Check out our most popular compounded medications! Get Started
The Dexamethasone Phosphate 0.1%/Tobramycin 0.3% Nasal Spray is a compounded liquid formulation intended for intranasal delivery. This combination medication is designed to exert both anti-inflammatory and antibiotic effects within the nasal cavity.
This nasal spray is primarily used in the treatment of chronic rhinosinusitis, nasal polyposis, and other inflammatory nasal conditions where bacterial infection is present or there is a risk of infection. The dual action of the corticosteroid and antibiotic helps to alleviate symptoms such as nasal congestion, discharge, and discomfort, while also targeting the underlying bacterial pathogens.
By delivering the medication directly to the site of infection and inflammation, this nasal spray formulation offers the advantage of localized treatment, which may reduce the potential for systemic side effects commonly associated with oral or parenteral administration of these medications.
Licensed to fill prescriptions for patients in RI, MA, CT, NJ, NH, FL, ME and PA. New York patients are served on a limited basis while nonresident registration is pending.
The Dexamethasone Phosphate 0.1%/Tobramycin 0.3% Nasal Spray is a compounded medication that combines the anti-inflammatory properties of dexamethasone phosphate, a corticosteroid, with the antibiotic action of tobramycin. This liquid formulation is specifically designed for nasal administration, providing a convenient and direct delivery method for treating localized nasal conditions or for achieving systemic effects through the highly vascularized nasal mucosa. The spray form ensures a uniform distribution of the medication across the nasal passages.
Dexamethasone is a potent corticosteroid that reduces inflammation by inhibiting multiple inflammatory cytokines, resulting in decreased edema, fibrin deposition, capillary leakage, and migration of inflammatory cells. It is included in this formulation for its ability to treat bacterial infections of the nasal passages and sinuses, such as bacterial rhinosinusitis.
When combined, these two agents provide a synergistic effect for conditions where both infection and inflammation are present. The concentration of dexamethasone phosphate at 0.1% and tobramycin at 0.3% has been chosen to maximize therapeutic effects while minimizing potential side effects. The formulation is compounded under strict aseptic conditions to ensure patient safety and medication efficacy.
Patients prescribed this nasal spray should be instructed on proper administration techniques to maximize the medication's benefits and reduce the risk of side effects. Prescribers should consider the patient's medical history, potential drug interactions, and the presence of any contraindications before prescribing this medication. Regular monitoring may be necessary to assess the treatment's effectiveness and to adjust dosages or discontinue use if adverse reactions occur.
Bayview Pharmacy is committed to providing high-quality compounded medications tailored to meet individual patient needs. Our team of knowledgeable compounding pharmacists is available to answer any questions regarding the Dexamethasone Phosphate 0.1%/Tobramycin 0.3% Nasal Spray formulation. We are here to support both patients and prescribers in the safe and appropriate use of this medication. If you have any questions or require further information, please do not hesitate to reach out to us.
The combination of Dexamethasone Phosphate and Tobramycin in a nasal spray formulation is used for its anti-inflammatory and antibiotic properties, respectively. This formulation is typically prescribed for the treatment of nasal polyps, sinusitis, or other inflammatory nasal conditions where infection is a concern or has been established.
When considering drug interactions, it is important to note that systemic absorption of both dexamethasone and tobramycin can occur with nasal administration, although it is generally lower than with oral or intravenous routes. However, the potential for systemic effects and interactions still exists, especially with prolonged use or in patients with compromised nasal mucosa.
Dexamethasone may interact with drugs that induce or inhibit hepatic enzymes, particularly CYP3A4. Enzyme inducers such as phenytoin, barbiturates, rifampin, and carbamazepine may reduce the efficacy of dexamethasone by increasing its metabolism. Conversely, CYP3A4 inhibitors like ketoconazole, itraconazole, and certain protease inhibitors may increase dexamethasone levels, potentially leading to increased risk of systemic corticosteroid side effects such as adrenal suppression, osteoporosis, and immunosuppression.
Concomitant use of dexamethasone with other medications that cause immunosuppression, such as other corticosteroids, TNF blockers, or immunosuppressive drugs, can increase the risk of infections and reduce the immune response to vaccines. Caution is advised when using live or live-attenuated vaccines with this formulation.
Tobramycin may interact with other nephrotoxic or ototoxic drugs, such as aminoglycosides, cisplatin, and loop diuretics, potentially increasing the risk of kidney damage and hearing loss. Monitoring kidney function and auditory function is recommended when using this formulation in conjunction with such medications.
Additionally, the use of nonsteroidal anti-inflammatory drugs (NSAIDs) with corticosteroids may increase the risk of gastrointestinal ulceration or bleeding. Patients should be monitored for signs of gastrointestinal distress.
Patients with myasthenia gravis should use tobramycin with caution, as aminoglycosides can exacerbate muscle weakness. Similarly, patients with pre-existing renal impairment should be closely monitored due to the potential for tobramycin to cause nephrotoxicity.
It is crucial for prescribers to review the patient's current medication list for potential interactions before prescribing this nasal spray formulation. Patients should be advised to inform their healthcare provider of all medications they are taking, including over-the-counter drugs and herbal supplements. If you have any questions or require further information regarding drug interactions with this formulation, please reach out to us at Bayview Pharmacy for assistance.
The Dexamethasone Phosphate 0.1%/Tobramycin 0.3% Nasal Spray is a compounded medication that combines the anti-inflammatory effects of dexamethasone phosphate, a corticosteroid, with the antibiotic properties of tobramycin. This liquid formulation is designed to be delivered as a spray, allowing for direct application to the nasal cavity. The spray mechanism ensures that the medication is dispersed evenly throughout the nasal passages, targeting the site of infection or inflammation.
Dexamethasone phosphate is a potent corticosteroid that works by reducing inflammation and suppressing the immune response in the nasal mucosa. This can be particularly beneficial in treating allergic rhinitis, nasal polyps, and other inflammatory conditions of the nasal passages. It operates by inhibiting the release of substances in the body that cause inflammation, thereby reducing swelling, redness, and pain.
It functions by binding to the bacterial ribosome, inhibiting protein synthesis, and ultimately leading to bacterial cell death. This makes it useful in treating bacterial infections of the nasal passages, such as bacterial sinusitis.
When combined, these two agents work synergistically to both reduce the symptoms of inflammation and eliminate the bacterial infection that may be present. The nasal spray formulation allows for the medication to be absorbed locally within the nasal passages, which can provide quick relief from symptoms. Additionally, some systemic absorption may occur, which can contribute to treating infections or inflammation that extend beyond the local site.
This nasal spray is particularly useful for patients who require both an anti-inflammatory and antibiotic treatment for their nasal condition. It is important for prescribers to consider the patient's medical history, potential allergies, and the presence of any other nasal conditions before prescribing this medication. Patients should be instructed on the proper use of the nasal spray to ensure optimal delivery of the medication.
For more detailed information on the Dexamethasone Phosphate 0.1%/Tobramycin 0.3% Nasal Spray, or if you have any questions regarding this formulation, please do not hesitate to reach out to us at Bayview Pharmacy. Our team of compounding pharmacists is here to provide guidance and support to both patients and prescribers to ensure the safe and appropriate use of this medication.
This nasal spray is a compounded medication used to treat nasal conditions that may benefit from the potent anti-inflammatory properties of dexamethasone phosphate, in combination with the broad-spectrum antibiotic tobramycin to treat or prevent bacterial infections. It is typically prescribed for conditions where local treatment in the nasal cavity is beneficial or necessary.
The spray delivers a combination of dexamethasone phosphate and tobramycin directly to the nasal cavity. Dexamethasone phosphate is a corticosteroid that reduces inflammation and immune responses, while tobramycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis, effectively eliminating susceptible bacterial pathogens.
It is important to follow your doctor's specific instructions when using this nasal spray. Generally, you should gently shake the bottle, clear the nostrils, tilt your head slightly forward, insert the nozzle into one nostril, press the pump to deliver the prescribed number of sprays while inhaling gently, and then repeat in the other nostril if directed. Do not blow your nose immediately after using the spray.
Side effects can include nasal irritation, dryness, or discomfort, bleeding or sores in the nose, and allergic reactions. Systemic side effects are less common due to the localized administration but may include suppression of the immune system, weight gain, and elevation of blood sugar. Consult your healthcare provider if you experience unusual symptoms.
Pregnancy and breastfeeding may require special consideration as corticosteroids and aminoglycosides can potentially have effects on the fetus or infant. It is imperative to consult your healthcare provider before using this nasal spray if you are pregnant, planning to become pregnant, or are breastfeeding.
The safety and efficacy of Dexamethasone Phosphate/Tobramycin Nasal Spray in children have not been fully established. Use in pediatric patients should be under the direct supervision of a physician and with careful consideration of the potential benefits against potential risks.
Using other nasal products in conjunction with this nasal spray could lead to increased nasal irritation or other adverse interactions. Always consult with a healthcare provider before combining treatments to ensure safety and efficacy.
The spray should be stored at room temperature away from direct sunlight and heat. Do not freeze. Keep the bottle tightly closed and out of reach of children. Follow any additional storage instructions provided by the compounding pharmacy or your healthcare provider.
If you miss a dose, administer it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and return to your regular dosing schedule. Do not double up on doses to make up for a missed one.
Long-term use of any medication including corticosteroids may lead to complications such as the development of tolerance, dependence, or side effects like nasal mucosa changes or systemic effects from the corticosteroid component. It's important to have regular medical check-ups and discuss the duration of treatment with your healthcare provider to avoid potential complications.
This formulation is compounded by Bayview Pharmacy on a prescriber's order for an individual patient. It is not an FDA-approved drug product, and the FDA has not evaluated it for safety, effectiveness, or manufacturing quality.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice. Discuss your situation with a licensed healthcare provider.
Search by NCPDP 4106882, or by name and ZIP: Bayview Pharmacy, Warwick, RI 02886. Select it as the destination pharmacy and save it as a favorite. Click any value to copy it.
Compounded preparations have no NDC, so this formula will not appear in your EHR's drug search. Use your system's compound, non-formulary, or free-text prescription entry and name the preparation exactly as written in step 3. If your EHR forces you to pick a listed drug, pick the closest entry for the active ingredient and put the full formula in the prescription body (the Sig or directions field), not in Notes to Pharmacy.
Compounded preparations have no NDC and will not appear in your drug search. For EPCS to validate, select a drug entry your EHR recognizes as controlled, usually the bulk powder entry for the active ingredient (for example Ketamine (bulk) powder, not a branded product), then put the full formula from step 3 in the prescription body. A free-text entry that does not validate as controlled will be rejected by your EPCS module.
Quantity and directions are starting points for this dose form, not treatment recommendations. Dosing remains the prescriber's responsibility.
Transmit from your EHR. For this non-controlled preparation we also accept fax to (401) 284-4506 and phoned orders at (401) 284-4505. Order forms are on the formulation pages and in the prescriber portal.
Transmit with two-factor authentication through your EPCS-enabled EHR. No order form is offered for this preparation; e-prescribing guides for our controlled preparations are on the formulation pages.
Licensed to dispense in RI, MA, CT, NJ, NH, FL, ME, and PA; New York is served on a limited basis while nonresident registration is pending. Compounded preparations are not FDA-approved. A valid prescription is required. Full guide, including steps by EHR: How to e-prescribe to Bayview. Questions about this formula: call (401) 284-4505.
Inhale intranasally
