Sublingual Semaglutide (generic OzempicĀ®) now available! Get Started
Dashboard
Formulas

Tramadol HCl 50 mg Oral Slow Release (MEM4) Capsules

Our Tramadol HCl 50 mg Oral Slow Release (MEM4) Capsules are expertly crafted to provide patients with consistent and prolonged pain relief. Utilizing Methocel E4M, a sophisticated controlled-release polymer, these capsules are engineered to deliver the active ingredient, Tramadol HCl, slowly over an extended timeframe. This meticulous design ensures a steady therapeutic effect, minimizing the need for frequent dosing and enhancing patient adherence to treatment regimens. Tramadol is an opioid analgesic commonly prescribed for the management of moderate to moderately severe pain in adults, including conditions such as chronic pain, postoperative pain, and pain associated with osteoarthritis. By offering a controlled and sustained release of Tramadol, our formulation is tailored to provide effective pain management for these disease states, improving the overall quality of life for patients.

Want a different strength?
Click the Text Us button below.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
Starting at
Must be E-Prescribed
Get Started
Generate LeafletShow Leaflet
This medication requires a prescription from your doctor
Are you a prescriber? Sign Up
Trusted by 60,357 patients to date.
A group of faces of our past satisfied patients.
A svg symbol of a mortar and pestle with ingredients going in.
Custom made in our compounding labs.
Sliders that show the customization of ingredients.
Personalized treatment for better results.
User with a gear showing the personalization of the formulation.
All strengths and ingredients are tailored to your needs.
This medication is not available at retail pharmacies. It is compounded, and may be more effective at treating you or your patient.
Slow Release Capsules
65d8fa76cf58e4ea439d1b8f
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Loading icon rotating.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Dosing Calculator

Get general dosing information for a patient by using this calculator.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Loading icon rotating.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

Formula Information

A small arrow pointing down

Tramadol HCl 50 mg Oral Slow Release (MEM4) Capsules are a sophisticated pharmaceutical formulation designed to manage moderate to moderately severe pain over an extended period. These capsules are compounded using Methocel E4M, a high-viscosity grade hydroxypropyl methylcellulose (HPMC), which is a controlled-release polymer that plays a crucial role in the gradual release of tramadol hydrochloride. The incorporation of Methocel E4M into the capsule matrix allows for a consistent and controlled release of the active ingredient, tramadol, into the patient's system, thereby maintaining therapeutic plasma concentrations for an extended duration.

The slow-release mechanism of these capsules is particularly beneficial for patients who require round-the-clock pain management, as it can potentially reduce the need for frequent dosing. This not only enhances patient compliance but also minimizes the risk of peaks and troughs in drug levels, which can lead to side effects or periods of inadequate pain control. Tramadol works by binding to mu-opioid receptors and inhibiting the reuptake of norepinephrine and serotonin in the brain, altering the perception and response to pain.

These capsules are indicated for various disease states that involve chronic pain, such as osteoarthritis, neuropathic pain, and certain chronic musculoskeletal conditions. By providing a sustained analgesic effect, Tramadol HCl 50 mg Oral Slow Release (MEM4) Capsules can improve the quality of life for patients suffering from these conditions. It is important for prescribers to consider the patient's overall pain management plan, potential drug interactions, and individual response to tramadol when prescribing this formulation.

As with any medication, there are potential side effects associated with tramadol, including but not limited to nausea, dizziness, constipation, headache, and somnolence. It is also important to note that tramadol has the potential for abuse, addiction, and misuse, which should be taken into account when prescribing and dispensing this medication. Patients should be monitored for signs of abuse and addiction. Additionally, tramadol should be used with caution in patients with a history of seizures or those taking medications that lower the seizure threshold.

For more detailed information on Tramadol HCl 50 mg Oral Slow Release (MEM4) Capsules, or if you have any questions regarding this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is committed to providing high-quality, patient-specific formulations and is available to assist healthcare providers in optimizing pain management strategies for their patients.

Drug Interactions

A small arrow pointing down

Tramadol HCl is an opioid analgesic used to manage moderate to moderately severe pain. When formulated as a 50 mg Oral Slow Release (MEM4) Capsule with Methocel E4M, tramadol is released gradually over time, which can help maintain a consistent level of pain relief. However, due to its pharmacological properties, tramadol can interact with a variety of medications and substances, which may affect the safety and efficacy of the treatment.

One significant interaction is with central nervous system (CNS) depressants, including other opioids, benzodiazepines, alcohol, anxiolytics, hypnotics, and sedatives. Concurrent use can result in additive CNS depression, leading to increased risk of respiratory depression, profound sedation, coma, or even death. Patients should be closely monitored, and the dosage of one or both agents should be adjusted accordingly.

Tramadol is metabolized by the liver enzyme CYP2D6, and co-administration with CYP2D6 inhibitors, such as fluoxetine, paroxetine, or bupropion, can lead to increased tramadol levels and risk of seizures and serotonin syndrome. Conversely, CYP2D6 inducers like rifampin or St. John's Wort may reduce tramadol's efficacy by increasing its metabolism.

Additionally, tramadol can increase serotonin levels and should be used with caution in combination with other serotonergic drugs, including SSRIs, SNRIs, MAO inhibitors, triptans, and certain tricyclic antidepressants. This can lead to serotonin syndrome, a potentially life-threatening condition. Symptoms include agitation, hallucinations, fever, sweating, shivering, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Anticoagulants, such as warfarin, may also interact with tramadol. Tramadol has been reported to affect the INR and prothrombin times in patients taking warfarin, thus close monitoring of INR and adjustment of the warfarin dose may be necessary when tramadol is initiated or discontinued.

Patients with a history of seizures or those taking medications that lower the seizure threshold, such as certain antipsychotics or antidepressants, should be cautious when using tramadol, as it may increase the risk of seizures.

It is important to note that this is not an exhaustive list of all potential drug interactions. Patients should be advised to inform their healthcare provider of all medications, supplements, and herbal products they are taking before starting tramadol therapy. Healthcare providers should review the patient's medication history to identify potential interactions and adjust therapy accordingly to ensure safe and effective use of tramadol slow-release capsules.

If you have any questions or require further information regarding drug interactions with Tramadol HCl 50 mg Oral Slow Release (MEM4) Capsules, please do not hesitate to reach out to us at Bayview Pharmacy. Our team is here to provide the necessary support and guidance.

How Does it Work

A small arrow pointing down

The Tramadol HCl 50 mg Oral Slow Release (MEM4) Capsules are a sophisticated formulation designed to manage pain effectively over an extended period. Tramadol is an opioid analgesic that works by binding to the mu-opioid receptors in the brain, inhibiting the reuptake of serotonin and norepinephrine, which are neurotransmitters associated with pain and mood. This dual mechanism of action allows tramadol to alter the perception of and response to pain, providing relief.

The key to the slow-release feature of these capsules lies in the use of Methocel E4M, a type of hydrophilic polymer known as hypromellose or hydroxypropyl methylcellulose. Methocel E4M swells and forms a gel when it comes into contact with gastric fluids. This gel matrix creates a barrier through which the tramadol is slowly released. The rate of drug release is controlled by the rate at which the gastric fluid penetrates the gel layer and the rate at which the drug diffuses out into the surrounding environment. This controlled-release mechanism ensures a steady level of medication in the bloodstream, which can help maintain pain relief over a longer duration without the peaks and troughs associated with immediate-release formulations.

By using a controlled-release system, patients may experience more consistent pain management, which is particularly beneficial for chronic conditions requiring around-the-clock treatment. This can lead to improved patient compliance, as the need for frequent dosing is reduced. Patients can take the medication less often, which simplifies their medication regimen and can improve their quality of life.

Tramadol slow-release capsules are indicated for the management of moderate to moderately severe chronic pain in adults who require continuous treatment for an extended period. It is important to note that tramadol has the potential for addiction, abuse, and misuse, which can lead to overdose and death. Therefore, it should be prescribed with caution and used in accordance with the established dosing guidelines.

For prescribers, it is crucial to consider the patient's overall pain management plan, potential drug interactions, and the individual's risk factors for opioid addiction or abuse when prescribing tramadol slow-release capsules. Regular monitoring of patients for efficacy, side effects, and signs of misuse is recommended.

If you have any questions or require further information about Tramadol HCl 50 mg Oral Slow Release (MEM4) Capsules and their use in pain management, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the support and guidance needed to ensure the safe and effective use of this medication.

Other Uses

A small arrow pointing down

While Tramadol HCl 50 mg Oral Slow Release (MEM4) Capsules are primarily prescribed for the management of moderate to moderately severe pain that requires continuous, around-the-clock treatment, the unique formulation utilizing Methocel E4M offers potential for other applications where a steady, controlled release of active ingredients is beneficial. For instance, in cases where a patient is experiencing chronic conditions that necessitate long-term and consistent pain management, such as osteoarthritis or cancer pain, the slow-release properties of these capsules could provide more uniform symptom control compared to immediate-release formulations.

Additionally, this delivery system may also be advantageous in the management of certain types of neuropathic pain where sustained plasma concentrations of tramadol are desired to maintain analgesic effects. Furthermore, for patients who have difficulty adhering to a strict medication schedule or those with cognitive impairments who may forget to take frequent doses, the prolonged release mechanism of these capsules can enhance compliance, leading to better overall management of their condition. It is important to note, however, that tramadol's use should be individualized and should follow a thorough evaluation of the patient's pain and response to therapy. The long-acting nature of this formulation is not suitable for the treatment of acute pain or for post-operative pain where a rapid onset of analgesia is necessary.

It is crucial for prescribers to consider the pharmacokinetic properties of Tramadol HCl Oral Slow Release Capsules, as individuals with renal or hepatic impairment may require modified dosing to prevent accumulation and potentially serious adverse effects. In addition, tramadol is classified as a Schedule IV controlled substance by the U.S. Drug Enforcement Administration and should be used with caution because of the potential for abuse, addiction, or misuse.

Lastly, it is essential for patients receiving this medication to be monitored for adverse effects, including but not limited to nausea, dizziness, constipation, and CNS effects such as sedation and respiratory depression. Monitoring is also necessary to watch for signs of serotonin syndrome, a potentially life-threatening condition that can occur with tramadol, particularly when used in combination with other serotonergic drugs.

If there are any questions or if further clarification is needed on the potential other uses of Tramadol HCl 50 mg Oral Slow Release (MEM4) Capsules or the specifics of its sustained-release mechanism, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is ready to provide additional information and support to ensure the safe and effective use of this medication.

Frequently Asked Questions

A small arrow pointing down

What is Tramadol HCl 50 mg Oral Slow Release (MEM4) Capsule?

Tramadol HCl 50 mg Oral Slow Release (MEM4) Capsule is a controlled-release medication that contains Tramadol Hydrochloride as its active ingredient. It's formulated with Methocel E4M, a controlled-release polymer, to gradually release the medication over an extended period of time, which helps in providing sustained pain relief.

How does Methocel E4M enhance the effectiveness of Tramadol HCl 50 mg Capsules?

Methocel E4M is a type of hydrophilic polymer that swells and forms a gel when in contact with gastric fluids, controlling the release rate of Tramadol HCl from the capsule. By doing so, it ensures a slow and extended release of the drug into the system, maintaining a consistent therapeutic effect and minimizing the need for frequent dosing.

How often should I take the Tramadol HCl 50 mg Oral Slow Release Capsules?

The dosing frequency of Tramadol HCl 50 mg Oral Slow Release Capsules is typically less frequent than immediate-release formulations due to its sustained release mechanism. It's important to follow your healthcare provider's instructions regarding dosage, as it may vary depending on individual needs and response to treatment.

Will the Tramadol HCl 50 mg Oral Slow Release Capsules provide immediate pain relief?

No, these capsules are designed for a controlled and prolonged release of medication. As such, they will not provide immediate pain relief but are aimed at offering a consistent and extended analgesic effect to manage chronic pain.

Can I crush or chew the Tramadol HCl 50 mg Oral Slow Release Capsule if I have difficulty swallowing pills?

No, crushing or chewing the capsule can interfere with the controlled-release mechanism provided by Methocel E4M, potentially releasing the entire dose at once and increasing the risk of side effects. If you have trouble swallowing pills, consult your healthcare provider for alternatives.

Is there a risk of addiction with Tramadol HCl 50 mg Oral Slow Release Capsules?

As an opioid analgesic, Tramadol carries a risk of addiction, abuse, and misuse, even at the prescribed dosage. The risk may be lower with a controlled-release formulation, but it's still important to use the medication strictly as prescribed by your healthcare provider.

What are the potential side effects of taking Tramadol HCl 50 mg Oral Slow Release Capsules?

Possible side effects include dizziness, nausea, constipation, headache, drowsiness, and vomiting. While the controlled-release formulation may reduce the incidence of side effects, it's important to monitor your response and notify your healthcare provider if you experience any adverse effects.

Can the Tramadol HCl 50 mg Oral Slow Release Capsule be taken with other medications?

Before taking any new medication, including the Tramadol HCl Oral Slow Release Capsule, you should discuss potential interactions with your healthcare provider. Certain medications may interact with Tramadol and affect how it works or increase the risk of serious side effects.

What should I do if I miss a dose of Tramadol HCl 50 mg Oral Slow Release Capsules?

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up to make up for a missed dose without consulting your healthcare provider.

How should I store the Tramadol HCl 50 mg Oral Slow Release Capsules?

Store the capsules at room temperature, away from direct light, moisture, and heat. Keep the medication out of reach of children and pets, and do not use the capsules past the expiration date indicated on the packaging.

Can I drink alcohol while taking Tramadol HCl 50 mg Oral Slow Release Capsules?

Consuming alcohol while taking Tramadol HCl can increase the risk of respiratory depression, dizziness, and may lead to other harmful side effects. It is generally advised to avoid alcohol while on this medication. Always consult with your healthcare provider for advice on alcohol consumption with opioid analgesics.

Related Formulas

Related Products
Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.