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Active pharmaceutical ingredient

Simvastatin

Simvastatin is a lipid-lowering medication primarily used to manage high cholesterol and reduce the risk of cardiovascular disease.

Compounded to order
Prescription required
Warwick, Rhode Island

About this ingredient

Simvastatin is a lipid-lowering medication that belongs to the class of drugs known as statins, which are widely used to manage hyperlipidemia and reduce the risk of cardiovascular disease. It functions by inhibiting HMG-CoA reductase, an enzyme crucial for cholesterol biosynthesis in the liver, thereby decreasing low-density lipoprotein (LDL) cholesterol and triglycerides while modestly increasing high-density lipoprotein (HDL) cholesterol levels.

Due to its efficacy in lowering cholesterol, simvastatin is often prescribed for patients with elevated cholesterol levels, particularly those at risk for atherosclerosis-related conditions such as coronary artery disease, stroke, and peripheral vascular disease. The therapeutic benefits of simvastatin extend beyond lipid regulation, as it also exhibits anti-inflammatory properties and improves endothelial function, contributing to its protective cardiovascular effects.

Simvastatin is typically administered orally, and its dosage may vary based on the patient's specific medical condition, response to treatment, and concurrent use of other medications. It is crucial for prescribers to consider potential drug interactions, as simvastatin is metabolized by the cytochrome P450 3A4 enzyme, and concomitant use with certain drugs can increase the risk of myopathy and rhabdomyolysis.

Patients on simvastatin therapy should be monitored regularly for liver function and muscle-related side effects, as these are important considerations in the management of treatment. Additionally, lifestyle modifications such as diet, exercise, and weight control are recommended to enhance the effectiveness of simvastatin in achieving optimal lipid levels and reducing cardiovascular risk.

Available formulations

Compounded formulations containing this ingredient

Each of these is compounded to order at our Warwick, Rhode Island pharmacy and requires a prescription.

We do not have a patient page for this ingredient yet. That does not mean we cannot make it. Bayview compounds this ingredient to a prescriber's order, and our full compounding formulary lists every preparation we make. Viewing the formulary requires a prescriber account.

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Compounding formulary

Formulas we compound with this ingredient

A sample of preparations from our formulary. Strengths and dose forms are customised to the prescription.

Common questions

Frequently asked questions

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Related

Related active ingredients

Other salt forms of this molecule, and ingredients commonly compounded alongside it.

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Important information

This page describes an active pharmaceutical ingredient, not a finished drug product. Bayview Pharmacy compounds preparations containing it only on a prescriber's order for an individual patient.

Compounded preparations are not FDA-approved, and the FDA has not evaluated them for safety, effectiveness, or manufacturing quality. Nothing on this page is a claim that any preparation is effective for any condition.

A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.

Talk to a compounding pharmacist

Our pharmacists work with prescribers to build preparations around a patient's dose, form and tolerances. Ask us what is possible with this ingredient.