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Scopolamine Hydrobromide is an anticholinergic (antimuscarinic) medicine that Bayview compounds to a prescriber's order.
Scopolamine hydrobromide is an anticholinergic (antimuscarinic) agent. FDA-approved scopolamine is indicated for the prevention of nausea and vomiting associated with motion sickness and with recovery from anesthesia and surgery.[2] Scopolamine is a competitive inhibitor at postganglionic muscarinic receptor sites of the parasympathetic nervous system.[2] Off-label uses described in the literature include gastrointestinal spasms.[1]
Its pharmacological action extends to the central nervous system, where at therapeutic doses it mostly produces sedation, along with antiemetic and amnestic effects; excitement and restlessness can occur at higher doses.[1]
Other off-label uses that have been described include depression.[1] The FDA-approved dosage form is a transdermal system (patch). Bayview's scopolamine transdermal gel is a compounded preparation made on a prescriber's order; compounded preparations are not FDA-approved, and FDA does not verify their safety, effectiveness, or quality.[3]
Prescribers should be aware of its side effect profile, which includes dry mouth, drowsiness, dizziness, and blurred vision.[2][1] Scopolamine is contraindicated in angle-closure glaucoma, and neuropsychiatric reactions such as confusion, agitation, and hallucinations have been reported.[2]
Compounded at Bayview
Patient guides for the preparations we make most often. Each one is compounded to order and requires a prescription.
For prescribers
Every preparation in our formulary that contains this ingredient. Strength, base and dose form are set by the prescription.
Scopolamine, the medicine in the motion sickness patch, prepared by Bayview as a transdermal gel, oral capsules or troches, an oral suspension, or a nasal spray in the strength your prescriber orders. In the United States scopolamine is manufactured only as the patch and an injection, so the other forms are compounded. They are not FDA-approved, their use is off-label, and a prescription is required.
Anyone with angle-closure glaucoma or an allergy to scopolamine or other belladonna alkaloids. Talk with your prescriber first if you have an enlarged prostate or trouble urinating, a bowel obstruction, a seizure disorder, heart disease, myasthenia gravis, or a history of psychosis, if you are over 65, or if you are pregnant or breastfeeding. It is not established as safe in children, and other anticholinergic medicines and sedatives add to its effects.
Other salt forms of this molecule, and ingredients commonly compounded alongside it.
This page describes an active pharmaceutical ingredient, not a finished drug product. Bayview Pharmacy compounds preparations containing it only on a prescriber's order for an individual patient.
Compounded preparations are not FDA-approved, and the FDA has not evaluated them for safety, effectiveness, or manufacturing quality. Nothing on this page is a claim that any preparation is effective for any condition.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.
Our pharmacists work with prescribers to build preparations around a patient's dose, form and tolerances. Ask us what is possible with this ingredient.
