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Active pharmaceutical ingredient

Propafenone Hydrochloride

Propafenone Hydrochloride is a potent antiarrhythmic agent primarily used to manage and treat certain types of serious irregular heartbeats, such as atrial fibrillation and ventricular arrhythmias.

Compounded to order
Prescription required
Warwick, Rhode Island

About this ingredient

Propafenone Hydrochloride is a potent antiarrhythmic agent used primarily in the management of various cardiac arrhythmias. It functions by blocking sodium channels, which stabilizes the cardiac cell membrane and reduces excitability, thereby helping to restore normal heart rhythm. This mechanism of action makes it particularly effective in treating conditions such as atrial fibrillation, ventricular tachycardia, and other supraventricular arrhythmias.

Due to its beta-blocking properties, Propafenone Hydrochloride also exhibits mild non-selective beta-adrenergic blocking activity, which can contribute to its antiarrhythmic effects. It is important for prescribers to consider the pharmacokinetics of Propafenone, as it is metabolized primarily in the liver and exhibits a high degree of first-pass metabolism. This can lead to variability in plasma concentrations among patients, necessitating careful dose adjustments and monitoring.

Propafenone Hydrochloride is available in various formulations, allowing for tailored therapeutic approaches to meet individual patient needs. Its use requires careful consideration of potential drug interactions, as it can interact with other medications metabolized by the cytochrome P450 system. Additionally, prescribers should be aware of contraindications, such as in patients with significant structural heart disease or severe obstructive pulmonary disease, due to the risk of exacerbating these conditions.

Overall, Propafenone Hydrochloride is a valuable tool in the management of arrhythmias, offering flexibility in treatment regimens. Its efficacy and safety profile make it a preferred choice for many healthcare providers, provided that patient-specific factors are thoroughly evaluated to optimize therapeutic outcomes. As with any antiarrhythmic therapy, ongoing monitoring and patient education are crucial to ensure effective and safe use of Propafenone Hydrochloride in clinical practice.

Available formulations

Compounded formulations containing this ingredient

Each of these is compounded to order at our Warwick, Rhode Island pharmacy and requires a prescription.

We do not have a patient page for this ingredient yet. That does not mean we cannot make it. Bayview compounds this ingredient to a prescriber's order, and our full compounding formulary lists every preparation we make. Viewing the formulary requires a prescriber account.

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Compounding formulary

Formulas we compound with this ingredient

A sample of preparations from our formulary. Strengths and dose forms are customised to the prescription.

Common questions

Frequently asked questions

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Related

Related active ingredients

Other salt forms of this molecule, and ingredients commonly compounded alongside it.

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Important information

This page describes an active pharmaceutical ingredient, not a finished drug product. Bayview Pharmacy compounds preparations containing it only on a prescriber's order for an individual patient.

Compounded preparations are not FDA-approved, and the FDA has not evaluated them for safety, effectiveness, or manufacturing quality. Nothing on this page is a claim that any preparation is effective for any condition.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.

Talk to a compounding pharmacist

Our pharmacists work with prescribers to build preparations around a patient's dose, form and tolerances. Ask us what is possible with this ingredient.