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The Dexamethasone 1 mg/Diphenhydramine HCl 50 mg/Lorazepam 1 mg/Metoclopramide HCl 11.82 mg Rectal Suppository is a solid dosage form designed for insertion into the rectum. Upon insertion, the suppository dissolves or melts, allowing for the local or systemic absorption of its active ingredients. This particular formulation combines the anti-inflammatory effects of Dexamethasone, the antihistamine properties of Diphenhydramine, the anxiolytic action of Lorazepam, and the antiemetic benefits of Metoclopramide.
This combination medication is primarily used to treat nausea and vomiting associated with chemotherapy. Dexamethasone and Metoclopramide work synergistically to prevent chemotherapy-induced emesis, while Lorazepam helps manage the anxiety that often accompanies chemotherapy. Diphenhydramine is included for its ability to reduce allergic reactions and also to potentiate the anti-nausea effects of Metoclopramide. The rectal route of administration is particularly useful for patients who are unable to take medications orally.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
The Dexamethasone 1 mg/Diphenhydramine HCl 50 mg/Lorazepam 1 mg/Metoclopramide HCl 11.82 mg Rectal Suppository is a compounded medication designed to provide relief from various symptoms associated with certain medical conditions. This solid dosage form is specifically created for rectal administration, where it dissolves or melts to release the active ingredients for both local and systemic absorption. The combination of these four medications offers a multi-faceted approach to treatment, targeting different aspects of the patient's condition.
Dexamethasone is a potent corticosteroid that acts as an anti-inflammatory and immunosuppressant. It is commonly used to treat conditions that involve inflammation, such as allergic reactions, certain types of arthritis, and even some cancers. By including dexamethasone in this formulation, it can help to reduce inflammation and alleviate associated pain and swelling.
It also possesses sedative properties, which can help to alleviate anxiety and promote sleep, making it beneficial for patients who are experiencing discomfort and restlessness.
Lorazepam, a benzodiazepine, is included for its anxiolytic, sedative, and anticonvulsant properties. It is particularly useful in reducing anxiety and providing sedation, which can be helpful for patients undergoing stressful medical procedures or experiencing acute anxiety episodes.
Metoclopramide HCl is a medication that works as a prokinetic agent, enhancing gastrointestinal motility. It is often used to treat nausea, vomiting, and gastroparesis. By stimulating gastric emptying, metoclopramide can help to alleviate symptoms of delayed gastric emptying and prevent the discomfort associated with these conditions.
This combination suppository is particularly useful in palliative care settings, where patients may require a multifaceted approach to manage symptoms such as nausea, vomiting, anxiety, and allergic reactions. The rectal route of administration is advantageous for patients who may have difficulty swallowing or require rapid symptom control. It is important for prescribers to consider the individual components of this formulation and their potential interactions when prescribing this medication. Additionally, patients should be monitored for any adverse effects that may arise from the systemic absorption of these medications.
For more detailed information or if you have any questions regarding this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is dedicated to providing the highest quality of care and is available to assist with any inquiries you may have.
The formulation in question combines dexamethasone, diphenhydramine HCl, lorazepam, and metoclopramide HCl into a rectal suppository. This combination of medications is often used to treat nausea, vomiting, and allergic reactions, as well as to provide sedation and reduce inflammation. However, it is important to consider potential drug interactions when using this formulation.
Dexamethasone is a corticosteroid that can interact with a variety of medications. It may reduce the effectiveness of vaccines and increase the risk of side effects from live vaccines. Concurrent use with other corticosteroids can increase the risk of systemic corticosteroid effects. Dexamethasone can also interact with antidiabetic agents, potentially reducing their efficacy and necessitating adjustments in antidiabetic medication dosages. Additionally, the use of dexamethasone with nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of gastrointestinal ulceration or bleeding.
Diphenhydramine HCl is an antihistamine that can cause sedation and has additive effects when used with other central nervous system depressants, such as lorazepam. This can lead to increased sedation and impairment of cognitive and motor skills. Patients should be advised to avoid activities requiring mental alertness, such as driving or operating heavy machinery, until they know how this combination affects them. Diphenhydramine should be used with caution in combination with other anticholinergic drugs, as this can increase the risk of anticholinergic side effects such as dry mouth, urinary retention, and constipation.
Lorazepam is a benzodiazepine that can cause CNS depression, and its sedative effects are enhanced by other CNS depressants, including alcohol, opioids, and other benzodiazepines. The use of lorazepam with opioid medications can result in profound sedation, respiratory depression, coma, and death. Caution is advised when co-administering lorazepam with other drugs that have CNS depressant effects. Additionally, lorazepam may interact with certain antidepressants, antipsychotics, and antiepileptic drugs, potentially affecting their levels and effects.
Metoclopramide HCl is a prokinetic agent that can interact with drugs that are likely to cause extrapyramidal symptoms, such as antipsychotics. The use of metoclopramide with other serotonergic drugs, such as SSRIs, can increase the risk of serotonin syndrome, a potentially life-threatening condition. Metoclopramide can also affect the absorption of other drugs by altering gastric motility, potentially requiring dose adjustments of concomitant medications.
It is crucial for prescribers to review the patient's current medication list for potential interactions before prescribing this formulation. Patients should be advised to inform their healthcare provider of all medications they are taking, including over-the-counter drugs and herbal supplements. If you have any questions or require further information regarding this formulation and its potential drug interactions, please reach out to us at Bayview Pharmacy.
The Dexamethasone 1 mg/Diphenhydramine HCl 50 mg/Lorazepam 1 mg/Metoclopramide HCl 11.82 mg Rectal Suppository is a multi-drug compound designed to provide relief from various symptoms associated with different medical conditions. This solid dosage form is specifically created for rectal administration, where it is inserted into the rectum. Upon insertion, the suppository base, typically made from substances like cocoa butter or a synthetic substitute, begins to melt or dissolve due to the warmth of the body. As the base dissolves, it releases the active medications for local and systemic absorption through the rectal mucosa.
Dexamethasone is a potent corticosteroid that works by reducing inflammation and modulating the immune response. It is commonly used in the management of inflammatory and autoimmune conditions, as well as to control nausea and vomiting associated with chemotherapy. Diphenhydramine HCl is an antihistamine that provides relief from allergic reactions and can also have a sedative effect, helping to alleviate anxiety and promote sleep. Lorazepam, a benzodiazepine, is included for its anxiolytic, sedative, and anticonvulsant properties, making it useful in reducing anxiety and preventing nausea and vomiting. Lastly, Metoclopramide HCl is a prokinetic agent that enhances gastrointestinal motility and accelerates gastric emptying, which can be beneficial in treating gastroparesis and preventing the delayed gastric emptying associated with certain medications and conditions.
When combined, these four active ingredients provide a comprehensive approach to managing symptoms such as severe nausea, vomiting, anxiety, and allergic reactions. The rectal route of administration is particularly useful for patients who are unable to take medications orally due to vomiting or those who require rapid medication absorption. This formulation is often used in palliative care settings or in patients undergoing chemotherapy to improve their comfort and quality of life.
It is important for both patients and prescribers to understand the pharmacokinetics and pharmacodynamics of each component in this formulation, as well as the potential interactions and side effects. The use of this suppository should be guided by a healthcare professional with consideration of the patient's overall health status and other medications they may be taking. If you have any questions or require further information about this formulation, please reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide the necessary support and guidance.
This compounded medication is a combination of dexamethasone, diphenhydramine HCl, lorazepam, and metoclopramide HCl, and it is typically used to treat symptoms of nausea, vomiting, allergic reactions, anxiety, and inflammation in patients undergoing chemotherapy or other treatments that may cause these side effects.
To use the rectal suppository, wash your hands thoroughly before and after application. Remove the wrapper and moisten the suppository with water. Lie on your side with your lower leg straightened out and your upper leg bent forward. Gently insert the suppository into the rectum, narrow end first, and push it in as far as it will comfortably go. Remain lying down for a few minutes to ensure the suppository stays in place and starts to dissolve.
Yes, rectal suppositories often require refrigeration to maintain their shape and effectiveness. Store this medication in the refrigerator as directed by your pharmacist or healthcare provider.
The frequency of use for the suppository will be determined by your healthcare provider, based on your medical condition and response to treatment. Follow the prescribed dosage instructions closely and do not use it more often than recommended.
If you miss a dose, use it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double up to make up for a missed dose.
Yes, as with any medication, there may be potential side effects. Common side effects include drowsiness, dizziness, dry mouth, upset stomach, or headache. If you experience any severe side effects such as difficulty breathing, swelling, or severe abdominal pain, contact your healthcare provider immediately.
You should discuss the use of this medication if you are pregnant or breastfeeding with your healthcare provider. They will evaluate the potential risks and benefits before recommending use.
Each component of the suppository works together to provide relief. Dexamethasone is a corticosteroid that reduces inflammation, diphenhydramine HCl is an antihistamine that relieves allergies and aids in sleep, lorazepam is a benzodiazepine that helps with anxiety, and metoclopramide HCl is an antiemetic that controls nausea and vomiting.
Avoid consuming alcohol and using other central nervous system depressants while using this medication, as they may increase drowsiness and dizziness. Also, be sure to check with your healthcare provider before starting any new medications, supplements, or herbal remedies.
Unused or expired suppositories should be disposed of in a secure manner to prevent accidental ingestion or misuse. Do not flush them down the toilet. Check your local guidelines for medication disposal, or ask your pharmacist if they offer a take-back program.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
This preparation is a controlled substance. Additional prescribing, refill, and shipping restrictions apply, and the states Bayview can dispense it to are narrower than for non-controlled preparations.
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Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Insert 1 unwrapped suppository
