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Amphotericin B is a potent antifungal agent widely used in the treatment of severe systemic fungal infections.
Amphotericin B is a potent antifungal agent widely used in the treatment of severe systemic fungal infections. It belongs to the polyene class of antifungals and works by binding to ergosterol, a key component of fungal cell membranes, leading to increased membrane permeability and ultimately cell death. This mechanism makes Amphotericin B effective against a broad spectrum of fungi, including Candida, Aspergillus, and Cryptococcus species.
Despite its efficacy, Amphotericin B is known for its potential nephrotoxicity and infusion-related reactions, which necessitate careful monitoring and management during treatment. In compounding pharmacy settings, formulations of Amphotericin B are tailored to optimize therapeutic outcomes while minimizing adverse effects. These formulations may include lipid-based preparations that have been shown to reduce toxicity and improve patient tolerance.
Amphotericin B is often reserved for serious infections where other antifungal treatments have failed or are not suitable, underscoring its importance in the antifungal armamentarium. Prescribers should consider patient-specific factors, such as renal function and potential drug interactions, when selecting Amphotericin B as a treatment option. The versatility of compounded formulations allows for personalized dosing regimens, which can be crucial in managing complex fungal infections effectively.
Each of these is compounded to order at our Warwick, Rhode Island pharmacy and requires a prescription.
A sample of preparations from our formulary. Strengths and dose forms are customised to the prescription.
It is prescribed for vaginal yeast that has not responded to standard azole treatment such as fluconazole, most often non-albicans species like Candida glabrata. Topical amphotericin B appears among the options in IDSA candidiasis guidance for azole-refractory cases; it is not part of CDC treatment guidance. Your prescriber decides whether it is appropriate for you.
Amphotericin B is an antifungal. Given by vein in the hospital for life-threatening fungal infections, it can damage the kidneys and cause fever-and-chills infusion reactions. The preparations described here are topical, eye drops, a nasal spray, or a vaginal suppository or cream, and are barely absorbed, so those body-wide toxicities are not expected by these routes.
Other salt forms of this molecule, and ingredients commonly compounded alongside it.
This page describes an active pharmaceutical ingredient, not a finished drug product. Bayview Pharmacy compounds preparations containing it only on a prescriber's order for an individual patient.
Compounded preparations are not FDA-approved, and the FDA has not evaluated them for safety, effectiveness, or manufacturing quality. Nothing on this page is a claim that any preparation is effective for any condition.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.
Our pharmacists work with prescribers to build preparations around a patient's dose, form and tolerances. Ask us what is possible with this ingredient.
