or potential drug interactions, please reach out to us at Bayview Pharmacy for further assistance.

How Does it Work

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The Sodium Thiosulfate 20%/Zinc Oxide 20% Topical Ointment is a specialized medication formulated for the treatment of various skin conditions. This semi-solid formulation is designed to be applied externally to the skin, where it serves as a localized treatment. The ointment is dispensed in a tube, providing a convenient method for patients to apply the medication directly to the affected areas. The greasy or oily base of the ointment not only facilitates the delivery of the active ingredients but also provides a protective layer over the skin, which can help to retain moisture and aid in the healing process.

Sodium thiosulfate is a substance with several therapeutic properties, including anti-inflammatory and antifungal effects. In this formulation, it works by neutralizing reactive substances on the skin that can contribute to inflammation and irritation. Sodium thiosulfate has also been shown to have an antidotal effect on certain skin conditions caused by the exposure to irritants and allergens. Its inclusion in the ointment at a 20% concentration ensures that it is present in a sufficient amount to exert its therapeutic effects on the skin.

Zinc oxide, the other active ingredient in this formulation, is well-known for its protective, soothing, and astringent properties. At a 20% concentration, zinc oxide provides a significant barrier to the skin, which can protect against irritants and ultraviolet (UV) radiation. It also has mild antiseptic properties, which can help to prevent infection in damaged or broken skin. Furthermore, zinc oxide promotes the healing of chapped, burned, or otherwise injured skin by forming a physical barrier against moisture loss and by reflecting UV radiation away from the skin.

Together, sodium thiosulfate and zinc oxide in this topical ointment work synergistically to treat skin conditions such as eczema, psoriasis, contact dermatitis, and other inflammatory skin disorders. The ointment can also be beneficial in the healing of minor wounds, burns, and ulcers, where it can help to prevent infection and promote faster healing. The formulation's base aids in the adherence of the active ingredients to the skin, ensuring that they remain in contact with the affected area for an extended period, which is essential for effective treatment.

For patients and prescribers considering the use of this formulation, it is important to apply the ointment as directed, typically to clean, dry skin. The frequency and duration of application will depend on the specific condition being treated and the advice of a healthcare professional. As with any medication, potential side effects and contraindications should be discussed with a pharmacist or physician before use. If you have any questions or require further information about the Sodium Thiosulfate 20%/Zinc Oxide 20% Topical Ointment, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the support and guidance you need to ensure safe and effective treatment.

Other Uses

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Welcome to Bayview Pharmacy. The Sodium Thiosulfate 20%/Zinc Oxide 20% Topical Ointment you inquired about is indeed a versatile formulation designed for a variety of skin conditions. While it is commonly used for inflammatory skin conditions, infections, or promoting wound healing, this specialized ointment has a breadth of other applications that warrant exploration. Sodium thiosulfate is known for its ability to neutralize chemical irritants and is sometimes used in the treatment of conditions caused by exposure to certain toxins or allergens. It has been effectively used in the detoxification of cyanide poisoning when used systemically and can aid in the relief of allergic reactions to certain medications when applied topically. Zinc oxide, on the other hand, offers protective properties as a physical barrier on the skin, which can be helpful in preventing diaper rash in infants or protecting minor burns and scrapes from infection. The anti-inflammatory properties of zinc oxide may also provide symptomatic relief for those with mild eczema or seborrheic dermatitis. Furthermore, because zinc is an essential mineral important for wound healing and tissue repair, this ointment might be beneficial in the management of chronic ulcers or pressure sores, as long as there are no contraindications for its use.

The greasy or oily base of our semi-solid formulation not only facilitates the direct application and absorption of the active ingredients but also serves to moisturize the skin, which can be particularly helpful in conditions associated with dry, cracked, or scaling skin. However, this formulation should be used with caution in individuals with a known hypersensitivity to either sodium thiosulfate or zinc oxide, and care should be taken when applying near the eyes or mucous membranes. Although this ointment is chiefly used topically, it can be adapted for use as a protective barrier in occupational settings where skin irritation is a risk. It is important to note that while the ointment provides a range of benefits, it is essential to consult a healthcare provider to ensure that it is appropriate for the specific condition being treated. For individualized advice or clarification, do not hesitate to reach out to our knowledgeable team of pharmacists here at Bayview Pharmacy. We are committed to providing guidance and support to both patients and prescribers utilizing this formulation.

Frequently Asked Questions

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What is Sodium Thiosulfate 20%/Zinc Oxide 20% Topical Ointment used for?

This topical ointment is used for the treatment of various skin conditions that may benefit from the protective, anti-inflammatory, and healing effects of the active ingredients. It is often used for skin inflammation, infections, or promoting wound healing.

How should I apply Sodium Thiosulfate 20%/Zinc Oxide 20% Topical Ointment?

Clean and dry the affected area first. Then apply a thin layer of the ointment to the skin, gently rubbing it in until it is evenly distributed. Use as directed by your healthcare provider, usually 1-3 times a day.

Can this ointment be used on open wounds?

While it may promote wound healing, it's essential to consult with your healthcare provider before applying the ointment on open wounds as it may not be suitable for all types of wounds.

Are there any side effects of using this ointment?

As with all medications, some side effects can occur. These may include localized skin irritation, redness, or itching. If you experience any severe or persistent side effects, contact your healthcare provider.

Can this ointment be used on all types of skin?

While it is formulated for various skin types, those with sensitive skin or allergies to any of the ingredients should use it cautiously. It's always advisable to do a patch test before applying it to a larger area.

How should I store the ointment?

Store the tube at room temperature, away from direct light and moisture. Keep it out of reach of children and pets.

Can I use Sodium Thiosulfate 20%/Zinc Oxide 20% Topical Ointment with other skin products?

It's essential to discuss with your healthcare provider before combining this ointment with other skin products to avoid interactions or over-medication of the skin.

What should I do if I miss a dose?

If you miss a dose, apply the ointment as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Can I cover the treated area with a bandage?

Unless directed by your healthcare provider, it is usually not necessary to cover the treated area. If bandaging is advised, use a breathable, non-occlusive bandage to allow some air circulation to the area.

Is this ointment safe for children?

The safety and effectiveness of this medication in children have not been established. Please consult with a pediatrician or dermatologist before using this medication on a child.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.
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