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Trilostane is a potent active pharmaceutical ingredient primarily used in the management of endocrine disorders, particularly in the treatment of hyperadrenocorticism, commonly known as Cushing's syndrome.
Trilostane is a potent inhibitor of the enzyme 3β-hydroxysteroid dehydrogenase, which plays a crucial role in the biosynthesis of adrenal steroids, including cortisol and aldosterone. By blocking this enzyme, Trilostane effectively reduces the production of these steroids, making it a valuable therapeutic agent in the management of conditions like Cushing's syndrome and primary hyperaldosteronism.
In veterinary medicine, Trilostane is commonly used to treat hyperadrenocorticism in dogs, a condition analogous to Cushing's syndrome in humans. Its ability to modulate steroid production helps in alleviating symptoms associated with excessive cortisol levels, such as increased thirst, urination, and appetite.
Trilostane's pharmacokinetics involve rapid absorption and metabolism, with its effects typically observed within a few hours of administration. The compound is metabolized primarily in the liver, and its metabolites are excreted via the kidneys, necessitating careful dose adjustments in patients with hepatic or renal impairments.
Prescribers should be aware of potential side effects, including electrolyte imbalances, gastrointestinal disturbances, and adrenal insufficiency, which may require monitoring and dose adjustments. Regular monitoring of adrenal function and electrolyte levels is recommended to ensure therapeutic efficacy and minimize adverse effects.
Trilostane's use in compounded formulations allows for tailored dosing regimens, providing flexibility in managing individual patient needs. This customization is particularly beneficial in cases where commercially available dosages do not align with the specific requirements of the patient, ensuring optimal therapeutic outcomes.
Each of these is compounded to order at our Warwick, Rhode Island pharmacy and requires a prescription.
A sample of preparations from our formulary. Strengths and dose forms are customised to the prescription.
Veterinarians prescribe trilostane to help manage Cushing's disease (hyperadrenocorticism) in dogs, a condition of too much cortisol. It lowers the cortisol the adrenal glands produce.
Yes, Vetoryl is FDA-approved for dogs in fixed capsule sizes. Bayview compounds trilostane only when your veterinarian needs a strength between those sizes for an individual dog. The compounded version is not FDA-approved.
Other salt forms of this molecule, and ingredients commonly compounded alongside it.
This page describes an active pharmaceutical ingredient, not a finished drug product. Bayview Pharmacy compounds preparations containing it only on a prescriber's order for an individual patient.
Compounded preparations are not FDA-approved, and the FDA has not evaluated them for safety, effectiveness, or manufacturing quality. Nothing on this page is a claim that any preparation is effective for any condition.
A valid prescription is required. Availability depends on Bayview's licensure in your state. This page is general information, not medical advice — discuss your situation with a licensed healthcare provider.
Our pharmacists work with prescribers to build preparations around a patient's dose, form and tolerances. Ask us what is possible with this ingredient.
