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Formulas

Trichloroacetic Acid 20% Topical Lotion

Trichloroacetic Acid 20% Topical Lotion is a specially formulated liquid to semi-liquid preparation intended for external use on the skin. This lotion is designed to have a smooth and spreadable consistency, making it easy to apply to affected areas. It is crafted to provide moisturizing and soothing effects, while also delivering therapeutic benefits. The active ingredient, Trichloroacetic Acid at a 20% concentration, is known for its efficacy in promoting the absorption into the skin for localized treatment.

This topical lotion is primarily used in the management of various skin conditions, including the treatment of warts, molluscum contagiosum, and for the chemical peel of skin to improve and smooth its texture by removing damaged outer layers. It is a potent chemical exfoliant that can also be used in the treatment of actinic keratosis, a precancerous skin growth caused by sun exposure. Additionally, it may be employed in the removal of benign skin growths and for the reduction of acne scars, thereby enhancing the overall appearance of the skin.

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Topical Lotion
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Formula Information

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Trichloroacetic Acid (TCA) 20% Topical Lotion is a specially compounded formulation designed for the treatment of various skin conditions. As a liquid or semi-liquid preparation, it is intended for external application to the skin, providing a consistency that is both smooth and spreadable. This allows for ease of use and ensures that the active ingredient, Trichloroacetic Acid, is effectively absorbed into the skin for localized treatment. The concentration of 20% TCA in the lotion is potent and should be used with care, following the specific instructions provided by a healthcare professional.

The primary use of Trichloroacetic Acid in dermatology is for chemical peeling, which can help in the management of conditions such as acne, photoaging, hyperpigmentation, and superficial scars. The mechanism of action involves the caustic effect of TCA, which leads to the coagulation of proteins in the skin. This results in the peeling of the outer layers of the skin, promoting the regeneration of new skin with improved texture and tone. The 20% concentration is considered a medium-depth peel and is effective in reaching the superficial to mid-dermis layer of the skin, making it suitable for more pronounced skin issues that require a deeper peel.

Patients should be aware that the use of TCA can be associated with a burning sensation upon application, and the recovery period may involve redness, peeling, and crusting of the treated area. It is crucial to follow post-procedure care instructions to minimize complications and achieve the best results. Sun protection is also essential after treatment to protect the new skin and prevent further damage. Prescribers should ensure that patients are well-informed about the potential side effects and the importance of adhering to the recommended aftercare regimen.

It is important to note that TCA peels should only be performed under the guidance of a qualified healthcare professional who can assess the suitability of the treatment for each individual patient. Factors such as skin type, skin condition, and the patient's overall health must be considered before proceeding with the treatment. Additionally, prescribers should be aware of any contraindications, such as active infections, history of keloid formation, or hypersensitivity to the ingredients.

At Bayview Pharmacy, we are committed to providing high-quality compounded medications tailored to the specific needs of our patients. Our team of compounding pharmacists is available to answer any questions and provide guidance on the use of Trichloroacetic Acid 20% Topical Lotion. If you have any questions or require further information, please do not hesitate to reach out to us. We are here to support both patients and prescribers in the safe and effective use of this formulation.

Drug Interactions

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Trichloroacetic Acid (TCA) 20% Topical Lotion is a caustic agent used primarily for chemical peeling of the skin. It is indicated for the treatment of various skin conditions such as acne scars, wrinkles, fine lines, and hyperpigmentation. When considering the use of TCA 20% Topical Lotion, it is important to be aware of potential drug interactions that may affect the safety and efficacy of the treatment.

Firstly, TCA should be used with caution in patients who are currently using medications that increase the sensitivity of the skin to light, such as certain antibiotics (e.g., tetracyclines), sulfa drugs, and retinoids (e.g., isotretinoin). These medications may enhance the potential for a more intense reaction to the chemical peel, increasing the risk of skin irritation and damage.

Concomitant use of other topical skin treatments, particularly those with exfoliating, drying, or irritating properties (such as benzoyl peroxide, salicylic acid, or topical retinoids) should be avoided or used with caution. These agents may exacerbate the effects of TCA, leading to excessive skin irritation, peeling, or discomfort. It is advisable to discontinue the use of these products for a period before and after the application of TCA 20% Topical Lotion as directed by a healthcare professional.

Patients using corticosteroids, either systemically or topically, may also experience altered skin responses to TCA peels. Corticosteroids can thin the skin and reduce its ability to heal, potentially increasing the risk of adverse reactions to the peel. A thorough review of the patient's medication regimen should be conducted to assess the risk of interactions.

Additionally, it is important to consider the use of any over-the-counter products, supplements, or herbal preparations that may affect skin sensitivity or healing. Products containing astringents, witch hazel, or alcohol should be used with caution as they may increase skin dryness and irritation in conjunction with TCA treatment.

It is also crucial to avoid the use of TCA 20% Topical Lotion in patients who have a known allergy to trichloroacetic acid or any of the other ingredients in the formulation. An allergic reaction could result in severe skin irritation, redness, and swelling.

Patients should be advised to avoid direct sunlight and to use effective sun protection before and after the application of TCA 20% Topical Lotion to minimize the risk of post-inflammatory hyperpigmentation and sunburn. The use of broad-spectrum sunscreen products is recommended.

Given the potential for drug interactions and adverse reactions, it is essential for patients and prescribers to communicate openly about all medications and products being used. This will help ensure the safe and effective use of TCA 20% Topical Lotion. If you have any questions or concerns regarding the use of this formulation or its interactions with other drugs or products, please reach out to us at Bayview Pharmacy for further assistance.

How Does it Work

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Trichloroacetic Acid (TCA) 20% Topical Lotion is a chemical cauterant and keratolytic agent that, when applied to the skin, causes the top layers of cells to dry up and peel off over a period of several days to one week. The 20% concentration of TCA in this topical lotion formulation is specifically designed to treat a variety of skin conditions, such as warts, skin tags, and some types of hyperpigmentation. It is also used in the cosmetic treatment of fine lines, acne scars, and the overall improvement of skin texture.

The mechanism of action of TCA involves the coagulation of proteins in the skin. When applied, it causes the denaturation of epidermal proteins, leading to necrosis (cell death) of the outermost skin layers. As the skin heals, new cell growth is stimulated, resulting in a smoother, more even-toned complexion. The depth of the peel and the extent of skin regeneration depend on the concentration of TCA used, with a 20% solution being on the milder side of peeling agents, suitable for more superficial skin concerns.

For patients, it is important to understand that the application of TCA can cause a burning sensation, and the treated area will likely turn white (frosting) shortly after application. This indicates the protein coagulation effect. Post-treatment care is crucial to ensure proper healing and to minimize the risk of complications such as infection or scarring. Sun protection is also essential after treatment, as the new skin will be more sensitive to UV radiation.

Prescribers should be aware that TCA peels are not suitable for all skin types, particularly those with darker complexions, due to the risk of post-inflammatory hyperpigmentation. A thorough patient history and skin evaluation should be conducted prior to prescribing this treatment. Additionally, prescribers should instruct patients on the proper use of the lotion, including the amount to apply, frequency of application, and the importance of adhering to post-treatment care instructions.

As compounding pharmacists at Bayview Pharmacy, we ensure that the Trichloroacetic Acid 20% Topical Lotion is prepared with the highest quality standards, ensuring consistency and efficacy of the formulation. We are available to answer any questions and provide guidance to both patients and prescribers regarding the use of this formulation. If you have any questions or need further information, please do not hesitate to reach out to us.

Other Uses

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Trichloroacetic Acid (TCA) 20% Topical Lotion is traditionally employed in dermatology for the treatment of a variety of skin conditions. While its primary use is for the removal of warts, including plantar and genital warts, it is also effective in the management of superficial skin malignancies like actinic keratoses, which are precursors to squamous cell carcinoma. Moreover, this formulation has found utility in cosmetic dermatology for chemical peeling procedures aimed at improving the appearance of photo-aged skin, diminishing fine lines, wrinkles, and hyperpigmentation, as well as stimulating collagen synthesis for a rejuvenated skin texture.

Beyond these applications, TCA 20% Topical Lotion may be considered for off-label use in the treatment of xanthelasma, which are cholesterol-filled lesions commonly located on the eyelids. It is a non-invasive alternative to surgical removal. TCA has also been used in the management of molluscum contagiosum, a viral skin infection that typically affects children, where it acts by destroying the molluscum bodies to promote healing.

Additionally, some practitioners might use Trichloroacetic Acid lotion for less commonly known dermatological conditions that can benefit from its keratolytic properties, such as pruritus ani, lichen sclerosis, and certain types of cutaneous sarcoidosis. However, caution is warranted as TCA is a potent agent that can cause serious side effects and should be used with meticulous care under professional guidance to avoid complications such as scarring, infection, or pigmentary changes.

For individuals seeking to utilize TCA 20% Topical Lotion for applications outside of the standard protocols, a thorough evaluation by a healthcare professional is essential to determine the appropriateness of use for their specific condition. Patients must adhere strictly to the instructions provided by the prescriber to ensure safety and efficacy. Skincare professionals should evaluate each case individually and consider the physical and phototype, location and size of the lesion, and the patient's overall health status before proceeding with treatment using this formulation.

If you have any questions about the use of Trichloroacetic Acid 20% Topical Lotion or its potential applications for various skin conditions, please reach out to us. Our team of compounding pharmacists at Bayview Pharmacy is ready to provide the necessary information and support to ensure that both patients and healthcare providers make informed decisions about this potent dermatological agent.

Frequently Asked Questions

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What is Trichloroacetic Acid 20% Topical Lotion used for?

Trichloroacetic Acid (TCA) 20% Topical Lotion is used for treating various skin conditions such as warts, skin tags, and to perform chemical peels for removing the outer layer of the skin, helping to reduce the appearance of fine lines, small scars, and sun damage. It's a chemical exfoliant that promotes skin renewal.

How do you apply Trichloroacetic Acid 20% Topical Lotion?

Before applying the lotion, clean the affected skin area with water and a gentle cleanser. Apply a small amount of the lotion to the targeted area using a cotton swab or gauze, avoiding contact with healthy skin surrounding the area. Do not rub it in. Follow your healthcare provider's instructions regarding the duration and frequency of application.

What are the potential side effects of Trichloroacetic Acid 20% Topical Lotion?

Common side effects include a temporary burning sensation during application, redness, swelling, peeling, and crusting of the treated skin. In rare cases, there may be scarring, changes in skin color, or infection. If you experience severe discomfort or signs of an allergic reaction, seek medical attention immediately.

Can I use Trichloroacetic Acid 20% Topical Lotion on all parts of my body?

Trichloroacetic Acid 20% Topical Lotion should only be used on the specific areas of the skin as directed by your healthcare provider. It is not typically recommended for use on sensitive areas such as around the eyes or on the genitalia unless directed by a professional.

How often should I apply Trichloroacetic Acid 20% Topical Lotion?

The frequency of application should be strictly as per the instructions provided by your healthcare provider. This can vary depending on the specific skin condition being treated and your skin's sensitivity to the medication.

Should I use a moisturizer after applying Trichloroacetic Acid 20% Topical Lotion?

Your skin may become dry after the use of Trichloroacetic Acid lotion. While the lotion itself has moisturizing properties, your healthcare provider may recommend applying a moisturizer to help soothe the treated area; however, you should wait until the lotion has fully dried or as directed by the healthcare provider.

Can I wear makeup over the treated area after applying Trichloroacetic Acid 20% Topical Lotion?

It is generally advisable to avoid applying makeup to the treated skin area immediately after applying the TCA lotion, as this can interfere with the treatment and healing process. It's best to consult with your healthcare provider for specific post-application care recommendations.

What should I do if I experience excessive irritation after applying Trichloroacetic Acid 20% Topical Lotion?

If you experience excessive irritation, such as severe redness, swelling, pain, or blistering, you should stop using the lotion and contact your healthcare provider immediately. They may provide additional instructions or alternative treatments to manage the irritation.

Is it safe to go out in the sun after applying Trichloroacetic Acid 20% Topical Lotion?

After applying TCA lotion, your skin will be more sensitive to sunlight, increasing the risk of sunburn. It is recommended to avoid prolonged sun exposure and tanning beds. When going outdoors, wear protective clothing and use a broad-spectrum sunscreen with a high SPF as advised by your healthcare provider.

How should I store Trichloroacetic Acid 20% Topical Lotion?

Store Trichloroacetic Acid 20% Topical Lotion at room temperature away from direct sunlight and heat. Keep it tightly closed and out of reach of children. Dispose of any unused lotion after the expiration date or as instructed by your healthcare provider or pharmacist.

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Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.