How to Prescribe Testosterone w/ E2, E3 Topicals

Learn how to prescribe Testosterone w/ E2, E3 Topicals as a controlled compound.

Effective January 2, 2020, Rhode Island prescribers must sign and transmit electronic prescriptions in schedules II, III, IV, and V to comply with RI Law §21-28-3.18 section 3.

How to Electronically Prescribe Testosterone w/ E2, E3 Topicals

  1. Select Testosterone (bulk) powder as the drug.  The drug selected needs to be a controlled substance
  2. In the instructions, directions, or notes field, please indicate:
    a. The concentration of the preparation
    b. The directions (ex. Apply 1mL topically once daily)
    c. An ICD-10 diagnosis code
    d. A quantity of dose units dispensed. Federal law prohibits more than 100 dosage units
    e. Refills (maximum of 5)
  3. Do not use the name brands (Androgel®, Fortesta®, or Natesto®) when prescribing Testosterone containing compounds

The prescription needs to be sent by the prescriber with the controlled substance selected as the active drug for the Electronic Prescriptions for Controlled Substances (EPCS) signature to be validated.

Most Common Formulations

Here are the most requested formulations of this controlled compound:

  • Testosterone/E2/E3 1-0.2-0.8mg/ml Topical Cream

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