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Arbutin 4%/Ascorbic Acid 20%/Glutathione 10%/Kojic Acid 4% Topical Cream

FDA-approved generic
Dose form
Topical Cream
Active ingredients
Arbutin
Ascorbic Acid
Glutathione
Kojic Acid

This formulation is a semisolid preparation of Arbutin 4%, Ascorbic Acid 20%, Glutathione 10%, and Kojic Acid 4% dispensed in a pump mechanism. It is designed for convenient and controlled application on the skin for localized treatment or absorption of active ingredients. The cream is specifically formulated to treat hyperpigmentation, melasma, and age spots. It also aids in skin lightening and rejuvenation, providing a more even skin tone and improved skin texture.

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For prescribers
Prescription details
RxThis formula
Dose formSee below
Quantity____
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription detailsOrder form
Controlled substance: e-prescribe (EPCS) from your EHR. Faxed and phoned prescriptions cannot be accepted for this preparation.
Send it from your EHR, or fax to (401) 284-4506. How to e-prescribe this formula
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
To prescribe, you must be a verified prescriber.
To prescribe, you must be in a state where we hold an active out-of-state pharmacy license.
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This medication requires a prescription from your doctor
Ships within 1 to 2 business days after pharmacist verification
HSA and FSA eligible
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Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.

For prescribersSign in for prescription details and order forms.
Compounded preparations are prepared by Bayview pursuant to a prescription for an individual patient. They are not FDA-approved and have not been evaluated by FDA for safety or effectiveness.
Arbutin
Ascorbic Acid
Glutathione
Kojic Acid
Topical Cream
65309a0056fb9f2282fff2ee
Service area

Can we ship this formula to your state?

Bayview fills prescriptions for patients in Connecticut, Florida, Maine, Massachusetts, New Hampshire, New Jersey, Pennsylvania and Rhode Island. New York patients are served on a limited basis while nonresident pharmacy registration is pending.

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Formula Information

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This formulation is a topical cream composed of Arbutin (4%), Ascorbic Acid (20%), Glutathione (10%), and Kojic Acid (4%). It is a semisolid preparation dispensed in a pump mechanism, designed for convenient and controlled application on the skin. This formulation is intended for localized treatment or absorption of active ingredients.

Arbutin is a molecule extracted from the bearberry plant that prevents the formation of melanin. It is used in a variety of skincare products for its skin lightening properties. Ascorbic Acid, also known as Vitamin C, is a potent antioxidant that can neutralize free radicals in the skin. It also helps boost collagen production and can lighten dark spots, leading to a more even skin tone.

Glutathione is an antioxidant naturally found in human cells that neutralizes free radicals, boosts the immune system, and detoxifies the body. It can also cause skin lightening by converting melanin to a lighter color and deactivating the enzyme tyrosinase, which helps produce the pigment. Kojic Acid is a chemical produced by certain fungi, which has the ability to inhibit the production of melanin in the skin. It is often used in skin lightening products and can treat pigment problems such as melasma, age spots, and freckles.

This formulation is primarily used to treat hyperpigmentation, melasma, age spots, and other skin discolorations. The combination of these four active ingredients works synergistically to inhibit melanin production, lighten existing dark spots, and prevent the formation of new ones. It also provides antioxidant benefits, protecting the skin from damage caused by free radicals and promoting overall skin health.

Patients should apply this cream as directed by their healthcare provider, typically once or twice daily. It is important to use sun protection while using this product, as some ingredients can make the skin more sensitive to the sun. Side effects may include mild skin irritation or allergic reactions. If these occur, discontinue use and consult your healthcare provider.

Prescribers should consider this formulation for patients with hyperpigmentation or other skin discolorations who have not responded to other treatments. It may also be beneficial for patients seeking to improve their overall skin health and appearance. As with any medication, it is important to consider the patient's overall health status, other medications, and potential for allergic reactions when prescribing this product.

If you have any questions about this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is here to assist you.

Drug Interactions

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This topical cream formulation contains four active ingredients: Arbutin, Ascorbic Acid (Vitamin C), Glutathione, and Kojic Acid. These ingredients are known for their skin-lightening and antioxidant properties. However, like all medications, these ingredients may interact with other drugs, which could affect their effectiveness or increase the risk of side effects.

Arbutin is generally considered safe and has no known significant drug interactions. However, it may increase skin sensitivity to sunlight, so it's important to use sun protection while using products containing Arbutin. Ascorbic Acid, or Vitamin C, can interact with certain medications, including chemotherapy drugs, statins, and warfarin. If you're taking any of these medications, consult your healthcare provider before using this cream.

Glutathione, a powerful antioxidant, has no known significant drug interactions. However, it may interact with chemotherapy drugs and could potentially reduce their effectiveness. If you're undergoing chemotherapy, consult your healthcare provider before using this cream. Kojic Acid is generally considered safe and has no known significant drug interactions. However, it may increase skin sensitivity, particularly in individuals with a history of allergic reactions or skin sensitivity.

It's important to note that while this formulation is designed for topical use, some absorption into the bloodstream can occur. Therefore, if you're taking any systemic medications, particularly those that could interact with Ascorbic Acid or Glutathione, it's important to discuss this with your healthcare provider. Additionally, if you're pregnant or breastfeeding, consult your healthcare provider before using this cream, as the safety of these ingredients during pregnancy and lactation has not been fully established.

As with all medications, it's important to use this cream as directed by your healthcare provider. If you experience any unusual symptoms or side effects, discontinue use and contact your healthcare provider immediately. Always inform your healthcare provider of all medications and supplements you're taking, including over-the-counter products and herbal supplements, to ensure they're aware of potential drug interactions.

If you have any questions about this formulation or its potential interactions with other medications, don't hesitate to reach out to us at Bayview Pharmacy. Our knowledgeable team of compounding pharmacists is here to help.

How Does it Work

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This topical cream formulation combines four active ingredients: Arbutin, Ascorbic Acid (Vitamin C), Glutathione, and Kojic Acid. Each of these ingredients plays a unique role in treating various skin conditions, primarily hyperpigmentation and skin aging.

Arbutin, at a concentration of 4%, works by inhibiting tyrosinase, an enzyme that plays a crucial role in the production of melanin. By blocking this enzyme, Arbutin helps to reduce the production of melanin, thereby lightening the skin and reducing the appearance of dark spots and hyperpigmentation.

Ascorbic Acid, also known as Vitamin C, is present at a concentration of 20%. This potent antioxidant aids in neutralizing harmful free radicals that can cause damage to the skin. It also boosts collagen production, which can help to reduce the appearance of wrinkles and fine lines. Furthermore, Ascorbic Acid can also inhibit melanin production, contributing to a brighter and more even skin tone.

Glutathione, at a concentration of 10%, is another powerful antioxidant that can protect the skin from oxidative damage. It also has the ability to inhibit the production of melanin. Additionally, Glutathione can improve skin elasticity and reduce the signs of aging.

Kojic Acid, present at a concentration of 4%, is a by-product of the fermentation process of certain types of fungi. It works by inhibiting the function of tyrosinase, thereby reducing the production of melanin.

The cream is dispensed in a pump mechanism, which allows for convenient and controlled application. The semisolid preparation is designed for localized treatment, ensuring that the active ingredients are absorbed directly into the area of the skin that requires treatment.

Overall, this formulation is designed to treat hyperpigmentation, reduce the signs of aging, and improve the overall appearance of the skin. It is important to use this product as directed by a healthcare professional, and to protect the skin from sun exposure, as some of the ingredients can make the skin more sensitive to UV rays.

If you have any questions about this formulation, or if you would like more information on how it can benefit your skin, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of knowledgeable compounding pharmacists is always here to help.

Other Uses

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In addition to the formulation's primary role in treating hyperpigmentation, dark spots, and uneven skin tone due to its active ingredients, this compound also provides several other skincare benefits. The combination of Arbutin, Ascorbic Acid, Glutathione, and Kojic Acid can contribute to a good skincare routine.

Ascorbic Acid, also known as Vitamin C, is not only an antioxidant which helps to protect the skin from free radicals, but it also stimulates the production of collagen. This helps to keep the skin firm and youthful, reducing the appearance of wrinkles over time.

Glutathione, another potent antioxidant, not only lightens the skin by converting melanin to a lighter color and deactivating the enzyme that helps to produce the pigment, but it also plays a significant role in detoxification and promotes a healthier complexion.

Kojic Acid, beyond its skin-lightening properties, can reduce the appearance of sun damage, scarring, and age spots. It can also improve the appearance of redness and swelling associated with rosacea.

Arbutin is noteworthy for its gentleness on the skin, making it suitable for sensitive skin types. It is less irritating than other skin-lightening agents, and can also reduce the degree of skin's darkening after sun exposure by blocking the production of tyrosinase.

Together, these components provide a multi-faceted approach to skincare. It should be noted, this compound also offers potential antioxidant defenses, anti-aging benefits, and skin restoration aspects. With consistent use, this formulation can result in an overall more youthful and even complexion.

This information is to offer broad application possibilities, and prescriber discretion is advised to decide the appropriateness in a given patient case. If you have questions about this formulation and its potential uses beyond treating hyperpigmentation and uneven skin tone, feel free to reach out to us at Bayview Pharmacy. Our compounding pharmacists are ready to provide in-depth information and counselling throughout the usage of this formulation.

Frequently Asked Questions

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What is the compounded formulation of Arbutin 4%/Ascorbic Acid 20%/Glutathione 10%/Kojic Acid 4% Topical Cream?

It's a compounded pharmaceutical product, a semi-solid cream designed for use on the skin. The active ingredients are Arbutin (4%), Ascorbic Acid (20%), Glutathione (10%), and Kojic Acid (4%). It is dispensed through a pump mechanism for precise, controlled application.

What are the main ingredients and their proportions in this compounded formulation?

The main ingredients of this formulation are Arbutin, accounting for 4% of the total composition; Ascorbic Acid representing a 20% fraction; Glutathione which constitutes 10%; and Kojic Acid making up another 4%.

How do I apply this compounded formulation?

Simply depress the pump mechanism to dispense a controlled amount of the cream. Apply the product locally on your skin as instructed by your healthcare provider.

What is the purpose of the pump mechanism in this product?

The pump mechanism in this product is for providing a convenient and controlled method of application on the skin. This allows for localized treatment or absorption of active ingredients without wasting any product.

Is this compounded formulation safe?

Yes, This formulation is generally safe as long as it is used as directed by your healthcare provider. However, like any medication, side effects may occur. Always report any adverse effects to your healthcare provider immediately.

Can this cream be used all over the body?

Not necessarily. This cream is intended for localized treatment, which means it is usually applied to specific problem areas of the skin rather than the whole body. Always follow your healthcare provider's instructions regarding where and how to apply the cream.

What are the benefits of this compounded formulation?

The active ingredients in this formulation are known to offer a range of skin benefits. For instance, Arbutin and Kojic Acid can reduce pigmentation, Ascorbic Acid (Vitamin C) can help rejuvenate the skin and boost collagen production, while Glutathione is a potent antioxidant.

Does the Arbutin 4%/Ascorbic Acid 20%/Glutathione 10%/Kojic Acid 4% Topical Cream require a prescription?

Yes, generally compounded formulations like this require a prescription from your healthcare provider. Always consult with your healthcare provider regarding any topical creams or treatments you wish to use.

What are the possible side effects of this compounded formulation?

Some potential side effects may include skin irritation, redness, or sensitivity. These reactions are typically mild but if you experience any severe or lasting side effects, stop using the product and contact your healthcare provider immediately.

Can this compounded formulation be used in combination with other skincare products?

As with any skincare product, you should always check with your healthcare provider or a skincare professional before adding a new product to your routine. Some ingredients could potentially react negatively with others or disrupt the effectiveness of the cream.

About this compounded preparation

This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.

The conditions listed on this page are indications prescribers have ordered this preparation for. They are not FDA-approved indications, and listing them is not a statement that this preparation is effective for them.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.

Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.

No compounded medications are reviewed by the FDA for safety or efficacy.
For prescribers

How to e-prescribe this formula

Controlled substance: e-prescribe only (EPCS). Faxed, phoned, and handwritten prescriptions cannot be filled. Rhode Island law (R.I. Gen. Laws § 21-28-3.18) requires Schedule II to V prescriptions to be transmitted electronically.
1

Find Bayview in your EHR's pharmacy directory

Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.

NCPDP4106882NPI1750455143Address3844 Post Rd, Warwick, RI 02886Phone(401) 284-4505Fax(401) 284-4506
2

Enter the formula as a compound

Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.

Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.

3

Copy the prescription details

RxFormula name
Dose formDose form
Quantity________
SigAs directed by prescriber
Refills____
PharmacyBayview Pharmacy, Warwick RI, NCPDP 4106882
Copy prescription details

Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.

4

Send it

Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.

Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.

Do not use Notes to Pharmacy for the formula. Some EHRs keep that field internal and never transmit it. A prescription that arrives without the formula is delayed while we call your office.

Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.

Arbutin 4%/Ascorbic Acid 20%/Glutathione 10%/Kojic Acid 4% Topical Cream
Topical Cream
30 g
controlled

Apply topically to affected area(s)

Once daily at bedtime