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This formulation is a liquid solution of Apomorphine HCL 2.5 mg/ml and Phentolamine Mesylate 2.5 mg/ml, delivered as a nasal spray. It is specifically designed for administration into the nasal cavity, providing targeted local or systemic effects through the nostrils. The formulation is used to treat various disease states, including Parkinson's disease, erectile dysfunction, and hypotension. The nasal spray delivery method allows for rapid absorption and onset of action.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
This formulation combines Apomorphine HCL and Phentolamine Mesylate, both at a concentration of 2.5 mg/ml, in a nasal spray. Apomorphine HCL is a non-selective dopamine agonist that stimulates dopamine receptors in the brain. It is commonly used to manage motor fluctuations in patients with Parkinson's disease, as it can help to reduce periods of "off" time when symptoms of the disease return between doses of regular medication. Phentolamine Mesylate is an alpha-adrenergic blocker that works by relaxing and widening blood vessels, which can help to improve blood flow. It is often used to treat high blood pressure and sweating associated with pheochromocytoma, a rare tumor of the adrenal gland.
The nasal spray formulation allows for the medication to be absorbed directly into the bloodstream through the nasal mucosa, bypassing the digestive system. This can result in a faster onset of action compared to oral medications, making it particularly useful for conditions that require rapid relief of symptoms. The spray form also offers a convenient and non-invasive method of administration, which can be beneficial for patients who have difficulty swallowing tablets or capsules.
It's important to note that this formulation should be used exactly as prescribed by a healthcare provider. The dose and frequency of use will depend on the individual patient's condition and response to treatment. Potential side effects may include nasal irritation, dizziness, nausea, and headache. Patients should seek immediate medical attention if they experience severe or persistent side effects.
As compounding pharmacists, we can customize this formulation to meet the specific needs of individual patients. This includes adjusting the concentration of the active ingredients, altering the delivery method, or adding flavorings to improve taste.
If you have any questions about this formulation, or if you would like to discuss a customized medication solution, please don't hesitate to reach out to us at Bayview Pharmacy. We are here to help and provide you with the information you need to make informed decisions about your healthcare.
Apomorphine HCL and Phentolamine Mesylate are both potent medications that can interact with a variety of other drugs. It's crucial to understand these potential interactions to ensure safe and appropriate use of this nasal spray formulation.
Apomorphine HCL is a non-selective dopamine agonist that is primarily used for the treatment of Parkinson's disease. It can interact with several classes of drugs, including antipsychotics, antiemetics, and certain antihypertensives. Antipsychotics and antiemetics, which often work by blocking dopamine receptors, can reduce the effectiveness of Apomorphine. Concurrent use with antihypertensives can lead to additive hypotensive effects, potentially causing dizziness, fainting, or even serious cardiovascular complications.
Phentolamine Mesylate is an alpha-adrenergic blocker used to manage hypertensive crises often associated with tumors of the adrenal gland (pheochromocytoma). It can interact with beta-blockers, leading to unopposed alpha stimulation and severe hypertension. It can also interact with other alpha-blockers, leading to additive hypotensive effects. Additionally, Phentolamine can interact with erectile dysfunction drugs, potentially causing a dangerous drop in blood pressure.
Both Apomorphine and Phentolamine can interact with alcohol, leading to additive sedative effects and potentially dangerous drops in blood pressure. Patients using this nasal spray should avoid alcohol consumption.
It's also important to note that both Apomorphine and Phentolamine can have additive effects with other medications affecting the central nervous system, such as sedatives, hypnotics, and opioids. These combinations can lead to increased sedation, respiratory depression, and other serious complications.
Patients should always inform their healthcare provider of all medications they are currently taking, including over-the-counter drugs, dietary supplements, and herbal products. This will help the provider to monitor for drug interactions and adjust the treatment plan as necessary.
This nasal spray formulation is designed to deliver the medications directly to the bloodstream through the nasal mucosa, bypassing the digestive system and potentially reducing some side effects. However, it's still crucial to monitor for signs of drug interactions and report any unusual symptoms to your healthcare provider immediately.
If you have any questions about this formulation or its potential interactions with other medications, please don't hesitate to reach out to us. Our team of compounding pharmacists is always here to help.
Apomorphine HCL and Phentolamine Mesylate nasal spray is a unique formulation that combines two potent medications to provide relief for specific disease states. This formulation is delivered as a liquid spray into the nasal cavity, allowing for rapid absorption and targeted effects.
Apomorphine HCL is a non-selective dopamine agonist that works by stimulating dopamine receptors in the brain. This action can help to alleviate symptoms of Parkinson's disease, such as stiffness, tremors, spasms, and poor muscle control. It is also used off-label for erectile dysfunction due to its ability to stimulate the area of the brain responsible for sexual arousal.
Phentolamine Mesylate, on the other hand, is an alpha-adrenergic blocker. It works by blocking the alpha-adrenergic receptors in the body, which in turn helps to relax and widen blood vessels. This action can help to treat conditions such as high blood pressure and erectile dysfunction.
When combined in a nasal spray, these two medications can provide targeted relief for the aforementioned conditions. The nasal spray formulation allows for the medication to be rapidly absorbed into the bloodstream, providing quicker relief than oral medications. Furthermore, the nasal spray can be self-administered, providing convenience for the patient.
It's important to note that while this formulation can provide relief for these conditions, it is not a cure. It is meant to manage symptoms and improve the quality of life for patients. As with any medication, it's important to discuss potential side effects and interactions with your healthcare provider.
If you have any questions about this formulation, or if you're interested in learning more about how it can benefit you, please don't hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is here to help.
This is a compounded formulation designed for administration into the nasal cavity. Each milliliter of the solution contains 2.5 mg of Apomorphine HCL and 2.5 mg of Phentolamine Mesylate.
This medication is delivered in a spray form and is specially designed for administration into the nasal cavity to provide either localized or system-wide effects.
Not necessarily. The medication is designed to absorb through the lining of your nostrils, so a normal inhalation is sufficient.
The medication may have a specific scent or taste due to its ingredients. However, it is designed for nasal administration, so any smell or taste should be minimal.
It's recommended to consult with your healthcare provider if you have nasal congestion or any other nasal issues before using this spray. It might affect the drug's absorption.
You should discuss your medical history, including nosebleeds, with your healthcare provider before using this medication. They will guide you on the safest option for your situation.
Yes, the spray can be administered into either nostril. Follow your healthcare provider's instructions regarding the best usage practices for your individual prescription.
No, this medication is prescribed for individual use only. Sharing this medication could cause harm to others.
Take the missed dose as soon as you remember unless it's almost time for your next dose. You should not take two doses at the same time to compensate for a missed one.
Store this medication in a cool and dry place, away from light and out of reach from children. Always check the expiry date before use.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.
Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.
Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Inhale intranasally
