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Cisapride Monohydrate is a prokinetic agent primarily used to enhance gastrointestinal motility by increasing the release of acetylcholine at the myenteric plexus.
Cisapride Monohydrate is a prokinetic agent primarily used to enhance gastrointestinal motility. It functions by increasing the release of acetylcholine at the myenteric plexus, thereby stimulating peristalsis and improving gastric emptying. This mechanism makes it particularly beneficial in managing conditions like gastroesophageal reflux disease (GERD) and gastroparesis, where delayed gastric emptying is a concern.
Despite its efficacy, Cisapride Monohydrate's use is limited due to potential cardiac side effects, such as QT interval prolongation, which can lead to serious arrhythmias. Therefore, it is typically reserved for patients who have not responded to other treatments and is often used under strict medical supervision. Compounded formulations of Cisapride Monohydrate allow for tailored dosing, which can be crucial in minimizing risks while maximizing therapeutic benefits.
In a compounding pharmacy setting, Cisapride Monohydrate can be customized to meet specific patient needs, offering flexibility in administration forms and dosages. This customization is particularly advantageous for pediatric or geriatric patients who may require non-standard doses or alternative delivery methods. By providing a personalized approach, compounded Cisapride Monohydrate formulations can improve patient adherence and outcomes in managing complex gastrointestinal disorders.
Each of these is compounded to order at our Warwick, Rhode Island pharmacy and requires a prescription.
A sample of preparations from our formulary. Strengths and dose forms are customised to the prescription.
Veterinarians most often prescribe cisapride for cats with constipation or megacolon, a large, poorly-contracting colon, to help move contents through the gut. It is also used for other motility problems and in dogs.
The human product (Propulsid) was withdrawn from the US market over rare heart-rhythm risks, and no FDA-approved animal version was ever made. It is available only through compounding, used off-label at your veterinarian's direction.
Other salt forms of this molecule, and ingredients commonly compounded alongside it.
This page describes an active pharmaceutical ingredient, not a finished drug product. Bayview Pharmacy compounds preparations containing it only on a prescriber's order for an individual patient.
Compounded preparations are not FDA-approved, and the FDA has not evaluated them for safety, effectiveness, or manufacturing quality. Nothing on this page is a claim that any preparation is effective for any condition.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.
Our pharmacists work with prescribers to build preparations around a patient's dose, form and tolerances. Ask us what is possible with this ingredient.
